Best Large Grants for Nonprofit Organizations in Indiana

The Basil O'Connor Starter Scholar Research Awards, offered by March of Dimes, support emerging researchers in maternal and child health. With a $150,000 grant over two years, the program prioritizes projects addressing preterm birth and health equity. Eligible applicants must be within four to nine years of completing their clinical training or terminal degree, holding a tenure-track position. This initiative aims to foster impactful research that enhances clinical treatments for serious maternal and newborn health conditions.

The SCALE initiative aims to combat injury, violence, overdose, and suicide, the leading causes of morbidity and mortality among individuals aged 0-44. By enhancing implementation and outreach, this funding opportunity seeks to empower organizations to implement effective prevention strategies, especially in underserved communities, including tribal areas. The program encourages collaboration and continuous improvement to achieve sustainable reductions in these critical public health issues.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

The Comcast NBCUniversal Foundation offers Local Impact Grants to nonprofit organizations in 11 markets, providing $225,000 to support local programs addressing community issues. Eligible organizations must be 501(c)(3) nonprofits with a revenue exceeding $100,000 and must operate in one of the specified television markets. The grants aim to empower youth through education, promote diverse storytelling, and enhance community engagement. This initiative underscores Comcast's commitment to fostering inclusion and equitable opportunities for underserved communities.

The Rheum for Kids: Pediatric Skin and Joint Grant, offered by the Arthritis National Research Foundation, is aimed at early-career researchers focused on pediatric joint and skin diseases. This grant provides funding of up to $50,000 for one year to support innovative research projects. It encourages applications from diverse fields to advance the understanding and treatment of rheumatic diseases in children, fostering new insights and potential breakthroughs in pediatric healthcare.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

HIV, AIDS, and prevention

Help with healthcare costs for HIV, AIDS, and prevention

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

HIV, also known as human immunodeficiency virus or acquired immunodeficiency syndrome, is a virus that attacks the immune system. When left untreated, it can develop into AIDS. HIV is a chronic disease that affects the immune system.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The Special Emphasis Limited Project Grant from the American Society of Colon and Rectal Surgeons aims to address health disparities in colorectal surgery. It focuses on improving care for racial/ethnic minorities, women, LGBTQ+ populations, and individuals with disabilities. Proposals should concentrate on patient-oriented interventions and may explore quality improvement, access to services, and enhancing workforce diversity. Funding of up to $20,000 is available for innovative projects that promote equity in colorectal healthcare.

The Mary J. Proctor Grant supports charitable organizations focused on children and youth in the Indianapolis area. Administered by JPMorgan, it funds nonprofit entities recognized under section 501(c)(3) of the IRS tax code. The program encourages initiatives in arts, education, community development, and social services, while individuals are not eligible to apply. This grant aims to enhance the well-being and opportunities for young people in the community.

The Comis Foundation Grant aims to provide equitable opportunities for children to thrive through education and community engagement. It supports innovative programs that enhance educational outcomes, focusing on areas such as capacity building and pilot projects. With funding ranging from $5,000 to $75,000, the foundation prioritizes nonprofit organizations that foster inclusive environments. By emphasizing trust and collaboration, Comis Foundation strives to create lasting impacts in the communities it serves.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Skilled Trades Scholarship

The Greater Milan Area Community Fund is proud to support students pursuing skilled trades and hands-on career pathways that build practical skills, open doors to stable employment, and strengthen our local community.

Scholarship awards are typically paid directly to the accredited trade program or educational institution and are generally non-taxable.

Applications are evaluated two times each year for awarding in the six months after application and selection.

The Sonnentag Foundation Grant supports organizations in cities where County Materials Corporation operates, focusing on four key areas: Hunger & Homelessness Support, Service Members & Veterans Support, Sexual Abuse & Domestic Assault Services, and Mentoring & Skills Building. Eligible applicants must be 501(c)(3) recognized organizations that serve the broader community. The foundation aims to empower vulnerable populations, including veterans, to lead fulfilling lives and provide essential services for healing and personal development.

The William T. Grant Scholars Program provides crucial support for early-career researchers aiming to expand their expertise through innovative research and mentoring. This five-year program focuses on reducing inequality and improving the use of research evidence to benefit young people in the U.S. By emphasizing the development of new disciplines and methods, the program encourages applicants to take bold risks in their research trajectories, ultimately fostering a supportive academic community.

The Elizabeth M. Pfriem Foundation, established in 2015 in Rye Brook, New York, is committed to enhancing the human condition through grants to 501(c)(3) public charities. Focusing primarily on the greater Bridgeport, Connecticut area, it supports initiatives in education, healthcare, food security, and housing. The foundation prioritizes organizations demonstrating fiscal responsibility and innovative programs with significant impact potential, ensuring sustainable support for vulnerable populations, especially children and families in need.

