Best Large Grants for Nonprofit Organizations in Massachusetts

The National Institute of Mental Health (NIMH) is launching a funding opportunity to establish a research network focused on rapid-acting psychotropic interventional drugs (RAPIDs), including ketamine and psilocybin. This initiative seeks to generate real-world evidence on the effectiveness and safety of these treatments for serious mental illnesses. By addressing critical questions around their implementation in clinical practice, the NIMH aims to facilitate the safe integration of RAPIDs into healthcare, ultimately improving mental health outcomes.

The Tri Kappa Scholarship, established by the Crown Point Community Foundation, aims to enrich the quality of life in South Lake County by providing financial assistance to graduating high school seniors who are residents of Crown Point, IN, and involved in community service. This non-renewable scholarship invites awardees to a special Scholarship Awards Night on May 7, 2026, at the Halls of St. George.

The St. Mary Catholic Community School Scholarship, established in 1989 by Dr. John Birdzell and the Crown Point Rotary, aims to enrich the quality of life in South Lake County. This non-renewable scholarship is available to graduating high school seniors who are alumni of St. Mary's Catholic Community School and actively involved in religious activities. Award recipients are invited to a special Scholarship Awards Night on May 7, 2026.

The Marie K. Coleman Scholarship, offered by the Elk Grove Regional Scholarship Foundation, aims to support students pursuing educational opportunities. This scholarship awards $2,000 to eligible candidates who demonstrate financial need and hold a minimum GPA of 2.5. Priority is given to first-generation college students, particularly those interested in business or accounting. Applicants must provide two letters of recommendation and participate in school and community activities.

The Viola A. and Henry W. Turner Memorial Scholarship, established by the Community Foundation of Eastern Connecticut, supports high school seniors from Southeastern CT pursuing a four-year degree, particularly in education. Since 1983, over $11.9 million in scholarships have been awarded. The scholarship provides approximately $500, with awards sent to colleges by August 1, and is primarily need-based.

The William Emberton Scholarship, established in memory of Bill Emberton, awards $1,000 to students in Eastern Connecticut who demonstrate a strong interest in literature and poetry. Since 1983, the Community Foundation has distributed over $11.9 million in scholarships. This scholarship honors Bill's legacy as a passionate literary advocate and civic volunteer, supporting local students in their educational pursuits and fostering a love for literature.

The Shirley Bradway Serafin Scholarship, established by the Community Foundation of Eastern Connecticut, provides financial support to residents of Northeastern Connecticut pursuing nursing studies. Since 1983, over $11.9 million in scholarships have been awarded to help students achieve their educational goals. Eligible applicants must demonstrate financial need and can receive up to $5,000 over four years, with awards disbursed to colleges by August 1.

The Sean Duzant Memorial Scholarship, established in memory of a talented athlete and lab technician, provides $2,000 to students from Southeastern CT pursuing studies in biology or demonstrating excellence in soccer. This scholarship honors Sean's legacy and passion for education, aiming to support those who share his dedication. Since 1983, the Community Foundation has awarded over $11.9 million in scholarships, helping students achieve their educational goals and rewarding careers.

The Dermatology Foundation offers Career Development Awards to support the academic growth of emerging investigators in various dermatologic fields. With an annual stipend of $55,000, these awards foster research addressing significant health issues, including public health, diversity, and women's health. Eligible applicants must demonstrate strong institutional support and meet specific educational requirements. The awards can be renewed for up to three years, contingent on the recipient's progress and commitment to advancing dermatological science.

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Business /Enhancement Grants (BDE)

The Foundation is committed to preserving initiatives, which are beneficial to the continued economy of the East Boston community and recognizes that the promotion of business objectives within the community, especially as they may relate to and benefit from the airport will help to serve as a means of minimizing various economic impacts that might be associated with the operations of Logan International Airport.

The Foundation will consider applications for business enhancement, which meet the following criteria:

• The proponent identifies an issue affecting the business community which specifically relates to enhancing business opportunities in all of East Boston’s business districts, including opportunities relating to Logan Airport;
• The proponent develops a plan to address the needs of the business community created by this issue and which is designed to provide education, assistance, and resources to the business community at large;
• The proponent receives at least 50% of its funding from sources other than the East Boston Foundation; (e.g. matching funds) and the Grant sought from the Foundation shall not exceed 50% of the applicant’s average total cash revenue (excluding in kind support) for the two (2) years preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General
• The allocation of the Foundation’s grant money may be used for expenses related to salaries, wage benefits, and professionals, however the amount allocated may not exceed 50% of the amount granted.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget

The Lowell Teachers Scholarships, offered by Harvard University, allow middle and high school teachers to enroll in one Extension School course per term at half the tuition cost. This initiative promotes professional development by making Harvard's rigorous academic programs accessible to educators. Limited scholarships are available, encouraging early application. Note that these scholarships cannot be used for summer courses or combined with other financial aid, ensuring focused support for teachers dedicated to enhancing their skills.

