Best Large Grants for Nonprofit Organizations in Kentucky

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5424 - Adaptive Control Frameworks to Unlock Full-Scale BNR Potential

Grant Information

• Identify and categorize the dominant failure modes of current aeration and process control implementations under real-world operating conditions.
• Develop guidance on data and instrumentation requirements for utilities to support adaptive control, including the characterization of existing sensor infrastructure and the use of soft sensors where hard sensors are limited.
• Develop practical adaptive control frameworks and implementation guidance that utilities can deploy without dependence on proprietary black-box tools or specialized data science expertise, including hybrid approaches that augment conventional controls with data-driven models (e.g., artificial intelligence (AI)/machine learning (ML), digital twins) for variable flow and concentration conditions.
• Benchmark control performance against biological capacity indicators across multiple full-scale facilities to quantify the gap between achievable and realized biological nutrient removal (BNR) performance.

The South Arts State Fellowship offers a $5,000 grant to artists reflecting the rich visual arts culture of the Southern U.S. It aims to support individual artists or collaborative teams creating original works. Each state will select one awardee based on artistic excellence. Applicants must be legal U.S. residents and provide proof of residency. The application deadline is December 10, 2025, and awardees must attend an awards ceremony in summer 2026.

The Emerging Traditional Artists Program (ETAP), presented by South Arts Inc., supports early-career traditional artists from Appalachian Regional Commission-designated counties. With a $5,000 award, artists can access training, networking, and mentorship opportunities to enhance their skills and community impact. This initiative aims to preserve traditional arts and culture while fostering a new generation of artists dedicated to their craft and cultural heritage.

The Southern SARE: On-Farm Research Grant supports agricultural professionals in collaborating with farmers to conduct innovative on-farm research projects focused on sustainable agriculture. This initiative emphasizes building strong relationships between researchers and farmers while addressing agricultural production challenges. By fostering new practices in production and marketing, it aims to enhance sustainability in the agricultural sector, thereby benefiting local communities and the environment.

The South Arts Southern Prize provides a unique opportunity for individual artists in the Southern region of the U.S. to showcase their scriptwriting talents. With a total of $35,000 in grants available, including a $25,000 Southern Prize and a $10,000 runner-up prize, this program supports artistic excellence and offers a two-week residency at The Hambidge Center. Eligible applicants must be legal residents of the Southern states and adhere to specific requirements. The program celebrates the rich cultural diversity of the American South.

The Corning Nonprofit Grants program supports community-based initiatives in education, human services, and culture. Eligible nonprofits that align with our criteria may apply for funding on a rolling basis. The application window for invited organizations runs from February 10 to September 15. We emphasize local impact within a 20-mile radius of Corning, NY, ensuring that our contributions foster collective growth and engagement in the community.

The KOHC: Oral History Grants - Technical Assistance Grants, administered by the Kentucky Historical Society, provide essential resources for local oral history projects. These grants offer audio recording equipment, training, and support to individuals and organizations with limited experience. Since 1976, KOHC has awarded over $1 million, facilitating the collection of 35,000 interviews that capture Kentucky’s rich history. Applications are accepted on an ongoing basis, with award notifications issued within 60 days.

The Kentucky Oral History Commission (KOHC) provides grants to support oral history projects that preserve and document Kentucky's rich history. These grants include Project Grants for creating research projects, Transcription and Indexing Grants for existing interviews, and Presentation Grants for showcasing oral histories through various media. Funding amounts range from $2,500 to $7,500 depending on the grant type. These initiatives aim to foster participation and ensure the preservation of significant narratives across the state.

Community Foundation of Louisville

Founded in 1984, the Community Foundation of Louisville mobilizes people, networks, and capital to spark meaningful change in and beyond Louisville. Just as our name signifies, here, community comes first. With over $874 million in assets, over 2,200 charitable funds, and collaborations with hundreds of local partners, we connect real investments with relevant causes. The Foundation has addressed and continues to address a wide range of community needs. The key priorities of the Foundation’s mission are to remove barriers to accessing capital and resources and to open opportunities for all. Working with neighbors, changemakers, and community investors, we’re inspiring greater generosity to move us all forward.

