Best Operating Grants for Nonprofits in Virginia

The Small Business Transition Grant for New Entrepreneurs, funded by the NIH, supports new investigators in entrepreneurship. This grant aims to enhance the entrepreneurial skills of researchers while facilitating their research and development efforts in small businesses. It encourages the employment of Program Directors/Principal Investigators (PDs/PIs) who possess strong scientific expertise but limited entrepreneurial experience, fostering innovation aligned with NIH's mission to improve health and save lives.

Scholarships support aspiring college students who hold the promise of tomorrow’s progress.

Together, our competitive grants and scholarships help our region rise thanks to the vision and generosity of our donors.

Thomas William Bennett Memorial Scholarship Fund

He believed that a person could do anything if they sat down and read how to do it. When WWII started, he was the first man from the state of South Carolina to enlist in the U.S. Army. He quickly rose to captain and spent most of the war in the Pacific (the Queen of Fiji considered him a friend). Later, Thomas had a long career at Harcourt Brace publishing.

The Michael J. Campbell Memorial Scholarship supports high school seniors in vocational programs and college freshmen pursuing degrees in construction-related fields. Established by The Community Foundation for the Greater Capital Region, this scholarship aims to empower students from Albany, Columbia, Greene, Rensselaer, Saratoga, Schenectady, Schoharie, Warren, and Washington Counties in New York. The program reflects the foundation's commitment to enhancing community quality of life through education and opportunity.

Stealth Biotherapeutics is dedicated to supporting innovative programs that enhance disease awareness and therapeutic management. Their charitable contributions focus on accredited institutions, promoting educational initiatives for health care providers and patient communities. Funding is prioritized for unique and cost-effective projects that align with their therapeutic interests, including rare genetic disorders, neurodegenerative diseases, and ophthalmic conditions. By fostering community awareness, they aim to make a significant impact in the healthcare landscape.

The Kretler Scholarship offers up to $1,000 to high school seniors from selected schools in Noble County pursuing degrees in Tool and Die or Mechanical Engineering. This scholarship aims to support students in achieving their educational goals, reflecting the commitment of its donors to invest in local talent. Eligible candidates must maintain a GPA of 3.00 and can reapply in subsequent years, fostering continued academic success in their chosen fields.

Holcomb Family Education Scholarship

This scholarship was established in 2008 by the Hall County Optimist Club to honor long-time educators, J.H. Holcomb and his sisters, Margaret, Mildred, and Nell. Applicants must have demonstrated financial need and have a minimum 3.0 GPA. In 2026, one scholarship award of $1,000 will be offered.

The Ford Philanthropy Scholarship, offered by the LULAC National Educational Service Centers (LNESC), supports students pursuing STEM careers in the automotive and mobility sectors. It covers tuition, fees, and essential resources, enabling students to thrive academically. Applicants must major in relevant fields such as Computer Science or Engineering and maintain a GPA of 3.5 or higher. This initiative enhances educational access and fosters leadership, preparing students for future success.

The Damon Runyon Physician-Scientist Training Award aims to address the shortage of physician-scientists by supporting U.S. Specialty Board eligible physicians in cancer research. This award provides funding for up to four years, enabling awardees to dedicate 80% of their time to research while maintaining clinical skills. The program seeks to eliminate financial barriers, allowing talented clinicians to transform into leading researchers capable of advancing cancer treatment and prevention.

Alliance for Cancer Gene Therapy

Unlike surgery, chemotherapy and radiation, cell and gene therapies harness the power of your immune system to destroy cancer cells without harming healthy tissue. We fund the research that will make this vision a reality.

Collaborating with partners and funding research fellows, we are transforming cancer treatments today while bringing the world closer to a cure for all cancers tomorrow.

ACGT Investigator Award in Cell and Gene Therapy for SOLID TUMOR CANCERS 

Purpose

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds breakthrough research that is transforming cancer treatment through cell and gene therapy. This ACGT grant award is for those conducting translational cell and gene therapy research specifically in solid tumor cancers.

