Best Large Grants for Nonprofit Organizations in Kentucky

A Little HOPE, Inc. is a charitable foundation that provides grants to organizations offering bereavement support services and grief counseling for children and young adults who have lost a loved one. The grant amounts vary based on project scope and budget. Applications are by invitation only, sent out each October, and interested organizations should submit an email with necessary details for consideration.

The NASPGHAN Foundation/APGNN Susan Moyer Research Grant supports impactful research and quality improvement initiatives aimed at enhancing nursing care for children with gastrointestinal and nutritional disorders. Grants ranging from $500 to $5000 are available for eligible Registered Nurses who are APGNN members. Awardees must present their findings at the NASPGHAN Annual Meeting and adhere to specific funding guidelines, including IRB approval and acknowledgment of support in publications.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

George Dila Memorial Scholarship

This scholarship has been made possible by the generosity of Wayne and Jeanie Mortenson, who established the George Dila Memorial Scholarship Fund of the Community Foundation for Mason County to honor the memory of their dear friend, George Dila.

This scholarship is for graduating senior(s) of Ludington High School pursuing a degree or certification at any two or four-year accredited college, university, or vocational/technical school.

Tyson Foods Community Giving Grants support initiatives that enhance the quality of life for communities and their members. With a focus on scaling existing effective programs, these grants are aimed at organizations that operate in underserved areas. Eligible nonprofits must have a 501(c)(3) status and local Tyson plant support. Applications are accepted annually, with priority given to projects addressing systemic community issues. Notable past support includes a $25,000 grant to the Arkansas Foodbank Mobile Pantry Initiative.

The Path to a Cure — Collaborative Research Grant, offered by the Cystic Fibrosis Foundation, aims to support research in developing new therapies for cystic fibrosis, particularly focusing on CFTR gene repair and replacement strategies. This program prioritizes collaborations that integrate new investigators and innovative technologies into CF research. Applicants can request up to $1,000,000 annually for three years, with proposals requiring preliminary data to demonstrate feasibility and potential impact.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders

There remains a scientific gap in understanding of the role of anti-TFPImediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Project Types and Area of Interest

Potential applicants are encouraged to identify and address preclinical/basic science data generation for TFPI modulation/rebalancing in their local setting. This may include:

• Rare bleeding disorders which arise from deficiencies in different clotting factors or pathway components but converge on a common functional endpoint which is an impaired thrombin generation (e.g., Factor II, Factor V, Factor VII, Factor X and Factor XI deficiencies, as well as von Willebrand disease).
• Other diseases such as Glanzmann's thrombasthenia (GT) that have a distinct pathophysiological mechanism.
• Other rare bleeding disorders whose mechanisms are not well understood (e.g., Bleeding Disorder of Unknown Cause, BDUC).

The AABCF Research Grants, offered by the American Association of Birth Centers Foundation, provide funding up to $5,000 for research projects focused on the birth center model of care. Open to individuals and organizations, these grants aim to enhance knowledge and practices in maternity and women's health care. Projects must demonstrate a clear plan and ability to complete the research on schedule, ensuring impactful contributions to the field.

The SAA Shakespeare Publics Award, presented by the Shakespeare Association of America, celebrates innovative efforts that engage diverse publics with Shakespeare's works. Open to SAA members, the award recognizes projects that promote teaching, scholarship, performance, and activism. Since its inception in 1972, the SAA has fostered dialogue and collaboration among scholars, enhancing the appreciation of Shakespeare's impact on culture. This award highlights the importance of broadening access to Shakespeare's legacy in today's society.

The OREF/Goldberg Arthritis Research Grant aims to support innovative research proposals focused on arthritis treatment, particularly arthroplasty. It seeks to foster new investigators by providing seed funding for projects that demonstrate clinical relevance and potential for practical application. Proposals must highlight their orthopaedic significance and aim to advance research that could lead to larger scale funding opportunities, enhancing the field of orthopaedics.

About Pfizer Grants

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Biochemical and Molecular Characterization of Marstacimab and TFPI Pathways 

This competitive grant encompasses research aimed at elucidating molecular and cellular mechanisms underlying marstacimab-TFPI interactions, including but not limited to differential expression of tissue factor and TFPI in various tissues, binding kinetics, and other biochemical properties. Projects should seek to advance foundational understanding of these interactions through innovative approaches in biochemistry, molecular biology, and related disciplines.