Scholarships

Since 1984, the Community Foundation of Louisville has provided tens of millions of dollars in scholarships to support students with their educational goals. We assist donors in establishing scholarship funds so that a quality education can be available for everyone.

Keep Going Scholarship

The Keep Going Scholarship in Honor of Travis Nagdy was established by Cities United, incubating partner of Russell: A Place of Promise, and Youth Resistance Collective LC, a Kentucky limited liability nonprofit company, utilizing a grant from the Public Welfare Fund, a component fund of the Foundation, to honor the life of Travis Nagdy, a 21 year-old social justice leader in Louisville who lost his life in late 2020. Travis was beloved by the community. His optimism and motivational activism, highlighted in his signature motto "Keep Going!" was vital to the social justice uprisings in Louisville and across the country in 2020. This scholarship recognizes his fight for justice and the continued pursuit of justice by Louisville youth. Specifically, this Fund is designed to provide scholarship assistance in the form of grants to help defray college or university expenses of black students from West Louisville, Kentucky.

The Toy Foundation Program offers a unique opportunity for nonprofit organizations to apply for toy donations to support children in need. The application period runs from January to June, with approved applicants receiving toys by the end of the year. This initiative, part of the Toy Chest program, has positively impacted over 35 million children since 2003, promoting play as essential for emotional and educational development.

The 2027 Continuing Education Grant is made possible by funding from the Grants to States program administered by the Institute of Museum and Library Services (IMLS).  This grant aligns with Kentucky Department for Libraries and Archives' (KDLA) five-year strategic plan to enhance Institutional Capacity to “enhance the knowledge and skills of public library and archival staff through professional development and training opportunities. This grant will only cover conferences taking place between October 1, 2026, and September 30, 2027.  The goal is to provide essential funding to Kentucky's public libraries, enabling them to expand and enhance their staff’s learning opportunities.

Awards shall be disbursed as follows-

• $5000 large libraries (40+ full-time staff)
• $4000 medium libraries (15 – 39 full-time staff)
• $3000 small libraries (6 – 14 full-time staff)
• $2000 very small libraries (1 – 5 full-time staff)

The Tree Campus Higher Education Program in Kentucky, led by the National Arbor Day Foundation, encourages colleges to cultivate their community forests. This initiative promotes environmental awareness, improves campus aesthetics, and supports student well-being through green spaces. By meeting five essential standards, institutions can earn annual recognition, fostering pride and commitment to sustainability. Participation benefits both the campus community and the planet, emphasizing the vital role trees play in our health and environment.

The Dunkin' Joyful Spaces Grant supports children's hospitals and community health centers in creating joyful environments for pediatric patients. Launched in 2022, this initiative helps fund play areas, healing gardens, and other kid-friendly spaces, enhancing the hospital experience. Grants typically range from $25,000 to $65,000 annually, with a maximum of $150,000 over three years. This opportunity encourages creativity in designing spaces that provide comfort and joy to children and their families during hospital stays.

Community Foundation of Louisville

Founded in 1984, the Community Foundation of Louisville mobilizes people, networks, and capital to spark meaningful change in and beyond Louisville. Just as our name signifies, here, community comes first. With over $874 million in assets, over 2,200 charitable funds, and collaborations with hundreds of local partners, we connect real investments with relevant causes. The Foundation has addressed and continues to address a wide range of community needs. The key priorities of the Foundation’s mission are to remove barriers to accessing capital and resources and to open opportunities for all. Working with neighbors, changemakers, and community investors, we’re inspiring greater generosity to move us all forward.

Scholarships

Since 1984, the Community Foundation of Louisville has provided tens of millions of dollars in scholarships to support students with their educational goals. We assist donors in establishing scholarship funds so that a quality education can be available for everyone.

