Best Small Grants for Nonprofits in West Virginia

Beatrice T. And Virgil D. Gutierrez Legacy Scholarship

The Beatrice T. Gutierrez and Virgil D. Gutierrez Legacy Scholarship was established in 2018 by the children of Beatrice and Virgil Gutierrez. Mr. and Mrs. Gutierrez devoted their lives to teaching in Taos Public Schools.

The scholarship will be available to seniors graduating from High Schools in Taos County, with a preference to those students who intend to pursue studies in mathematics, education or science (including but not limited to social, biological and environmental sciences) by attending a 4 year college or university with an overall goal of providing service to their family and/or community upon graduation. The 4 year institution award is up to $14,000, paid out across 4 years if a 3.0 GPA is maintained.

The scholarship will also be available to seniors graduating from High Schools in Taos County, with a preference to those students who intend to pursue a 2-year vocational program with an overall goal of providing service to their family and/or community upon graduation. The 2 year institution award is up to $4,000, paid out across 2 years.

The Distressed Cities Technical Assistance (DCTA) Program provides competitive funding for eligible applicants to deliver technical assistance to local governments serving economically distressed communities of 50,000 or fewer residents. Selected awardees collaborate closely with HUD to enhance the capabilities of UGLG officials and staff, ensuring they effectively address community needs. Applicants may focus on broad HUD jurisdictions or specific areas as specified in the program's NOFO.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

Awards

The NRA is proud to recognize the contributions of those who have demonstrated dedication to the promotion of the Second Amendment, significantly impacted the preservation of the shooting sports, advanced the purposes and goals of the NRA and exemplified leadership through public service. Each year, women, youth, clubs, law enforcement officers and NRA Foundation volunteers are awarded for their efforts in pursuit of these principles.

NRA Law Enforcement Officer Of The Year Award

NRA's Law Enforcement Officer of the Year Award was established in 1993 and recognizes an exceptional act or service by a law enforcement officer and is administered by the NRA Law Enforcement Division. Nominations are accepted from anyone having knowledge of the nominee's actions. This includes, but is not limited to, the nominee's agency head, other law enforcement officials, elected officials, fellow officers, community leaders, interested citizens, and NRA members.

The Baugh Foundation supports progressive, inclusive, nonprofit organizations that reflect the love of Christ by providing assistance to those in need, enriching the lives of children and youth, keeping faith communities informed and engaged, and guarding the wall of separation between church and state.We welcome applications from progressive, faith-based organizations. At this time, the vast majority of our funding goes to progressive Baptist organizations or initiatives, and organizations that work to guard the separation of church and state. We believe that a free church in a free state is dependent upon a functioning democracy.Funding Priorities: 

• Social justice and advocacy
• Progressive faith-based journalism
• Meeting basic human needs
• Progressive faith-based post-secondary education
• Inclusivity initiatives
• Arts and enrichment

The Kretler Scholarship offers up to $1,000 to high school seniors from selected schools in Noble County pursuing degrees in Tool and Die or Mechanical Engineering. This scholarship aims to support students in achieving their educational goals, reflecting the commitment of its donors to invest in local talent. Eligible candidates must maintain a GPA of 3.00 and can reapply in subsequent years, fostering continued academic success in their chosen fields.

About Americans for the Arts

Building Collective Power for the Arts

Americans for the Arts is the nation's leading arts advocacy organization. We mobilize advocates, produce trusted research, and secure bipartisan wins that protect funding and expand arts access nationwide — work we've been doing for more than 65 years.

Americans for the Arts advances the people, organizations, and systems supporting arts and culture across America through advocacy, research, and national convening.

We envision a nation where freedom of creative expression is upheld as a fundamental human right, where arts and culture are woven into the fabric of civic life, resourced in every community, and accessible to everyone.

Request for Proposals (RFP)

Strengthening Leadership Capacity of Local Arts Agencies

Given the essential role of LAAs, and to meet this important moment, AFTA seeks an energized and experienced consulting team with expertise to help it develop a comprehensive strategy to strengthen leadership and field capacity across the LAA ecosystem. This work is not intended to operate in isolation, but rather to complement and build upon existing efforts already underway in the field. The focus is on identifying where AFTA can add value through targeted, strategic support that enhances and aligns with broader sector-wide initiatives. 

