Best Large Grants for Nonprofit Organizations in Indiana

The CAPTRUST Community Foundation provides Crisis Grants to support nonprofit organizations aiding families impacted by natural disasters or emergencies. By dedicating over 10% of its annual budget for crisis assistance, the foundation ensures that funds directly benefit those in need. Grants can be requested up to $5,000 to help rebuild lives during challenging times, reflecting the foundation's commitment to integrity and support for children and families in crisis.

The AES Hawaiʻi Foundation Grant supports communities near AES Hawaiʻi’s renewable energy projects, focusing on social justice, education, environmental stewardship, and community health. Preference is given to nonprofit organizations in these areas, but statewide entities may also apply. Successful projects should align with the Foundation’s impact pillars, demonstrate measurable community benefits, and address unmet needs, ensuring long-term positive effects on the local community.

The Good Deeds Grant, offered by the Community Foundation of Wabash County, provides small to mid-sized grants (up to $5,000) to nonprofit organizations addressing basic needs and enrichment for Wabash County citizens. Eligible organizations include those defined as tax-exempt under 501(c)(3) or those with charitable causes. Grants prioritize projects that meet human needs, create opportunities, and enhance organizational capacity for serving limited-resource communities.

About Us

We are a philanthropic organization committed to catalyzing the impact of social entrepreneurs who are expanding access and opportunity in America. 

At New Profit, we partner with social innovators, philanthropists, and other impact leaders who are creating a more inclusive and prosperous America. We invest in and support leaders and organizations that are transforming our education, economic, and democratic systems. And we are guided by the belief that those who are most proximate to the communities we serve are the best positioned to develop effective and sustainable solutions.

We seek and support leaders and organizations with scalable solutions that match the size of the problems we face and expansive visions that match the scale of our ambitions for America.

Connected Futures Cohort Grant

New Profit is launching Connected Futures, a Catalyze cohort for organizations that bridge divides and bring people together to solve problems collectively. Submit a Discovery Form to signal your interest and to be considered to submit an application for this funding cycle. 

New Profit’s Catalyze cohorts support innovative social impact organizations expanding access and opportunity in America. This model brings together cohorts of organizations with similar focus areas and stages, providing each with a one-year $100,000 unrestricted grant, a $10,000 grant for leadership development, and strategic advisory support.

Social Entrepreneurs* participate in a year-long cohort experience designed to build community, facilitate peer learning, and provide capacity-building support, including workshops on topics such as board development, fundraising, scenario planning, and storytelling. 

About Connected Futures

Connected Futures is a new Catalyze cohort for organizations that help people move across active divides to take action toward common goals. We are looking for organizations that build trust, strengthen collaboration, and create ways for people to act together when mistrust, polarization, exclusion, or disconnection would otherwise keep them apart and prevent them from solving problems together.

These organizations may work in the health, economic mobility, democracy, and/or education sectors. What connects them is not a single issue area, but a common approach to bridgebuilding: creating the relationships, skills, and structures people need to work together toward positive change.

Catalyze cohorts are at their best when cohort members are fully engaged. The Social Entrepreneurs that lead selected organizations are expected to participate in the Catalyze support model and peer learning community in the following ways:

• Social Entrepreneurs attend three in-person convenings, each of which are held over 3-4 days in cities across the United States. Convening dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs attend three virtual learning sessions, each lasting 2-3 hours. Webinar dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs engage with the New Profit team via 1:1 strategic advising, including a minimum of six virtual sessions over the yearlong cohort.
• Entrepreneurs receive a $10,000 stipend specifically to support their own leadership development goals.
• Programming requires a commitment of 6-8 hours per month on average. New Profit covers the cost of travel, accommodation, and meal expenses for each in-person convening.

The Community Foundation of Muncie and Delaware County offers Community Grants aimed at enhancing the quality of life in Muncie and Delaware County, Indiana. This program supports initiatives in arts, culture, education, and community betterment, encouraging nonprofits to provide compelling cases for funding. Grants are awarded on a rolling basis to 501(c)(3) organizations and other public charities, focusing on projects that yield substantial benefits and foster long-term change for the community.

The SHAPE America Major of the Year Award recognizes exemplary undergraduate students in health, physical education, recreation, and dance. This prestigious accolade aims to highlight nominees who demonstrate academic excellence and commitment to service within their communities. Faculty members from colleges and universities are encouraged to nominate one outstanding student per major, ensuring that the next generation of health educators is celebrated for their achievements and contributions to the field.

The Cyrus M. Quigley Foundation Grant supports tax-exempt organizations that empower young people through initiatives focusing on courage, self-reliance, and service. Since its inception in 1993, the foundation has awarded over $300,000 in grants, with amounts ranging from $1,000 to $7,500. The foundation emphasizes physical challenges and community service to help develop essential life skills. Grant proposals are accepted annually until the third Friday in April, with decisions communicated by May 31.

