Best Cherokee County Grants for Nonprofits in South Carolina

The Piedmont Natural Gas Company Grant Program, part of the Duke Energy Foundation, supports community vitality through grants of $20,000 or less. Focus areas include vibrant economies, climate resiliency, and promoting opportunity and inclusion. Eligible organizations must have tax-exempt status and serve communities without discrimination. The foundation prioritizes measurable community impact and does not fund certain entities, including for-profits and religious organizations. Applications are accepted year-round on a rolling basis.

The Indigo Hope Foundation offers grants to organizations in the Upstate of South Carolina, focusing on addiction, homelessness, at-risk youth, veterans, and first responders. They award between $250 and $100,000, prioritizing projects that demonstrate measurable results and address critical community needs. Eligible applicants must be 501(c)(3) tax-exempt or government units, with only one application allowed per grant period. The foundation emphasizes collaboration and favors faith-based organizations.

The Spartanburg Regional Foundation, established in 1991, plays a crucial role in enhancing community health in the Upstate of South Carolina. By supporting projects and initiatives, the Foundation has contributed over $100 million to healthcare efforts. It allocates funds to priority areas such as maternal health, behavioral health, and workforce development. The Foundation aims to empower change through innovative grantmaking, benefiting both Spartanburg Regional Healthcare System and community partners dedicated to improving health outcomes.

The Weyerhaeuser Giving Fund provides grants to support communities in the U.S. and Canada where the company operates. Focused on affordable housing, education, environmental stewardship, and more, the fund emphasizes projects that meet local needs and demonstrate community support. Eligible organizations include nonprofits and educational institutions. Applications are accepted year-round with a deadline for 2025 on September 30. National initiatives related to working forests are funded by invitation only.

The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.

The Westinghouse Charitable Giving Program aims to strengthen community ties by providing financial support in key areas such as education focused on STEM, environmental sustainability, and community safety. This program welcomes applications from eligible organizations that meet specific grant criteria, including being tax-exempt and located within 50 miles of a Westinghouse site. The initiative underscores Westinghouse's commitment to advancing education, promoting environmental stewardship, and enhancing community well-being.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The ARISE Grants, offered by the Appalachian Regional Commission, aim to drive regional economic transformation across 13 Appalachian states. With funding of up to $63.5 million for implementation grants and $10 million maximum awards, the initiative supports collaborative projects that enhance community capacity and economic growth. The program encourages innovative partnerships to strengthen local economies and achieve socioeconomic parity, benefiting over 26 million residents in the Appalachian Region.

The Bank of America Charitable Foundation focuses on supporting organizations that empower communities through basic needs, income creation, and stable housing. By investing in health and job opportunities, they aim to enhance economic mobility for low- and moderate-income families. Their partnerships target vulnerable populations, ensuring equitable access to resources that foster community vitality and resilience. This initiative emphasizes the importance of stable housing as a foundation for personal and communal growth.

The Neighborhood Builders Program, supported by Bank of America, empowers 501(c)(3) nonprofits through a two-year leadership development initiative. Participants receive funding, training, and networking opportunities to enhance their impact in communities. Since its inception, the program has invested over $346 million, training more than 4,000 leaders. The initiative focuses on advancing social mobility and economic opportunities, ensuring affordable housing, and fostering resilient communities. This program is vital for nonprofits aiming to strengthen their leadership and community engagement.

The Spinks Family Foundation offers small grants to support non-profit organizations dedicated to improving community life in South Carolina. Eligible organizations must be 501(c)(3) certified, with a focus on volunteer engagement and community services. Applications are accepted on a rolling basis and reviewed quarterly, providing essential funding for initiatives in education, health, and food security. This philanthropic effort aims to foster strong, healthy communities and enhance the well-being of residents.

The Spinks Family Foundation provides large grants of $10,000 and above annually to support non-profit organizations focused on education, food security, health, and mental health initiatives. Organizations must be 501(c)3 certified and demonstrate community impact with at least 500 volunteer hours. Applications are accepted from March 1 to March 30, and awards are announced by September 15. This initiative aims to empower nonprofits to effectively address pressing community needs.