This effort will focus on empowering LAA agency leaders—a critical component of AFTA’s strategic direction—to expand their capacity, foster innovation, and advance equity in a rapidly evolving environment. Building on existing efforts across the field, AFTA will invest in strong, effective LAA leadership, broaden cultural access and participation nationwide, and position the field for a more vibrant, resilient, and sustainable future. 

With approximately 2,200 LAAs nationally validated in AFTA’s LAA Wayfinder, the selected consulting team will help AFTA gain a deeper understanding of the gaps, needs and opportunities shaping LAA leadership capacity, with attention to Native, rural, small, midsize, and large communities, and identify where AFTA is uniquely positioned to contribute. These insights will guide AFTA’s future direction in its service to LAAs nationwide and ensure AFTA’s contributions complement—rather than duplicate—the work of other entities, collectively strengthening the broader LAA ecosystem.  

In addition, by intentionally working in partnership with peer organizations and stakeholders across the field—and by understanding gaps in coverage and opportunities for growth—AFTA will be positioned to work with partners to support the expansion of the LAA network in communities where local public cultural infrastructure is limited or absent. This collaborative approach will help ensure more equitable access to arts and culture while reinforcing the role of LAAs as essential community anchors, particularly in underserved regions. 

The ROSES 2025: A.17 Hydrosphere program by NASA aims to enhance our understanding of Earth's water systems, focusing on Ocean Physics, Precipitation Science, and Terrestrial Hydrology. This initiative invites proposals targeting specific priorities within these disciplines to advance knowledge on water distribution and movement across the Earth. Proposals will undergo rigorous peer review to ensure transparency and scientific integrity, aligning with NASA's commitment to reproducible and collaborative research.

The Community Foundation of Carroll County supports nearly 70 academic, sports, special circumstances, and 4-H scholarships. Search scholarships by name, or sort by application type.

Georgia E Frank Scholarship

The mission of the Georgia E. Frank Scholarship Fund is to support graduating Carroll County high school students of all backgrounds and needs as they pursue their dreams of being a teacher. As Georgia was a life-long Family and Consumer Science teacher in Carroll County, this fund aims to invigorate, encourage, and support aspiring young educators as they transition from high school to the collegiate stages of their training. As a teacher, Georgia encouraged her students to love what they do, to do it well, in order to make the world around them a better place to live. We hope this fund provides assistance to similarly minded young people as they pursue their future teaching career.

Jane Burns DeWitt Baumann Scholarship

Jane Burns DeWitt Baumann was a life-long resident and educator from Columbus. She attended Columbus City Schools from elementary school through graduation from South High School in 1949, subsequently majoring in Fine Arts and Education at Ohio University. She taught English for twenty years at Linden-McKinley high school and influenced hundreds of students with her passion for reading and writing, inspiring many to pursue their college educations despite trying circumstances. She was a committed advocate of public education. This scholarship honors her service and commitment to public education by supporting a future educator who would not otherwise have the means to attend college.

Award Amount:

• $20,000 payable over four years at $5,000 per academic year

Proteus Fund

Proteus Fund partners with foundations, individual donors, activists, and other allies to work strategically towards racial, gender, queer, and disability justice and an inclusive, fully-representative democracy. We curate an ecosystem of mutually reinforcing, aligned donor collaboratives and fiscally sponsored projects that deploy a creative array of strategies and tactics to further this vision.

RISE Together Fund: Small Grants

Call For Application

RISE Together Fund (RTF), an initiative of Proteus Fund, is announcing an open call for inquiries for our 2026 Small Grants Fund for U.S. public charity organizations or fiscally sponsored projects of such organizations, that support Black, African, Arab, Middle Eastern, Muslim and South Asian (BAMEMSA) communities.

As part of RTF’s commitment to prioritizing the needs and sustainability of the fields we collectively support, RTF will provide organizations with general operating grants to allow for organizational flexibility when possible. 

About RTF's Small Grants Fund

BAMEMSA movements have a strong history of organizing and collaboration, and are well poised with the knowledge, learning and experience to build an inclusive, multiracial democratic future and respond to the current unconstitutional threats facing the country. Through this fund, RTF aims to resource community power building organizations that use a multiplicity of approaches to create change rooted in the strength and leadership of BAMEMSA movements.

