Best Large Grants for Nonprofit Organizations in Indiana

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34) aims to support high-risk, multi-center clinical studies by facilitating early peer review and assessment of study designs. This program helps in the development of necessary operational documents and essential elements for conducting hypothesis-driven studies focused on diseases relevant to NIDDK. Applications are due by 5:00 PM local time, and consulting with NIDDK staff is strongly encouraged.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.

The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Healthcare Access Initiative

The Healthcare Access Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to essential healthcare services for uninsured and medically underserved individuals. Free and charitable clinics and pharmacies play a critical role in ensuring that patients who fall outside traditional healthcare systems can receive timely, high-quality care. However, many clinics face barriers related to staffing, care coordination, technology, and patient outreach that limit their ability to meet growing community needs. Through this initiative, NAFC will provide $20,000 grants to member clinics and pharmacies to strengthen programs that increase access to primary care, specialty services, and preventive care. Funding will support innovative and practical approaches that reduce barriers to care, improve patient engagement, and expand the capacity of clinics to serve vulnerable populations.

The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.

Loene Pooler Guthrie Scholarship Fund

The Loene P. Guthrie Scholarship fund benefits music students in Benton, Linn, and Lincoln counties who plan to engage in the teaching of piano, voice, and orchestral music.

This scholarship fund promotes the teaching of piano, voice and orchestral music by aiding music students in Benton, Linn, and Lincoln Counties who plan to engage in the teaching of piano, voice, and orchestral music. Students who will graduate from Linn, Benton, or Lincoln County high schools or graduates of those high schools currently studying music at an institution of higher learning may apply. The Linn-Benton Chapter of the Oregon Music Teachers Association reviews the applications and selects individuals to perform at an audition open to the public.

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

The Nicholas B. Ottaway Foundation offers grants through its Education Committee to support programs enhancing educational opportunities for economically disadvantaged students. These grants focus on initiatives like tutoring, college preparation, and internship programs. To qualify, organizations must be tax-exempt under 501(c)(3). Preference is given to projects that provide ongoing support to students post-graduation, particularly in specific geographic areas such as San Diego County and the New York Metropolitan Area.

The AWWA Arcadis Scholarship offers a $5,000 award to graduate-level students from underrepresented racial and ethnic minority groups pursuing STEM fields. This initiative by the American Water Works Association aims to promote diversity and inclusion in the water service industry, recognizing the critical role of future leaders in ensuring sustainable water supply. Eligible candidates include Black, Latinx, and American Indian or Alaska Native students with the potential for impactful contributions in the sector.

The AWWA Abel Wolman Fellowship, established in 1984, supports highly qualified students conducting meaningful research in water supply through doctoral programs. Named after Dr. Abel Wolman, this prestigious award recognizes excellence and creativity in the water sector. The fellowship provides up to two years of financial support, with an initial award of $30,000 for the first year, aimed at fostering the next generation of water professionals in the U.S., Canada, and Mexico.

The AWWA Scholarship Program, specifically the Carollo Engineers Bryant L. Bench Scholarship, offers a $10,000 award to graduate students dedicated to advancing their careers in the water consulting engineering field. Established in honor of Bryant L. Bench, this scholarship aims to support future leaders who will enhance drinking water quality through innovative engineering solutions. The American Water Works Association emphasizes the importance of investing in students to secure the future of the water industry.

The AWWA Hazen Scholarship supports graduate-level candidates dedicated to improving water quality and resources. Awarded by the American Water Works Association, this scholarship aims to empower future leaders in the water industry. Candidates must demonstrate commitment to addressing critical challenges in drinking water, water reuse, and sustainable practices. This initiative reflects AWWA's mission to invest in the next generation of water supply professionals, ensuring a sustainable future for water resources.

The HDR One Water Institute Scholarship, offered by the American Water Works Association, provides $10,000 in funding to support graduate students pursuing degrees that will lead to careers as consultants in the water industry. This initiative highlights the importance of investing in future water professionals and fostering innovative research to address pressing water challenges.

The AWWA Scholarship Program, specifically the Mueller HBCU Scholarship, supports undergraduate students from historically black colleges and universities pursuing careers in the water sector. Offered by the American Water Works Association (AWWA), this scholarship recognizes the vital role of future professionals in addressing water industry challenges. AWWA aims to invest in students who will contribute to sustainable water management and innovation within their communities.

