Best Health Care Grants in South Carolina

Lexington Medical Center Foundation Inc

Since 1971, Lexington Health has grown and expanded to meet the needs of our community. The Lexington Health Foundation Remains Committed to Quality Care. Foundation-funded programs aim to enhance patient experiences and touch the various areas of care at Lexington Health — Patient, Employee, and Community Care.

Event and Project Sponsorship

Lexington Medical Center supports local organizations and nonprofits throughout the Midlands.

We support local events and causes that enhance the health and vibrance of our community. You can request sponsorship or other assistance for a project or event based in the South Carolina Midlands community.

Nonprofit 501(c)(3) organizations providing healthcare, especially mental and behavioral health services, to those most in need in Greenville County, South Carolina can seek program funding. Hathaway Family Foundation also supports related food access, shelter, and conservation efforts that benefit vulnerable residents in upstate communities.

South Carolina nonprofits and public agencies providing senior nutrition and food distribution services can receive USDA commodity foods through the South Carolina Commodity Supplemental Food Program, improving low-income seniors’ diets. South Carolina Department of Agriculture administers CSFP statewide, with local agencies handling eligibility, food distribution, nutrition education, and referrals to other health and welfare programs.

Focused on capital projects, Yawkey Foundation invites South Carolina 501(c)(3) nonprofits providing direct health care, human services, education, youth athletics, arts, or conservation programs to seek major facilities funding. Eligible organizations in Georgetown County can request up to US $5,000,000 to develop or improve physical spaces that enhance high-quality services.

Public bodies, community-based nonprofits, and Federally Recognized Tribes in South Carolina rural areas can apply for USDA Rural Development’s Community Facilities funding to develop essential community facilities. Support can cover purchasing, constructing, or improving facilities and equipment for health care, public safety, community services, education, utilities, and local food systems in eligible small communities.

South Carolina 501(c)(3) nonprofits working on health, social services, hunger, poverty, education, agriculture, environment, or public safety can access funding via Franklin P. and Arthur W. Perdue Foundation. Grants up to US $1,000 support community-benefit programs, with priority for areas near Perdue facilities and projects endorsed by a Perdue associate.

Nonprofits and community groups hosting outreach, events, trainings, or workshops that support health care access, housing security, or economic mobility for people experiencing poverty in South Carolina can seek up to US $1,500 in one-time funding. Sisters of Charity Foundation of South Carolina prioritizes grassroots efforts, especially in persistent poverty counties and communities of color.

South Carolina 501(c)(3) health and rehabilitation nonprofits can access funding through the Philip L Van Every Foundation for special projects and capital needs. Grants of US $10,000 - US $50,000 support healthcare, rehabilitation, prevention, wellness, substance abuse services, and related human and community service programs benefiting residents of North and South Carolina.

Nonprofit organizations addressing changing healthcare needs in the CSRA region of South Carolina and Georgia can apply for competitive grants up to US $15,000. Focused on improving health outcomes, Community Foundation for the Central Savannah River Area supports health service education, uninsured medical care, and hospice or homelessness around health care for partners in good standing.

Nonprofit 501(c)(3) organizations providing youth baseball or softball programs and small capital projects in South Carolina can apply for Yawkey Foundation support, with awards up to US $100,000. Grants fund discrete, timebound program needs, projects, or equipment for direct services, with eligibility in Georgetown County within the foundation’s geographic priorities.

Health care and human services nonprofits in South Carolina’s Georgetown County can seek US $250,000 - US $1,000,000 to implement board-approved strategic growth plans. Yawkey Foundation’s Strategic Investment Grants support regional expansion, collaborations, and mergers for organizations delivering direct services in its health care and related priority areas.

South Carolina nonprofits, government agencies, and tax-exempt educational or research institutions working on health access and outcomes can seek funding for projects serving economically vulnerable residents. South Carolina health organizations can access funding through Blue Cross and Blue Shield of South Carolina Foundation to improve oral health, mental health, community health education, primary care, and related health care services.

Grants from Spartanburg County Foundation help South Carolina health-focused nonprofits and other 501(c)(3) entities improve quality of life, educational achievement, and economic mobility for Spartanburg County residents. Organizations may receive up to US $35,000 for programs such as physical and mental health services, wellness activities, and related supports that strengthen community well-being.

