Best Large Grants for Nonprofit Organizations in Alabama

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Chapman Prize, established by the Daniel and Barbara Chapman Trust, honors individuals and organizations making significant contributions to American society. Each year, the award focuses on a theme; in 2025, it will spotlight Economic Prosperity. Eligible applicants include U.S. citizens and nonprofits with three years of charitable work demonstrating impact in the chosen field. Approximately $100,000 will be awarded annually to support endeavors that enhance economic prosperity through various initiatives.

About

A History Of Making Waves

Carnival Foundation oversees the many philanthropic endeavors of Carnival Corporation as well as its employee-driven service group, the “Friends Uniting Neighbors” (F.U.N.) Team.

Carnival Foundation’s contributions are widespread, touching the communities where the brands visit and operate. From the cities where our brands are headquartered to ports we visit around the world, we endeavor to make a difference to the lives of many.

Through monetary and in-kind donations, innovative philanthropic programs, employee fundraisers and hands-on volunteer initiatives, Carnival Foundation and the brands of Carnival Corporation support a variety of organizations. Whether it’s providing meals to the homeless and abuse prevention or working toward medical advancement and educating youth, Carnival Foundation’s reach is communitywide.

In-Kind Donations

To apply for an in-kind donation from Carnival Foundation, submit an online application complete with the following information:

• A letter of request with a brief description of the organization including its legal name, history, activities, purpose and governing board
• Contact name and information, including phone number and address for the individual who is organizing the event
• Name and date of the event
• Average amount of funds raised from the auction in previous years and estimated number and demographics of the event audience
• Description of how funds raised from the donation will be used within the organization
• List of other cruise suppliers, if any, participating in the event
• An outline with details of Carnival’s publicity/promotional opportunities associated with the event
• Copy of Internal Revenue Service determination letter indicating 501© (3) tax-exempt status as an organization that is not a private foundation.
• Copy of organization’s most recent 990 filed with the Internal Revenue Service
• Geographical area(s) served

About

A History Of Making Waves

Carnival Foundation oversees the many philanthropic endeavors of Carnival Corporation as well as its employee-driven service group, the “Friends Uniting Neighbors” (F.U.N.) Team.

Carnival Foundation’s contributions are widespread, touching the communities where the brands visit and operate. From the cities where our brands are headquartered to ports we visit around the world, we endeavor to make a difference to the lives of many.

Through monetary and in-kind donations, innovative philanthropic programs, employee fundraisers and hands-on volunteer initiatives, Carnival Foundation and the brands of Carnival Corporation support a variety of organizations. Whether it’s providing meals to the homeless and abuse prevention or working toward medical advancement and educating youth, Carnival Foundation’s reach is communitywide.

Grants Or Sponsorships

To apply for a grant or sponsorship from Carnival Foundation, prospective applicants must complete an online application and include the following information and documents:

• A letter of request with a brief description of the organization, including its legal name, history, activities, purpose and governing board
• Purpose for which the grant is requested
• Grant amount requested
• Listing of other sources of financial support
• Operating budget of the project for which the funds are requested
• Organization’s annual budget
• Copy of the organization’s most recent audited financial statement
• Copy of organization’s most recent 990 filed with the Internal Revenue Service
• Copy of Internal Revenue Service determination letter indicating 501© (3) tax-exempt status as an organization that is not a private foundation
• Organization’s completed W-9 form
• Geographical area(s) served
• Organizations applying for a grant renewal must submit a final report detailing use of the prior grant award. Interim and final reports will be submitted through our online portal.

The Milton & Phyllis Berg Family Respite Care Grants, offered by the Alzheimer’s Foundation of America, support member organizations in providing respite care scholarships to families affected by Alzheimer's. This initiative enhances the quality of life for both individuals and caregivers by promoting social engagement and offering essential breaks for caregivers. Grants are awarded biannually in memory of Barry E. Berg's parents, who faced Alzheimer's and caregiving challenges.

