Best Large Grants for Nonprofit Organizations in Indiana

This grant mechanism will focus on furthering the development of novel strategies towards improving the treatment of Small Cell Lung Cancer (SCLC). Work supported through this mechanism will address important areas of need across the entire care continuum and have the immediate potential to increase survivorship. It is expected that correlative translational research will be proposed that will enhance the understanding of SCLC.The overarching theme of the proposals should be centered around understanding the biology of SCLC and developing strategies toward improving outcomes for patients with SCLC. We will encourage applications on a wide variety of topics related to SCLC, including but not limited to the following:

• Advanced Screening and Diagnostic Technologies
  • Utilize liquid biopsies and circulating tumor DNA (ctDNA) to enhance early detection and monitoring of SCLC, providing non-invasive diagnostic and prognostic solutions
  • Investigate the clinical utility of blood-based biomarkers for improving SCLC diagnosis, monitoring treatment response, and predicting outcomes
  • Leverage artificial intelligence for the early detection of SCLC

• Disease Progression and Acquired Resistance
  • Study of molecular + clinical characteristics of rapid progressors vs. long-term responders in SCLC to tailor personalized treatment approaches
  • Leverage radiomics to identify predictive or prognostic factors such as treatment response, risk of pneumonitis, and likelihood of brain metastases
  • Investigate the underlying mechanisms of primary and acquired resistance to chemotherapy and immunotherapy in SCLC
  • Identify and validate biomarkers indicative of disease progression and/or therapeutic resistance

• Biomarkers and Immuno-Oncology
  • Identify and validate biomarkers that can predict greater responses to immunotherapy treatments in SCLC, enhancing patient selection and treatment efficacy

• Biospecimen-based research
  • Leverage real-world patient tissue and/or blood samples to enable:
    • Longitudinal studies of SCLC progression from limited-stage to extensive-stage disease
    • Investigation of tumor and microenvironmental changes before, during, and after treatment to understand the evolution of resistance
  • Develop a centralized infrastructure for biospecimen collection, with standardized protocols and accessible repositories to facilitate broad research collaboration

These awards provide a maximum of $500,000 in funding over a period of three years.

The Teaching Health Center Graduate Medical Education (THCGME) Program aims to ensure the sustainability of primary care residency training in community-based ambulatory patient care centers. By providing essential funding, this program supports the development of healthcare professionals who are equipped to deliver high-quality care, particularly in rural and underserved areas, enhancing the capacity to meet diverse health needs across various populations.

The Craft Archive Fellowship supports archival research on underrepresented craft histories in the U.S., including feminist, queer, Black, Indigenous, and other marginalized communities. It offers a $5,000 stipend for scholars and artists to conduct research in chosen archives, encouraging innovative approaches. Participants will present their findings in a virtual program, and their work will be published in Hyperallergic, broadening accessibility and awareness of vital craft research.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Committed Scholarship

The Napa Valley Community Foundation Committed Scholarship benefits one graduating senior who attends a high school in Napa County, is the first person in their family to attend college, and who grew up in a household where English was not the first language spoken. Applicants must have a strong academic record coupled with demonstrated leadership qualities, extra-curricular activities, and heavy involvement in the community. They must also have a desire and a plan to return to the Napa Valley area to give back to the community after graduation. Recipients must attend a four-year college/university and will receive funding for up to four years of undergraduate study.

Scholarship award amount is renewable for up to four years. It will be based upon overall financial aid already received and any remaining funding gaps.

About

Community Foundation of Greenville bridges philanthropy and purpose in Greenville County, helping people make their charitable giving simpler and more powerful for 70 years. We strategically match diverse needs and opportunities in Greenville County with philanthropic resources.

Vision:

Community Foundation of Greenville will be the leading catalyst for developing assets and unlocking potential to meet the needs of an inclusive and equitable community.

Mission:

Community Foundation of Greenville improves the lives of Greenville County residents through strategic philanthropy, community investment, and collaborative leadership.

Obermier Scholarship Fund in Memory of John N. Obermier, Edith M. Obermier and Mary Belle Obermier

Purpose

Mary Belle Obermier established this scholarship with a gift from her estate in 2012. Her intent was to help academically deserving students who need financial assistance to be able to attend college and to give preference to qualified students who are committed to a career in the United States Navy. The preference for naval students is in recognition of the US Navy careers of her deceased husband, John, and his deceased first wife, Edith, who were both veterans of World War II.

Criteria:

• Applicants must demonstrate financial need (economically disadvantaged).
• Applicants must have a current academic GPA of 3.0 or higher.
• Applicants must be enrolled/accepted to an institution of higher learning prior to applying.
• Applicants must submit one letter of recommendation from a teacher, employer, or clergy.

