Best Unrestricted Grants for Nonprofits in Colorado

Alliance for Cancer Gene Therapy

Unlike surgery, chemotherapy and radiation, cell and gene therapies harness the power of your immune system to destroy cancer cells without harming healthy tissue. We fund the research that will make this vision a reality.

Collaborating with partners and funding research fellows, we are transforming cancer treatments today while bringing the world closer to a cure for all cancers tomorrow.

ACGT Investigator Award in Cell and Gene Therapy for SOLID TUMOR CANCERS 

Purpose

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds breakthrough research that is transforming cancer treatment through cell and gene therapy. This ACGT grant award is for those conducting translational cell and gene therapy research specifically in solid tumor cancers.

Research Objectives

Cell and gene therapy for solid tumors poses major challenges driven by antigen heterogeneity, physical exclusion, immunosuppressive microenvironments, genomic instability, and safety limitations. This RFA seeks innovative, translational cell and gene therapy strategies that directly address these barriers.

Proposed approaches should demonstrate the capacity to: (1) overcome antigen escape through multi-targeted designs that broaden patient populations and account for heterogeneity and resistance due to antigen loss; (2) enhance trafficking, infiltration, and persistence within solid tumor sites; (3) resist or reprogram the immunosuppressive tumor microenvironment; and (4) incorporate built-in safety and controllability mechanisms suitable for clinical translation. Successful proposals will integrate these elements to enable durable, precise, and scalable therapeutic impact in solid tumors.

Building on the priorities outlined above, this RFP encourages proposals spanning a broad range of cell and gene therapy (CGT) platforms and rational combinations, including but not limited to:

• Engineered T Cell Approaches
• Innate and Alternative Immune Cell Platforms
• Gene Editing & Synthetic Biology Strategies
• Microenvironment-Modulating Strategies
• Combinatorial Approaches

Proposals that integrate multiple strategies to overcome trafficking, suppression, antigen escape, and safety barriers in a coordinated manner are strongly encouraged. Preference will be given to approaches with clear mechanistic rationale and a credible path toward clinical translation in solid tumors.

The National PTA Outstanding Advocacy Awards recognize exemplary efforts by state, local, and individual PTA advocates dedicated to improving the education, health, and well-being of children. Established by the National PTA, these awards highlight four categories of advocacy: Outstanding State PTA Advocacy, Outstanding Local PTA Advocacy, Shirley Igo Advocate of the Year, and Outstanding Youth Advocate of the Year. Awardees will be celebrated at the National PTA’s Legislative Conference in March 2026.

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Ken and Clara Kolberg Family Scholarship

This scholarship has been made possible by the generosity of Ken Kolberg and family, who established the Ken and Clara Kolberg Family Scholarship of the Community Foundation for Muskegon County. Teaching is the family business of the Kolberg Family. Ken started teaching in Muskegon Public Schools after WWII and did so for thirty-seven years. Ken and Clara raised five children, of whom four became teachers - two working in Muskegon. Through the establishment of this Fund, the family is assured of having an impact on students far into the future. This Fund will support Muskegon students pursuing careers in education, especially minority students so greatly needed as teachers in our school systems.

This funding opportunity aims to advance mechanistic research for precision probiotic therapies. It invites R33 applications focused on characterizing individual differences in probiotic responses, identifying responder subgroups, and enhancing clinical outcomes. The goal is to develop strategies addressing barriers to effective probiotic use, accounting for human variability. Proposals should include innovative studies using animal models or human subjects, supported by preliminary data to test biological patterns and their effects on health outcomes.

The Firehouse Subs Public Safety Foundation Grants aim to enhance the life-saving capabilities of public safety organizations. Established in 2005, the foundation supports funding for life-saving equipment, prevention education, scholarships, and disaster relief initiatives. Eligible applicants include public safety entities located within 60 miles of a Firehouse Subs restaurant. This program emphasizes early application submission, as only a limited number of applications are accepted quarterly.

The Michigan Health Endowment Fund offers Scholarships for Conferences and Professional Development to support health-related events. These scholarships, up to $2,500 per person and $5,000 per organization, are available for current or past grantees and partners. Applications are accepted on a rolling basis, with a requirement to submit at least four weeks before the event. Priority is given to organizations that haven't received funding in the previous year, ensuring equitable access to professional development opportunities.