The FY26 Pancreatic Cancer Research Program (PCARP) Idea Development Award promotes innovative, high-risk research aimed at significant advancements for pancreatic cancer outcomes. This award supports projects with preliminary data, focusing on impactful discoveries. It features a Partnering Principal Investigator option, enhancing funding for collaborations between experienced mentors and early-career researchers. All applications must align with the FY26 PCARP Focus Areas, ensuring relevance and potential for transformative results in pancreatic cancer research.

The FY26 Pancreatic Cancer Research Program (PCARP) Translational Research Partnership Award encourages collaboration among clinicians and scientists to expedite the clinical application of innovative pancreatic cancer research. A minimum of two Principal Investigators is required, with one designated as the Initiating PI. This award supports preliminary data collection and various research methodologies, excluding large-scale clinical trials, to enhance pancreatic cancer understanding and treatment.

The NINDS Exploratory Clinical Trials for Small Business (R41/R42) program supports Small Business Concerns in conducting investigator-initiated exploratory clinical trials. This funding opportunity emphasizes projects that align with the NINDS mission, evaluating diverse products including drugs, biologics, and devices. Only STTR Phase II and Fast-Track applications are eligible, fostering innovation in neurological disorder treatments. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the deadline.

The FY26 DoW Pancreatic Cancer Research Program Focused Pilot Award aims to drive innovative and impactful research in pancreatic cancer, enhancing patient quality of life. This award encourages the development of preliminary data to support future clinical or real-world applications. While allowing for clinical research studies, it does not permit clinical trials or preclinical animal studies, ensuring a strong patient-centered approach in its research focus.

The Hearing Health Foundation's Emerging Research Grants (ERG) program supports innovative research in hearing and balance, providing up to $50,000 per year for promising projects. Since 1958, it has fostered early-career researchers and led to significant advancements in the field. Eligible applicants must be affiliated with U.S. institutions and hold relevant advanced degrees. The program emphasizes underfunded areas and encourages applications that expand knowledge and research capabilities in hearing health.

The Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement aims to enhance the effectiveness of HIV prevention and care planning for RWHAP Parts A and B recipients. Through the provision of training, tools, and technical assistance, this initiative seeks to optimize resource allocation and strengthen the overall system of HIV care and treatment, ultimately improving health outcomes for those affected by HIV.

The Thoroughbred Education and Research Foundation (TERF) offers grants to support thoroughbred health, welfare, and education. Focused on enhancing equine research and safety in racing, TERF prioritizes funding for scholarships, educational programs, and veterinary medicine. Eligible applicants must be recognized 501(c)(3) organizations, with a commitment to transparency in reporting. This initiative aims to significantly impact the thoroughbred industry by fostering improved care and understanding of these horses, contributing to their overall welfare.

The National Trappers Foundation (NTF) offers grants to individuals and organizations for projects related to furbearers. Founded in 1988, NTF supports educational and conservation initiatives that promote the management and restoration of furbearers and natural resources. Grants are available for research, habitat development, and educational programs. Contributions to NTF are tax-deductible, reflecting its commitment to conservation and community engagement.

The Allergic Respiratory Diseases Award, supported by the American Lung Association and the American Academy of Allergy, Asthma & Immunology, aims to bolster research in allergic respiratory diseases. Designed for faculty in Clinical Allergy and Immunology at academic medical centers, this award offers $75,000 annually for up to two years. It seeks to empower researchers at pivotal points in their careers, enhancing understanding and treatment of these conditions while promoting lung health.

The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.

The Thoroughbred Education and Research Foundation (TERF) offers grants to support education and research related to Thoroughbred horses. The foundation prioritizes funding for scholarships, educational programs, and equine research aimed at promoting thoroughbred health and welfare. Eligible applicants include qualified 501(c)(3) organizations, while those previously funded must submit reports before applying again. Notably, TERF does not provide funds for facilities caring for unwanted horses or cover overhead costs for grants.