Project Types and Area of Interest

Projects that will be considered for Pfizer support will focus on basic science and fundamental biological understanding of Tissue Factor Pathway Inhibitor (TFPI), anti-TFPI Monoclonal Antibodies, and marstacimab. The areas of interest may include (but are not limited to):

• Basic biology of TFPI including interactions among key regulatory proteins in the intrinsic and/or extrinsic clotting cascades (e.g. Protein S being a co-factor for both Protein C and TFPI).
• Impact of differential TFPI expression within tissues and the role of various TFPI pools/isoforms in the regulation of coagulation.
• Pharmacology resulting from concomitant therapies added to anti-TFPI

The Rural Changemaker RFP by Interact for Health aims to enhance health and well-being in rural areas across Ohio, Indiana, and Kentucky. With funding ranging from $10,000 to $70,000, the initiative targets grassroots projects that address vital health conditions. This year, a total of $600,000 is available for organizations that serve at least one of Interact for Health’s rural counties. The grant duration is between 12 to 18 months, fostering community-driven solutions.

The Retina Society, Inc.

The Retina Society was founded in 1968 exclusively for educational and scientific purposes concerning the diagnosis, care and treatment of diseases and injuries to the retina. The Retina Society began as an outgrowth of alumni meetings of Retina Associates, a retina practice founded in Boston in 1951 by Charles L. Schepens. Dr. Schepens is credited with establishing retina surgery as a sub-specialty.  

Our mission is to reduce worldwide visual disability and blindness by promoting the education and professional interaction of vitreoretinal specialists, providing optimal care for patients with vitreoretinal diseases, and encouraging, through clinical and basic research, the discovery and development of new means to further patient care.

Retina Society Underrepresented in Medicine (RESOURCE) Mentoring Program

The Retina Society Underrepresented in Medicine (RESOURCE) Mentoring Program was created to engage and interest ophthalmology residents from underrepresented populations* in research and in pursuing careers in the retina subspecialty through dedicated mentoring exposure. The program will pair ophthalmology residents from underrepresented backgrounds with Retina Society mentors, with the goal of providing the residents with research and career mentorship.

*The American Association of Medical Colleges definition of underrepresented in medicine is: "Underrepresented in medicine means those racial and ethnic populations that are underrepresented in the medical profession relative to their numbers in the general population." We define the following groups as underrepresented: Black (African American or African), Latino/Hispanic, American Indian, Alaska Native, Native Hawaiian or Pacific Islander. We will also be considering applicants from LGBTQIA+ and socioeconomically underprivileged backgrounds.

Mentors will work with their designated mentees on research projects that will be presented at the Retina Society Annual Meeting in 2027 and submitted for publication consideration. Mentors and mentees will be acknowledged at the Retina Society Annual Meeting.

The Shubert Foundation provides unrestricted grants to not-for-profit professional theatre and dance companies in the U.S. Its focus is on organizations with a proven track record in artistic and administrative excellence. Eligible applicants must have a minimum annual budget of $150,000 and demonstrate financial stability, strong community engagement, and the ability to generate income. The foundation does not fund individuals, project-specific requests, or organizations without 501(c)(3) status.

Accreditation Sustainability Learning Community RFA

The Association of State and Territorial Health Officials (ASTHO), through the Public Health Infrastructure Grant (PHIG), is currently accepting applications for participation in a learning lab that will foster health department capacity to build a sustainable public health accreditation culture within their agencies. This opportunity is open to applicants from direct PHIG awardees at the state-, big city-, and county-level.

The Monticello College Foundation Grant supports projects that promote female education. Eligible applicants include professional educational associations and accredited colleges in the Midwest. The foundation prioritizes innovative proposals that demonstrate significant need. Grants are given for a single fiscal year, with ongoing requests requiring annual re-application. Proposals should be submitted by August 31 for fall consideration and by February 28 for spring review. Funding is not available for direct grants to individuals or capital purposes.

The Trans Justice Funding Project (TJFP) provides grants to grassroots trans-led organizations in the U.S. and territories, focusing on those with budgets under $250,000. TJFP supports initiatives that address varying needs within trans communities, including health, legal aid, and mutual aid projects. The organization prioritizes groups led by trans people of color and emphasizes the importance of centering marginalized voices in the fight for trans justice.