James W. Hardaway Memorial Scholarship

The James W. Hardaway Memorial Scholarship of First Harrison Bank was established by a bequest made in memory of James W. Hardaway, who served the bank for over 58 years. Specifically, this is designed to provide scholarship assistance in the form of grants to help defray college or university expenses of students graduating from high schools in Bullitt County, KY.

The Dollar General Literacy Foundation offers the DGLF Summer Reading Grants, which support the development and expansion of summer reading programs aimed at Pre-K to 12th grade students, particularly new and below-grade-level readers, including those with learning disabilities. Eligible organizations, such as nonprofits, schools, and libraries within 15 miles of a Dollar General store, can apply for grants up to $3,000 to foster literacy and education initiatives.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

The Kentucky Academy of Science offers the KAS Undergraduate Research Supply Grants to support undergraduate students in Kentucky conducting research under faculty supervision. These grants provide essential supplies and expendables that are not typically available from their institutions. This initiative aims to promote scientific discovery and understanding while empowering students to engage in meaningful research activities.

The Summer Undergraduate Research Grants, offered by the Kentucky Academy of Science, support undergraduate students at Kentucky colleges and universities in their faculty-supervised research during the summer. These grants cover essential budget items such as supplies, travel, and stipends, fostering scientific discovery and understanding in Kentucky. Eligible students must work under a faculty member who is a Kentucky Academy of Science member, ensuring a collaborative and enriching research experience.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

Nature's Path's Gardens for Good program empowers communities by funding organic gardens that address food insecurity. Since 2010, it has donated $930,000 CAD to support 120 gardens. In 2023, grants of $6,500 each will be awarded to 20 gardens across the U.S. and Canada. Eligible applicants must be registered non-profits with urban organic agriculture projects that serve low-income communities, promoting sustainable practices and inclusivity.

The Dale Jr. Foundation, founded by NASCAR driver Dale Earnhardt Jr., has raised over $8 million since 2007 to support various charities focusing on youth and underprivileged communities. The foundation emphasizes empowerment, education, wellness, hunger relief, and hope, aiming to provide resources that enhance confidence and opportunities for children facing hardships. Through fundraising efforts and partnerships with organizations like Make-A-Wish, the foundation strives to positively impact lives and foster a sense of normalcy among children in need.

The Kentucky Arts Partnership Grant provides vital operating support to arts organizations in Kentucky, ensuring that residents have access to year-round arts programming. This grant is aimed at independent arts groups and local arts agencies, helping to foster strong community engagement and cultural diversity. Organizations must demonstrate fiscal responsibility and maintain IRS tax-exempt status to qualify. This initiative not only enhances art participation but also strengthens the overall arts delivery system across the state.

Project Lead The Way (PLTW) offers grants for schools to implement the PLTW Computer Science program from 2025 to 2028. Schools must provide at least one PLTW course in the first year and two courses in the second year. The total grant is $14,000, covering participation fees and training costs. Eligible institutions include public, private, and charter schools located in the U.S., with special encouragement for those serving low-income or minority-majority populations.

The SESAPS Francis Slack Award, established by the Southeastern Section of the American Physical Society, honors individuals who have selflessly contributed to advancing physics in the Southeast. It recognizes efforts in enhancing research facilities, strengthening academic departments, and fostering regional physics organizations. Nominations remain active for three years, with a focus on encouraging women and minority candidates. This prestigious award commemorates the legacy of Francis G. Slack, a pivotal figure in the development of the Southeastern Section.

The ASB Research Award (Professional), offered by the Association of Southeastern Biologists, honors outstanding research by professional members (not students) with a $1000 grant. Applicants must be the primary author of a manuscript published after the last ASB annual meeting and must present their findings at the upcoming annual meeting. The awardee is recognized at the Closing Banquet, emphasizing the importance of attendance. This initiative promotes scientific advancement and networking among biology professionals.