Research Objectives

Cell and gene therapy for solid tumors poses major challenges driven by antigen heterogeneity, physical exclusion, immunosuppressive microenvironments, genomic instability, and safety limitations. This RFA seeks innovative, translational cell and gene therapy strategies that directly address these barriers.

Proposed approaches should demonstrate the capacity to: (1) overcome antigen escape through multi-targeted designs that broaden patient populations and account for heterogeneity and resistance due to antigen loss; (2) enhance trafficking, infiltration, and persistence within solid tumor sites; (3) resist or reprogram the immunosuppressive tumor microenvironment; and (4) incorporate built-in safety and controllability mechanisms suitable for clinical translation. Successful proposals will integrate these elements to enable durable, precise, and scalable therapeutic impact in solid tumors.

Building on the priorities outlined above, this RFP encourages proposals spanning a broad range of cell and gene therapy (CGT) platforms and rational combinations, including but not limited to:

• Engineered T Cell Approaches
• Innate and Alternative Immune Cell Platforms
• Gene Editing & Synthetic Biology Strategies
• Microenvironment-Modulating Strategies
• Combinatorial Approaches

Proposals that integrate multiple strategies to overcome trafficking, suppression, antigen escape, and safety barriers in a coordinated manner are strongly encouraged. Preference will be given to approaches with clear mechanistic rationale and a credible path toward clinical translation in solid tumors.

About Americans for the Arts

Building Collective Power for the Arts

Americans for the Arts is the nation's leading arts advocacy organization. We mobilize advocates, produce trusted research, and secure bipartisan wins that protect funding and expand arts access nationwide — work we've been doing for more than 65 years.

Americans for the Arts advances the people, organizations, and systems supporting arts and culture across America through advocacy, research, and national convening.

We envision a nation where freedom of creative expression is upheld as a fundamental human right, where arts and culture are woven into the fabric of civic life, resourced in every community, and accessible to everyone.

Request for Proposals (RFP)

Strengthening Leadership Capacity of Local Arts Agencies

Given the essential role of LAAs, and to meet this important moment, AFTA seeks an energized and experienced consulting team with expertise to help it develop a comprehensive strategy to strengthen leadership and field capacity across the LAA ecosystem. This work is not intended to operate in isolation, but rather to complement and build upon existing efforts already underway in the field. The focus is on identifying where AFTA can add value through targeted, strategic support that enhances and aligns with broader sector-wide initiatives. 

This effort will focus on empowering LAA agency leaders—a critical component of AFTA’s strategic direction—to expand their capacity, foster innovation, and advance equity in a rapidly evolving environment. Building on existing efforts across the field, AFTA will invest in strong, effective LAA leadership, broaden cultural access and participation nationwide, and position the field for a more vibrant, resilient, and sustainable future. 

With approximately 2,200 LAAs nationally validated in AFTA’s LAA Wayfinder, the selected consulting team will help AFTA gain a deeper understanding of the gaps, needs and opportunities shaping LAA leadership capacity, with attention to Native, rural, small, midsize, and large communities, and identify where AFTA is uniquely positioned to contribute. These insights will guide AFTA’s future direction in its service to LAAs nationwide and ensure AFTA’s contributions complement—rather than duplicate—the work of other entities, collectively strengthening the broader LAA ecosystem.  

In addition, by intentionally working in partnership with peer organizations and stakeholders across the field—and by understanding gaps in coverage and opportunities for growth—AFTA will be positioned to work with partners to support the expansion of the LAA network in communities where local public cultural infrastructure is limited or absent. This collaborative approach will help ensure more equitable access to arts and culture while reinforcing the role of LAAs as essential community anchors, particularly in underserved regions. 

