Best Greenville Grants for Nonprofits in South Carolina

With a mission to strengthen communities, PNC Foundation provides Greenville, South Carolina nonprofits with funding for early childhood education and economic development initiatives. Eligible 501(c)(3) organizations serving low- and moderate-income children and families in areas where PNC has a significant presence may seek support for education, community development, affordable housing, arts, and essential human services.

The Spinks Family Foundation provides large grants of $10,000 and above annually to support non-profit organizations focused on education, food security, health, and mental health initiatives. Organizations must be 501(c)3 certified and demonstrate community impact with at least 500 volunteer hours. Applications are accepted from March 1 to March 30, and awards are announced by September 15. This initiative aims to empower nonprofits to effectively address pressing community needs.

The Brinker International Charitable Giving Program focuses on giving back to communities through support for kids, hunger, and education. Organizations eligible for funding must be 501c(3) non-profits and submit requests at least six weeks prior to events. The program does not support individuals, political or religious organizations, or explicit discrimination policies. Funding is provided through monetary donations or in-kind contributions like dining certificates.

Nonprofit 501(c)(3) organizations serving underrepresented children, PreK–12 students, or families in Greenville, South Carolina may be eligible for community-focused funding that supports direct program needs. Focused on education, child wellbeing, and community-based family support, the ScanSource Charitable Foundation prioritizes impactful services and meaningful volunteer opportunities within its Greenville County footprint.

Project Lead the Way inc.

School and district leaders need a solution that cultivates confidence and career readiness—and PLTW checks all the boxes. As a nonprofit organization founded by educators and driven by education leaders, we've spent more than 28 years equipping students with the technical knowledge, transferable skills, and career confidence they need to thrive—through programs that integrate real-world industry partnerships, best-in-class teacher training, and our proven activity-, project-, problem-based (APB) instructional model. At PLTW, we're on a mission to create a transformative learning environment and empower students to develop in-demand knowledge and skills necessary to thrive in an evolving world. 

PLTW Engineering

PLTW Engineering students adopt a problem-solving mindset, are engaged in compelling, real-world challenges that help them become better collaborators and thinkers, and are prepared with skills to step into any career path they take. Each PLTW Engineering course engages students in interdisciplinary activities like working with a client to design a home, programming electronic devices or robotic arms, or exploring algae as a biofuel source. These activities not only build knowledge and skills in engineering, but also empower students to develop essential skills such as problem solving, critical and creative thinking, communication, collaboration, and perseverance.

PLTW Engineering - New Program (3M) 

3M forms lasting partnerships with communities and provides resources to help them succeed and grow – ensuring a more interconnected and thriving world. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities
• Enhancing the quality of STEM teaching
• Providing professional development opportunities for students

3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM.

Project Lead the Way inc.

School and district leaders need a solution that cultivates confidence and career readiness—and PLTW checks all the boxes. As a nonprofit organization founded by educators and driven by education leaders, we've spent more than 28 years equipping students with the technical knowledge, transferable skills, and career confidence they need to thrive—through programs that integrate real-world industry partnerships, best-in-class teacher training, and our proven activity-, project-, problem-based (APB) instructional model. At PLTW, we're on a mission to create a transformative learning environment and empower students to develop in-demand knowledge and skills necessary to thrive in an evolving world. 

PLTW Computer Science

PLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not. Empower your students to become creators of the technology all around them. PLTW Computer Science engages students in collaborative projects that help them develop in-demand computer science knowledge as well as transportable skills like creative thinking and communication. And whether they’re creating an online art gallery or using automation to process and analyze DNA-sequence data, PLTW Computer Science students are seeing how their learning connects to the real world.

PLTW Computer Science - New Program (3M)

3M forms lasting partnerships with communities and provides resources to help them succeed and grow – ensuring a more interconnected and thriving world. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities
• Enhancing the quality of STEM teaching
• Providing professional development opportunities for students

3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM.

Project Lead the Way (PLTW) provides innovative, hands-on learning experiences for students in PreK-5, fostering confidence and career readiness. With support from 3M, PLTW Launch aims to enhance STEM education by increasing exposure, supporting experiential learning, and improving teaching quality. This partnership ensures that students and teachers have the necessary tools and resources to thrive in a rapidly evolving world, empowering the next generation of leaders in science and technology.

