Best Greenville Grants for Nonprofits in South Carolina

The Spinks Family Foundation provides large grants of $10,000 and above annually to support non-profit organizations focused on education, food security, health, and mental health initiatives. Organizations must be 501(c)3 certified and demonstrate community impact with at least 500 volunteer hours. Applications are accepted from March 1 to March 30, and awards are announced by September 15. This initiative aims to empower nonprofits to effectively address pressing community needs.

The IMA Foundation Grant focuses on empowering communities by supporting nonprofit organizations dedicated to workforce development, financial security for families, and enhancing emergency preparedness. With a mission to provide philanthropic assistance, the foundation seeks partners that align with its vision and operational reach. Organizations must be 501c3 nonprofits and serve areas where IMA has offices, ensuring that their initiatives directly impact youth under 26 years of age.

The Prisma Health-Upstate Foundation Micro-Grant Program, established in 2023, aims to enhance the patient experience and quality of care by providing clinical care teams with resources. Individual awards can reach up to $5,000, with funds available to selected applicants in February, to be utilized by the end of the fiscal year. Award recipients are expected to report on the impact of their funding, contributing to a legacy of compassionate care in the Upstate community.

The Ferguson Cares Grant is an essential aspect of Ferguson's Sustainability strategy, focusing on social challenges and community wellbeing. This grant supports nonprofit organizations in the U.S. dedicated to affordable housing, skilled trades workforce development, clean water access, and enhancing local economic quality of life. Ferguson aims to create lasting partnerships that drive positive impact within their operational regions, reflecting their commitment to social responsibility and community support.

The Spartanburg Regional Foundation, established in 1991, plays a crucial role in enhancing community health in the Upstate of South Carolina. By supporting projects and initiatives, the Foundation has contributed over $100 million to healthcare efforts. It allocates funds to priority areas such as maternal health, behavioral health, and workforce development. The Foundation aims to empower change through innovative grantmaking, benefiting both Spartanburg Regional Healthcare System and community partners dedicated to improving health outcomes.

Indigo Hope Foundation: Addiction Recovery Programs Grant

Funding programs that offer treatment, counseling, recovery support services, and harm reduction for individuals battling addiction.

Key Focus Areas:

• Treatment Services
• Recovery Support
• Harm Reduction
• Family Programs

Example Programs We Fund:

• Outpatient counseling programs
• Peer recovery support
• Addiction Recovery Residential Programs
• Family therapy services

Indigo Hope Foundation: At-Risk Youth Development Grant

Empowering programs that provide mentorship, education, life skills training, and opportunities for young people facing challenges.

Key Focus Areas:

• Mentorship Programs
• Educational Support
• Life Skills Training
• Career Development

Example Programs We Fund:

• After-school tutoring and mentorship
• Job readiness training
• Leadership development

Indigo Hope Foundation: First Responder Wellness Grant

Supporting programs that provide mental health resources, training, family support, and wellness services for our first responders.

Key Focus Areas:

• Mental Health Support
• Family Services
• Training Programs
• Peer Support

Example Programs We Fund:

• Critical incident stress management
• Family counseling services
• Peer support programs
• Wellness and resilience training

The CFG Capacity Building Grants support established 501(c)(3) organizations in Greenville County, SC, aiming to enhance their operational capabilities and governance. Funding opportunities include projects for client engagement, management innovation, collaborative ventures, technology improvements, and revenue diversification. Examples of capacity building encompass financial planning, organizational assessments, strategic planning, and leadership development. Grants are awarded competitively, allowing one application per agency per year, excluding individuals and certain ineligible expenses.

The TD Bank Community Sponsorships Program, supported by the TD Charitable Foundation, provides funding for events and activities that positively impact communities from Maine to Florida. This initiative aims to enhance community awareness and foster partnerships among diverse groups, promoting economic development, cultural enrichment, and social responsibility. Organizations can apply for funding to support community-oriented programs, with applications reviewed quarterly. It's essential to submit applications at least 90 days before the event deadlines.

