Best Clay County Grants for Nonprofits in South Dakota

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

The Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN) Grant, offered by the Patient Advocate Foundation, provides crucial financial assistance to patients facing this cancer type. It covers out-of-pocket healthcare costs, including medication copays and insurance premiums, ensuring those affected can access necessary treatments. With a focus on personalized case management, the foundation has supported millions in navigating their healthcare needs, emphasizing the importance of timely and affordable care for patients diagnosed with MPN.

The Richard L and Freda K Flerlage Foundation

Our Mission

Working to empower underserved populations through small grants in support of literacy, healthcare, reduction of poverty, and the promotion of social and environmental justice.

We are a small family foundation, when possible we aim to support organizations with relatively small operating funds where our small grants will have their greatest possible impact.

Our average grant is $3,800.

Our Mission

UNCF envisions a nation where all Americans have equal access to a college education that prepares them for rich intellectual lives, competitive and fulfilling careers, engaged citizenship and service to our nation.

UNCF’s mission is to build a robust and nationally-recognized pipeline of under-represented students who, because of UNCF support, become highly-qualified college graduates and to ensure that our network of member institutions is a respected model of best practice in moving students to and through college.

UNCF’s North Star is to increase the total annual number of African American college graduates by focusing on activities that ensure more students are college-ready, enroll in college and persist to graduation. This is done through a three-pillar strategy. Positioning member institutions as a viable college option for students and investing in institutional capacity to improve student outcomes; creating transformational support programs to ensure students are enrolling and persisting through college completion; building awareness of educational attainment and cultivating college-going behaviors within the African American community.

About the UNCF Lighted Pathways Program

Increasing the number of Black investment management professionals one opportunity at a time

According to The American College and the CFP Board, African Americans only make up 5% of financial advisors and 2% of certified financial planners (CFP), even though African Americans represent 13.4% of the U.S. population.

The UNCF Lighted Pathways programs meets the disparity and lack of Black talent in asset management through the UNCF Lighted Pathways initiative which provides scholarships and internships to African American undergraduate students interested in the investment management industry. Through this initiative, UNCF Lighted Pathways aims to create a career pathway to attract, develop, and retain Black talent for the asset management industry.

The UNCF Lighted Pathways Program excites, educates, and empowers young people by supporting personal and professional development, driving company performance, and providing the asset management industry the talent they need to meet today’s challenges and tomorrow’s opportunities. This program offers students a glimpse inside the dynamic, global asset management industries and the career opportunities, potential and rewards within them.

Students are afforded the opportunity to receive $5,000 in scholarships and/or participate in internships in the financial industry provided by the program’s partners.

The National Institutes of Health (NIH) is seeking to enhance the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) through the establishment of a Clinical Coordinating Center (CCC) and Data Coordinating Center (DCC). This initiative aims to improve emergency care outcomes by supporting trials that focus on effective treatments for non-stroke neurological and cardiovascular emergencies. Although applications are not currently being solicited, this notice allows potential applicants to prepare collaborative proposals.

The National Institute on Aging (NIA) is inviting applications for the Alzheimer's Drug-Development Program (U01 Clinical Trial Optional). This initiative seeks to support pre-clinical and early-stage clinical development of innovative drug candidates aimed at preventing Alzheimer's disease or treating its symptoms. The program encourages collaboration among researchers and aims to enhance the therapeutic pipeline for AD through targeted approaches. This notice allows potential applicants time to prepare robust projects.

The National Institutes of Health (NIH) is dedicated to advancing emergency care through the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN). This initiative seeks to establish clinical enrollment hubs that will enhance the network's ability to conduct trials aimed at improving outcomes for patients experiencing neurological and cardiovascular emergencies. Although applications are not currently being accepted, this notice encourages potential applicants to prepare collaborative and impactful proposals.

The Established Clinician Investigator Award to Support Mentoring (KS1) is designed to provide established clinician investigators with dedicated time for mentoring early-career clinician research scientists. This initiative by the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to enhance the quality of mentorship, fostering the development of future leaders in clinical research. It supports a sustained commitment to training and guidance, ensuring a robust pipeline of skilled professionals.

The Mentored Career Transition Award (KT1/R00) offers a biphasic funding opportunity for up to 5 years, supporting the transition of postdoctoral researchers to independent faculty positions. The first phase provides 1-2 years of mentored career development, while the second phase grants up to 3 years of independent research support, contingent upon satisfactory progress and faculty appointment. This grant aims to enhance the capacity of early-career researchers in achieving research-intensive roles.

The Mentored Clinician Research Scientist Career Development Award (KC1) from the NIH supports clinician research scientists for up to five years, providing dedicated time for intensive research career development. This award aims to guide candidates with clinical doctoral degrees towards achieving research independence by pairing them with experienced mentors who can help navigate their career paths.

The Mentored Research Scientist Career Development Award (KR1) offers crucial support for researchers aiming for independence. Funded by the US Dept. of Health & Human Services through the NIH, this award allows candidates to engage in intensive research training under a mentor's guidance for up to five years. It is designed for those with research doctoral degrees, facilitating their transition into independent research roles and enhancing their contributions to the scientific community.

