Best Fairfield County Grants for Nonprofits in South Carolina

501(c)(3) public charities and government entities in Fairfield County, South Carolina can apply for Duke Energy Foundation’s Local Impact Grants, with awards up to US $20,000 for community programs. Funding supports workforce development, STEM education, climate resiliency, disaster preparedness, land and water conservation, and opportunity and inclusion initiatives in Duke Energy–served communities.

Nonprofit 501(c)(3) organizations, public schools, and qualified local government entities supporting education, environment, entrepreneurship, or community enrichment in Fairfield County, South Carolina may be eligible for community-focused funding. Georgia-Pacific Foundation supports projects near its manufacturing communities that enhance long-term well-being and sustainability, so local Fairfield County programs meeting these priorities can apply.

Nonprofit 501(c)(3) and other charitable organizations in Fairfield County, South Carolina can seek funding for capacity-building projects such as strategic planning, board development, technology planning, and governance improvements. Central Carolina Community Foundation’s Capacity Building Mini-Grants provide up to US $5,000 to strengthen organizational infrastructure, stability, and growth across eligible Midlands counties, including Fairfield County.

Fairfield County adult education and literacy providers can access funding via the WIOA Adult Education and Family Literacy Act (AEFLA) Adult Education Program Subgrant, Round Three. This South Carolina Department of Education opportunity offers US $40,000 to establish or operate programs that improve adult literacy, support parents’ education, and help adults progress toward diplomas and employment.

Grants from National Fish and Wildlife Foundation help Fairfield County, South Carolina conservation and land management organizations restore, enhance, and conserve longleaf pine and bottomland hardwood forests. Eligible projects within the historical longleaf pine range can request US $250,000 - US $3,000,000 for on-the-ground habitat and ecosystem restoration work in partnership with federal and private funders.

Nonprofit 501(c)(3) organizations and government entities in Fairfield County, South Carolina can seek up to US $20,000 for community development, workforce training, K–12 energy education, and environmental resiliency projects. With a mission to strengthen communities, Duke Energy Foundation supports programs that build vibrant economies, enhance climate resiliency, and expand opportunity and inclusion in its service areas.

Nonprofit organizations, schools, and government entities serving Fairfield County, South Carolina communities where Weyerhaeuser operates can seek grants for housing, youth development, environmental stewardship, human services, culture, workforce development, and inclusion. Weyerhaeuser Giving Fund awards more than US $1,000, with applications accepted year-round and local advisory committees shaping priorities in each community.

Nonprofit organizations with a physical location in Fairfield County, South Carolina can seek funding for health, well-being, and education programs, including life skills and pediatric cancer support, through the Aflac Charitable Fund Competitive Grant. Grants from Central Carolina Community Foundation range from US $1,000 - US $10,000 for locally focused initiatives in South Carolina counties it serves.

Nonprofit 501(c)(3) organizations improving community life in Fairfield County, South Carolina can apply for small grants up to US $5,000 to support education, health, food security, addiction prevention, and other community initiatives. With a mission to grow strong, healthy communities, Spinks Family Foundation provides cash or in-kind support, reviewed quarterly and awarded annually per organization.

Graduating high school seniors and current undergraduates in Fairfield County, South Carolina pursuing two- or four-year degrees can apply for Central Carolina Community Foundation’s renewable Opportunity Scholarship, averaging $2,000. First-generation college students with financial need who are active in their communities and attending eligible local nonprofit institutions may qualify.

Nonprofit 501(c)(3) organizations serving Fairfield County, South Carolina can seek large grants of more than US $10,000 for education, food security, health, and substance abuse or mental health programs. Grants from Spinks Family Foundation help Fairfield County nonprofits with strong volunteer engagement and local facilities support community-focused services across the Upstate, Midlands, and Lowcountry regions.

Nonprofit 501(c)(3) organizations in Fairfield County, South Carolina that run existing digital literacy or broadband education programs for families or seniors can access funding from Charter Communications; awards US $2,500 - US $50,000 for technology access and digital education. Programs must serve Spectrum markets, partner with low-income or multicultural communities, and report participant impact metrics.

Nonprofit 501(c)(3) organizations and eligible schools in Fairfield County, South Carolina can seek funding for STEM education, environmental sustainability, or community safety and vitality projects through the Westinghouse Charitable Giving Program. Grants from Westinghouse help improve STEM literacy, preserve or restore land, air, water, or biodiversity, and enhance community safety, health, and wellness near Westinghouse sites.

