Best Large Grants for Nonprofit Organizations in Indiana

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Delta Dental Foundation provides in-kind dental donations, including educational materials and hygiene products, to support organizations in Michigan, Ohio, and Indiana. These donations aim to promote oral health awareness and equity among underserved communities. Interested organizations should plan ahead, as applications are reviewed after the submission period closes. Supplies may be limited, and quantity restrictions may apply. For more information, preview available materials through the Foundation's website.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The CHS Foundation supports initiatives that benefit the agriculture industry, focusing on 501c3 organizations within specific states. Their funding is aimed at empowering cooperative growth and sustainable practices. Local projects may also be eligible through the CHS Seeds for Stewardship program. However, funding is not available for individuals, sports teams, or religious groups, ensuring that the support remains directed towards community and cooperative development.

The Seed Grant for Research on Lottery Gambling, announced by the International Center for Responsible Gaming and the Hoosier Lottery, promotes studies focusing on responsible gambling and gambling disorders related to lottery activities. Researchers are encouraged to explore various projects, including pilot studies, preliminary research, and follow-up testing. Emphasizing the connection to Indiana, the initiative seeks to develop insights that inform responsible gambling practices and policies.

Letha's Youth Outdoors Fund Grant provides financial support for field trips that connect youth groups in Indiana with nature. Ideal for educators, this grant fosters outdoor learning experiences, emphasizing the importance of native plants and their habitats. Since 2008, it has enabled over 15,000 youth to explore environmental education centers and parks, especially those with limited access to such opportunities. Grants range from $50 to $700, covering transport and educational activities.

The Chicago Board of Trade Foundation Grant offers funding to non-profit organizations in the Chicago area, focusing on initiatives that assist children, seniors, and individuals with disabilities. Eligible organizations must be 501(c)(3) tax-exempt and must not discriminate based on race, religion, or sexual orientation. Applications will be assessed based on program effectiveness, community impact, and organizational management. The foundation does not fund individuals, political candidates, or organizations without tax-exempt status.

Brown County Community Foundation

BCCF operates as a 501 (c)(3) corporation. It professionally manages and distributes income from charitable bequests consistent with the donor’s wishes and interests. In other words, BCCF manages charitable funds, making grants to local, nonprofit organizations based on advice from donors. Donors can specify a specific organization or a general area of concern within the community to which their gift be directed.

Scholarships

The Foundation manages several academic scholarship funds, many established expressly for Brown County High School graduates. 

Additionally, through the Foundation’s affiliation with The Lilly Endowment Inc., over forty Brown County residents have received four-year full-tuition scholarships through the Endowment’s Community Scholars Program.

BCCF Scholarships are available to current high school graduates, students currently enrolled in college, past graduates planning to enroll, as well as G.E.D. graduates.

John A. and Cheryl J. Eyed Scholarship

Purpose: To provide tuition assistance to Brown County residents pursuing a two or four year degree on a full or part-time basis at any Ivy Tech State College location.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

The Teacher Creativity Fellowship Program by Lilly Endowment supports K-12 educators in Indiana by providing grants up to $15,000 for renewal projects. These projects aim to restore educators' enthusiasm and stimulate creativity, enhancing student educational experiences. The program encourages meaningful exploration and reflection rather than typical vacations. Approximately 125 grants will be awarded in 2025, with a focus on activities that are intellectually enriching and personally renewing.

Steuben County Community Foundation

The Steuben County Community Foundation plays a unique role in making this community the best it can be for the people who call it home. We believe that through our work, our community members can live the lives they’ve always dreamed of. They’ll pay it forward, lift one another up, and make our community even better. Investing in our community today, positions it for a brighter tomorrow.

Lilly Endowment Community Scholarship Fund

This scholarship was established in 1998 by Lilly Endowment Inc. to help raise the level of educational attainment in Indiana. The scholarship covers a full four-year tuition and an annual $900 stipend for books and equipment. 

The EDA Chicago FY 2016–FY 2019 Planning Program and Local Technical Assistance Program aims to enhance regional economic development through comprehensive planning and technical assistance. By supporting the development and implementation of Comprehensive Economic Development Strategies (CEDS), EDA empowers designated organizations, including Indian Tribes, to create jobs and foster economic resilience in distressed areas. This initiative focuses on strategic investments to facilitate effective economic development practices, ensuring sustainable growth and prosperity across regions.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The Allen Whitehill Clowes Charitable Foundation provides grants to support charitable organizations dedicated to promoting and preserving the Arts and Humanities, particularly in Central Indiana. Grants can range from $1,000 to $1,000,000 for specific projects such as renovations or unique program offerings. Eligible applicants must be recognized as public charities under IRC Section 501(c)(3), while individual applications and endowments are not accepted. This foundation continues the legacy of Mr. Clowes by supporting similar initiatives.

Indiana Clinical & Translational Sciences Institute

The Indiana Clinical & Translational Sciences Institute (CTSI) has been at the forefront of translational research since 2008. From the lab bench to clinical trials and beyond, we help researchers move their scientific findings through the development pipeline.

Research Project Development Teams (PDTS): Project Revision (external resubmissions)

Research Project Development Teams (PDTs) are groups of experienced senior faculty located on each of the Indiana CTSI campuses who will connect you with resources, collaboration opportunities, and small (typically up to $15,000) awards for preliminary or additional data. Each PDT is designed around a common research theme.

There are biostatisticians and regulatory experts on each team, and other experts are added, as needed, to the team when your application is discussed. You will have access to the expertise and knowledge you need all in one place.