The National PTA Outstanding Advocacy Awards recognize exemplary efforts by state, local, and individual PTA advocates dedicated to improving the education, health, and well-being of children. Established by the National PTA, these awards highlight four categories of advocacy: Outstanding State PTA Advocacy, Outstanding Local PTA Advocacy, Shirley Igo Advocate of the Year, and Outstanding Youth Advocate of the Year. Awardees will be celebrated at the National PTA’s Legislative Conference in March 2026.

The Park Foundation Grants for Civic Participation aim to enhance democracy through active civic engagement. Focused on mobilizing voters and protecting their rights, this program supports grassroots organizations addressing social injustices. By fostering year-round involvement rather than just election-focused efforts, the foundation seeks to empower communities and ensure robust participation in the democratic process, ultimately contributing to a more equitable society.

The Community Foundation Of The Dan River Region

The Community Foundation of the Dan River Region (commonly known as The Foundation) is an independent public charity established in September 1996 by a group of local civic leaders to create permanent charitable resources for the region. Originally named the DPC Community Foundation, it serves areas including Danville, Pittsylvania and Halifax counties in Virginia as well as Caswell County in North Carolina. The Foundation’s mission is to improve and enrich the lives of residents by encouraging and facilitating donations, managing and investing those gifts responsibly, and distributing funds in alignment with donor intentions while addressing community needs. It envisions a region recognized for its generous communities, high quality of life, and support for those in need. The Foundation operates with values of transparency, equity, effective operations, strong community relationships, and celebration of local success stories. It is accredited under national community foundation standards and invests pooled charitable assets to make grants and awards that create lasting impact throughout its service area.

William H. Payne Jr. and Agnes T. Payne Scholarship Fund

The William H. Payne Jr. and Agnes T. Payne Scholarship Fund provides financial assistance to graduating students from Danville, Pittsylvania County, Halifax County, or Caswell County who are majoring in education. Preference is given to students who have completed two years of post-secondary education and to those attending a local four-year university who intend to pursue teaching careers within the Foundation’s service area. The scholarship supports the preparation of future educators and encourages graduates to return and serve their local communities.

The Northeast Asia Council Japan Studies Grants support American citizens and permanent residents conducting scholarly research on Japan within the U.S. Offering up to $2,500, including daily expenses, these grants aim to enhance the quality of teaching and research in Japanese studies. Eligibility includes being an AAS member and not having received funding in the last three years. Applications are reviewed based on project merit and financial need, prioritizing those with limited access to institutional funding.

The Japanese Teaching Material Purchase Grant, provided by the Japan Foundation, Los Angeles, supports U.S. educational institutions in acquiring resources for Japanese language courses. Grants, not exceeding $1,000, can be used for textbooks, audio-visual aids, and other teaching materials. Eligible applicants include non-profit organizations and Japanese heritage schools. However, the grant does not cover electronics or consumable supplies, and materials purchased become institutional property, not personal.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

Awards

The NRA is proud to recognize the contributions of those who have demonstrated dedication to the promotion of the Second Amendment, significantly impacted the preservation of the shooting sports, advanced the purposes and goals of the NRA and exemplified leadership through public service. Each year, women, youth, clubs, law enforcement officers and NRA Foundation volunteers are awarded for their efforts in pursuit of these principles.

NRA Law Enforcement Officer Of The Year Award

NRA's Law Enforcement Officer of the Year Award was established in 1993 and recognizes an exceptional act or service by a law enforcement officer and is administered by the NRA Law Enforcement Division. Nominations are accepted from anyone having knowledge of the nominee's actions. This includes, but is not limited to, the nominee's agency head, other law enforcement officials, elected officials, fellow officers, community leaders, interested citizens, and NRA members.

The Owen Family Foundation Grant supports charitable organizations primarily in East Texas and the Minneapolis/St. Paul area, focusing on health, education, human services, and religious initiatives. Organizations must have a 501(c)(3) status and past funding is required for Twin Cities applicants. The foundation is committed to promoting philanthropy and ensuring access to funding for eligible charities, while maintaining a non-discriminatory policy.