About PLTW Computer SciencePLTW Computer Science students are technology trailblazers who are empowered through transportable skills and prepared to start their career, whether that is in computer science or not.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities enhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Computer Science program.
  • Example expansion activities include but are not limited to adding an additional PLTW Computer Science  course not previously offered,
  • and/or adding additional class periods of an existing PLTW Computer Science courses previously offered,
  • and/or training additional teachers in PLTW Computer Science courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $5,000
  • 2027-2028: $5,000

About PLTW EngineeringPLTW Engineering students adopt a problem-solving mindset, are engaged in compelling, real-world challenges that help them become better collaborators and thinkers, and are prepared with skills to step into any career path they take.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunitiesEnhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• Grantee must use their grant funds to expand their existing PLTW Engineering program.
  • Example expansion activities include but are not limited to adding an additional PLTW Engineering course not previously offered,
  • and/or adding additional class periods of an existing PLTW Engineering courses previously offered,
  • and/or training additional teachers in PLTW Engineering courses for the 2027-2028 academic year. 

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

About PLTW GatewayPLTW Gateway (6-8) opens paths that create meaningful futures. It connects students to careers in areas they can, and can't, imagine.3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunitiesEnhancing the quality of STEM teaching
• Providing professional development opportunities for students

Program Requirements:

• The purpose of this grant is to assist the grantee's implementation of the PLTW Gateway program.
• Grantee must offer at least one PLTW Gateway unit in the 2027-2028 academic year.
• Grantee may implement any PLTW Gateway unit of their choosing.

Grant Award and Distribution Schedule:

• Total Award: $10,000
  • 2027-2028: $10,000

The Robert B. and Ruth K. Lee Foundation Grant aims to enhance the quality of life in Greenville County, South Carolina. Established in 2000, the foundation supports diverse areas including arts, education, health, and human services. With no geographic limitations, it primarily funds programs benefiting the local community. Grants typically range from $2,000 to $5,000, emphasizing initiatives for the elderly, children’s programs in the arts, and literary projects. Organizations must be 501(c)(3) exempt to be eligible.

Nonprofit 501(c)(3) organizations serving Greenville, South Carolina can seek funding for programs that advance economic mobility, education, housing, transportation, and employment. With a mission to remove systemic barriers, Hollingsworth Funds provides US $15,000 - US $500,000 for general operating, capital, or project support benefiting Greenville County residents, especially low-income Black and Hispanic/Latinx communities.

Nonprofit organizations, public agencies, tribes, and higher education institutions in eligible parts of Greenville, South Carolina can seek funding for critical infrastructure, public transportation, broadband, and workforce or business development projects. With a mission to strengthen Appalachian communities, Appalachian Regional Commission provides flexible, locally driven support across its 13-state Appalachian region.

Nonprofits and public entities planning or implementing multi-state economic and community development projects that include Greenville, South Carolina can seek ARISE funding for regional initiatives. Appalachian Regional Commission supports economic development, workforce readiness, community revitalization, and tourism across eligible Appalachian counties; awards up to US $10,000,000 for planning and implementation efforts.

Nonprofit 501(c)(3) organizations, public schools, and qualified local governments can receive funding to provide job-related classes and courses for their employees, including one-day sessions and certification programs. Grants from TD Charitable Foundation help Greenville, South Carolina nonprofits and other TD Bank market-area organizations strengthen staff skills while serving low- to moderate-income and historically underserved communities in areas like financial literacy, housing, education, and business development.

The Spinks Family Foundation offers small grants to support non-profit organizations dedicated to improving community life in South Carolina. Eligible organizations must be 501(c)(3) certified, with a focus on volunteer engagement and community services. Applications are accepted on a rolling basis and reviewed quarterly, providing essential funding for initiatives in education, health, and food security. This philanthropic effort aims to foster strong, healthy communities and enhance the well-being of residents.

ATI Physical Therapy is dedicated to enhancing community health and wellness through its sponsorship and donation initiatives. With a mission to exceed customer expectations, ATI actively engages in philanthropic efforts that improve lives and promote quality care beyond clinic walls. They encourage requests for support while emphasizing a review process that ensures timely responses. Partnering with local organizations, ATI aims to elevate awareness of health and wellness, impacting thousands of lives each year.

Nonprofit 501(c)(3) organizations with budgets under $1 million serving Greenville, South Carolina communities with a Truliant branch can seek project support for financial wellness, social mobility, and workforce education initiatives. Truliant Federal Credit Union supports efforts like financial literacy, food security, affordable housing, transportation access, and career skills development through its quarterly Community Giving program.