The Fisheries Innovation Fund's Electronic Monitoring and Reporting Grant Program aims to enhance fisheries management through electronic technologies. Administered by the National Fish and Wildlife Foundation (NFWF), this initiative will support U.S. fisheries in implementing electronic monitoring tools to improve data collection, accessibility, and management. The program is open to various fisheries, including commercial and recreational sectors, promoting sustainable practices and fostering stakeholder involvement for better fishery information systems.

Michael L. Hamaker Memorial Scholarship

A scholarship awarded to a graduating senior or previous graduate from Marshall, Olivet or the surrounding area seeking a career in engineering, manufacturing or industrial technologies with programs such as, but not limited to, architecture, construction, drafting, electronics, welding and/or other related technologies. Applicants must demonstrate financial need. GPA is not a qualifying factor; however, transcripts and test scores are requested. Students who receive this scholarship are encouraged to apply for further support in subsequent years.

The OVW Fiscal Year 2026 Electronic Service Protection Order Court Pilot Program supports state and Tribal courts in implementing electronic communication methods for serving protection orders. This initiative, part of the Violence Against Women Act, aims to enhance the efficiency and effectiveness of protection order enforcement, ensuring safety for victims of domestic violence, sexual assault, and stalking. Applications are due by October 8, 2026, at 4:59 pm through JustGrants.

Bucks County Foundation

Since our founding in 1979, the staff at BCF have been working closely with donors, local leaders, and nonprofit organizations to improve the quality of life in Bucks County. Our work with local charitable organizations helps to improve the health and wellbeing of children and families across the county.

Scholarships

The Bucks County Foundation is proud to support students throughout Bucks County in their pursuit of higher education and attainment of academic, trade and life skills that translate into economic self-sufficiency. Through the generosity of donors in our region, we manage over 100 scholarship distributions for a wide variety of students with diverse educational journeys.

Millennium Medical Women in Science and Medicine Scholarship

Provides scholarships to students attending high school in Bucks County who are planning to pursue a professional career in a scientific or medical related field such as Pre-Med, Nursing, Biology, Pharmacy, Chemistry, etc.

The National Bycatch Reduction Engineering Program (BREP) for FY2026/27 offers competitive grants aimed at supporting non-Federal researchers. This initiative, governed by the Magnuson-Stevens Fishery Conservation and Management Act, focuses on developing innovative fishing practices and gear technologies to minimize bycatch and reduce post-release mortality of non-target species. By addressing bycatch reduction, the program seeks to enhance the sustainability of U.S. fisheries and aquaculture, aligning with the National Marine Fisheries Service's conservation goals.

The BIE Science Post Graduate Scholarship Fund offers financial assistance to American Indian and Alaska Native students pursuing full-time degrees in STEM fields at accredited institutions. This need-based award ranges from $100 to $30,000 per academic year, based on financial aid information provided by the institution's Financial Aid Office. Eligible students must demonstrate Tribal affiliation through a Tribal Eligibility Certificate.

The Jeffers, Danielson, Sonn & Aylward Law Scholarship supports Chelan and Douglas County high school graduates pursuing a degree in Law or Paralegal studies. Applicants must maintain a minimum 3.0 GPA and demonstrate financial need through the FAFSA. This scholarship encourages local students to advance their legal education, fostering a new generation of legal professionals committed to serving their communities.

The Start-Up Research Grant aims to support early-career researchers establishing independent research careers. Grants are awarded for two years, enabling applicants to submit future proposals. The program emphasizes scientific excellence and collaboration between Israeli and American scientists. Eligible junior principal investigators (PIs) must be within ten years of their PhD or MD completion. Notably, the grant does not cover PI salaries and requires adherence to BSF's application standards.

The Michael & Anna Kurty Scholarship for Engineering students supports college juniors, seniors, and graduate students pursuing degrees in engineering. Established by Mr. and Mrs. George Kurty, this scholarship aims to honor Mr. Kurty's parents while promoting educational opportunities in fields such as chemical, electrical, civil, and mechanical engineering. Applicants must demonstrate financial need and maintain a GPA of 2.5 or higher, ensuring that deserving students have the chance to succeed in their academic and career pursuits.

The Frankenthaler Climate Initiative's Catalyst Grant supports organizations in the visual arts sector to take quick, impactful actions toward sustainability. Since 2021, the initiative has awarded over $10 million, fostering a shift to carbon-neutral operations. Eligible applicants include nonprofit entities that prioritize visual arts, aiming to reduce environmental impact through clean energy, efficiency improvements, and innovative practices. This grant promotes a greener future while enhancing the importance of arts education and ecological stewardship.

The Diaper Distribution Demonstration Research Pilot (DDDRP), funded by the US Dept. of Health & Human Services, aims to provide essential diaper supplies to low-income families. With $29 million available, the program will evaluate partnerships between community organizations to enhance diaper distribution and improve family health and economic stability. Activities include training, bulk purchasing, and referrals to supportive services, ensuring families receive the resources they need for a better quality of life.