RTF supports groups that build community power, strengthen movement bases, defend civil and human rights including freedom of protest, speech, religion, and association, end the criminalization and surveillance of our communities, and respond to the rise in xenophobia, Islamophobia, and hate. RTF values groups that are intersectional in their approach and have or are developing sustainable long-term strategies to support BAMEMSA communities and movements.

Priority Issue Areas

• Protecting and advancing the rights of immigrant and refugee BAMEMSA communities by responding to harmful policies and practices, and strengthening community-led advocacy at the local, state, or federal level.

• Mobilizing BAMEMSA communities for nonpartisan civic engagement and election protection by increasing nonpartisan voter participation, combating voter suppression, and building sustained civic infrastructure ahead of, during, and between elections.

• Advocating for U.S. policy changes that end violence in Gaza and the West Bank by elevating Palestinian voices, influencing public discourse, and engaging in advocacy that shifts U.S. political, diplomatic, or funding decisions.

• Challenging harmful national security frameworks and their impacts on BAMEMSA communities by documenting, exposing, and organizing against surveillance, Islamophobia, and policies rooted in the War on Terror, particularly in the context of 9/11’s 25-year legacy.

• Responding to emerging opportunities and threats affecting BAMESMA communities such as influencing policy developments, addressing civic issues in the U.S., or developing narratives to change public discourse. This includes work addressing weaponizing issues around bodily autonomy and LGBTQ+ identity to fracture movements and communities.

Priority Strategies

RTF values organizations that take an intersectional approach and are intentionally building long-term community power. We prioritize support for groups that strengthen movement ecosystems, deepen their base, and defend the rights of BAMEMSA communities through the following strategies:

• Convening, Collaboration, and Movement Coordination: Bringing together organizations, leaders, and coalitions to align shared goals, coordinate strategies to advance shared visions, and reduce fragmentation across the field. This includes facilitating strategic convenings, developing platforms for collaboration, building cross-issue or cross-regional partnerships, developing shared agendas or issue campaigns, and strengthening trust and alignment among movement actors.
• Community Power-Building, Base Building, Civic Engagement, and Organizing: Expanding and activating a grassroots base within BAMEMSA communities to drive collective action and policy change. This includes community leadership development, public education campaigns, community organizing, nonpartisan voter engagement and election protection, and ongoing nonpartisan civic participation efforts that build sustained community power.
• Legal and Policy Advocacy Infrastructure: Advancing legal strategies and policy advocacy that expand and protect the rights of BAMEMSA communities. This includes impact litigation, legal advocacy, know-your-rights efforts, policy development, and advocacy at a local, state, or federal level.
• Communications and Narrative Strategy: Shaping public discourse and advancing narratives that reflect the experiences, dignity, and demands of BAMEMSA communities. This includes developing messaging strategies, producing and amplifying media, countering harmful or divisive narratives (including those targeting immigrants, religious minorities, LGBTQ+ communities, and reproductive rights), and increasing the voice share of BAMEMSA community members.
• Bolstering Movement Infrastructure: Strengthening the internal capacity and long-term sustainability of organizations and the broader movement ecosystem. This includes organizations supporting leadership development and pipelines, data and technology infrastructure, security and safety, and other core functions that enable groups to operate effectively and respond to evolving challenges.

Limited funding may be available for requests above $25,000.

The Schilling Scholarship, offered by the Community Foundation of the Ozarks, provides six $3,000 scholarships to graduating high school seniors from select schools. Renewable for up to three years, recipients must maintain a 3.0 GPA, enroll in 12 credit hours, and major in Agriculture. An essay submission is required, and applicants must demonstrate financial need by submitting their FAFSA-SAI. This scholarship aims to support students pursuing degrees in various Agriculture fields.

Scholarships support aspiring college students who hold the promise of tomorrow’s progress.

Together, our competitive grants and scholarships help our region rise thanks to the vision and generosity of our donors.

Thomas William Bennett Memorial Scholarship Fund

He believed that a person could do anything if they sat down and read how to do it. When WWII started, he was the first man from the state of South Carolina to enlist in the U.S. Army. He quickly rose to captain and spent most of the war in the Pacific (the Queen of Fiji considered him a friend). Later, Thomas had a long career at Harcourt Brace publishing.

NASA Internships

Background

NASA has developed a single, one-stop Agency system for the recruitment, application, selection and career development of undergraduate and graduate students in science, technology, engineering and mathematics disciplines. Students access information about internship and fellowship opportunities across NASA to engage in research, aerospace education and space exploration. A student completes a single internship and/or fellowship application to express interest in up to 15 specific opportunities for each summer, fall, spring or year-long session.