The DARPA Tactical Technology Office (TTO) seeks innovative proposals to enhance national security through cutting-edge technology. This initiative focuses on Design/Build/Buy, Surge and Sustain, Long Range Effects, and Disruptive Innovation. By fostering rapid adaptation and sustainable force structures, TTO aims to demonstrate revolutionary systems that are not only effective but also affordable and responsive to emerging challenges.

The FY 2027 DoN HBCU/MI Program aims to enhance the research capabilities of Historically Black Colleges and Universities and Minority Institutions. This initiative promotes innovative solutions to naval science challenges while engaging students and faculty in STEM fields. Key objectives include strengthening research infrastructure and fostering collaborative efforts across institutions. White papers are due by September 18, 2026, and should clearly outline the proposed advancements in naval-relevant science and technology.

The EDA FY25 Disaster Supplemental program provides critical funding to support communities recovering from severe economic distress caused by natural disasters in 2023 and 2024. With no submission deadlines for Readiness and Implementation Paths, and a specific deadline for Industry Transformation applications, this initiative aims to enhance community resilience and improve economic trajectories through strategic projects that engage local stakeholders and private industries.

The Domtar Community Investment Grant supports nonprofits and charities in areas where the company operates, focusing on education, environmental sustainability, and community humanitarian needs. Eligible organizations include charitable groups, while ineligible entities encompass individuals, discriminatory organizations, and political causes. Applications are accepted online from January 1 to November 30, with reviews conducted bi-monthly. This initiative aims to create meaningful connections between charitable efforts and the social benefits derived from Domtar's business operations.

The XENO PRIZE for Artists’ Books offers a $5000 grant to support the publication of an artist's book addressing the themes of book banning and burning. Open to independent artists in the U.S., the prize will be awarded based on submissions to be accepted starting March 1, 2025. A minimum of 100 copies must be printed, with winners announced in September 2025. This initiative aims to highlight and preserve avant-garde art forms and their cultural significance.

The Edward M. Nagel Endowed Scholarship, provided by the United Negro College Fund, supports undergraduate students pursuing business-related studies. With a focus on academic excellence and leadership, applicants must maintain a GPA of 3.0 or higher and demonstrate financial need. This scholarship plays a vital role in promoting education for future leaders, reflecting UNCF's mission to empower minority students for over seventy years.

The Robert Glenn Rapp Foundation, established in 1951 in Oklahoma, aims to support charitable organizations across the U.S., with a focus on education and local initiatives. Grants are awarded to qualified 501(C)(3) organizations, prioritizing projects that align with the foundation's mission in areas such as education, health, arts, and literacy. Interested applicants must submit a Letter of Inquiry before applying for funding, ensuring alignment with the foundation's priorities.

The Dorsey & Whitney Foundation Grant supports charitable initiatives in communities where Dorsey attorneys reside. Established in 1982, it focuses on organizations that provide legal services to the disadvantaged and engages attorneys in volunteer roles. Each year, around 200 direct grants are awarded across North America, alongside additional support for numerous other organizations through a matching program. This commitment highlights the foundation's dedication to cultural, civic, educational, and social welfare.

Academy Sports + Outdoors, a leading sporting goods retailer, supports community initiatives by providing donations to registered 501(c)(3) organizations. Their focus is on promoting safety and responsibility in sports and outdoor activities. Proposals must foster community engagement and must not be affiliated with religious or political groups. Events should take place in areas with Academy stores, ensuring a positive local impact while encouraging active lifestyles and connection among community members.

The Piñon Foundation Grant supports 501(c)(3) organizations and educational institutions focused on enhancing the education, health, and well-being of children and the elderly. Although it primarily funds initiatives in West Texas, the Dallas Fort Worth area, and Oklahoma City, it is open to proposals from other regions that can positively impact community growth. The foundation believes in the transformative power of education and health to foster community success and development.