The Medical Student Research Supplement Award by the Dermatology Foundation supports medical students' research in dermatology, encouraging diversity and inclusion. This award offers $5,000 for direct research expenses, fostering the involvement of full-time students from underrepresented backgrounds. Eligible applicants must be current or former DF career development awardees and must recruit medical students pursuing MD or DO degrees who meet specific academic criteria. The award enhances research participation and strengthens the academic workforce in dermatology.

The Pfizer Scholarship, administered by the Community Foundation of Eastern Connecticut, provides $1,000 awards to graduating seniors from select high schools in New London County, CT, and Westerly High School, RI, pursuing STEM studies at accredited colleges. Since 1983, the foundation has awarded over $11.9 million in scholarships, supporting students in achieving their educational and career goals. Notably, children of Pfizer employees are ineligible for this scholarship.

The Cancer Research Education Grants Program (R25) aims to enhance research education in areas crucial to the NIH mission. This program supports innovative courses that develop skills in cancer research, covering topics such as prevention, diagnosis, and treatment. Grant applications are encouraged to be creative and state-of-the-art, addressing the needs of patients and their families. Key deadlines for applications span from January 2024 to September 2026, ensuring ongoing support for educational initiatives.

The Sanofi-Regeneron Diversity, Equity and Inclusion Mid-Career Award, funded by the Dermatology Foundation, supports exceptional researchers committed to addressing dermatological issues affecting underrepresented groups. Offering $100,000 annually for up to three years, this award emphasizes projects that enhance understanding and improve health equity in dermatology. Eligibility includes a strong research commitment, relevant training, and a faculty appointment within 12 years of becoming an Assistant Professor. It encourages minority applicants to foster diversity in medical research.

The East Boston Foundation

The foundation was formed in 1998 to administer a generous $9.6 million commitment from the Massachusetts Port Authority as part of community mitigation and to offset the impacts associated with Massport's $4.4 Billion Logan Airport Modernization Program.

Categories of Grants

The Board of Trustees of the East Boston Foundation has identified the following categories of grants, which in the discretion of the Board may be amended from time to time. Grant requests and applications shall be grouped into various categories and identified as follows:

Youth/Senior Recreation Support Grants (YSRS)

The Foundation recognizes the need to further promote, encourage and support youth and senior recreation programs in the community.

Participation in such programs should be encouraged for the community’s youth and seniors and the costs of participation should be minimal so as to not be cost prohibitive.

The Foundation will consider applications for youth recreation programs, which meet the following minimum criteria:

• The proponent have at least two (2) years of demonstrated experience in the successful coordination of such events or can demonstrate to the satisfaction of the Board its ability to carry out such objectives;
• The program is open to and is capable of providing a substantial benefit on the residents of the East Boston community regardless of gender, race, religion, ethnicity, national origin or handicap and seeks to encourage participation through outreach and/or registration drives as well as needs assessments;
• The Grant sought from the Foundation shall not exceed 50% of the applicant’s average total cash revenue (excluding in kind support) for the two (2) years preceding the application as demonstrated by the Applicant’s 990/990EZ filing or Form PC filed with the Massachusetts Attorney General;
• The allocation of the Foundation’s grant money may be used for expenses related to salaries and or wage benefits, however the amount allocated from the grant may not exceed 50% of the grant awarded.
• In certain circumstances, the proponent provides reasonable assistance to disadvantaged individuals who experience financial hardship and who would otherwise be prohibited from participation.
• A grant to the organization shall not result in the creation of a general
• unrestricted surplus for the program’s operating budget.
• The applicant adequately demonstrates an ability to generate the remaining revenue as contemplated under its proposed budget

The Patricia K. Drake Scholarship, established by Bill Mayo to honor his mother-in-law, supports New London high school seniors of color pursuing education in healthcare or human services. Since 1983, the Community Foundation has provided over $11.9 million in scholarships to help students achieve their career goals. Each award is approximately $800, with disbursements to colleges made by August 1. This initiative encourages diversity and empowers future leaders in critical service areas.

Helen Frankenthaler Foundation Inc

The Helen Frankenthaler Foundation supports the artist’s legacy through a variety of initiatives, including exhibitions, loans of artworks, research and publications, conservation, grants, educational programs for the public and the scholarly community, and the publishing of a catalogue raisonné. It is dedicated to promoting greater public interest in and understanding of the visual arts.