The Robert Glenn Rapp Foundation, established in 1951 in Oklahoma, aims to support charitable organizations across the U.S., with a focus on education and local initiatives. Grants are awarded to qualified 501(C)(3) organizations, prioritizing projects that align with the foundation's mission in areas such as education, health, arts, and literacy. Interested applicants must submit a Letter of Inquiry before applying for funding, ensuring alignment with the foundation's priorities.

The Graduate Education Fund offers scholarships for American and Australian graduate students to study in each other's countries. With deadlines in March and September, eligible applicants can receive up to $40,000 to support their education in fields like Science and Technology. This initiative fosters cross-cultural academic collaboration and requires applicants to be enrolled in accredited programs, ensuring a high standard of educational exchange.

The Martin Luther King Jr. (MLK) Corridor Community Grants, provided by Keep America Beautiful, aim to empower communities to revitalize and beautify MLK corridors across the U.S. These grants support various projects, including murals, community gardens, and cleanup efforts, contributing to the initiative's goal of beautifying 25,000 communities by 2026. Eligible applicants include nonprofits, local governments, and community organizations, with a focus on sustainable impacts and local engagement.

The Small Business Transition Grant for New Entrepreneurs, funded by the NIH, supports new investigators in entrepreneurship. This grant aims to enhance the entrepreneurial skills of researchers while facilitating their research and development efforts in small businesses. It encourages the employment of Program Directors/Principal Investigators (PDs/PIs) who possess strong scientific expertise but limited entrepreneurial experience, fostering innovation aligned with NIH's mission to improve health and save lives.

The Donor Advised Funds grant from the Town of Winter Park aims to enhance the quality of life in Grand County by supporting non-profit organizations. Eligible applicants include tax-exempt entities under the IRS code and other groups demonstrating need. The grant will not fund political campaigns or projects completed prior to the award. Collaborative requests are encouraged, and applicants must submit progress reports to qualify for funding. Decisions will be made by the end of the year.

The Small Business Transition Grant for New Entrepreneurs supports new investigators transitioning into entrepreneurship, particularly in small business settings. This NIH initiative aims to bolster their development as Program Directors or Principal Investigators while fostering their research and entrepreneurial skills. By promoting training and mentorship, this grant encourages the growth of promising technologies that align with NIH's mission to enhance health and save lives. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Project SEED Fellowship aims to provide high school students from economically disadvantaged backgrounds with hands-on summer research experiences in chemistry and related fields. Over 50 years, it has engaged more than 11,000 students, offering mentorship and support for college readiness. Participants work under the guidance of scientists for 8 to 10 weeks, with opportunities for scholarships and travel grants, thereby fostering interest in STEM careers and promoting diversity in the sciences.

The ENF Community Investments Program - Beacon Grants offers a unique opportunity for Elks Lodges to initiate and lead charitable projects in their local communities. This program encourages Lodges to develop sustainable initiatives, allowing them to address community needs effectively. By fostering collaboration and providing resources, the Beacon Grants enhance the quality of life for residents, including veterans and families. In 2025-26, all Lodges will have the chance to participate, promoting a culture of giving back.

The Japanese Teaching Material Purchase Grant, provided by the Japan Foundation, Los Angeles, supports U.S. educational institutions in acquiring resources for Japanese language courses. Grants, not exceeding $1,000, can be used for textbooks, audio-visual aids, and other teaching materials. Eligible applicants include non-profit organizations and Japanese heritage schools. However, the grant does not cover electronics or consumable supplies, and materials purchased become institutional property, not personal.

The Damon Runyon Scholars Program for Advancing Research and Knowledge (SPARK) aims to empower exceptional college seniors and recent graduates to excel in cancer research. This year-long program provides hands-on training in research labs, mentorship from Damon Runyon scientists, and support for graduate school applications. SPARK particularly encourages applicants from underrepresented backgrounds, fostering inclusivity in science and preparing future leaders in the fight against cancer. Through SPARK, young talents gain the skills and networks needed for successful careers in biomedical research.

