Best Small Grants for Nonprofits in Guam

The Jobs Plus NOFO for FY2026, issued by the US HUD's Office of Public and Indian Housing, aims to enhance job opportunities for public housing residents. This initiative encourages innovative programs that prepare individuals for employment in high-demand fields, ultimately fostering economic stability within communities. By focusing on workforce development, this funding opportunity seeks to empower residents through education and training, paving the way for long-term success and self-sufficiency.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) invites proposals for high-risk, multi-center observational studies on diseases relevant to NIDDK's mission. Applicants are encouraged to consult with NIDDK staff and must complete planning activities before submission. Key deadlines for applications span from February 2025 to October 2026, with optional Letters of Intent due 30 days prior to full proposals.

The FY26 Bureau of Land Management Invasive and Noxious Plant Management program focuses on preventing and controlling invasive species that threaten public lands and native plant communities. These invasive plants impose significant economic burdens and disrupt ecosystems. The program aims to enhance detection, rapid response, and education on invasive species, while also promoting rehabilitation efforts and biological control to protect valuable resources on public lands.

The Applied Drug Policy Research Experiences project aims to provide graduate students and recent post-graduates with hands-on research opportunities to support the National Drug Control Strategy. Through rigorous studies and data analyses, this initiative will explore the evolving dynamics of illicit drug supply and usage, assisting public health and safety officials in anticipating drug-related issues and crafting effective responses to safeguard the American public.

The NIAID Career Transition Award (K22) supports postdoctoral fellows transitioning to independent research positions, fostering their development into successful biomedical scientists. Key deadlines for applications span from February 2025 to June 2027, including specific dates for standard, renewal, and AIDS-related grants. This initiative, funded by the NIH, aims to enhance the career trajectory of emerging researchers in clinical and biomedical fields, ensuring a robust pipeline of innovative scientific talent.

The National Violent Death Reporting System (NVDRS) is a crucial surveillance initiative by the CDC aimed at understanding violent deaths and suicides. This funding opportunity supports state and local entities in modernizing NVDRS, enhancing data collection and reporting processes. Key activities include timely data updates, modernization assessments, and pilot projects for improved data systems. The goal is to create a sustainable national surveillance system that provides reliable data to inform public health actions and enhance violence and suicide prevention efforts.

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The Drug-Free Communities (DFC) Support Program aims to foster collaboration among community coalitions to combat youth substance use. Established by the Drug-Free Communities Act of 1997, it encourages partnerships among various stakeholders, including governmental and non-profit agencies. The program focuses on reducing substance use among youth and promoting protective factors within communities. This funding opportunity is available for those who have completed the initial funding cycle or experienced funding interruptions, supporting their ongoing efforts to create a healthier environment for youth.

The Drug-Free Communities (DFC) Support Program, initiated by the Drug-Free Communities Act of 1997, aims to bolster community coalitions dedicated to preventing youth substance use. Funded by the US HHS's Substance Abuse and Mental Health Services Administration (SAMHSA), this program focuses on collaboration among various stakeholders, including government and non-profit entities, to effectively reduce substance abuse among youth and promote protective factors within communities.

The Rural Communities Opioid Response Program focuses on enhancing behavioral health care services for children and adolescents in rural areas. By providing essential funding, this initiative aims to tackle mental health and substance use disorders, ensuring that young individuals receive the support they need. The program, administered by the Health Resources and Services Administration, is crucial in addressing the unique challenges faced by rural communities, promoting healthier outcomes for future generations.

The National Institute on Drug Abuse (NIDA) is launching a specialized entrepreneurship program aimed at life science researchers in the field of substance use disorders (SUD). This initiative will equip researchers with essential skills to transform their innovative ideas into viable products, focusing on aspects such as market evaluation, customer discovery, and intellectual property. The course will be delivered in a hybrid format to engage US-based SUD researchers effectively, fostering collaboration and advancing the field.

The CDC's National Center for Injury Prevention and Control invites research proposals aimed at reducing suicide and interpersonal violence among youth aged 10 to 24. This funding opportunity encourages the evaluation of pre-existing primary prevention strategies that have not yet been rigorously assessed. Proposed approaches may include community programs and policies designed to enhance social connectedness, mitigate harmful online behaviors, and address technology-facilitated interpersonal violence.

Ecolab Foundation

Ecolab Foundation is a philanthropic arm of Ecolab dedicated to advancing community well-being through programs that promote education, environmental stewardship, and public health. Its mission is to create positive social impact by supporting initiatives that strengthen communities and foster sustainable development.

The foundation’s primary areas of engagement include educational programs that enhance learning and workforce readiness, environmental projects that encourage conservation and sustainability, and health-related initiatives that improve hygiene and safety. It focuses on partnerships that deliver measurable benefits and long-term impact.

Ecolab Foundation operates primarily within the United States while also supporting global initiatives aligned with its corporate responsibility goals. Its geographic scope reflects a commitment to addressing local community needs and contributing to broader sustainability efforts.

