Best Large Grants for Nonprofit Organizations in Massachusetts

Project Lead The Way (PLTW)

Our Mission: Empower Students to Thrive in an Evolving World

Our Philosophy for Education: We believe all students – beginning at a young age – need access to real-world, applied learning experiences that empower them to gain the skills they need to thrive in college, career, and beyond.

We believe teachers play an immeasurable role in empowering students, and our programs provide teachers with the support and resources they need to devote more time to inspiring students.

PLTW Computer Science - New Program In Partnership With Lam Research

The Lam Foundation supports schools implementing or expanding a PLTW program in or near several of their U.S. communities. Schools seeking support for PLTW Gateway or PLTW Engineering will receive priority. The Lam Foundation is the philanthropic arm of Lam Research, a leading provider of equipment and services to the semiconductor industry.

Program Requirements

The purpose of this grant is to assist the grantee's implementation of the PLTW Computer Science program. Grantee must offer at least one PLTW Computer Science course in the 2027-2028 academic year and must offer one additional course in the 2028-2029 academic year (two different courses in two years). Grantee may implement any PLTW Computer Science courses of their choosing. Grantee must complete two years of grant reporting.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Ginny and Jim Thompson Scholarship

Selection based upon (in order of priority):

Financial need, academic ability, recommendations, and an essay, “Why is education important to me?”

Awards

• One $1,000 scholarship

The Felicia Rose Grant Program supports animal welfare nonprofits in Massachusetts and Southern New Hampshire, focusing on strengthening the human-animal bond and providing care for animals in need. With $120,000 awarded annually, eligible 501(c)(3) organizations can apply for grants up to $20,000 for operating expenses. This initiative honors Felicia Rose, a therapy dog who exemplifies the program's mission. Organizations must meet specific criteria, including location and experience, to qualify for funding.

About Us

Mission and Vision

The Mission of the Foundation is to improve the quality of life in the Coastal Bend by building community endowment and addressing social, educational, environmental, and cultural needs through the awarding of grants and scholarships.

Beck - O.J. Beck, Jr. Memorial Scholarship

Purpose:

Established in memory of O.J. (Junior) Beck, Jr., a respected general contractor and builder in the Coastal Bend with a reputation for attention to his projects and friendly relations with owners. He served his community as a member, director, vice president and president of the South Texas Chapter of the Association of General Contractors, the Business Development Commission, Chamber of Commerce, Ada Wilson Hospital, United Way, YWCA and many other organizations. He came to an untimely death on April 15, 1982.

The Ray Y Gildea Jr Award, provided by the Royal Geographical Society, offers grants of up to £1,000 to support innovative teaching methods in higher and secondary education. This endowed award aims to enhance geography education by funding projects that develop, research, or pilot new approaches, ultimately benefiting students directly. Eligible applicants must be actively teaching in the higher education or secondary school sectors in the UK or USA.

The J.M. Heberlig/B.J. Helterbran Scholarship Fund, established by dedicated educators, supports Pennsylvania residents pursuing degrees in Art Education or Recreation & Parks. This scholarship aims to alleviate the financial burden on students entering their second, third, or fourth year at a 4-year institution. With a focus on academic achievement, a minimum GPA of 2.8 overall and 3.0 in the major is required, alongside a demonstrated commitment to education and community service.

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The Maximizing Investigators' Research Award (MIRA) program, established by NIGMS, aims to enhance research funding efficiency by providing stable financial support to investigators. This allows for greater scientific flexibility and encourages innovative studies. MIRA is pivotal for distributing funding among promising researchers, fostering groundbreaking research. The program invites applications from eligible NIGMS-funded and NIH-defined New Investigators, as well as current MIRA grantees seeking renewal, ensuring a broad and inclusive approach to advancing science.

The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.

The Patient-Centered Outcomes Research Institute (PCORI) is offering funding up to $750,000 for studies aimed at addressing critical methodological gaps in patient-centered comparative clinical effectiveness research. This initiative focuses on enhancing the quality of evidence in clinical research by prioritizing areas such as artificial intelligence, study design improvements, support for data research networks, and ethical considerations. Successful proposals will contribute to advancing research methodologies and improving patient outcomes.