Preference in the selection process will be given in the following order to qualified students who are:

students who are committed to a career in the United States Navy

residents of Greer, SC

residents of South Carolina and

residents of all other states

The Ida Halpern Fellowship and Award, offered by the Society for Ethnomusicology, supports research on Native American music in the U.S. and Canada. Established scholars, recent Ph.D.s, and Ph.D. candidates are eligible, while previous awardees must wait three years to reapply. The fellowship includes a $4,000 grant and a $1,000 award for published research, with preference given to studies based on Dr. Halpern's Northwest Coast music collection.

Pfizer’s Core Values of Social Responsibility and Philanthropy

About

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. It was Charles Pfizer’s vision at the beginning and it holds true today.

Improving Health Outcomes in Patients with ATTR-CM Through the Development of a Shared Decision-Making Tool (Decision Aid)

Overview

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a progressive, lifethreatening condition associated with significant morbidity, mortality, and burden on patients, caregivers, and healthcare systems. The multisystemic disease course is often characterized by diagnostic delays, complex treatment pathways, and evolving therapeutic options, which can create uncertainty and decisional conflict for patients and clinicians alike. Shared decision-making (SDM) has emerged as a critical component of patientcentered care1, particularly in complex and preference-sensitive conditions such as ATTR-CM. Well-designed decision aids can support meaningful dialogue between patients and healthcare professionals by improving understanding of disease trajectory, treatment options, risks and benefits, and alignment of care with individual patient values and goals.

The Health Equity Innovation Award (U01) aims to support innovative research that enhances minority health and health equity. Key areas include promoting diversity in clinical trials, improving data visibility for underrepresented groups, and amplifying diverse patient perspectives. This initiative, funded by the US Department of Health and Human Services' FDA, seeks to ensure equitable health outcomes and address unmet needs within varied populations.

The REACHing Communities (REACH) Consortium (U01) Clinical Trials Optional grant aims to advance health equity among racial and ethnic minorities through cooperative agreements. It focuses on research, outreach, and mentoring diverse students and researchers. Although the grant information has not been updated in over six months, it remains under observation for potential updates. The initiative is part of the FDA Office of Minority Health and Health Equity's commitment to improving minority health.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Amy & Hank Stockton Scholarship

The Amy and Hank Stockton Scholarship benefits graduating high school seniors who attend public high schools in Napa County and will be pursuing post-secondary education in a trade, technical or vocational school, community college, or four-year college/university. Previous recipients of the scholarship are eligible to reapply; scholarship funding may not exceed 4 years of support.

Ethan J. Hazelwood Heart of Gold Memorial Scholarship

The Ethan J. Hazelwood Heart of Gold Memorial Scholarship was established in 2025 by family and friends of Ethan as a lasting tribute to his life and giving spirit.

Those who knew Ethan remember him as a kind, creative, and giving person. He was always helping others and once gave the boots on his feet to a fellow student who had none.

Open to individuals in Whitley and Noble County, the scholarship is for high school seniors as well as non-traditional students, who wish to pursue additional education in the field of agriculture or diesel mechanics.

The FY26 Bus Safety, Accessibility, and Innovation Notice of Funding Opportunity offers up to $10 million for innovative projects aimed at enhancing bus safety and accessibility. Administered by the Federal Transit Administration, this competitive grant invites applications for the development of concepts that improve safety for operators and vulnerable road users, ensuring that public transportation is safer and more accessible for all passengers.

The Lawrence A. Taylor Research Fund in Petrology and Geochemistry offers financial support to two PhD students demonstrating outstanding research in Petrology and/or Geochemistry. Funded by Dong-Hwa Shin (Dawn) Taylor, this grant aims to alleviate some financial burdens associated with their doctoral studies, fostering excellence in these critical fields. Eligible candidates must be AGU student members currently enrolled in relevant doctoral programs and engaged in applicable research.

Fred W. Homann Jr. Research and Education Scholarship

Scholarships awarded to Marshall area residents or former graduates pursuing higher education in the health sciences with preference given to applicants with a particular interest in research/preventative medicine. Applicants must maintain a 3.0 GPA average in their previous year of education, whether it be high school or college, or postgraduate. Students who receive this scholarship are encouraged to apply for further support in subsequent years. 

The National MS Society offers annual Research Grants for investigator-initiated proposals addressing key research questions from the Pathways to MS Cures Roadmap. These grants support diverse studies, including clinical and nonclinical research aimed at stopping MS disease activity, restoring function, and preventing new cases. Eligible applicants must hold an M.D. or Ph.D. and demonstrate relevance to the Society's research priorities. This funding opportunity promotes collaboration and focuses on underserved MS populations.

Arnold Ventures

Arnold Ventures (AV) is a philanthropy dedicated to improving the lives of Americans through evidence-based policy solutions that maximize opportunity and minimize injustice. We focus on improving systems where outcomes are falling short, incentives are misaligned, and the time is right for change. To advance this mission, we invest in rigorous research to strengthen the evidence base on what works to improve outcomes for individuals, families, and communities, and to inform policy and practice at scale.

AV’s Higher Education team seeks to fund rigorous, causal research on programs, policies, and practices that improve student outcomes and deliver stronger returns on investment for students and taxpayers. Our work focuses on strengthening the evidence base on effective student success models and aligning policy and funding incentives to support their adoption and scale.