The foundation collaborates with nonprofit organizations, educational institutions, and community-based groups. It prioritizes partnerships that demonstrate strong governance, clear objectives, and alignment with its mission of education, health, and environmental responsibility.

Ecolab Match Program

Ecolab established the Volunteer and Community Relations programs to encourage and reward Ecolab employee and alumni involvement in the communities where people live and work. There are three programs including the Board Leadership Volunteer Grant.

Board Leadership Volunteer Grant

Ecolab will donate up to $500 USD annually to a qualifying 501(c)3 organization (some restrictions apply) for which an eligible person serves on the Board of Directors. 

Focus Areas of Giving

• Youth and Education: programs that promote youth development, particularly for programs that ensure all students are successful
• Civic & Community Development: affordable housing, work readiness, crisis assistance and hunger relief
• Environment & Conservation: hands-on environmental learning programs, environment and conservation organizations
• Arts & Culture: arts education for children and youth as well as support for museums and the performing arts

The Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional) invites applications that address urgent research needs in substance use epidemiology and health services. This funding opportunity encourages pilot studies focusing on emerging drug issues, unexpected prescription drug abuse trends, and timely medical system challenges. Letters of Intent are recommended 30 days before the proposal deadline, emphasizing the necessity for rapid review and funding to address pressing scientific questions.

The Looking Out Foundation Grant supports social justice and humanitarian initiatives, having donated nearly $6 million to various causes globally. With an average donation of $25 per campaign, it aids organizations focused on disaster relief, racial justice, and support for marginalized communities. Eligible applicants must be tax-exempt public charities under Section 501(c)(3). The foundation prioritizes diverse funding sources and encourages organizations to adapt to changing needs, with grant allocations ranging from $5,000 to $25,000.

The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.

The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.

The NIH R25 program enhances clinician-scientists' involvement in research by supporting educational activities aimed at recruiting individuals from diverse backgrounds into biomedical, behavioral, and clinical sciences. This initiative promotes the development of research experiences and mentoring networks to foster a robust research workforce. Applications are due by 5:00 PM local time of the applicant's organization, providing an opportunity for engaging with the NIH's mission.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

This funding opportunity aims to enhance understanding of chemical-induced skin injuries, particularly those recognized as public health threats. The initiative encourages research focused on identifying commonalities in these injuries and exploring shared signaling pathways. By investigating therapeutic targets, this program seeks to develop effective medical countermeasures. Multiple application deadlines are set from 2025 to 2027, supporting diverse research proposals in this crucial area.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

The U.S. Department of Health & Human Services, through the NIH, invites applications for the U01 grant aimed at advancing gene-based therapies for ultra-rare neurological and neuromuscular disorders. This initiative focuses on IND-enabling studies and supports the development of innovative therapeutics with proven biological rationale. Applications must include robust data and compelling justification for the proposed clinical candidates, targeting a specific patient population to facilitate IND filing and subsequent clinical trials.

The NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required) grant supports small businesses in conducting innovative clinical trials relevant to neurological disorders. This funding opportunity encourages investigator-initiated projects evaluating drugs, devices, and therapies aligned with NINDS goals. Applications are accepted only from SBIR Phase II and Fast-Track applicants, with a submission deadline of 5:00 PM local time. Letters of Intent are encouraged 30 days prior to the full proposal deadline.

The Rural Maternity and Obstetrics Management Strategies Program (Rural MOMS) aims to enhance access to maternity and obstetrics care in rural areas through collaborative networks. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative focuses on innovative strategies to improve healthcare delivery for mothers and infants in underserved regions, ensuring that quality care is accessible where it is needed most.

The Substance Use/Substance Use Disorder Dissertation Research Award supports doctoral candidates in completing their dissertation research on substance use disorders. This initiative encourages diverse applicants and aligns with NIDA funding priorities. Key deadlines include February 16 and June 16 of 2025 and 2026 for standard applications, with specific dates for renewal and AIDS-related projects. This funding aims to enhance the research workforce in the field.

The WaterSMART Applied Science Grants aim to enhance water management and supply reliability through innovative research and data utilization. By inviting qualified entities to apply for funding, the program focuses on improving hydrologic data access, forecasting capabilities, and modeling tools. This initiative aligns with federal priorities to optimize resources, ensuring water managers can effectively address future demands and adapt to climate challenges, thus fostering resilience in water operations across the nation.

The T32 Training Program for Institutions That Promote Diversity aims to increase the involvement of individuals from underrepresented backgrounds in research related to cardiovascular, pulmonary, hematologic, and sleep disorders. This initiative seeks to support institutions dedicated to serving health disparity populations, ensuring they develop robust training programs. While trainees cannot lead independent clinical trials, they can gain valuable experience under the guidance of mentors, ultimately contributing to improved health outcomes for underserved communities.