Best Large Grants for Nonprofit Organizations in District of Columbia

The VIA Art Fund provides Artistic Production Grants to support innovative artistic commissions for public spaces. These grants, ranging from $25,000 to $100,000, are awarded twice a year to artists and organizations that exemplify artistic excellence and public engagement. Projects must have a confirmed exhibition venue, ensuring artworks reach diverse audiences and foster meaningful community experiences beyond traditional gallery settings.

The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) program invites applications to enhance communication and collaboration among researchers in digestive and liver diseases. Funded by the NIDDK, DDRCCs focus on shared resources that foster productivity and innovative research ideas. Each center must revolve around a central theme aligned with the NIDDK's mission, ensuring effective research support while avoiding overlap with other NIH Institutes' funding areas.

This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.

The Park Foundation Grants for the Environment focus on ensuring clean and accessible drinking water while opposing shale gas extraction and infrastructure expansion. They fund diverse initiatives aimed at promoting sustainable practices and policies, particularly within New York State. The Foundation supports advocacy, organizing, and corporate responsibility efforts that align with their mission to foster a just and sustainable environment, empowering communities to protect their natural resources.

Citizen Security Research Initiative

IPA's Citizen Security Research Initiative (CSRI) supports rigorous impact evaluations, pilot studies, infrastructure and public goods projects, and foundational and contextual research to inform policies and programs on building safer communities and strengthening justice and law enforcement systems. Funding for CSRI comes from the United States Department of State's Bureau of International Narcotics and Law Enforcement Affairs (INL).

Supported projects will generate actionable evidence to inform policy and programming in the citizen security and justice sector, with a focus on studies that challenge common beliefs, pioneer innovative interventions, and produce evidence where little currently exists. Priority areas of research include:

• Countering organized crime
• Combating drug trafficking and production
• Preventing crime and violence
• Strengthening law enforcement and criminal justice institutions

Budgets are expected to adhere to the budget caps outlined in our Call for Proposals (US$75,000 for pilots, US$400,000 for full impact evaluation studies, US$250,000 for infrastructure and public goods creation projects, US$75,000 for foundational and contextual research projects). In recognition that research in some locations or with some populations is more costly, on a case-by-case basis, we will consider budgets over the above award maximums with appropriate justification.

Awards are normally paid on a cost-reimbursable basis.

The Sidney R. Baer, Jr. Foundation focuses on improving the lives of individuals with schizophrenia and bipolar disorder through education grants. By funding programs that enhance educational opportunities, the foundation aims to reduce isolation and promote understanding. Grants are awarded to qualified organizations that prioritize mental health initiatives, ensuring that those affected have access to the resources and support necessary for a better quality of life. The foundation's mission is rooted in the belief that education can be transformative for those facing mental health challenges.

The Frankenthaler Climate Initiative's Catalyst Grant supports organizations in the visual arts sector to take quick, impactful actions toward sustainability. Since 2021, the initiative has awarded over $10 million, fostering a shift to carbon-neutral operations. Eligible applicants include nonprofit entities that prioritize visual arts, aiming to reduce environmental impact through clean energy, efficiency improvements, and innovative practices. This grant promotes a greener future while enhancing the importance of arts education and ecological stewardship.

The National Institute of Allergy and Infectious Diseases (NIAID) aims to enhance the development of diagnostic tests for infectious diseases through strategic partnerships between academia and industry. By fostering collaborations, NIAID seeks to overcome barriers to commercialization, ensuring promising diagnostics reach the market effectively. This initiative aligns with NIH's mission to advance innovative technologies that improve treatment and prevention strategies for infectious diseases, ultimately contributing to public health advancements.

Bucks County Foundation

Since our founding in 1979, the staff at BCF have been working closely with donors, local leaders, and nonprofit organizations to improve the quality of life in Bucks County. Our work with local charitable organizations helps to improve the health and wellbeing of children and families across the county.

Scholarships

The Bucks County Foundation is proud to support students throughout Bucks County in their pursuit of higher education and attainment of academic, trade and life skills that translate into economic self-sufficiency. Through the generosity of donors in our region, we manage over 100 scholarship distributions for a wide variety of students with diverse educational journeys.

Millennium Medical Women in Science and Medicine Scholarship

Provides scholarships to students attending high school in Bucks County who are planning to pursue a professional career in a scientific or medical related field such as Pre-Med, Nursing, Biology, Pharmacy, Chemistry, etc.

The Gertrude L. Hirsch Charitable Trust, founded in New Jersey, aims to support 501(c)(3) organizations for charitable and educational purposes. It focuses on various program areas including arts, education, environment, health, and human services. Although there are no geographic restrictions, preference is often given to organizations based in New Jersey. Additionally, funds awarded cannot be used outside the United States, ensuring that contributions remain within the country to benefit local communities.

Michael L. Hamaker Memorial Scholarship

A scholarship awarded to a graduating senior or previous graduate from Marshall, Olivet or the surrounding area seeking a career in engineering, manufacturing or industrial technologies with programs such as, but not limited to, architecture, construction, drafting, electronics, welding and/or other related technologies. Applicants must demonstrate financial need. GPA is not a qualifying factor; however, transcripts and test scores are requested. Students who receive this scholarship are encouraged to apply for further support in subsequent years.

The Jeffers, Danielson, Sonn & Aylward Law Scholarship supports Chelan and Douglas County high school graduates pursuing a degree in Law or Paralegal studies. Applicants must maintain a minimum 3.0 GPA and demonstrate financial need through the FAFSA. This scholarship encourages local students to advance their legal education, fostering a new generation of legal professionals committed to serving their communities.