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Fifth Third Foundation in Evansville, IN, focuses on funding programs that foster community development, health services, education, and the arts. Eligible applicants include 501(c)(3) nonprofits serving designated regions, such as Evansville and Chicago. The foundation prioritizes organizations with a history of recent funding. Notably, grants cannot support individuals or certain event sponsorships. This strategic approach aims to create meaningful impacts in communities by aligning resources with local needs.

Rotary Club of Dubois County: Community Grants

The Rotary Club of Dubois County is an active social and service club comprised of dynamic and diverse professionals who make a lasting difference in our community and around the world.

Annually the Club raises funds that are put back into the community through a grant process. The grant is awarded to an organization/ project that aligns with the Rotary seven areas of focus and who provide an opportunity for Rotary Club members to participate and be active in the implementation. Rotary’s seven areas of focus include:

• Basic Education and Literacy;
• Maternal and Child Health;
• Peace and Conflict Prevention/Resolution;
• Disease Prevention and Treatment;
• Clean Water, Sanitation and Hygiene;
• Economic and Community Development;
• Improving the Environment

Complete the application linked above to be considered for this partnership and grant funds of up-to $20,000. 

The 2026 Vilcek Prizes for Creative Promise in Biomedical Science will award three $50,000 prizes to exceptional young immigrant scientists in the U.S. This prestigious prize recognizes innovative research contributions in biomedical science. Eligible candidates must be under 38 years old, hold a doctoral degree, and have made significant achievements in their field. The Vilcek Foundation aims to highlight the impact of immigrant scientists on the advancement of biomedical research, fostering diversity and excellence.

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The PCC Foundation offers community grants aimed at enhancing the quality of life in Parke County. These grants, available to both new and existing charitable organizations, support various initiatives including education, health services, and community development. Applications are accepted year-round, with quick decisions for smaller requests. This funding opportunity encourages projects that address community needs and build capacity, fostering a stronger, more resilient community.

About Us

Our team is working tirelessly to heal the planet and ensure that a just and livable future prevails.

With three decades of clean energy industry experience, our leadership team draws upon a long track record of environmental stewardship and meaningful throughput to confidently navigate today's unprecedented challenges.

We are teaming up with local philanthropists, nonprofit organizations, advocates and elected officials to implement effective solutions towards stopping the climate crisis.

Solar Moonshot Program Grant

The Solar Moonshot Program is helping nonprofit organizations across the United States afford the switch to clean energy.

Grants up to $25,000 are typically awarded, with grant amounts dependent on various factors, including the organization’s need for funding. 

In addition to grants given through the program, we also offer short-term, low-interest recoverable grants to help cover the project costs offset by the Investment Tax Credit.

Grants for 2026 are made possible by the BQuest Foundation and two anonymous donors, and the program is managed by Hammond Climate Solutions Foundation. Learn more about the program's status and participants below! 

Every Kindness is a Gift

Dollar Tree Gift Card Program 2026

Every Kindness is a Gift is a gift card grant program made possible through the generosity of Dollar Tree and managed by the team here at Gift Card Bank. We are a nonprofit organization that specializes in the distribution of gift cards and our mission is to improve well-being and build financial stability by supporting people through their time of need.

Through Every Kindness is a Gift, nonprofit organizations and Title I schools located in the 48 contiguous states may apply to receive a grant of Dollar Tree gift cards.

Gift cards received through these grants are meant to be distributed directly to individuals and families in need. A primary goal of the program is to give gift card recipients the dignity of choice by empowering them to shop for what they need themselves. By putting gift cards directly in the hands of our neighbors in need, we are able to increase access to essentials like food, school supplies, paper products, cleaning products, and hygiene items.

In 2026, there will be two rounds of grant distributions. In each round, we will award a number of grants between $2,500 and $10,000.

Round One is a summer distribution. Gift cards awarded in Round One will arrive in late June, while kids are on break and back-to-school is around the corner. Round Two is a holiday distribution. Gift cards awarded in Round Two will arrive in early November, as the end-of-year holidays approach.

We know that these are times of year when budgets are tight. Through these gift card grants, we hope to connect individuals and families directly to the essential resources they need during difficult months.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

The Pokagon Fund, established through a 2000 agreement, supports communities near Band Trust Lands by providing strategic grants aimed at reducing poverty, enhancing education, and promoting community vitality. With over $23 million awarded, the Fund focuses on initiatives that foster local development, including substantial educational support and assistance for food-insecure families. By investing in these communities, the Fund aims to create a thriving environment for residents of Hartford, Dowagiac, and South Bend.