Nonprofit 501(c)(3) organizations focused on conservation and wildlife projects in South Carolina can seek up to US $100,000 for discrete, timebound program or small capital needs. With a mission to invest in impactful nonprofits, Yawkey Foundation prioritizes direct services in Georgetown County and supports equipment or project-based needs rather than ongoing staff costs.

Nonprofit 501(c)(3) organizations providing higher education access and success programs for underserved young adults may receive up to US $100,000 for discrete, timebound program or small capital needs. Focused on educational access and equity, Yawkey Foundation invites organizations serving Eastern Massachusetts and Georgetown County, South Carolina to apply through its competitive Program and Small Capital Grants.

Nonprofit organizations in South Carolina working on systems change for economic mobility or housing security can apply for Sisters of Charity Foundation’s Systems Change Grants, with awards of US $15,000 - US $20,000. Funding can support general operations, programs, or capacity-building, and health care systems change grants are available by invitation only.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

South Carolina health and family service nonprofits addressing adverse childhood experiences (ACEs) and related trauma can access funding through Amerihealth Caritas Foundation, with awards of US $100,000 - US $150,000 for one-year, project-specific work. Eligible 501(c)(3)s must serve Medicaid-enrolled communities with comprehensive, community-led programs focused on healing behaviors, health care access, and empowering families.

South Carolina housing and community development organizations with proven affordable housing innovations can access funding via Enterprise Community Partners through the National Housing Innovation Grant competition. Eligible nonprofits, mission-oriented for-profits, and housing entities nationwide may apply for US $2,000,000 to scale solutions in design and construction, finance, or service delivery that expand affordable rental and ownership options.

Health-focused 501(c)(3) nonprofits, government entities, and academic institutions in South Carolina can seek funding for oral health education, prevention, treatment, capacity building, and equipment. Grants from Delta Dental of South Carolina help expand access to affordable, high-quality dental care, especially for children, indigent, rural, and other underserved populations, with awards from US $5,000 - US $100,000.

Nonprofit 501(c)(3)s, government agencies, and academic institutions improving oral health can seek US $5,000 - US $100,000 for programs, operations, equipment, or capacity building in South Carolina and Missouri. Delta Dental of MIssouri prioritizes projects expanding access to affordable dental care, especially in rural or provider-shortage areas and those with dollar-for-dollar matching funds.

Eligible organizations in South Carolina can apply for the Rural Health Transformation Program: Connections to Care Initiative, awarding US $100,000 - US $10,000,000 to modernize and expand digital health infrastructure. Funding supports implementation or enhancement of electronic health records and remote patient monitoring within the state’s rural healthcare ecosystem.

Rural South Carolina health providers and community organizations can seek funding to expand mobile crisis response and community-based care sites. Focused on rural health care and mental health services, the South Carolina Department of Health and Human Services invites proposals supporting face-to-face care delivery through mobile units, crisis teams, and local wellness sites, with awards from US $50,000 - US $2,000,000.

Nonprofit 501(c)(3) organizations providing direct human services or basic needs support in South Carolina, particularly Georgetown County, can seek up to US $100,000 for timebound program or small capital needs. Grants from Yawkey Foundation help cover discrete projects or equipment that advance core missions serving vulnerable and underserved people.

Eligible 501(c)(3) public charities, houses of worship, government entities, and fiscally sponsored projects in South Carolina’s Georgetown County can apply for Frances P. Bunnelle Foundation’s Grants for the Common Good, awarding US $2,500 - US $15,000 for general operating or special projects. Health care access, basic needs, poverty, literacy, environment, and economic vitality programs may be supported.

501(c)(3) nonprofits serving children and families through arts and culture programs in South Carolina can apply for Yawkey Foundation’s Program and Small Capital Grants, with awards up to US $100,000 for discrete, timebound projects or equipment. Organizations in Georgetown County may be eligible if they align with the foundation’s arts and culture priorities.

Health-focused 501(c)(3) nonprofits providing direct care, improving access, or addressing health disparities in South Carolina may be eligible for Yawkey Foundation Program and Small Capital Grants up to Up to US $100,000. Focused on health care access, children’s mental health, and social determinants, these competitive grants support discrete, timebound program needs, small projects, or equipment purchases in Georgetown County.