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Best Grants for 501(c)(3) in Massachusetts

Find the perfect Grants for 501(c)(3) in Massachusetts on Instrumentl. 10,000+ Grants for 501(c)(3) in Massachusetts in the United States.

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$5K

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$2.65B total
$5K median

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9,887 Results based on applied filters

Chronic Lymphocytic Leukemia Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.
Cancer / Oncology Leukemia Health Care Access & Delivery +1 more

Tick-borne Pathogen Award

Bay Area Lyme Foundation
Private
United States
US $150,000
The Tick-borne Pathogen Award, sponsored by Bay Area Lyme Foundation, offers $150,000 to support innovative research on non-Borrelia tick-borne pathogens. This grant aims to attract scientific talent to explore co-infections with Lyme disease and other related infections. Eligible candidates include researchers from academia or the private sector at the post-doctoral level or higher, with a focus on improving diagnostics and therapies for tick-borne diseases. Applications must present a viable proof-of-concept project.
Microbiology Infectious & Parasitic Diseases Lyme Disease +1 more

Bernice Ash Memorial Award

Namm Foundation
Private
United States
US $5,000
The Bernice Ash Memorial Award honors the legacy of a retail music visionary by providing a $5,000 grant to mid-career professionals employed by NAMM member companies. This award aims to support emerging leaders in the music industry through professional development opportunities and a one-year mentorship with NAMM Young Professionals. Eligible applicants must have at least five years of experience and agree to use the funds for professional training, enhancing their leadership skills and career growth.
Music Music Education Workforce Preparation & Job Readiness +1 more

Community Experts Fund Grant

Peter & Elizabeth C Tower Foundation Tr
Private
Barnstable County, Massachusetts, Dukes County, Massachusetts +4 more
Up to US $25,000
The Community Experts Fund Grant, provided by the Peter & Elizabeth C. Tower Foundation, aims to improve the lives of young people facing mental health and developmental challenges in targeted counties. With $350,000 available in 2025, the fund emphasizes mentoring initiatives that empower youth-driven goals. By strengthening existing programs, it seeks to build capacity and support young individuals through quality one-on-one mentoring, distinct from traditional case management, addressing the pressing needs of this vulnerable population.
Tutoring & Mentoring Mental Health & Psychiatric Diseases Intellectual / Developmental Disabilities +2 more

PennHOSA Foundation Scholarship

The Foundation for Enhancing Communities
Private
United States
US $2,500
The PennHOSA Foundation Scholarship promotes healthcare careers by providing scholarships to HOSA student members in Pennsylvania. It aims to enhance compassionate care delivery and community needs. Additionally, the Helen Heidelbaugh Aspire Award is given to one student focusing on community service. Eligible applicants must be HOSA members and enrolled in accredited healthcare programs, demonstrating financial need. This scholarship is a one-time award, reinforcing the commitment to future healthcare professionals.
Education - Higher Education Volunteerism & Philanthropy Medical Education & Professional Training +3 more

State Pilot Program for Treatment for Pregnant and Postpartum Women (363808)

Substance Abuse and Mental Health Services Adminis
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The State Pilot Program for Treatment for Pregnant and Postpartum Women aims to enhance the state's capacity to deliver integrated and evidence-based services for substance use disorders and maternal mental health. The initiative focuses on supporting pregnant and postpartum women and their families, ensuring they receive comprehensive care tailored to their unique needs. Funded by the Substance Abuse and Mental Health Services Administration, this program is a vital step toward improving health outcomes for vulnerable populations.
Mental Health & Psychiatric Diseases Family Services Addiction & Substance Use Disorders +2 more

Investigator Sponsored Studies Program

Alkermes
Corporate
United States
Up to US $300,000

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Investigator Sponsored Studies Program

Alkermes seeks to support research designed and conducted by independent clinicians and scientists through our Investigator Sponsored Studies (ISS) program. Alkermes may occasionally announce a Request for Proposals (RFP) for research in clinical areas where gaps in data have been identified. 

The ISS research Alkermes supports must be based in the United States and is typically conducted by experienced researchers who have an established history of successfully completing research with independent funding. Alkermes can provide its marketed products to the ISS programs it supports. In addition, there may be financial support available, but please note that study budgets cannot exceed $300,000 (inclusive of overhead).

  • ISS Areas of Interest
    • Sleep Disorders
    • Schizophrenia & Bipolar I Disorder
    • Schizophrenia
Patient Care & Services Sleep Schizophrenia +2 more

Brave Beginnings Grants

Will Rogers Motion Picture
Private
United States
Unspecified amount
Brave Beginnings Grants, under the Will Rogers Motion Picture Pioneers Foundation, focus on enhancing neonatal care by providing vital equipment to hospitals. Since 2006, the program has awarded approximately $1 million annually to Neonatal Intensive Care Units (NICUs) across the U.S. Following a suspension due to COVID-19, the 2026 grant cycle is now open, with applications due by February 13, 2026. This initiative aims to ensure the availability of lifesaving equipment for newborns in critical need.
Obstetrics & Neonatal Care Children’s Health & Pediatrics