The PDT application process is contingent on the stage of the project. You have selected the application process for pilot funding from the PDTs for an external resubmission. If you are seeking pilot funding prior a first time external submission please use Research Project Development Teams (PDTs): Project Refinement.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

The Allen Whitehill Clowes Charitable Foundation provides Operations Grants to support arts and humanities organizations in Central Indiana. These grants, ranging from $1,000 to $75,000, aim to help smaller organizations fulfill their core missions. First-time applicants must submit a Letter of Intent, while previous recipients are exempt. Successful proposals demonstrate effective mission execution, leadership, and measurable outcomes to complement other funding sources.

Benefitting people in the places making the AI future possible

The Future is for Everyone Fund

Meta is investing directly in education, community enhancement, workforce development and sustainability projects in locations where we have a data center in the United States.

The AI future we are building is for everyone. That starts with making sure everyone in the places that are home to a Meta data center feel the benefits in their communities. We want students to have bright futures, small businesses to flourish and communities to be prosperous.

Our commitment to the communities we call home.

The Future is for Everyone Fund supports investments and programs that address local community priorities in the United States, where we have a Meta data center:

We invest in the people and shared spaces that help a community thrive. That includes the parks, trails, and gathering places where neighbors come together, the technology and access that keep them connected, and first responders - like police officers, firefighters, and paramedics — who keep our communities safe.

We support the people and organizations that power local economies - helping workers gain the skills, certifications, and hands-on experience the modern economy rewards, and backing initiatives that create jobs and give a community its character.

We fund the programs, spaces, and tools that help learners of every age discover what they're capable of - from early literacy and the arts to hands-on science, technology, and problem-solving - and we equip the educators who make it happen with the resources to bring their most ambitious lessons to life.

We invest in the long-term health of the land, water, and wildlife that make our communities home - supporting things like habitat restoration and resource conservation that connects people to the natural world.

What is the Future is for Everyone Fund?

The Future is for Everyone Fund is Meta’s $1 billion commitment to invest directly in the U.S. communities that are home to a Meta data center. The Fund supports local schools, nonprofits, and community organizations and is organized into four focus areas that reflect local priorities: Community Enhancement, Economic Vitality, Education, and Sustainability. It builds on the over $70 million in grant funding we’ve provided to our data center communities since 2011.

The Neighborhood Assistance Program (NAP) is a program of the State of Indiana, established by Indiana Code 6-3.1-9 and administered by IHCDA through approved local non-profit organizations. The purpose of the program is to provide a means for these organizations to fund certain neighborhood-based programs and projects that improve distressed neighborhoods and the lives of the families that live there by encouraging individuals and businesses to make donations in exchange for Indiana State tax credits.

Each year, IHCDA awards up to a total of $2.5 million in Indiana tax credits to qualifying organizations. Each prospective participant organization submits a project application to IHCDA in the spring and, if approved, is awarded an allocation of tax credits. The organization then distributes these tax credits as an incentive to individuals or businesses who donate to the organization.

All donor contributions raised in exchange for NAP credits go toward the program or project described in the organization’s application. Eligible projects include affordable housing, counseling, child-care, educational assistance, emergency assistance, job training, medical care, recreational facilities, downtown rehabilitation, and neighborhood commercial revitalization. All projects must benefit economically disadvantaged areas and/or persons.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

The IAC Arts Organization Support Grant provides vital annual operating support to eligible arts organizations in Indiana, helping them fulfill their artistic and administrative missions. By aligning with IAC funding priorities, these grants enable organizations to deliver quality arts and educational activities while promoting inclusion, diversity, equity, and access. The grant amount is determined based on several factors, ensuring support reaches those with the greatest need and least access to other funding.

The Dale Jr. Foundation, founded by NASCAR driver Dale Earnhardt Jr., has raised over $8 million since 2007 to support various charities focusing on youth and underprivileged communities. The foundation emphasizes empowerment, education, wellness, hunger relief, and hope, aiming to provide resources that enhance confidence and opportunities for children facing hardships. Through fundraising efforts and partnerships with organizations like Make-A-Wish, the foundation strives to positively impact lives and foster a sense of normalcy among children in need.

Project Lead The Way (PLTW) offers grants for schools to implement the PLTW Computer Science program from 2025 to 2028. Schools must provide at least one PLTW course in the first year and two courses in the second year. The total grant is $14,000, covering participation fees and training costs. Eligible institutions include public, private, and charter schools located in the U.S., with special encouragement for those serving low-income or minority-majority populations.

The W.R. & Floy A. Sauey Family Foundation, established in 1998, aims to enhance community welfare through philanthropy. It prioritizes local charities that support child and family issues, particularly in areas where Nordic Group Member Companies operate. The foundation seeks to create lasting impacts by funding initiatives that directly benefit the families associated with these companies, fostering a stronger quality of life in the communities served.

The Mind Trust

The Mind Trust is a nonprofit that invests in public education to transform lives and increase academic achievement in Indianapolis, across Indiana, and beyond. This includes managing student-centered programming, growing new high-quality public charter schools, supporting existing schools and educators, and engaging the community in every region we serve.

Indiana Charter School Fellowship

The Indiana Charter School Fellowship is a competitive, statewide opportunity for experienced educators and school leaders who are ready to grow high-quality public charter schools across Indiana. The fellowship supports the growth of new school models, replication of existing models, or expansion of existing schools.

Fellows receive tailored support to design a school that meets real community needs, delivers strong academic results, and has sustainable operational and financial systems. Through one-on-one coaching, visits to high-performing schools across the country, access to expert partners, and protected time to plan, Indiana Charter School Fellows leave the program with a clear path to launching or growing a great school.

Whether you’re an established leader with a proven track record or someone with a bold new idea for what school could be, the fellowship gives you the space, structure, and support to bring that vision to life. As Indiana’s charter sector continues to grow, we’re looking for leaders who are ready to build the next generation of public schools—schools that are excellent, student-focused, and deeply connected to the communities they serve.