The Metropolitan Arts Council (MAC) offers the Arts Organization Quarterly Project Grant Program, prioritizing projects that enhance community impact through arts. Funding up to $3,000 with a 2:1 match encourages initiatives supporting artists, promoting cultural tourism, and ensuring access to the arts for all. This grant facilitates economic growth and aims to attract new audiences to artistic programming, fostering a vibrant cultural landscape in Greenville.

The Bank of America Charitable Foundation focuses on supporting organizations that empower communities through basic needs, income creation, and stable housing. By investing in health and job opportunities, they aim to enhance economic mobility for low- and moderate-income families. Their partnerships target vulnerable populations, ensuring equitable access to resources that foster community vitality and resilience. This initiative emphasizes the importance of stable housing as a foundation for personal and communal growth.

Public and private K–12 schools that are identified ArtsNOW partner schools can access funding to expand arts integration and professional learning in Greenville, South Carolina. Grants from South Carolina Arts Commission support multi-year arts integration training, demonstration lessons, curriculum mapping, and planning to engage students, equip educators, and strengthen school communities.

Project Lead the Way inc.

School and district leaders need a solution that cultivates confidence and career readiness—and PLTW checks all the boxes. As a nonprofit organization founded by educators and driven by education leaders, we've spent more than 28 years equipping students with the technical knowledge, transferable skills, and career confidence they need to thrive—through programs that integrate real-world industry partnerships, best-in-class teacher training, and our proven activity-, project-, problem-based (APB) instructional model. At PLTW, we're on a mission to create a transformative learning environment and empower students to develop in-demand knowledge and skills necessary to thrive in an evolving world. 

PLTW Gateway

PLTW Gateway (6-8) opens paths that create meaningful futures. It connects students to careers in areas they can, and can't, imagine. Through explorations of skilled trades, coding and robotics, flight and space, human body systems, and more, PLTW Gateway fuels students’ passion for discovery. As they engage in hands-on, collaborative problem solving focused on real-world challenges, students use and stretch their imaginations in brand-new ways that connect their learning to life. All the while, students step into roles spanning the career landscape—a crucial experience during this transitional time in their lives, long before they enter their degreed or skilled trade professions. 

PLTW Gateway - Program Expansion (3M)

3M forms lasting partnerships with communities and provides resources to help them succeed and grow – ensuring a more interconnected and thriving world. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities
• Enhancing the quality of STEM teaching
• Providing professional development opportunities for students

3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM.

Project Lead the Way inc.

School and district leaders need a solution that cultivates confidence and career readiness—and PLTW checks all the boxes. As a nonprofit organization founded by educators and driven by education leaders, we've spent more than 28 years equipping students with the technical knowledge, transferable skills, and career confidence they need to thrive—through programs that integrate real-world industry partnerships, best-in-class teacher training, and our proven activity-, project-, problem-based (APB) instructional model. At PLTW, we're on a mission to create a transformative learning environment and empower students to develop in-demand knowledge and skills necessary to thrive in an evolving world. 

PLTW Launch (PreK-5)

Young learners are naturally wired for discovery. PLTW Launch is designed with activities that let them see what they can be and build skills to discover what they can do. Students are immersed in hands-on activities, projects, and problems that build upon each other and relate to the real world. They experience integrated learning that blends computer science, engineering, biomedical science, and more. Throughout the modules, even the youngest learners apply their math and English Language Arts (ELA) skills, learn science to standards, and adopt skills that are foundational across disciplines.

PLTW Launch - Program Expansion (3M)

3M forms lasting partnerships with communities and provides resources to help them succeed and grow – ensuring a more interconnected and thriving world. 3M inspires the next generation of science leaders through the following goals:

• Increasing STEM exposure in K-12 classrooms
• Supporting experiential learning opportunities
• Enhancing the quality of STEM teaching
• Providing professional development opportunities for students

3M has partnered with PLTW to ensure students and teachers have the tools, resources and knowledge they need to succeed in STEM.

The SC INBRE: Mentored Student Pilot Projects (MSP) program offers undergraduate and graduate students in South Carolina funding of $3,000 for one year to conduct small, well-defined research projects under faculty mentorship. This initiative supports career development and hands-on training in biomedical research, enhancing the research capacity of member institutions. Applications are encouraged from students who have not previously held an SIRP award, fostering diversity in research participation.