Causal Research to Improve Outcomes for Part-Time Students

Purpose of the RFP

This RFP seeks to fund rigorous causal research that builds the evidence base on effective programs and policies for part-time students and identifies scalable, cost-effective approaches to improve completion and labor market outcomes. Findings should generate actionable insights to inform institutional practice, system-level decision making, and state policy, with the goal of improving outcomes and maximizing return on investment for students and taxpayers.

Population of Interest

Because enrollment intensity is fluid, proposals do not need to limit eligibility to students who are enrolled part-time at baseline. Instead, studies should focus on interventions that primarily serve or are expected to meaningfully impact students who are more likely to enroll part-time, including:

• Adult learners (age 25+)
• Student parents and caregivers
• Working adults

Interventions may serve mixed-enrollment populations, so long as the proposed study is clearly designed to improve outcomes for these populations.

"Slipperman” Music Scholarship in Memory of Timothy J. Gilles

The “Slipperman” Music Scholarship in Memory of Timothy J. Gilles recognizes the hard-working graduates of Herkimer and Oneida counties pursuing their secondary education in a music-related field.

Candidates are identified by Utica Dollars for Scholars.

The APSF/FAER Mentored Research Training Grant aims to enhance anesthesia patient safety by funding promising anesthesiologists who are within 10 years of their first faculty appointment. This two-year grant, totaling $300,000, supports the development of independent researchers focused on perioperative safety. Recipients must allocate 60% of their time to research and career development. With this initiative, the APSF and FAER seek to cultivate the next generation of safety scientists in anesthesia.

The Investigator Initiated Research (IIR) Grants program by the Anesthesia Patient Safety Foundation aims to enhance patient safety in anesthesia care through innovative research. Grants up to $200,000 (or $300,000 with waiver) are available for projects addressing critical safety issues, with a focus on studies leading to measurable improvements in outcomes. The program encourages collaboration and creativity, prioritizing research that lacks alternative funding sources, while also supporting junior investigators with mentorship opportunities.

The Quality Improvement Awards, sponsored by the Anesthesia Patient Safety Foundation (APSF), aim to enhance patient safety during anesthesia care. This initiative invites current trainees and recent graduates to showcase their quality improvement projects. Winners will receive sponsorship to attend the Stoelting Conference in Massachusetts, where they will present their work. The APSF is committed to promoting a culture of safety and learning in anesthesia, ensuring that no one is harmed by anesthesia care.

The William L. and Diane C. Wilson Scholarship for Karst Science, established in 2002, honors the legacy of William L. Wilson and aims to support innovative karst scientists. Funded by Diane C. Wilson, it provides a one-time award of $2,500 and recognition at the KWI spring banquet. Eligible candidates must be enrolled in a master's program focused on karst science and its subfields, while PhD students are excluded. This scholarship fosters the growth of new talent in karst research.

A Little HOPE, Inc. is a charitable foundation that provides grants to organizations offering bereavement support services and grief counseling for children and young adults who have lost a loved one. The grant amounts vary based on project scope and budget. Applications are by invitation only, sent out each October, and interested organizations should submit an email with necessary details for consideration.

Tyson Foods Community Giving Grants support initiatives that enhance the quality of life for communities and their members. With a focus on scaling existing effective programs, these grants are aimed at organizations that operate in underserved areas. Eligible nonprofits must have a 501(c)(3) status and local Tyson plant support. Applications are accepted annually, with priority given to projects addressing systemic community issues. Notable past support includes a $25,000 grant to the Arkansas Foodbank Mobile Pantry Initiative.

The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.

The Edward Payson and Bernice Piilani Irwin Scholarship honors Bernice Pi'ilani Irwin, a notable figure in Hawaiian journalism. Open to undergraduate and graduate students residing in Hawaii, the scholarship aims to support those pursuing careers in journalism or communications. Applicants must demonstrate financial need and maintain a minimum GPA of 2.75 while attending an accredited U.S. college or university. This scholarship is an excellent opportunity for aspiring journalists to follow in Bernice's footsteps.

Patrick Caroselli Scholarship

To provide financial assistance for college to high school seniors in Monroe County whose parents immigrated to the United States and attained citizenship.

Number and Size of Awards

Number of recipients and award amounts vary; award amount may be split between two or more recipients. Award paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters. Average award $5,000; not to exceed the cost of tuition.

Allowed Use of Award

Awards must be used for costs related to enrollment in a higher education program, prioritizing tuition fees.

The INCLUDE Project aims to enhance the health and quality of life for individuals with Down syndrome by generating comprehensive genomic and multi-omics data. This initiative encourages applicants to submit samples to NIH-supported resources, facilitating the exploration of molecular mechanisms related to health conditions associated with Down syndrome. The data will be shared via the INCLUDE Data Hub, promoting collaboration within the research community, though no direct funding is available to applicants.