Objectives

NASA Internships are competitive awards to support educational opportunities that provide unique NASA-related research and operational experiences for high school, undergraduate, and graduate students, as well as educators. These opportunities serve students by integrating interns with career professionals emphasizing mentor-directed, degree-related tasks, while contributing to the operation of a NASA facility or the advancement of NASA’s missions.

Award Level

Levels may vary per opportunity.

The Domtar Community Investment Grant supports nonprofits and charities in areas where the company operates, focusing on education, environmental sustainability, and community humanitarian needs. Eligible organizations include charitable groups, while ineligible entities encompass individuals, discriminatory organizations, and political causes. Applications are accepted online from January 1 to November 30, with reviews conducted bi-monthly. This initiative aims to create meaningful connections between charitable efforts and the social benefits derived from Domtar's business operations.

The GCA: Catherine H. Beattie Fellowship in Conservation Horticulture, provided by the Garden Club of America, offers an annual research grant of up to $4,500 for graduate students in biology or horticulture. This fellowship aims to promote the conservation of rare and endangered flora in the U.S., particularly focusing on the southeastern region. Eligible applicants must be U.S. citizens or permanent residents enrolled in a U.S.-based institution, with preference given to those studying plants native to the Carolinas.

About AWS

We Move Welding Forward

Founded in 1919, the American Welding Society is a nonprofit organization with a global mission: to advance the science, technology, and application of welding and allied joining and cutting processes worldwide, including brazing, soldering, and thermal spraying.

By fostering knowledge, embracing change, and providing real-world opportunities through scholarships, fellowships, and workforce development, AWS provides the tools to help members succeed—and to inspire future generations of welding professionals.

Welding Educator Professional Development Scholarships

AWS Foundation Welding Educator Professional Development Scholarships provide funding for welding educators to advance their skills and impact in teaching. Aimed at current educators in welding-related fields, these scholarships demonstrate AWS's dedication to enriching welding education.

District Educator Scholarships

Each of AWS’s 22 Districts awards educator scholarships worth $500 to $2,000.

To see which District your school is in, view the AWS District and Section Directory.

Funds are paid directly to the educational institution or organization providing the training.

The AWS Educator Professional Development Scholarships are awarded annually in May or June.

About AWS

We Move Welding Forward

Founded in 1919, the American Welding Society is a nonprofit organization with a global mission: to advance the science, technology, and application of welding and allied joining and cutting processes worldwide, including brazing, soldering, and thermal spraying.

By fostering knowledge, embracing change, and providing real-world opportunities through scholarships, fellowships, and workforce development, AWS provides the tools to help members succeed—and to inspire future generations of welding professionals.

Welding Educator Professional Development Scholarships

AWS Foundation Welding Educator Professional Development Scholarships provide funding for welding educators to advance their skills and impact in teaching. Aimed at current educators in welding-related fields, these scholarships demonstrate AWS's dedication to enriching welding education.

National Educator Scholarships

Five donor-funded scholarships worth $1,000 to $5,000

• Bechtel Group Foundation Educator Scholarship
• Earl C. Lipphardt Educator Scholarship
• Jackson Safety Educator Scholarship
• Tim Turner Educator Scholarship
• William Kielhorn Educator Scholarship

Funds are paid directly to the educational institution or organization providing the training.

The AWS Educator Professional Development Scholarships are awarded annually in May or June.

The Owen Family Foundation Grant supports charitable organizations primarily in East Texas and the Minneapolis/St. Paul area, focusing on health, education, human services, and religious initiatives. Organizations must have a 501(c)(3) status and past funding is required for Twin Cities applicants. The foundation is committed to promoting philanthropy and ensuring access to funding for eligible charities, while maintaining a non-discriminatory policy.

About Boeing

A leading global aerospace company and top U.S. exporter, Boeing develops, manufactures and services commercial airplanes, defense products and space systems for customers in more than 150 countries. Our U.S. and global workforce and supplier base drive innovation, economic opportunity, sustainability and community impact. Boeing is committed to fostering a culture based on our core values of safety, quality and integrity.

