Best Clay County Grants for Nonprofits in South Dakota

Mary O' Neill Mini Grant

Dr. Barbara O’Neill, an AFCPE member and Past President of AFCPE, has made a restricted donation to AFCPE in honor of her late mother, Mary O’Neill, a financially capable woman. The donation will support an annual $5,000 mini-grant for development and implementation of an innovative, high-impact financial educational nonprofit project. 

Winner is notified by October 1 and announced at AFCPE Symposium.

The Vineyard Family Foundation

The Vineyard Family Foundation is the product of decades of work across three generations and five states. Having enjoyed the benefits of our hard work and community patronage, the Vineyard family has chosen to provide to others what so many have graciously provided to us. 

What Sets Us Apart

The Vineyard family has always been committed to its communities. Whether supporting Boys & Girls Clubs, pediatric hospitals, the Ronald McDonald House, arts organizations, or youth recreation leagues, the family has taken a great interest in the care, health, and education of children and the families that nurture them. We take great pride in personally administering our Foundation’s charitable giving, resulting in fewer expenses and more funding for those organizations aligned with the Foundation’s purpose.

Grants

• Supporting Our Communities and Their Families
• Working Towards the Health, Education, and Overall Well-Being of Parents and Their Children

You are steps away from creating an opportunity to receive full or partial funding of your charitable organization. So that you use your time wisely, we offer the following advice for your efforts:

• As a family foundation, we are prohibited from funding individuals or any entity that is not an IRS-recognized Section 501(c)(3) tax-exempt entity or a Section 509(a)(1), (2), or (3) support organization. Thus, while we cannot award a scholarship to an individual, we can fund a 501(c)(3) charity that provides such scholarships.

• If you qualify as a Section 501(c)(3) tax-exempt organization or a support organization pursuant to Section 509(a)(1-3), we will need the IRS Determination Letter confirming as much, as well as a statement signed by your organization’s President or Chief Executive Officer verifying that your organization’s purposes, structure, and operations have not changed substantially since the date of the IRS’s Determination Letter.

• If you are a “supporting organization” under IRS Code section 509(a)(1-3), please provide a list of the public charities that you support. Please also advise whether you are a Type I, Type II, or Type III supporting organization. If you are a Type III supporting organization, please advise whether you are “functionally integrated” with your supported public charity and provide an explanation of that relationship.

Supported Charities

The Vineyard family has historically provided funding for family-related charities such as the Ronald McDonald House, the Boys & Girls Clubs of America, pediatric hospitals, autism-related organizations, and youth recreational leagues. The Foundation looks forward to continuing this support and extending itself to educational, research, and cultural experiences that focus on the needs of children and their parents.

The Air Force Basic Research Sciences Conference and Workshop Support program encourages proposals from U.S. institutions of higher education and nonprofit organizations for conferences and workshops that promote research and technology interchange. These events are vital for sharing recent findings and educational techniques in key scientific areas. The program specifically invites Historically Black Colleges and Universities, Minority-serving Institutions, and Tribal Colleges to participate, aiming to foster collaboration and knowledge exchange among researchers.

The ROSES 2025: D.4 program by NASA focuses on enhancing theoretical and computational astrophysics through collaborative networks. It aims to address grand challenges in Time Domain Multi-Messenger Astrophysics by integrating diverse expertise from various fields. Researchers from U.S. institutions are encouraged to propose innovative tools for modeling complex multi-messenger phenomena, fostering interdisciplinary collaboration across academic, national laboratory, and private sectors to prepare the next generation of scientists.

The IUSE: Innovation in Two-Year College STEM Education (ITYC) program, funded by the National Science Foundation (NSF), aims to enhance STEM education at two-year colleges. This initiative encourages innovative projects that promote student success in foundational STEM courses. Eligible institutions can request up to $500,000 for three years, with an extra $100,000 for those without NSF funding in the last five years, facilitating a total budget of $600,000 for impactful educational projects.

This grant provides essential support to the Tribal Radioactive Materials Transportation Committee, facilitating engagement with the U.S. Department of Energy. The focus is on planning for the transportation of commercial used nuclear fuel and high-level radioactive waste, ensuring that the concerns of federally-recognized Tribal governments are addressed. By fostering communication and collaboration, the initiative aims to mitigate potential impacts on Tribal areas from large-scale transportation activities.

This grant aims to enhance national immunization programs in the Eastern Mediterranean Region by focusing on capacity building, disease control, and outbreak response. It seeks to eliminate vaccine-preventable diseases, reduce morbidity and mortality, and improve access for under-immunized populations. The initiative will promote sustainability through evidence-based decision-making and program evaluation, aligning with CDC goals to address public health threats and improve overall immunization impact in the region.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Critical Shelter Infrastructure

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Strengthening Shelter Essentials

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Increasing Spay/Neuter Surgeries

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Spay/Neuter Major Capital Projects

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

The ASPCA is offering up to $14 million in Spay/Neuter Grants for shelters and clinics across the U.S. to enhance spay/neuter services for vulnerable animals. Proposals can address critical infrastructure needs and major capital projects to increase spay/neuter capacity. Only one application per organization is permitted, and applicants must choose one funding category. The focus is on compelling proposals that meet the most urgent needs.

The Amy Adina Schulman Memorial Fund

The Amy Adina Schulman Memorial Fund is a Princeton, New Jersey-based endowment fund providing grants to individuals, young adults who volunteer or intern for progressive social action projects or programs in an area of their interest and commitment. The Amy Adina Fund also sponsors a lecture each year on a relevant and timely topic related to its educational mission.