The BIE Science Post Graduate Scholarship Fund offers financial assistance to American Indian and Alaska Native students pursuing full-time degrees in STEM fields at accredited institutions. This need-based award ranges from $100 to $30,000 per academic year, based on financial aid information provided by the institution's Financial Aid Office. Eligible students must demonstrate Tribal affiliation through a Tribal Eligibility Certificate.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The NRA Foundation Frontline Heroes Scholarship

The NRA Foundation Board of Trustees has established the Frontline Heroes Scholarship to institute a memorial to this distinguished group of First Responders, Law Enforcement Officers, and Military personnel*, who have served continuously and unselfishly in the highest tradition of our great nation.

The Frontline Heroes Scholarship will give a one-time annual award of up to $10,000** for one eligible candidate.

The Sustainable Development Grant Program, funded by The Rockefeller Brothers Fund, aims to combat climate change by promoting ecological stewardship, economic viability, and social equity. It supports initiatives that enhance public understanding, implement clean energy solutions, and foster international cooperation. The program prioritizes projects that address the urgent threats posed by climate change while ensuring that development efforts are sustainable and inclusive for future generations.

The Marv VandenBosch Scholarship, established by Sandra VandenBosch and her children in memory of Marv VandenBosch, supports Tri-Cities students pursuing careers in criminal justice or law enforcement. This scholarship considers financial need and requires applicants to have a minimum GPA of 2.5. The Grand Haven Area Community Foundation administers the scholarship through a competitive process, ensuring that each applicant is thoroughly reviewed to promote academic achievement and community involvement.

The Start-Up Research Grant aims to support early-career researchers establishing independent research careers. Grants are awarded for two years, enabling applicants to submit future proposals. The program emphasizes scientific excellence and collaboration between Israeli and American scientists. Eligible junior principal investigators (PIs) must be within ten years of their PhD or MD completion. Notably, the grant does not cover PI salaries and requires adherence to BSF's application standards.

The National Bycatch Reduction Engineering Program (BREP) for FY2026/27 offers competitive grants aimed at supporting non-Federal researchers. This initiative, governed by the Magnuson-Stevens Fishery Conservation and Management Act, focuses on developing innovative fishing practices and gear technologies to minimize bycatch and reduce post-release mortality of non-target species. By addressing bycatch reduction, the program seeks to enhance the sustainability of U.S. fisheries and aquaculture, aligning with the National Marine Fisheries Service's conservation goals.

The Fisheries Innovation Fund's Electronic Monitoring and Reporting Grant Program aims to enhance fisheries management through electronic technologies. Administered by the National Fish and Wildlife Foundation (NFWF), this initiative will support U.S. fisheries in implementing electronic monitoring tools to improve data collection, accessibility, and management. The program is open to various fisheries, including commercial and recreational sectors, promoting sustainable practices and fostering stakeholder involvement for better fishery information systems.

The Allstate Foundation - College Service Grants support youth empowerment through community service initiatives at community colleges and HBCUs across the U.S. Grants of $10,000 aim to enable youth-led projects that redefine service in the wake of a global pandemic. With over $1 million allocated to this effort, the program encourages innovative approaches to civic engagement and volunteerism, fostering a new generation of community leaders.

The Puffin Foundation's Annual Artist Grant Program focuses on supporting artists and organizations that are often marginalized. In even years, proposals are accepted in fine arts, music, and photography. With a maximum grant size of $3,500, it aims to empower individuals and groups with limited resources to flourish creatively. This initiative reflects the Foundation's commitment to ensuring diverse artistic expressions thrive in society. Applicants must be U.S. citizens or residents, and only one proposal is permitted per year.

The Rockefeller Family Fund's Climate Grant focuses on reducing fossil fuel production to combat climate change. It supports initiatives that hold polluters accountable and fosters citizen engagement for climate action. The fund prioritizes programs that seek to limit oil and gas production, enforce climate damages in court, and promote sustainable energy solutions. By addressing the fossil fuel industry's resistance, the grant aims to create meaningful progress towards climate goals and ensure that those responsible for climate disruption contribute to adaptation efforts.

CHEJ Small Grants Program

The Small Grants Program has officially relaunched. Applications are now open.The Center for Health, Environment & Justice’s (CHEJ) Small Grants Program is for grassroots groups working on environmental health and justice issues related to the presence of “toxics” (toxic chemicals or hazardous substances) in their immediate communities. CHEJ prioritizes community-based organizations aiming to have local, state and regional impact through their own strategies and actions.

The Katie Moore Memorial Nursing Scholarship, administered by the Community Foundation of North Central Washington, supports students pursuing a Bachelor of Science degree in nursing. Preference is given to those specializing in pediatric nursing and with relevant experience. Eligible candidates must have completed two years of college with a minimum GPA of 3.5 or be enrolled in an RN to BSN program. This scholarship honors Katie Moore's legacy and aims to foster compassionate care for children.

The McKnight Endowment Fund for Neuroscience offers the Neurobiology of Brain Disorders Award to support innovative research aimed at understanding and treating brain disorders. It provides up to four awards of $100,000 each year for three years, encouraging proposals that explore biological mechanisms and environmental contributions to neurological disorders. The program emphasizes inclusivity and collaboration among researchers to advance the field and improve therapeutic interventions for conditions such as Alzheimer's and Parkinson's disease.

The NIA Advanced Postdoctoral Career Transition Awards aim to enhance diversity in the translational research workforce for Alzheimer's disease and related dementias (AD/ADRD). This initiative supports early career researchers from diverse backgrounds in acquiring essential research skills applicable to various AD/ADRD studies. The goal is to cultivate a more diverse pool of researchers capable of leading interdisciplinary approaches in treatment, prevention, and management of AD/ADRD. Notably, independent clinical trials are not permitted under this award.