The Employees Community Fund (ECF) of The Boeing Company

One of the largest employee-managed funds of its kind in the world, the Employees Community Fund (ECF) of The Boeing Company has empowered employees to make a greater impact by pooling their tax-deductible donations for more than 60 years. Employee-led grantmaking committees at 20 Boeing sites provide combined employee donations to nonprofits in their communities through ECF grants.

Charitable or educational organizations can apply for grants from the Employees Community Fund (ECF) of The Boeing Company.

Puget Sound Chapter

The Employees Community Fund (ECF) of Boeing Puget Sound is a pooled fund consisting of recurring payroll contributions from generous Boeing employees. It funds local nonprofits that help thousands of families and individuals in the Puget Sound region where Boeing employees live and work.

ECF focus areas

ECF makes grants to 501(c)(3) Health & Human Service nonprofits such as food banks, job-training programs, shelters, transitional housing, mental health services, and low-income medical clinics. ECF seeks the direct client benefit of each grant to ensure that our employees’ contributions directly help those in need.

ECF funding criteria

ECF has two distinct grant categories – Supporting Grants and Capital Campaign Grants.

ECF of Boeing Company: Puget Sound Chapter Supporting Grants

Consideration is given to nonprofits/agencies that are performing well and are seeking to upgrade, replace or modify elements of their infrastructure.

• Supporting grants cannot exceed $50,000. The requested amount cannot be more than 10% of an agency’s gross annual revenue.
• Supporting grants will be considered only for agencies benefiting residents in the Puget Sound Region.
• Supporting grants help agencies continue to effectively provide services through enhanced direct client benefit by aiding them in procuring and/or paying for items such as:
  • Equipment (ex. office, kitchen, industrial, furniture, etc.)
  • Vehicles used to support clients and/or transport food and/or goods (cost of vehicle and accommodations, tax, and licensing only; operating expenses, such as insurance, fuel, etc. is not allowed)
  • Phone systems
  • Cell phones for direct client use
  • Remodels and/or renovations (must hold at least a 10-year lease or own the building)
  • Purchase or construction of new buildings
  • Computers or tablets for direct client benefit and/or use
  • Software for direct client benefit and/or use (ex. Augmentative and alternative communication (AAC) device)
  • Information Technology expenses, without which procured tools would not work
  • External improvements for client safety (i.e. security system, exterior lighting, improved ADA accessibility, new or refinished pavement or concrete)
• Supporting grants which are accepted must be spent as approved within nine (9) months.

The ARL Distinguished Postdoctoral Fellowships offer early career researchers a chance to engage in independent research aligned with the Army Research Laboratory's mission. Candidates should demonstrate exceptional scientific abilities and a potential for leadership, having addressed significant scientific or engineering challenges during their doctoral studies. Fellowships provide a stipend of $115,000 per year, along with health insurance and other benefits. Applicants must have completed their Ph.D. by October 1, 2025, and are required to undergo a Department of Defense clearance.

The Pittsburgh Foundation provides scholarship opportunities for students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four–year universities, graduate schools, and career/technical schools.

Lightbown Family Scholarship Fund

The Lightbown Family Scholarship Fund was created at The Pittsburgh Foundation to provide scholarships for students from Allegheny County pursuing a career in education. Corinne Elsie Lightbown passed away peacefully on Jan. 7, 2017 at the age of 86 having lived a full and rewarding life. Connie, as she was known to friends, loved life, people, friends and family as well as traveling and discussing movies, political issues and literature. She was an English teacher for 34 years with the Mt. Lebanon High School and taught in London, England, and Japan. A firm believer in the value of a good education, she established this scholarship fund in her name to support students in their academic studies. She never married so had no children of her own, yet her many students became a part of her extended family through the years. Many remained in touch with her and considered her as a mentor and friend. It was her wish that this scholarship would continue beyond her life in this same spirit.

• Award varies
• Award Type: Single Year. Previous recipients are encouraged to re-apply in consecutive years.

The Celia C. Newcomb Memorial Scholarship, managed by the Crown Point Community Foundation, aims to enrich the lives of South Lake County residents. This scholarship supports Lake County, IN residents pursuing degrees in Education, including high school graduates and adult learners. Applicants must provide an additional essay and meet specific eligibility criteria. It embodies the foundation's mission to address community needs through charitable giving.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR)—Formula Grants Program aims to support states and local governments in enhancing their DNA analysis capabilities. By providing funding for existing crime laboratories, this initiative seeks to increase the processing capacity for DNA samples, thereby reducing the backlog in forensic DNA analysis and ensuring timely entry into the Combined DNA Index System (CODIS). Applications are due by November 5, 2026.