The Amy Adina Schulman Memorial Fund was started in 1987 one year after Amy Adina, 20, died suddenly while a student and activist at Rutgers University. It is a realization of her family and her communities’ desire to celebrate her life, to fulfill her dreams and her potential. Since its inception, almost 1,500 grants have been awarded for work in Africa, Asia, Latin America, the Middle East, and the United States—nearly $1,000,000 in total. The Amy Adina Schulman Memorial Fund is a 501(c)3 nonprofit organization.

About Our Grants

Small grants (depending on length of service), are awarded to as many applicants as possible rather than giving larger amounts to fewer individuals. The number of awards has grown each year thanks to annual contributions as well as to gifts sent to the Fund to honor special occasions and life cycle events.

The Fiscal Year 2027 AmeriCorps Seniors RSVP Competition invites communities to apply for funding aimed at engaging adults aged 55 and older in addressing pressing local needs. Through national service and volunteerism, AmeriCorps strengthens communities and fosters civic engagement. This open competition spans all states and territories, encouraging organizations to harness the skills and expertise of older adults to enhance community well-being and promote a culture of service.

The OVC FY 2026 Services for Victims of Human Trafficking aims to enhance victim service programs across the United States. This initiative supports victims by providing critical services to address their diverse needs, including mental health support and assistance with legal challenges. By funding comprehensive programs, the Office for Victims of Crime seeks to combat human trafficking effectively and promote recovery for affected individuals, ensuring their rights and well-being are prioritized.

The OVC FY 2026 Preventing Trafficking of Girls program aims to provide crucial prevention and early intervention services for girls at risk of human trafficking. This initiative, backed by the US DOJ's Office of Justice Programs, supports efforts to protect vulnerable populations, including young women up to age 25, from both sex and labor trafficking. Applicants are encouraged to outline their strategies to effectively serve survivors and address diverse needs in their proposals.

The OVC FY 2026 grant aims to improve outcomes for child and youth victims of human trafficking by integrating policies at state and Tribal levels. This funding opportunity focuses on developing strategic plans to address the challenges faced by minor victims, enhance coordination among systems like child welfare and juvenile justice, and ensure effective identification and prosecution of traffickers. By fostering multidisciplinary approaches, the program seeks to provide comprehensive support and services to these vulnerable populations.

The Agriculture Risk Management Education Partnerships Competitive Grants Program (ARME) aims to educate agricultural producers on various risk management activities, including crop insurance, debt reduction, and market assessment. Emphasizing farm viability, the program seeks to provide technical assistance and outreach to farmers and ranchers to improve their risk management strategies, as outlined in the Agriculture Risk Protection Act of 2000. This initiative is funded by the USDA's National Institute of Food and Agriculture (NIFA).

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

The FY26 Breast Cancer Research Program's Breakthrough Award supports transformative research aimed at significant advancements in breast cancer treatment. This award offers various funding levels, including Population Science Studies, allowing for innovative approaches that can lead to clinical applications. Each application must align with overarching BCRP challenges, ensuring a focus on impactful research. The program acknowledges both individual and collaborative Principal Investigators, emphasizing the importance of timely submissions to avoid administrative issues.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is set to renew a Notice of Funding Opportunity (NOFO) focused on advancing translational research in maternal and pediatric pharmacology. This initiative aims to enhance precision medicine by developing innovative tools and therapeutics for pregnant and lactating women, infants, and children. The goal is to improve the safety and efficacy of medications while ensuring effective patient-provider communications. Applications are not currently being solicited.

The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) program is designed to enhance research on muscular dystrophy through a collaborative, center-based approach. By fostering interdisciplinary projects and providing essential training for emerging scientists, the MDSRCs aim to drive innovation in both basic and clinical research. Engaging patient and advocacy communities is a key component, ensuring research is patient-centered and informed by real-world needs. This initiative is supported by various legislative authorities.

The National Institutes of Health is funding a groundbreaking project to enhance our understanding of Type 1 diabetes (T1D) through multimodal AI. This initiative aims to integrate diverse datasets to explore the interactions of biological processes in T1D development. By leveraging advanced AI models, the research will uncover critical insights, identify biomarkers, and pave the way for personalized medicine approaches, ultimately improving prevention and treatment strategies for this complex disease.

The SCORCH Program: Phase 2 aims to enhance the understanding of single cell biology in the context of HIV and Substance Use Disorder (SUD). Building on previous research, this initiative will explore new single cell approaches to investigate the interactions between SUD and HIV progression at various biological levels. By leveraging advanced techniques, the program seeks to identify candidate mechanisms and potential therapeutic targets, ultimately contributing to innovative solutions for SUDs and HIV-related challenges.

The National Violent Death Reporting System (NVDRS) is a crucial surveillance initiative by the CDC aimed at understanding violent deaths and suicides. This funding opportunity supports state and local entities in modernizing NVDRS, enhancing data collection and reporting processes. Key activities include timely data updates, modernization assessments, and pilot projects for improved data systems. The goal is to create a sustainable national surveillance system that provides reliable data to inform public health actions and enhance violence and suicide prevention efforts.

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

American Academy of Family Physicians Foundation

The AAFP Foundation focuses on improving health for everyone, and your support makes an immediate impact on the good work we do—from leadership development and education scholarships to funding social and health care services.

The AAFP Foundation strives to create a sense of belonging through an inclusive environment that embraces the family medicine community by recognizing individual uniqueness and contributions to family medicine.

Richard D. Feldman, M.D. Student and Resident Essay Contest

Each year, the Center for the History of Family Medicine (CHFM) sponsors a contest to encourage medical students and family medicine residents to write scholarly essays relevant to the history of family medicine in the United States. The first-place winner will receive $2,000 and the second-place winner will receive a $1,000 award.

We encourage all to apply and are committed to developing scholarly essays relevant to the history of Family Medicine in the United States by medical students and residents who reflect the rich diversity of the specialty and the patients served.