ATI Physical Therapy is dedicated to enhancing community health and wellness through its sponsorship and donation initiatives. With a mission to exceed customer expectations, ATI actively engages in philanthropic efforts that improve lives and promote quality care beyond clinic walls. They encourage requests for support while emphasizing a review process that ensures timely responses. Partnering with local organizations, ATI aims to elevate awareness of health and wellness, impacting thousands of lives each year.

The Jean Griswold Foundation

The Jean Griswold Foundation (JGF) is a non-profit organization dedicated to supporting Caregivers through educational opportunities and scholarships. 

Our Mission

The mission of the Jean Griswold Foundation is to support Caregivers by providing educational scholarships* to enable them to further their training, enhance their careers, and better assist the clients they serve.

By offering educational scholarships*, our Foundation will not only make a positive impact on the Caregivers themselves, but also the clients they assist and the home healthcare agencies where they are employed, as well as help advance the overarching home-care industry.

Scholarships will be paid directly to the federally accredited educational institutions of the winning Scholars’ choosing.

Empowering Caregivers Through Education

The Jean Griswold Foundation Scholarship Program awards scholarships to deserving Caregivers who wish to further their education in a care-related field. Applicants do not have to be associated with Griswold in any way, and the funds will be paid directly to the institution where the caregiver will be receiving education.  

Our Winter 2026 Scholarship Application period is now open! Applications will be accepted until 11:59pm ET August 31, 2026. Join our email list to get the first notice of all Scholarship happenings.  

Where would we be without Caregivers? 

Their selflessness is astounding, yet they are often overlooked and underappreciated. 

The Jean Griswold Foundation is dedicated to supporting Caregivers, the backbone of the care industry. We provide educational scholarships so Care Professionals can further their training, enhance their skills, elevate their careers, and better assist the people they serve.

The Prisma Health-Upstate Foundation Micro-Grant Program, established in 2023, aims to enhance the patient experience and quality of care by providing clinical care teams with resources. Individual awards can reach up to $5,000, with funds available to selected applicants in February, to be utilized by the end of the fiscal year. Award recipients are expected to report on the impact of their funding, contributing to a legacy of compassionate care in the Upstate community.

The Spartanburg Regional Foundation, established in 1991, plays a crucial role in enhancing community health in the Upstate of South Carolina. By supporting projects and initiatives, the Foundation has contributed over $100 million to healthcare efforts. It allocates funds to priority areas such as maternal health, behavioral health, and workforce development. The Foundation aims to empower change through innovative grantmaking, benefiting both Spartanburg Regional Healthcare System and community partners dedicated to improving health outcomes.

Greenville, South Carolina 501(c)(3) nonprofits and government units can access funding through the Community Foundation of Greenville for high-impact projects in arts, education, environment, health, and human services. Greenville Women Giving awards US $50,000 - US $100,000 grants annually for initiatives serving residents of Greenville County, South Carolina.

The Walter Johnson Trust Grants, administered by the Community Foundation of Greenville, provide funding for staff development in social service agencies within Greenville County. Although no applications will be accepted in 2026 for the Staff Training Grant, scholarships will be available for the Together SC Summit in March 2026. The grants support specific training programs aimed at enhancing organizational stability and capacity building for eligible 501(c)(3) agencies.

Nonprofit 501(c)(3) organizations serving Greenville, South Carolina can seek funding for programs that advance economic mobility, education, housing, transportation, and employment. With a mission to remove systemic barriers, Hollingsworth Funds provides US $15,000 - US $500,000 for general operating, capital, or project support benefiting Greenville County residents, especially low-income Black and Hispanic/Latinx communities.

The CFG Capacity Building Grants support established 501(c)(3) organizations in Greenville County, SC, aiming to enhance their operational capabilities and governance. Funding opportunities include projects for client engagement, management innovation, collaborative ventures, technology improvements, and revenue diversification. Examples of capacity building encompass financial planning, organizational assessments, strategic planning, and leadership development. Grants are awarded competitively, allowing one application per agency per year, excluding individuals and certain ineligible expenses.