The ADDF-Harrington Scholar Program aims to transform academic discoveries into effective treatments for Alzheimer’s disease and related dementias. With funding of up to $600,000 annually, this program prioritizes innovative drug targets and supports research from hit-to-lead optimization to IND-enabling studies. Eligible applicants include academic investigators with a strong potential to advance meaningful therapeutics. The program emphasizes collaboration with industry experts, making it a significant opportunity for advancing dementia research.

Building Capacity for Communicating Impact Learning Community RFA

Learn how to communicate about Public Health Infrastructure Grant impact through a new community of practice! Through peer learning, technical assistance, and practical tools, participating teams will build strategic leadership and communications skills to more effectively translate public health achievements into compelling messages for key audiences. All directly funded PHIG recipients (big-city, county, state/territory-level governmental public health professionals) are eligible to apply.

The HIP Graduate Student Award supports first to third-year graduate students in the U.S., Canada, and Mexico aiming for a career in academic hematology. Offering a $40,000 annual stipend for two years, it funds tuition, research, and travel to the ASH annual meeting. Eligible candidates must conduct blood sciences research and demonstrate commitment to the field. This award enhances students' competitiveness for future opportunities in hematology research.

The HIP Medical Student Award by the American Society of Hematology supports underrepresented medical students in hematology research. Participants gain mentorship, a stipend up to $32,000, and valuable exposure to hematology practices. The program offers summer, flexible, and yearlong project options to accommodate students at different stages of their medical education. This initiative aims to foster diversity in the field and encourage long-term involvement in hematology.

The Headache Medicine Fellowship aims to enhance training in headache medicine by supporting programs focused on diversity, equity, and inclusion. Targeting regions with workforce challenges, the fellowship encourages clinical practice, research, and education to address healthcare disparities. Preference is given to institutions that serve underserved populations and demonstrate a commitment to mentorship and expert guidance for fellows. This initiative seeks to improve understanding and treatment of headache conditions.

The James S.T. Yao Resident Research Award encourages early-career physicians in the U.S. and Canada to engage in groundbreaking research on vascular diseases and therapies. Awarded by the SVS Basic and Translational Research Committee, it includes a $5,000 prize, a presentation opportunity at the Vascular Annual Meeting, and a subscription to the Journal of Vascular Surgery. This award honors the legacy of Dr. James S.T. Yao, a prominent figure in vascular research.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Arthur and Lois Jean Stuenkel Scholarship

This scholarship provides financial support to a graduating senior seeking to further his or her education beyond high school. The recipient must be in the top 25% of his or her graduating class and demonstrate financial need. This scholarship is for a worthy student who has participated in sports or extracurricular activities. 

The scholarship is renewable.

The Affiliate Grants - Chapter Activities Fund, offered by the American Musicological Society, provides financial support for chapter activities and programs. Each chapter can request up to $500, covering no more than 50% of total costs. Applications are accepted semi-annually, with deadlines of August 1 for summer and January 15 for winter. Notably, chapters can only receive funding once per twelve-month period, ensuring fair distribution of resources.

The AICEF Cultural Grant aims to enhance cultural ties between the United States and Indonesia by funding projects in the performing, visual, and literary arts. With grants ranging from $1,000 to $5,000, the foundation seeks to support distinguished individuals and groups whose work is accessible to the public and fosters goodwill between the two nations. This initiative not only promotes artistic excellence but also bridges cultural exchanges for a diverse audience.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Bryce A. Malsbary (BAM) Scholarship

The purpose of the Fund is to provide a scholarship for a person seeking higher education at an accredited institution, including but not limited to: vocational, technical, trade, college, or university levels of education. Assistance is for a resident of Henderson County or Polk County, North Carolina, leading to a degree. Candidate must show financial need, GPA 3.0 or higher, and have community service, work, or school activities. Student must be a legal resident of North Carolina.

The Manny Heaton Memorial Scholarship honors the legacy of Manny Heaton, a vibrant individual whose life was tragically cut short in April 2023. Established by his father, Tom Heaton, this annual scholarship supports the children of Toyota Motor Manufacturing Indiana (TMMI) employees. Eligible applicants must be graduating seniors with a minimum GPA of 2.0, planning to attend college or technical school, reflecting Manny's dedication and resilience.