PERF: Career Development Grants - CNS Shields Research Grant

Pediatric Epilepsy Research Foundation
Private
Canada, United States
US $150,000
The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.
Neuroscience Neurological Diseases & Disorders Children’s Health & Pediatrics +1 more

PERF: Career Development Grants - CNS Elterman Research Grant

Pediatric Epilepsy Research Foundation
Private
Canada, United States
US $150,000
The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.
Children’s Health & Pediatrics Epilepsy Neurological Diseases & Disorders +1 more

HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $140,000
The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.
Drug Use Disorder Addiction & Substance Use Disorders

Michigan Professional Insurance Agents Scholarship (MIPIA)

Four County Community Foundation
Private
United States
US $1,000 - US $2,000
The Michigan Professional Insurance Agents Scholarship (MIPIA) is offered by the Four County Community Foundation to seniors and recent graduates in Michigan planning to major in Insurance/Risk Management. This scholarship provides up to four awards and aims to foster education in the insurance field. Award recipients will be honored at the Foundation Scholarship Celebration in May, ensuring recognition of their achievements and contributions to the community.
Education - Higher Education Academic Scholarship Programs Business Education +2 more

Pershing Square Lotus Award for Ovarian Cancer Research

Pershing Square Sohn Cancer Research Alliance (PSSCRA)
Association/Society
United States
Up to US $750,000

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

  • deploying capital quickly, 
  • funding high-risk, high-reward ideas, 
  • bringing new perspectives into a field, 
  • encouraging collaboration, and 
  • leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

  • inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
  • empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.
Cancer / Oncology Reproductive Health Women's Health +1 more

Agriculture Innovation Center Grant Program (363833)

USDA: Rural Business-Cooperative Service (RB-CS)
Federal Government
American Samoa, Guam +4 more
US $600,000 - US $1,000,000
The Agriculture Innovation Center Grant Program aims to support Agriculture Innovation Centers by providing grants that facilitate technical assistance to agricultural producers. This initiative focuses on enhancing the marketing of value-added agricultural products, ultimately fostering growth in the agricultural sector. Funded by the USDA's Rural Business-Cooperative Service, this program is designed to empower producers and promote innovation in agricultural practices.
Agriculture Entrepreneurship Agricultural Economics +2 more

Homeless Veterans’ Reintegration Program (HVRP), Incarcerated Veterans’ Transition Program (IVTP), and the Homeless Women Veterans' and Homeless Veterans' with Children Reintegration Grant Program (HWVHVWC) (referred to collectively as HVRP)

US Department of Labor: Veterans' Employment and Training Service (VETS)
Federal Government
Guam, Puerto Rico +2 more
US $150,000 - US $500,000
The Homeless Veterans' Reintegration Program (HVRP) aims to assist veterans experiencing homelessness by providing tailored employment services. This federal initiative focuses on helping veterans transition to stable employment through job training, case management, and connections to local supportive services. HVRP aligns with national priorities to enhance career outcomes for veterans, ensuring they receive the necessary tools and resources for sustainable employment and integration into the workforce.
Military & Veterans Services Homelessness Services Workforce Preparation & Job Readiness +1 more

Community Charter Network Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Community Charter Network Scholarship, provided by the Central Indiana Community Foundation, assists students from Fall Creek Academy or University Heights Preparatory Academy in covering post-secondary educational expenses. This scholarship aims to support those who demonstrate financial need and excel academically. Eligible applicants include former students of these institutions or residents within the IPS district. Awards vary based on available funds and may cover tuition, fees, and other educational costs.
Education - Higher Education Vocational & Trade Education Academic Scholarship Programs +3 more

Limited Competition: Tribal Undergraduate and Graduate Research Training and Leadership Experiences (TURTLE) Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.
Education - Higher Education Workforce Preparation & Job Readiness Native American Services +1 more

NRF Foundation: Bright Futures Scholarship

NRF Foundation
Private
United States
Up to US $1,200
The NRF Foundation Bright Futures Scholarship provides a unique opportunity for undergraduate students to attend the 2026 NRF Foundation Student Program in New York City at no cost. This need-based scholarship allows students to explore career paths in the retail industry, meet leading recruiters, and gain insights from industry executives. Eligible students can receive free travel and accommodation for this enriching experience, which takes place from January 8-11, 2026.
Education - Higher Education Workforce Preparation & Job Readiness Academic Scholarship Programs +2 more

Mexican Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Mexican Scholarship, established by the former Consulate of Mexico in Indianapolis, aims to support students of Mexican descent in pursuing higher education. Funded by the Central Indiana Community Foundation, this scholarship is open to Indiana residents enrolled in accredited colleges or vocational schools. Applicants must demonstrate financial need, maintain a GPA of 3.0 or higher, and preference is given to those of Mexican heritage. Award funds can be utilized for tuition, fees, and essential educational expenses.
Education - Higher Education Education - High School Academic Scholarship Programs +3 more

Indigo Oak Fund: Grant for Women & Children's Issues

Vance R and Colleen H Andrus Family Foundation
Private
United States
Unspecified amount
The Indigo Oak Fund, a Colorado-based private foundation, focuses on empowering women and children through various initiatives. By funding organizations that address issues such as domestic abuse, food insecurity, and gender equity, the Fund aims to improve lives and foster lifelong learning. Their mission emphasizes recognizing individual potential and ensuring equal opportunity for all, making a significant impact in communities across Colorado and the Bay Area.
Women & Girl Services Women's Rights & Equality Women's Health +4 more

Strengthening Collaboration Between Tuberculosis Control Programs and Affiliated Partners in the United States.