The Rural Health Network Development Planning Program aims to enhance rural health care by fostering integrated health care networks. It focuses on collaboration among entities to bolster local capacity and improve care coordination in underserved areas. By achieving efficiencies and expanding access to essential services, the program seeks to strengthen the overall rural health system while promoting the use of health information technology and exploring innovative care delivery models.

The Rural Health Network Development Program aims to enhance health care access in rural areas by supporting integrated health care networks. It offers two funding tracts: the Network Advancement Tract for established networks to overcome operational barriers and the Network Development Tract for early-stage networks to plan and expand services. Both tracts focus on improving care coordination, health outcomes, and operational efficiency, thereby strengthening the rural health care system.

The Rural Maternity and Obstetrics Management Strategies Program (Rural MOMS) aims to enhance access to maternity and obstetrics care in rural areas through collaborative networks. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative focuses on innovative strategies to improve healthcare delivery for mothers and infants in underserved regions, ensuring that quality care is accessible where it is needed most.

The IUSE: Innovation in Two-Year College STEM Education (ITYC) program, funded by the National Science Foundation (NSF), aims to enhance STEM education at two-year colleges. This initiative encourages innovative projects that promote student success in foundational STEM courses. Eligible institutions can request up to $500,000 for three years, with an extra $100,000 for those without NSF funding in the last five years, facilitating a total budget of $600,000 for impactful educational projects.

The National Leadership Grants for Libraries (NLG-L) program, funded by the Institute of Museum and Library Services, aims to enhance library services across the nation. By supporting projects that promote adult reading, health and financial literacy, and effective use of new technologies, this initiative fosters community prosperity and builds partnerships among libraries, archives, and museums. The grants ensure that libraries can respond effectively to public needs and enhance their contributions to education and information access.

The Native American Library Services Enhancement Grants program, funded by the Institute of Museum and Library Services, aids Native Communities in enhancing library services. It empowers Tribal libraries to adapt to evolving information needs and serve as vital resource centers. By addressing the unique priorities of each community, this initiative fosters knowledge sharing and supports the overall wellness of Tribal members, ensuring they have access to essential information and resources.

The Native Hawaiian Library Services Grants (2027) aim to enhance library services for Native Hawaiian communities. Funded by the Institute of Museum and Library Services, this program empowers organizations to adapt to evolving information needs, promoting wellness and knowledge sharing. By supporting unique priorities across various islands, it fosters stronger community resource centers that serve the cultural and informational needs of Native Hawaiian users effectively.

The National Leadership Grants for Museums, offered by the Institute of Museum and Library Services, support innovative projects addressing critical needs in the museum sector. These grants aim to enhance museum services for the public by fostering the development and replication of effective practices, tools, and collaborations, particularly leveraging new technologies. Eligible projects can significantly advance the professional field, ensuring museums remain vital community resources.

The Museum Grants for American Latino History and Culture (2027) program aims to strengthen American Latino history and culture museums by enhancing their capacity to serve communities. It supports initiatives that foster professional development within these cultural institutions, ensuring they can effectively promote and preserve Latino heritage. This grant, offered by the Institute of Museum and Library Services, is crucial for advancing the growth of a dedicated workforce in the American Latino cultural sector.

The Native American/Native Hawaiian Museum Services (NANH) program, funded by the Institute of Museum and Library Services (IMLS), aims to support Native American Tribes, Alaska Native Villages, and organizations serving Native Hawaiians. It focuses on preserving heritage and culture through educational services, workforce development, capacity building, community engagement, and effective collections stewardship. This initiative is crucial for sustaining the rich cultural heritage of Native communities.

The 21st Century Museum Professionals (21MP) Program, funded by the Institute of Museum and Library Services, aims to enhance career pathways and professional networks in the museum sector. This initiative focuses on developing current museum staff, recruiting new professionals, and fostering partnerships that promote effective workforce training. By emphasizing peer learning and alternative career pathways, the program seeks to create a robust and diverse museum workforce across the nation.

The Museums for America (MFA) program, funded by the Institute of Museum and Library Services (IMLS), supports museums across the nation in enhancing their educational programs, community partnerships, and collection stewardship. This initiative aims to serve diverse audiences through experiential learning, address community needs, and ensure the proper management of collections. By investing in museums of all sizes, the MFA program plays a vital role in preserving America's cultural heritage for future generations.

The Inspire Grants for Small Museums (2027) initiative, funded by the Institute of Museum and Library Services, aims to empower small museums across various disciplines. This program focuses on project-based funding to enhance public service through educational programs, exhibits, and community partnerships. By supporting small, often underfunded institutions, Inspire seeks to strengthen their capacity to engage communities and improve collections management, fostering experiential learning and discovery.

The Museum Grants for African American History and Culture (AAHC) program, funded by the Institute of Museum and Library Services, aims to enhance the capacity of African American museums. This initiative supports professional development for museum staff and promotes accessibility to collections at these institutions and HBCUs. By fostering institutional growth, the program plays a vital role in preserving and showcasing African American history and culture through museum initiatives.