Best Large Grants for Nonprofit Organizations in Colorado

Colorado nonprofits focused on basic needs, education, economic development, or community safety can access funding through BOKF Foundation to enhance quality of life and economic wellbeing. Eligible organizations must serve communities where BOK Financial operates, with applications accepted online year-round to build long-term, local partnerships.

501(c)(3) nonprofits working on economic advancement, affordable housing, or community arts and culture in Colorado can apply for US Bank Foundation’s Community Possible Grant Program. Funding supports high-impact, collaborative programs that address work, home, and play, with priority for organizations led by people of color and serving designated U.S. Bank communities.

Colorado 501(c)(3) nonprofits with innovative approaches to human and social services, health, environment, arts, literacy, or community safety can apply for Creag Foundation’s invitation-only funding to tackle social problems. Organizations must have held 501(c)(3) status for at least one year and may begin by submitting a letter of inquiry.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

Colorado nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment can access funding through Cisco Systems Foundation, with awards up to US $100,000. Eligible organizations must primarily serve economically underserved communities and keep overhead at or below 25 percent; applications are accepted year-round starting with a brief LOI.

Focused on safety, education, and community development, State Farm invites Colorado educational institutions, government programs, and eligible 501(c)(3) and 501(c)(4) organizations to seek support for large, long-term initiatives. Funding may benefit nonprofits working on auto and home safety, disaster preparedness and recovery, affordable housing, financial literacy, food insecurity, and K–12 or higher education success.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

Grants from PNC Foundation help Colorado 501(c)(3) nonprofits fund early childhood education, community development, and services for low- and moderate-income residents in counties where PNC operates. Eligible organizations may propose programs in areas like preschool learning, workforce readiness, affordable housing, neighborhood revitalization, arts, and human services that build sustainable, inclusive local communities.

Grants to accredited charities in Colorado can support humanitarian, social development, science and education, community and environment, and contemporary arts and culture projects. Grants from La Roche help nonprofit organizations undertaking innovative, sustainable initiatives that may engage Roche expertise, logistics, and employees in cultural, educational, social, or environmental activities within the country where the affiliate operates.

Colorado nonprofits providing health, education, or humanitarian services to marginalized communities worldwide can access funding through Semnani Family Foundation. Grants support programs such as healthcare access, disaster relief, child welfare, women and girls’ services, literacy, and related human and social services in eligible countries, including the U.S.

Nonprofit 501(c)(3) organizations in Colorado seeking support for charitable, educational, scientific, or medical programs can apply for grants from the Sidney Stern Memorial Trust, with all funds used in the U.S. With a mission to strengthen broad-impact services, the Trust provides tax-exempt organizations with project or program funding that benefits general welfare.

Nonprofit and community organizations running arts, education, environmental, or health and wellness projects in Colorado can seek support for community initiatives or events. Grants from Stantec help Colorado groups near its offices fund programs like art education, K–12 and vocational learning, environmental stewardship, energy efficiency, and health facilities or clinics that strengthen local communities.

Nonprofits, NGOs, and institutions in Colorado with proven, large-scale social impact ideas can apply for TED’s Audacious Project support; awards fund multi-year plans across global challenges. Eligible initiatives must have an annual budget of at least $2M, with experienced teams ready to manage significant philanthropic investment for bold expansion.

Colorado nonprofit organizations working on environment, justice, human rights, or community development can access funding through the Zegar Family Foundation to advance impactful programs and research. Grants may also support related efforts in education, health, arts, human services, and economic opportunity; proposals are by invitation only, though the foundation welcomes new ideas from new sources.

Nonprofit 501(c)(3) organizations in Colorado seeking support for hunger relief, nutrition, youth development, or stronger communities can request cash, sponsorship, gift card, or product donations. Focused on ending hunger and reducing waste, Kroger Co. Foundation invites community-focused nonprofits to apply for support aligned with its Zero Hunger | Zero Waste impact plan.

Nonprofit 501(c)(3) organizations in Colorado seeking support for community programs can apply for more than US $1,000 to strengthen agriculture, education, health, environment, hunger relief, poverty services, and public safety. The Franklin P. and Arthur W. Perdue Foundation requires requests to be endorsed by a Perdue associate and prioritizes communities near its major facilities.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

Nonprofit 501(c)(3) organizations near TJX locations in Colorado can apply for TJX Foundation grants supporting basic needs, youth education, workforce readiness, and domestic violence safety programs. Eligible nonprofits must be within 15 miles of a TJX store, distribution center, or office and may receive funding after completing an eligibility questionnaire and invited application process.

Colorado 501(c)(3) nonprofits serving economically deprived, socially disadvantaged, or disabled residents in El Paso County can seek funding for youth-focused education, health, recreation, and human services projects. Focused on community development and civic activities, Luther T. McCauley Charitable Trust invites one request per organization each fiscal year, with grants rarely awarded more than once every two years.

J.B. Hunt Transport Services offers financial support for various community projects through its Company Giving program. Focused on four key areas—Health Care, Veterans' Support, Education, and Crisis Management—this initiative aims to enhance the well-being of local communities. Eligible applicants include 501(c)(3) organizations, schools, and civic groups, while organizations that primarily benefit their members or have high management overhead may be excluded. The program underscores J.B. Hunt's commitment to corporate social responsibility.

Nonprofits, local governments, and partner agencies in Colorado can apply for Colorado Parks & Wildlife’s Fishing is Fun matching grants, offering up to US $700,000 for sportfishing access and habitat projects. Grants from Colorado Parks & Wildlife help organizations build or improve fishing ponds, boat ramps, trails, piers, restrooms, and other public angling amenities.

Colorado nonprofits and public agencies serving families with children can access funding through Intermountain Community Care Foundation to support child and family mental well-being programs. Grants of US $5,000 - US $100,000 back efforts such as suicide prevention, reducing anxiety and depression, trauma-informed care, and strengthening community behavioral health capacity.

Colorado 501(c)(3) organizations and comparable public entities improving nutrition security or providing housing-related wraparound services can apply for Social Drivers of Health Grants, with awards from US $5,000 - US $100,000. Focused on community health, Intermountain Community Care Foundation supports new or existing, evidence-based programs that address key social determinants of health.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.