Greenville, South Carolina 501(c)(3) nonprofits focused on economic mobility, workforce readiness, entrepreneurship, or affordable housing can access funding through Bank of America Charitable Foundation’s Neighborhood Builders Program. Selected organizations receive a two-year leadership development experience plus capacity-building support, if they meet revenue thresholds and other organizational readiness requirements in eligible markets.

Nonprofit organizations, public agencies, tribes, and higher education institutions in eligible parts of Greenville, South Carolina can seek funding for critical infrastructure, public transportation, broadband, and workforce or business development projects. With a mission to strengthen Appalachian communities, Appalachian Regional Commission provides flexible, locally driven support across its 13-state Appalachian region.

The Metropolitan Arts Council (MAC) offers the Arts Organization Quarterly Project Grant Program, prioritizing projects that enhance community impact through arts. Funding up to $3,000 with a 2:1 match encourages initiatives supporting artists, promoting cultural tourism, and ensuring access to the arts for all. This grant facilitates economic growth and aims to attract new audiences to artistic programming, fostering a vibrant cultural landscape in Greenville.

Nonprofit 501(c)(3) organizations addressing basic needs, income creation, housing stability, or community empowerment in Greenville, South Carolina can access funding through Bank of America Charitable Foundation. Grants support economic mobility efforts for low- and moderate-income communities, including workforce development, small business resiliency, and community development for vulnerable populations such as families, youth, seniors, veterans, and people with disabilities.

The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.

The Hathaway Family Foundation Grant aims to enhance the lives of individuals in need within Greenville, South Carolina. This private foundation focuses on improving food security, access to quality healthcare, conservation efforts, and addressing homelessness. By supporting organizations that provide temporary shelters, mental health care, and food distribution, the foundation ensures targeted assistance for the most vulnerable populations. The foundation's commitment reflects a dedication to fostering community well-being and positive change.

Indigo Hope Foundation: Addiction Recovery Programs Grant

Funding programs that offer treatment, counseling, recovery support services, and harm reduction for individuals battling addiction.

Key Focus Areas:

• Treatment Services
• Recovery Support
• Harm Reduction
• Family Programs

Example Programs We Fund:

• Outpatient counseling programs
• Peer recovery support
• Addiction Recovery Residential Programs
• Family therapy services

Indigo Hope Foundation: At-Risk Youth Development Grant

Empowering programs that provide mentorship, education, life skills training, and opportunities for young people facing challenges.

Key Focus Areas:

• Mentorship Programs
• Educational Support
• Life Skills Training
• Career Development

Example Programs We Fund:

• After-school tutoring and mentorship
• Job readiness training
• Leadership development

Indigo Hope Foundation: First Responder Wellness Grant

Supporting programs that provide mental health resources, training, family support, and wellness services for our first responders.

Key Focus Areas:

• Mental Health Support
• Family Services
• Training Programs
• Peer Support

Example Programs We Fund:

• Critical incident stress management
• Family counseling services
• Peer support programs
• Wellness and resilience training

Indigo Hope Foundation: Veterans Support Services Grant

Assisting organizations that serve our veterans with housing, healthcare, job training, mental health services, and family support.

Key Focus Areas:

• Housing Assistance
• Mental Health Services
• Job Training
• Family Support

Example Programs We Fund:

• PTSD counseling services including canine training programs
• Job placement programs
• Emergency housing assistance
• Veterans court support

The SC INBRE: Mentored Student Pilot Projects (MSP) program offers undergraduate and graduate students in South Carolina funding of $3,000 for one year to conduct small, well-defined research projects under faculty mentorship. This initiative supports career development and hands-on training in biomedical research, enhancing the research capacity of member institutions. Applications are encouraged from students who have not previously held an SIRP award, fostering diversity in research participation.

Small 501(c)(3) nonprofits focused on social mobility, financial wellness, or workforce education in Greenville, South Carolina can seek Truliant Mini Grants for staff and board training or key program materials. Focused on community capacity building, Truliant Federal Credit Union offers up to US $2,500 to organizations in Truliant member communities with budgets under $500,000.