The Patient-Centered Outcomes Research Institute (PCORI) Funding Announcement aims to enhance methods for conducting patient-centered comparative clinical effectiveness research. This initiative seeks to address critical methodological gaps, focusing on improving the use of artificial intelligence in clinical research, study design, data research networks, and ethical protections in patient-centered CER. With a budget of up to $750,000, successful proposals will contribute to the quality and strength of evidence generated in CER studies.

The Tommy Wilson Memorial Grant, established by Dr. George T. Wilson and his wife Irene, honors their son Tommy, who had cerebral palsy. This grant supports recreational programs for individuals with disabilities and aims to positively impact their lives. Applicants must be nonprofit organizations with a successful history of programming for individuals with disabilities. The grant prioritizes programs serving economically disadvantaged individuals and may only fund applicants once every five years.

The Camille Dreyfus Teacher-Scholar Awards Program supports talented early career faculty in the chemical sciences by providing an unrestricted research grant of $100,000. Nominees must demonstrate outstanding research achievements and a commitment to education. Each institution can submit one nomination annually. The program emphasizes innovation and leadership in research while considering factors such as awards, publication success, and contributions to education, particularly at the undergraduate level.

The CFA Ministry Grants Initiative, part of the Kentucky Conference's mission, supports local churches in developing ministries focused on stewardship, technology, and leadership development. Eligible churches can apply for grants up to $500, with each church allowed to submit two applications annually. This initiative aims to foster generosity and enhance church leadership, providing essential resources to help congregations grow and effectively fulfill their mission of making disciples of Jesus Christ.

The Orphan Kitten Club’s Mightycat Grant Program offers financial assistance to individuals and organizations dedicated to saving neonatal kittens. Funding supports essential needs such as medical care, supplies, and innovative programs aimed at improving survival rates. Eligible applicants include 501(c)(3) organizations and independent rescuers with a proven track record in kitten care. The program's mission is to enhance rescue efforts and provide vulnerable kittens the opportunity to thrive and find loving homes.

Chautauqua Region Community Foundation

Mission: In partnership with our community, we ignite positive change and create a legacy of impact.

Scholarships

The Chautauqua Region Community Foundation annually awards more than $2 million in scholarships to students pursuing higher education, job training and certification. The Foundation hosts several different scholarship opportunities throughout the year. 

Space Camp Scholarship

Open to students (grades 4-12) or adults from Chautauqua County, NY or Warren County, PA to support the cost of attending U.S. Space Camp. 

The Bee a Rae of Sunshine Foundation – MaKenzi Rae Cash Memorial Animal Compassion Scholarship, offered by the Community Foundation of Carroll County, aims to support students dedicated to animal welfare. Eligible applicants must be graduating high school seniors from Carroll County, Maryland, with a minimum GPA of 3.0 and at least 125 service hours. This scholarship reflects MaKenzi Rae Cash's love for animals and her commitment to kindness and anti-bullying advocacy.

The NIH Science Education Partnership Award (SEPA) fosters innovative educational initiatives aimed at pre-college students, promoting their interest in STEM fields, especially in biomedical and behavioral sciences. This program supports both classroom projects and informal science education activities, such as after-school programs and library events. Emphasizing the development of quantitative and computational skills, SEPA seeks to inspire the next generation of scientists and thinkers through engaging educational experiences.

The Northern Bank Charitable Foundation has been dedicated to community giving for over 60 years, focusing on providing essential support in food, shelter, and housing to families. Through strategic partnerships, volunteering, and funding initiatives in Middlesex County, the foundation aims to uplift local communities. Key areas of focus include housing assistance, hunger relief, and financial literacy services for low-income residents. Their commitment to community development fosters sustainable growth and well-being for all.

Innovation in Religion and Spirituality Seed Grants Call for Proposals

The Religion and the Public Sphere program at the Social Science Research Council aims to foster research on the wider implications of new forms of religious and spiritual life. This program is offered with the support of the Luce Foundation, the John Templeton Foundation, and the Templeton World Charity Foundation.