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.
Epidemiology & Public Health Infectious & Parasitic Diseases Preventative Healthcare +1 more

Partners in Arts Scholarship

East Texas Communities Foundation
Private
United States
US $1,000
The Partners in Arts Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors from Smith County who have engaged in performing or visual arts and plan to pursue a related major in college. This scholarship highlights the importance of arts education and aims to empower students to achieve their academic goals. Eligible applicants must demonstrate a commitment to the arts and meet specific criteria, ensuring that funding is awarded to deserving candidates.
Art Education Music Education Education - Higher Education +4 more

Juliette Low’s Amazing Girls Scholarship

East Texas Communities Foundation
Private
United States
US $1,000
The Juliette Low’s Amazing Girls Scholarship, established in 2011 by the East Texas Communities Foundation, is aimed at female graduating seniors from Smith County who have been active in Girl Scouts. This scholarship supports educational pursuits for students attending any college in the U.S. Applicants must demonstrate financial need and have a minimum GPA of 3.00. The award amount is $1,000, and preference is given to recipients of the Girl Scout Gold Award. Reapplication is encouraged.
Academic Scholarship Programs Educational Access & Equity Education - Higher Education +3 more

Dr. Carol J. Chrisman Nursing Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.
Education - Higher Education Career / College Preparation Education - High School +3 more

Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs RFP

Water Research Foundation
Private
North America
Up to US $275,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5429 - Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs

Project Objectives

  • Survey and characterize dissolved organic nitrogen and phosphorus (DON/DOP) concentrations and speciation across North American wastewater facilities, including but not limited to influent, secondary effluent, tertiary effluent, digester supernatant, thermal hydrolysis process (THP) centrate, autothermal thermophilic digestion (ATAD) sidestreams, and dewatering recycle streams.
  • Understand the dynamics of DON/DOP in effluent, including quantifying the bioavailable fraction of DON/DOP in different relevant process streams, evaluating their transformation into nitrogenous disinfection by-product (N-DBP) precursors, determining bio-uptake rates representative of receiving water conditions, and measuring the timescale for biodegradation in receiving waters.
Water Resource Management Hydrology

Cohort Studies of HIV/AIDS and Substance Use (U01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.
HIV / AIDS Addiction & Substance Use Disorders

AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) (349962)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.
Patient Care & Services Home Health Care Health Care Access & Delivery +1 more

Grants for 501(c)(3) in Massachusetts Highlights

Looking for grants for 501(c)(3) in Massachusetts?


Read more about each grant below or start your 14-day free trial to see all grants for 501(c)(3) in Massachusetts recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grants for 501(c)(3) in Massachusetts

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Grants for 501(c)(3) in Massachusetts grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

95 Grants for 501(c)(3) in Massachusetts over $25K in average grant size

75 Grants for 501(c)(3) in Massachusetts over $50K in average grant size

60 Grants for 501(c)(3) in Massachusetts supporting general operating expenses

200+ Grants for 501(c)(3) in Massachusetts supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for grants for 501(c)(3) in Massachusetts?

Most grants are due in the first quarter.

Q1
32.0%
Q2
24.4%
Q3
18.8%
Q4
24.8%

Typical Funding Amounts

What's the typical grant amount funded for Grants for 501(c)(3) in Massachusetts?

Grants are most commonly $26,875.

$250 $250 Min.
$26,875 $26.9 K Median
$413,560 $413.6 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Massachusetts?

Grants are most commonly $124,010.

$124,010

Total Number of Grants

What's the total number of grants in Grants for 501(c)(3) in Massachusetts year over year?

In 2024, funders in Massachusetts awarded a total of 105,825 grants.

2022 103,608

2023 102,118

2024 105,825

Top Grant Focus Areas

Among all the Grants for 501(c)(3) in Massachusetts given out in Massachusetts, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Grants for 501(c)(3) in Massachusetts changing over time?

Funding has increased by 9.89%.

2022 $14,522,602,699

2023 $11,906,472,240
-18.01%

2024 $13,083,681,605
9.89%

Massachusetts Counties That Receive the Most Funding

How does grant funding vary by county?

Suffolk County, Middlesex County, and Norfolk County receive the most funding.

County Total Grant Funding in 2024
Suffolk County $7,016,988,269
Middlesex County $2,770,808,615
Norfolk County $554,651,103
Essex County $369,041,706
Worcester County $299,030,165