The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.

Tee It Up for the Troops Grant supports 501(c)3 organizations that aid military personnel and their families. Prioritizing employment, family support, housing, PTSD treatment, sports rehabilitation, and suicide prevention, the grant aims to enhance the lives of veterans. Organizations that do not engage in fundraising events are eligible for funding. This initiative seeks to create a positive impact within the military community through various support pillars.

The AAAP Foundation: Poultry Scholarship supports students pursuing careers in poultry health and food safety in North America. Offered by the American Association of Avian Pathologists, the scholarship aims to enhance scientific knowledge and promote the well-being of poultry. Eligible candidates must be enrolled in accredited veterinary colleges or universities with relevant programs. Scholarships may reach up to $1,500, with undergraduate awards capped at $500, fostering the next generation of poultry medicine professionals.

The 2026 National Urban and Community Forestry Challenge Cost Share Grant Program aims to tackle economic, health, and environmental issues in communities through innovative tree resource utilization. By transforming wood from various sources into valuable products like lumber and biochar, this initiative promotes local economies and enhances community resilience. Projects should align with community forestry plans, adhere to safety standards, and provide job creation opportunities, ultimately fostering sustainable urban forest management and utilization.

This funding opportunity aims to support urgent research evaluating policies that impact health behaviors related to obesity. It is designed for studies that can only be performed with expedited review due to the time-sensitive nature of the research. Applications must demonstrate a compelling need for immediate funding to explore new policies or programs affecting dietary habits and physical activity, with the expectation that successful proposals will receive funding within four months.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

The Dean John A. Knauss Marine Policy Fellowship offers a unique opportunity for early career professionals to engage in marine and Great Lakes science and policy within the U.S. government. This one-year, paid fellowship encourages graduate students from accredited programs to explore impactful coastal resource issues. Interested applicants should connect with their local Sea Grant program or the National Sea Grant Office for guidance, especially if they are from Massachusetts, to ensure a competitive application.

About Us

Hamilton County is an extraordinary place filled with dedicated people, exceptional resources, and vibrant, diverse, and growing communities. But even with all of our strengths, many of our neighbors still struggle. Over 21,000 people in Hamilton County don’t have enough reliable access to food. Around 10,000 households spend half or more of their income just on housing. And only 29% of local children have access to quality childcare. These are just a few of the challenges we face, but they are challenges we can tackle together. By working in partnership, we can improve the lives of all who call this community home.

Mission

To mobilize people, ideas and investment to make this a community where every individual has an equitable opportunity to reach their full potential—no matter their place, race or identity.

Hamilton County Community Foundation Flexible Grant

Flexible Grants support nonprofit organizations serving Hamilton County with funding for specific, time-bound, or targeted needs.

This may include organizations navigating funding gaps, transitions, or emerging community needs in:

• HCCF’s priority areas – housing, childcare, social services, workforce and education
• Other areas – Arts, culture, parks, recreation, and civic engagement efforts

These grants are intended to help organizations respond to opportunities or challenges that require timely, focused support.

Grant Details

• Funding Amount: Up to $30,000
• Use of Funds: Program, project, or other targeted support aligned with the request.
• Review Process: Applications are accepted and reviewed on a rolling basis. Funding is limited, and requests are considered as they are received.
• Decision Timeline: Applicants can typically expect a response within 3-4 weeks of submission.

The Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN) Grant, offered by the Patient Advocate Foundation, provides crucial financial assistance to patients facing this cancer type. It covers out-of-pocket healthcare costs, including medication copays and insurance premiums, ensuring those affected can access necessary treatments. With a focus on personalized case management, the foundation has supported millions in navigating their healthcare needs, emphasizing the importance of timely and affordable care for patients diagnosed with MPN.

Impact100 Cincinnati empowers women to enhance lives in Greater Cincinnati by funding transformative grants focused on culture, education, environment, family, and health. They aim to address community needs with measurable goals, ensuring grants are utilized effectively over 1-3 years. Eligible organizations must be 501(c)(3) charities and align projects with the mission of Impact100. The initiative fosters collaboration while prohibiting funding for operating costs, travel, and faith-based advancements.