The Marv VandenBosch Scholarship, established by Sandra VandenBosch and her children in memory of Marv VandenBosch, supports Tri-Cities students pursuing careers in criminal justice or law enforcement. This scholarship considers financial need and requires applicants to have a minimum GPA of 2.5. The Grand Haven Area Community Foundation administers the scholarship through a competitive process, ensuring that each applicant is thoroughly reviewed to promote academic achievement and community involvement.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The NRA Foundation Frontline Heroes Scholarship

The NRA Foundation Board of Trustees has established the Frontline Heroes Scholarship to institute a memorial to this distinguished group of First Responders, Law Enforcement Officers, and Military personnel*, who have served continuously and unselfishly in the highest tradition of our great nation.

The Frontline Heroes Scholarship will give a one-time annual award of up to $10,000** for one eligible candidate.

The Sustainable Development Grant Program, funded by The Rockefeller Brothers Fund, aims to combat climate change by promoting ecological stewardship, economic viability, and social equity. It supports initiatives that enhance public understanding, implement clean energy solutions, and foster international cooperation. The program prioritizes projects that address the urgent threats posed by climate change while ensuring that development efforts are sustainable and inclusive for future generations.

The Gertrude L. Hirsch Charitable Trust, founded in New Jersey, aims to support 501(c)(3) organizations for charitable and educational purposes. It focuses on various program areas including arts, education, environment, health, and human services. Although there are no geographic restrictions, preference is often given to organizations based in New Jersey. Additionally, funds awarded cannot be used outside the United States, ensuring that contributions remain within the country to benefit local communities.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

Beckley Area Foundation

Beckley Area Foundation was established in January 1985 by ten community-minded citizens. It began with a gift of $1.1 million from the Dr. Thomas Walker Memorial Health Foundation as “seed” money for this Raleigh County project. BAF assets have grown to over $70 million with over 500 different funds managed by our three trustee banks. Today, Beckley Area Foundation is one of West Virginia’s largest community foundations.

Since its inception, BAF has distributed over $23 million to charities and other worthy projects in the fields of education, public recreation, health & human services, the arts, animal services and beautification.

Scholarships

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Most of these scholarships must be awarded to students from our geographic area or at least preference given to such students. While the majority of scholarships benefit Raleigh County applicants there are others designated for Fayette, Summers, Webster, and Wyoming students. 

The File Girls Cystic Fibrosis Scholarship

Weighted for educational merit, personal achievement and financial need; West Virginia high school matriculating senior with a confirmed diagnosis of Cystic Fibrosis. Recipient will provide physician’s letter affirming a diagnosis of Cystic Fibrosis as part of the application process; The scholarship is to be awarded for post-secondary education through college, vocational or technical schools.

This scholarship is renewable.

Healthcare Assistance Grant

The MS Focus Healthcare Assistance Grant assists uninsured individuals with the cost of visiting their MS specialist as well as dental assistance. The grant, which can pay for one visit and one follow-up, is designed to assist those already diagnosed with MS who may need a visit to their treating physician to renew a prescription or handle other important needs. 

Applicants give MS Focus staff authorization to negotiate costs directly with the provider, and the fee is paid directly to the doctor. 

TryMarine Grant

The Reservoir Fish Habitat Partnership (RFHP) is seeking candidate pilot sites for evaluating two water quality treatment technologies—TryMarine and Oase Water Technology—in small urban fishing lakes (1–3 acres).

Urban fishing lakes are important community resources, providing accessible angling opportunities and supporting local outdoor recreation. Many of these lakes experience nutrient‑driven water quality impairments such as algal blooms, low dissolved oxygen, and reduced water clarity. These issues degrade fish habitat and diminish angler satisfaction.

This pilot initiative aims to identify lakes where these technologies can be tested to determine their effectiveness, feasibility, and potential for broader application across the RFHP network.

Objectives

Water Quality & Habitat Objectives

• Reduce nutrient concentrations (total phosphorus, total nitrogen).
• Improve water clarity and reduce turbidity.
• Reduce harmful algal blooms (HABs).
• Increase dissolved oxygen stability to support sportfish populations.
• Improve habitat conditions for stocked and naturally occurring fish species.
• Reduce internal nutrient loading from sediments.

RFHP Program Objectives

• Demonstrate scalable tools for improving fish habitat in small urban lakes.
• Support community‑based fisheries enhancement.
• Provide case studies and data for future RFHP guidance.
• Strengthen partnerships among agencies, municipalities, NGOs, and angling groups.

This program aims to enhance education for healthcare professionals regarding new therapies and patient management in ulcerative colitis (UC). It focuses on multi-channel educational strategies to address the evolving landscape of UC treatment. Key areas include educating on new oral therapies, transitioning to advanced therapies, and managing isolated proctitis. Organizations such as healthcare institutions and medical education companies are eligible to apply, ensuring a comprehensive approach to improving UC care.