The Jean Griswold Foundation

The Jean Griswold Foundation (JGF) is a non-profit organization dedicated to supporting Caregivers through educational opportunities and scholarships. 

Our Mission

The mission of the Jean Griswold Foundation is to support Caregivers by providing educational scholarships* to enable them to further their training, enhance their careers, and better assist the clients they serve.

By offering educational scholarships*, our Foundation will not only make a positive impact on the Caregivers themselves, but also the clients they assist and the home healthcare agencies where they are employed, as well as help advance the overarching home-care industry.

Scholarships will be paid directly to the federally accredited educational institutions of the winning Scholars’ choosing.

Empowering Caregivers Through Education

The Jean Griswold Foundation Scholarship Program awards scholarships to deserving Caregivers who wish to further their education in a care-related field. Applicants do not have to be associated with Griswold in any way, and the funds will be paid directly to the institution where the caregiver will be receiving education.  

Our Winter 2026 Scholarship Application period is now open! Applications will be accepted until 11:59pm ET August 31, 2026. Join our email list to get the first notice of all Scholarship happenings.  

Where would we be without Caregivers? 

Their selflessness is astounding, yet they are often overlooked and underappreciated. 

The Jean Griswold Foundation is dedicated to supporting Caregivers, the backbone of the care industry. We provide educational scholarships so Care Professionals can further their training, enhance their skills, elevate their careers, and better assist the people they serve.

The Georgia-Pacific Foundation Grant supports organizations in the Metro Atlanta area, focusing on education, entrepreneurship, community enrichment, and environmental sustainability. Established in 1958, the foundation prioritizes investments that align with its mission and values, promoting long-term well-being within communities where Georgia-Pacific operates. Eligible applicants include 501(c)(3) nonprofits, public schools, and local government entities located within 30 miles of GP manufacturing sites.

The Cherokee County Community Foundation Grant aims to inspire philanthropy and strengthen the local community by providing funding for projects that address critical needs in areas such as crime and safety, economic development, education, family and youth, and public health. Eligible organizations include 501(c)(3) nonprofits and educational institutions serving Cherokee County, SC. The Foundation prioritizes initiatives that create community gain and improve the quality of life for residents.

The Bank of America Charitable Foundation focuses on improving economic mobility and social progress through partnerships with nonprofits. It prioritizes basic needs, income creation, stable housing, and community empowerment. By supporting vulnerable populations, the foundation aims to enable individuals to achieve their goals and contribute positively to their communities. The foundation emphasizes sustainable progress, ensuring that all community members have access to essential resources and opportunities for growth.

Spectrum Digital Education Grants support nonprofit organizations in educating communities about broadband benefits and usage. These grants aim to bridge the digital divide, particularly for seniors and those with disabilities or ethnically diverse backgrounds. Applicants must demonstrate community partnership, address specific needs, and provide measurable impact metrics. With a focus on financial feasibility and meaningful outcomes, this initiative ensures that underrepresented urban and rural communities gain access to essential digital resources, fostering long-term improvement in their lives.

The Duke Energy Foundation offers Local Impact Grants to enhance the quality of life in South Carolina. Grants up to $20,000 support initiatives in vibrant economies, climate resiliency, and opportunity and inclusion. Eligible organizations must serve communities powered by Duke Energy and meet specific tax-exempt criteria. The foundation prioritizes projects that promote environmental sustainability and community development, while emphasizing non-discrimination and measurable impact.

Indigo Hope Foundation: Veterans Support Services Grant

Assisting organizations that serve our veterans with housing, healthcare, job training, mental health services, and family support.

Key Focus Areas:

• Housing Assistance
• Mental Health Services
• Job Training
• Family Support

Example Programs We Fund:

• PTSD counseling services including canine training programs
• Job placement programs
• Emergency housing assistance
• Veterans court support

Indigo Hope Foundation: First Responder Wellness Grant

Supporting programs that provide mental health resources, training, family support, and wellness services for our first responders.