Established and endowed by the artist during her lifetime (1928-2011), the Foundation became active in 2013, on the closing of Frankenthaler’s estate. As the principal beneficiary of Frankenthaler’s estate, the Foundation maintains an extensive collection of her work in a variety of mediums, as well as her collection of works by other artists and original papers and materials pertaining to her life and work.

Cultural Resilience Grant

The Helen Frankenthaler Foundation supports public engagement with the visual arts through philanthropic, educational, curatorial, and research initiatives. It has expanded its grantmaking to sustain museums and visual arts institutions, supporting exhibitions, scholarship, and education across the field. The Foundation’s grantmaking priorities are currently organized across three areas:

• Climate Action and Sustainability
• Visual Arts & Education
• Cultural Resilience
  • Unrestricted support to sustain institutional capacity and core programming across the visual arts field. 
  • The Foundation provides unrestricted support to organizations whose core work is centered in the visual arts. These grants are intended to sustain exhibitions, programs, and institutional activities; support staffing, operations, and organizational capacity; and to maintain continuity during periods of reduced public funding and broader pressures affecting the arts and culture sector.
    • Cultural Resilience support is not project-based and does not require a defined initiative. 

The DTA Foundation: Dental Scholarship aims to support dental students halfway through their education who show a commitment to community service. With over 20 years of experience in enhancing oral care, the foundation, backed by generous donations, empowers the next generation of dental professionals. In honor of Robert J. Sullivan, $125,000 was established to improve dental education across the U.S., with scholarships awarded to deserving students who embody the foundation's mission.

The J&B Family Scholarship Fund, managed by the San Antonio Area Foundation, supports students pursuing degrees in Science, Engineering, Technology, or Math. Eligible applicants include high school seniors and current college students under 40 with a minimum 3.0 GPA from Bexar County. The scholarship offers funding for tuition and other educational expenses for one student annually, fostering educational advancement and community development. This renewable scholarship can greatly assist those demonstrating financial need.

The Charter Fund: Seed Funding program supports nonprofit organizations operating high-performing public charter schools that aim to expand their reach by serving 250 to 1,000 additional students within two years. Eligible applicants must demonstrate proven leadership, strong academic performance, and a commitment to underserved communities. The fund offers general operating grants ranging from $250,000 to $600,000 to assist leaders in opening new schools, providing vital resources and cohort-based learning opportunities to foster growth and innovation.

The NWPA Food Council Scholarship, offered by the Erie Community Foundation, supports Erie County high school graduates with a minimum 3.0 GPA pursuing post-secondary education or training. With over $800,000 awarded in 2023, this scholarship is particularly aimed at those entering the food, grocery, or convenience store industries. This initiative underscores the Foundation's commitment to empowering local students and enhancing workforce development in essential sectors.

The Stazer Sisters’ Scholarship, provided by the Erie Community Foundation, supports U.S. citizens graduating from the Northwest Pennsylvania Collegiate Academy who are entering a four-year college. In 2023, over $800,000 was awarded to more than 500 students, based on their academic achievements, financial need, and extracurricular involvement. This scholarship aims to empower deserving students to achieve their educational goals and contribute positively to their communities.

The American Association of University Women Scholarship supports women who are resuming their education after interruptions, specifically targeting adult students aiming to complete a 4-year degree. Applications open on November 1 and close on February 1. This scholarship encourages women, particularly sophomores at Corning Community College planning to transfer to a 4-year institution, to pursue their academic goals without financial barriers, thereby enhancing educational opportunities in the community.

The Barbara Bass Community College Scholarship, offered by the East Texas Communities Foundation, supports graduating seniors who are first-generation college students living in Tyler, Texas. This renewable scholarship aims to assist students attending any community college in the United States while considering financial need through FASFA. Founded in 1989, the Foundation promotes educational opportunities, reflecting the belief in education's transformative power for young individuals.

The ASH-Roland B. Scott Award, presented by the American Society of Hematology, honors outstanding research on Sickle Cell Disease by a resident. This prestigious award includes a $16,000 honorarium, $2,000 for mentor research supplies, and $2,000 for travel to the annual meeting. It recognizes the legacy of Dr. Roland B. Scott, emphasizing the importance of innovative research in improving patient outcomes in hematology.

The FY 2027 State and Regional Primary Care Association (PCA) Cooperative Agreements aim to enhance the technical assistance provided to Health Center Program award recipients and look-alikes. This initiative focuses on improving access to preventive and primary health care, managing chronic diseases, and ensuring a capable health center workforce. By implementing value-based care strategies and leveraging data for operational improvements, the program seeks to support the health of vulnerable communities effectively.