The Miller Indigenous Economic Development Fellowship, established by the Native Forward Scholars Fund, provides financial assistance to American Indian and Alaska Native doctoral candidates engaged in economic research impacting Native communities. This fellowship supports costs associated with data collection, analysis, and travel. It aims to enhance the representation of Native scholars in economics, addressing the current underrepresentation in the field. Eligible candidates are encouraged to apply to further their research and contribute to their communities.

The Gary S. Wilmer / RAMI Music Scholarship supports local students aged 19 and under who are passionate about music and committed to furthering their education in the arts. Established in memory of Gary Wilmer, founder of RAM Magazine, this scholarship honors his legacy by providing financial assistance to aspiring musicians in Boone, Ogle, or Winnebago County. Applicants are required to submit an audition recording and a reference from a music teacher to demonstrate their dedication to musical excellence.

The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.

The Chipotle Cultivate Foundation Grant Program supports 501(c)3 non-profits dedicated to making real food accessible and fostering community growth. Established in 2011, this initiative aligns with Chipotle's mission to cultivate a better world. Eligible organizations can apply through an invitation-only process, focusing on those paving the way for a better future. The foundation also offers mentorship and resources to innovative ventures in the food industry.

The AIDS Drug Assistance Program (ADAP) Emergency Relief Funds aim to provide essential funding to states and territories. This initiative focuses on preventing, reducing, or eliminating waiting lists for ADAP services, ensuring timely access to necessary medications and support for individuals living with HIV/AIDS. This program addresses critical funding shortfalls, enhancing the healthcare infrastructure and improving health outcomes in affected communities.

The Bonnie Sorenson Scudder Scholarship aims to support female students aspiring to become teachers, particularly those passionate about women's physical education. Established in memory of Bonnie Sorenson Scudder, a dedicated physical education teacher at Harvard High School, this scholarship encourages future educators to continue her legacy. For more details, contact Marcia Miller at Harvard High School.

The Ryan White HIV/AIDS Program Part C Capacity Development Program aims to enhance the capabilities of community-based organizations, focusing on improving health outcomes and decreasing HIV transmission. This initiative supports individuals who have not yet accessed regular HIV care, emphasizing innovative care solutions and infrastructure development to address these critical needs.

The NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3) invites applications for the execution of investigator-initiated, interventional clinical trials across various phases. This program supports researchers in finalizing preparations necessary for trial initiation, including IRB establishment and staffing. Successful UG3 projects may transition to the UH3 phase, emphasizing the need for hypothesis-driven studies with significant clinical impact within NIAMS's research mission.

The ABPN Faculty Innovation in Education Award aims to support innovative educational projects that enhance residency training and lifelong learning for psychiatrists and neurologists. With a funding potential of $120,000 over two years, the award prioritizes projects focused on Diversity, Equity, and Inclusion, clinical skills evaluations, and professional competence. Applicants must hold a faculty position at an accredited U.S. medical school or submit a validated offer letter. Preference is given to first-time applicants and those at junior or mid-faculty levels.

The 1954 Project - Luminary Award seeks visionary nonprofit leaders dedicated to advancing educational equity for Black students. Awardees receive $1 million in funding, leadership development, and networking opportunities. The selection prioritizes leaders demonstrating strategic vision, community commitment, adaptability, and collaborative spirit. Applicants must align with one of three impact areas: Innovation in Teaching and Learning, Diversity in Education, or Pathways to Economic Mobility, ensuring their initiatives foster systemic change and uplift marginalized communities.

The HIV Care Grant Program, funded by the US HHS: Health Resources & Services Administration (HRSA), aims to enhance access to high-quality HIV care and treatment for low-income individuals. This initiative supports states and territories in developing comprehensive systems to address the needs of those living with HIV. By providing essential resources, the program seeks to improve health outcomes and ensure that vulnerable populations receive the necessary support and services.