The U.S.-Southeast Asia-Japan Collaboration and Exchange Initiative Grant, administered by the Japan Foundation, New York, aims to enhance Japanese Studies through collaborative research and academic exchanges. Targeting U.S. institutions with developing Japanese Studies programs, this initiative fosters meaningful connections between scholars in the U.S., Southeast Asia, and Japan, promoting interdisciplinary collaboration and resource sharing to strengthen academic networks across these regions.

The DARPA Tactical Technology Office (TTO) seeks innovative proposals to enhance national security through cutting-edge technology. This initiative focuses on Design/Build/Buy, Surge and Sustain, Long Range Effects, and Disruptive Innovation. By fostering rapid adaptation and sustainable force structures, TTO aims to demonstrate revolutionary systems that are not only effective but also affordable and responsive to emerging challenges.

The Reiman Foundation, established in 1986, is dedicated to supporting non-profit initiatives across the U.S., focusing on health care, education, the arts, and children. Managed by Hexagon, Inc., it aims to empower organizations that foster community development and leadership. The foundation invites grant applications that align with its mission, ensuring clear project outlines, beneficiary details, and administrative plans. Its commitment to impactful giving has transformed countless lives in Denver, Milwaukee, and beyond.

The Research on Research Security Program, funded by the National Science Foundation, aims to foster collaboration between STEM researchers and research security practitioners. It encourages interdisciplinary approaches to enhance evidence-based research on security issues. Proposals can include conferences, workshops, and planning grants, as well as international partnerships, to address U.S. concerns in research security. This initiative is vital for developing a robust community in this emerging field.

The Domtar Community Investment Grant supports nonprofits and charities in areas where the company operates, focusing on education, environmental sustainability, and community humanitarian needs. Eligible organizations include charitable groups, while ineligible entities encompass individuals, discriminatory organizations, and political causes. Applications are accepted online from January 1 to November 30, with reviews conducted bi-monthly. This initiative aims to create meaningful connections between charitable efforts and the social benefits derived from Domtar's business operations.

The Owen Family Foundation Grant supports charitable organizations primarily in East Texas and the Minneapolis/St. Paul area, focusing on health, education, human services, and religious initiatives. Organizations must have a 501(c)(3) status and past funding is required for Twin Cities applicants. The foundation is committed to promoting philanthropy and ensuring access to funding for eligible charities, while maintaining a non-discriminatory policy.

The Blueprint MedTech Translator program aims to support the advancement of therapeutic and diagnostic devices for nervous and neuromuscular disorders. This initiative encourages clinical feasibility studies and the implementation of clinical prototype devices, along with safety and efficacy testing. Participants will receive funding to conduct research in their own labs, collaborate with NIH consultants, and access contract research organizations for specialized testing, ensuring a comprehensive approach to device development.

The Damon Runyon Physician-Scientist Training Award aims to address the shortage of physician-scientists by supporting U.S. Specialty Board eligible physicians in cancer research. This award provides funding for up to four years, enabling awardees to dedicate 80% of their time to research while maintaining clinical skills. The program seeks to eliminate financial barriers, allowing talented clinicians to transform into leading researchers capable of advancing cancer treatment and prevention.

The Learning Engineering Tools Competition is a significant funding opportunity aimed at fostering educational technology innovations. It seeks to leverage digital tools, big data, and learning science to improve learner outcomes globally. This competition encourages diverse participants, from students to established companies, to develop solutions that can generate valuable learning data. By promoting collaboration among educators, researchers, and tech innovators, the initiative aims to advance the field of learning engineering and enhance educational practices.

Stealth Biotherapeutics is dedicated to supporting innovative programs that enhance disease awareness and therapeutic management. Their charitable contributions focus on accredited institutions, promoting educational initiatives for health care providers and patient communities. Funding is prioritized for unique and cost-effective projects that align with their therapeutic interests, including rare genetic disorders, neurodegenerative diseases, and ophthalmic conditions. By fostering community awareness, they aim to make a significant impact in the healthcare landscape.

The Shoup Foundation Grant supports Protestant churches and organizations aiding needy individuals or disaster relief in Northern Colorado. This foundation funds charitable, nonprofit organizations as defined by IRS section 501(c)(3). Key program areas include animal welfare, arts, civic activities, community development, education, environment, health research, and social services. Interested applicants must comply with eligibility requirements, as individuals cannot submit grant applications directly.