Key Focus Areas:

• Mental Health Support
• Family Services
• Training Programs
• Peer Support

Example Programs We Fund:

• Critical incident stress management
• Family counseling services
• Peer support programs
• Wellness and resilience training

Indigo Hope Foundation: At-Risk Youth Development Grant

Empowering programs that provide mentorship, education, life skills training, and opportunities for young people facing challenges.

Key Focus Areas:

• Mentorship Programs
• Educational Support
• Life Skills Training
• Career Development

Example Programs We Fund:

• After-school tutoring and mentorship
• Job readiness training
• Leadership development

Indigo Hope Foundation: Addiction Recovery Programs Grant

Funding programs that offer treatment, counseling, recovery support services, and harm reduction for individuals battling addiction.

Key Focus Areas:

• Treatment Services
• Recovery Support
• Harm Reduction
• Family Programs

Example Programs We Fund:

• Outpatient counseling programs
• Peer recovery support
• Addiction Recovery Residential Programs
• Family therapy services

The Educational Foundation of America (EFA) supports the Reproductive Health & Justice Grant Program to enhance access to abortion and contraception throughout the U.S., particularly in Appalachia, Alabama, and Florida. EFA funds innovative organizations that advocate for reproductive rights, provide direct support to abortion services, and leverage impact investing strategies. This commitment aims to ensure reproductive freedom, foster equity, and promote sustainability in underserved communities.

The Truliant Mini Grants program offers $1,500 grants to 501(c)(3) nonprofits serving Truliant member communities. These grants support capacity building through staff training and development, along with materials for programs aligned with Truliant's focus areas: Social Mobility, Financial Wellness, and Workforce Education. Eligible organizations must have an operating budget under $500,000, be tax-exempt, and have been operating for at least three years, ensuring community engagement and sustainability.

Literary Arts Fund

Grants Overview

The Literary Arts Fund will award at least $50 million in grants to the nonprofit literary arts field over the next five years, concluding in 2031.

With a short timeline, the fund’s grantmaking has a strategic focus on the areas of the literary arts ecosystem where it determined it could have the greatest impact— that is: supporting independent U.S.-based literary arts nonprofits whose primary mission is directly serving adult writers of creative nonfiction, fiction, poetry, and hybrid works in making their artistic work and sharing it with readers outside of school and academic settings. Please review the fund’s full eligibility requirements to learn more.

Innovation project grants provide funding to literary arts nonprofits for projects that may be collaborative and that aim to address critical challenges in one or more literary arts nonprofit organizations, presses, or publications that, if improved, would directly benefit creative writers’ artistic work and ability to share it with readers and audiences. These grants are disbursed to nonprofits in a single payment and intended for use during the project period.

The National Cancer Institute's PAIRS program aims to explore innovative cancer therapies by leveraging synthetic vulnerabilities that interact with tumor responses to radiation therapy. This initiative supports the development of targeted drug-radiation combinations, focusing on precision medicine to optimize treatment efficacy while minimizing harm to normal tissues. By consolidating prior funding opportunities, PAIRS encourages research that addresses context-dependent vulnerabilities, enhancing therapeutic strategies and aligning with NIH's scientific goals.

Literary Arts Fund

Grants Overview

The Literary Arts Fund will award at least $50 million in grants to the nonprofit literary arts field over the next five years, concluding in 2031.

With a short timeline, the fund’s grantmaking has a strategic focus on the areas of the literary arts ecosystem where it determined it could have the greatest impact— that is: supporting independent U.S.-based literary arts nonprofits whose primary mission is directly serving adult writers of creative nonfiction, fiction, poetry, and hybrid works in making their artistic work and sharing it with readers outside of school and academic settings. Please review the fund’s full eligibility requirements to learn more.

General Operating Grants Applications 2026 Guide

Background

The Literary Arts Fund was established in 2025 to dramatically increase funding for and the visibility of the nonprofit literary arts field toward ensuring a healthy and more robust U.S. literary culture in support of creative writers. The fund will award at least $10 million in grants to the nonprofit literary arts field in each of the next five years, concluding in 2031. The first open call is for 2026 general operating grant applications.