Lexington Medical Center Foundation Inc

Since 1971, Lexington Health has grown and expanded to meet the needs of our community. The Lexington Health Foundation Remains Committed to Quality Care. Foundation-funded programs aim to enhance patient experiences and touch the various areas of care at Lexington Health — Patient, Employee, and Community Care.

Event and Project Sponsorship

Lexington Medical Center supports local organizations and nonprofits throughout the Midlands.

We support local events and causes that enhance the health and vibrance of our community. You can request sponsorship or other assistance for a project or event based in the South Carolina Midlands community.

501(c)(3) organizations serving youth under 19 in Fairfield County, South Carolina can apply for Lipscomb Family Foundation grants to support positive youth development programs. Funding focuses on helping young people in the South Carolina Midlands grow into healthy, educated, creative, and responsible adults through character-building and related youth services.

Focused on community livability, Central Carolina Community Foundation invites Fairfield County, South Carolina nonprofits and public or faith-based entities to propose new or expansion projects improving quality of life and community attachment. Eligible 501(c)(3) and similar organizations can request US $10,000 - US $60,000 for challenge grants enhancing housing, jobs, health, safety, recreation, or arts access.

Eligible 501(c)(3) nonprofits in Fairfield County, South Carolina with budgets under $450,000 can apply for Central Carolina Community Foundation’s multi-year general operating support grants, awarding up to US $30,000 for unrestricted operational needs. Organizations must be Midlands Gives-registered, have at least one part-time paid staff member, and a recent grant history with the foundation.

Fairfield County, South Carolina 501(c)(3) nonprofits and selected public entities can access funding through Nord Family Foundation for programs in arts and culture, education, civic affairs, and health and social services. Organizations serving under-resourced children, youth, families, or communities, including those addressing basic needs or community and economic development, may be competitive applicants.

The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program, funded by the National Science Foundation, aims to transform open-source research into sustainable ecosystems that tackle national and societal challenges. This initiative promotes innovation across various sectors, including AI and cybersecurity, by fostering strong governance and broad user engagement. PESOSE invites proposals to establish and enhance open-source ecosystems, ensuring their safety, security, and effectiveness in meeting emergent needs.

The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.

The Lasker Clinical Research Scholars Program supports early-career clinical researchers aiming to enhance human health. It provides a unique opportunity to bridge NIH's intramural and extramural research environments over two phases: an initial 5-7 year tenure-track position at NIH followed by up to 3 years of extramural support. This program is designed to cultivate the next generation of leaders in clinical research and foster innovative health solutions.

The National Quantum and Nanotechnology Infrastructure (NQNI) program by the NSF aims to enhance research in emerging technologies like quantum computing and AI. By establishing a nationwide network of accessible research facilities, NQNI will facilitate innovation and collaboration among researchers. The program emphasizes user facility capabilities and plans for outreach, education, and workforce development, ultimately supporting the nation's quantum and nanotechnology advancements.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.

The Peter S. Slomianyj Scholarship Fund offers financial assistance to Subway employees and their children who meet specific eligibility criteria, including a minimum of 500 work hours over the past year and a GPA of 2.0 in high school or 2.5 in college. Applications for this scholarship will be open from December 16, 2025, to March 3, 2026. It is part of a broader initiative by the North Carolina Community Foundation to support students pursuing education at various institutions.

The National Science Foundation (NSF) is offering Postdoctoral Research Fellowships in Biology to support innovative research at the intersection of Artificial Intelligence (AI) and Biological Sciences. These fellowships aim to cultivate expertise in both fields, enabling scientists to leverage AI for breakthroughs in biotechnology and bio-system design. The program encourages proposals that utilize existing biological data and infrastructure to enhance discovery and innovation, ultimately benefiting human lives and the U.S. economy.

The BRAIN Initiative's BBQS Program aims to revolutionize the study of brain function by facilitating high-resolution tracking of complex behaviors alongside neural activity. This transformative research opportunity seeks to develop innovative tools for minimally intrusive measurements of various biobehavioral functions while accounting for environmental variables. Emphasizing transdisciplinary collaboration, it focuses on creating new analytical frameworks that model neurobehavioral function as dynamic systems influenced by an organism's surroundings, thereby advancing our understanding of behavior at the organismal level.

The ROSES25: B.2 Heliophysics Foundational Research program invites proposals for foundational research in heliophysics. The submission deadline for Step-1 proposals is May 1, 2026, with Step-2 deadlines announced 60 days prior. Amendments include an increase in Step-1 proposal length from two to three pages and clarification on budget expectations per award. Individuals may serve as Principal Investigators for only one proposal, with exceptions for specific institutional requirements.