Overview

In recent years, scholars have noted that religious and spiritual life is being substantively reshaped. “Innovation” is one way of framing these changes, but it remains a partial and contested analytic lens, and is popularly associated with the sudden emergence of a “new” element introduced into an otherwise static tradition. Scholarship on religion and spirituality, however, points to a more complex set of processes. The essays in an ongoing forum for The Immanent Frame have set out some initial parameters of these dynamics: rather than invention ex nihilio, what we often see is the strategic recombination of existing elements within a broader context of social, political, and cultural change.

Research Themes

This request invites proposals that examine the dynamics of religious and spiritual change that fall within the frame of “innovation.” Possible topics include, but are not limited to: 

• Explorations of innovations within transnational or diasporic religious and/or spiritual communities within the United States, particularly related to the circulation of ideas and culture from or to the Global South.   
• Gendered knowledge of innovation. 
• Studies of the process by which an innovation attains—or does not attain—legitimacy, relevance, or authority within a given community or institution. 
• The relationship between contemporary economic conditions—poverty, economic insecurity, and competitive pressures for time and money—and innovations in religion and spirituality. 
• Historical studies of innovations in religion and spirituality; the creation, reception, transformation, and longevity of an innovation over time.  
• Civic participation and the social mobilization of new or innovative religious identities, as well as the reinterpretation of religious or spiritual traditions or ideas in the service of particular political or ideological projects.

Program Terms 

The program offers research support over a period of up to 6 months. The grant funds will be up to $10,000 per award.

This FOA is intended for proposals related to basic and applied research in the STEM categories, and not related to the development of a specific system or hardware procurement.The proposal submission process has two stages:I. Applicants are encouraged to submit a white paper first to Grants@NPS.edu, ; andII. Applicants must submit a full proposal through Grants.gov (do not submit white papers through Grants.gov, only full proposals)Applicants are encouraged to submit a White Paper in advance of a Full Proposal to minimize the labor and other costs associated with the production of detailed full proposals that have little chance of being selected for funding. Based on an assessment of the white papers, the responsible Research Program Officer will provide informal feedback notification to the prospective awardees to encourage or discourage submission proposals. The Research Program Officer may also, on occasion, provide feedback encouraging re-work to strengthen a proposal. White Papers may be submitted at any time during the open period of this FOA. A separate White Paper is required for each research proposal.

The Sharing Language Diversity Fellowship supports Ph.D. students engaged in Indigenous language documentation and data archiving. Funded by the Endangered Language Fund, it encourages sustainable public sharing of linguistic materials, aiming for equitable access to research. With grants up to $30,000, recipients must publicly archive documentation materials within three years, ensuring compliance with community wishes and best practices. This initiative fosters a culture of Open Access in linguistics, benefiting both scholars and Indigenous communities.

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.

The GHI Doctoral and Postdoctoral Research Fellowships offer support for European and North American scholars pursuing research in German and European history, German-American relations, and North American history. Awarded by the German Historical Institute, these fellowships prioritize projects requiring primary sources in North America and are available for one to four months. Monthly stipends are € 2,000 for doctoral students and € 3,400 for postdoctoral scholars, with additional airfare reimbursement for European recipients.

The American Australian Association's Graduate Education Fund offers scholarships for American and Australian students pursuing Masters, Ph.D., or Postdoctoral research in various fields, including Science, Technology, and Sustainability. Established in 2002, the fund has awarded nearly $11 million to over 350 scholars. Scholarships up to $40,000 support travel, living, and tuition costs. Applications are accepted biannually, with specific periods for each direction of study. It also includes scholarships for Indigenous students.

Communities Foundation of Oklahoma

The Communities Foundation of Oklahoma stems from the vision of Tom McCasland Jr., and Gene Rainbolt. Two decades ago, these gentlemen formed a shared vision to create a single philanthropic organization to serve the charitable needs to rural communities across the great state of Oklahoma. Today, CFO has grown to assist hundreds of efforts in more than 45 counties.

Scholarship Opportunities

CFO offers over 100 diverse scholarship opportunities, empowering students across the state to pursue their educational goals. Each scholarship is tailored to meet unique needs, making higher education more accessible for all.

Ashley Parks Creative Scholarship

Supports continued education in the arts or creative fields for non-traditional students.

Ann Query Scholarship

Graduating senior who attends public, private, or home school and resides in the Zeeland Public School District area (student does not have to attend Zeeland Public Schools to be eligible)