The Northeast Asia Council Japan Studies Grants support American citizens and permanent residents conducting scholarly research on Japan within the U.S. Offering up to $2,500, including daily expenses, these grants aim to enhance the quality of teaching and research in Japanese studies. Eligibility includes being an AAS member and not having received funding in the last three years. Applications are reviewed based on project merit and financial need, prioritizing those with limited access to institutional funding.

The FY 2027 DoN HBCU/MI Program aims to enhance the research capabilities of Historically Black Colleges and Universities and Minority Institutions. This initiative promotes innovative solutions to naval science challenges while engaging students and faculty in STEM fields. Key objectives include strengthening research infrastructure and fostering collaborative efforts across institutions. White papers are due by September 18, 2026, and should clearly outline the proposed advancements in naval-relevant science and technology.

About

ASAE Research Foundation exists to advance the development of current and next-generation association professionals through scholarships and awards, and by providing relevant resources that all of us can use.

ASAE Research Foundation Mission

The ASAE Research Foundation transforms the association community through research, scholarships, and practical tools critical to our profession.

Sal Martino Foresight Award

The Sal Martino Foresight Award recognizes trailblazers who foster a culture of foresight in their organization.

Summary

The Sal Martino Foresight Award recognizes trailblazers who demonstrate exceptional creativity in fostering a culture of foresight, embedding foresight into their organizational strategy and operations, and effectively utilizing ASAE’s ForesightWorks and other futures-focused materials.

Award Details

The Sal Martino Foresight Award honors a visionary organization and its leaders who push boundaries, challenge conventional thinking, and pioneer groundbreaking use of foresight to build resilience and prepare for the future. This prestigious award recognizes trailblazers who demonstrate exceptional creativity in fostering a culture of foresight, embedding foresight into their organizational strategy and operations and effectively utilize foresight and other future-focused materials.

Each year, one organization will receive a cash award of up to $7,000 to advance the awardee’s foresight efforts. Awardees receive acknowledgement during an ASAE Research Foundation signature event, as well as participation in an ASAE Research Foundation webinar, logo recognition on the ASAE Research Foundation website, a formal press release citing the awardee’s foresight achievements, and a featured case study or article on the awardee’s foresight implementation efforts.

Alliance for Cancer Gene Therapy

Unlike surgery, chemotherapy and radiation, cell and gene therapies harness the power of your immune system to destroy cancer cells without harming healthy tissue. We fund the research that will make this vision a reality.

Collaborating with partners and funding research fellows, we are transforming cancer treatments today while bringing the world closer to a cure for all cancers tomorrow.

ACGT Investigator Award in Cell and Gene Therapy for SOLID TUMOR CANCERS 

Purpose

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds breakthrough research that is transforming cancer treatment through cell and gene therapy. This ACGT grant award is for those conducting translational cell and gene therapy research specifically in solid tumor cancers.

Research Objectives

Cell and gene therapy for solid tumors poses major challenges driven by antigen heterogeneity, physical exclusion, immunosuppressive microenvironments, genomic instability, and safety limitations. This RFA seeks innovative, translational cell and gene therapy strategies that directly address these barriers.

Proposed approaches should demonstrate the capacity to: (1) overcome antigen escape through multi-targeted designs that broaden patient populations and account for heterogeneity and resistance due to antigen loss; (2) enhance trafficking, infiltration, and persistence within solid tumor sites; (3) resist or reprogram the immunosuppressive tumor microenvironment; and (4) incorporate built-in safety and controllability mechanisms suitable for clinical translation. Successful proposals will integrate these elements to enable durable, precise, and scalable therapeutic impact in solid tumors.

Building on the priorities outlined above, this RFP encourages proposals spanning a broad range of cell and gene therapy (CGT) platforms and rational combinations, including but not limited to:

• Engineered T Cell Approaches
• Innate and Alternative Immune Cell Platforms
• Gene Editing & Synthetic Biology Strategies
• Microenvironment-Modulating Strategies
• Combinatorial Approaches

Proposals that integrate multiple strategies to overcome trafficking, suppression, antigen escape, and safety barriers in a coordinated manner are strongly encouraged. Preference will be given to approaches with clear mechanistic rationale and a credible path toward clinical translation in solid tumors.