Best Large Grants for Nonprofit Organizations in Massachusetts

The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.

The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.

The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.

The Hunger Relief Grant Program, established by the Foundation for MetroWest, aims to combat food insecurity across more than 30 communities in the MetroWest region. By providing grants ranging from $1,000 to $10,000, the program supports local nonprofits that address systemic barriers to food access. Eligible organizations must have 501(c)(3) status and serve specific MetroWest towns, ensuring that all residents can achieve food security and eliminate hunger.

The NBRC Frederic Helmholz, Jr., MD Educational Research Fund, established by the American Respiratory Care Foundation, supports educational and credentialing research in respiratory care. With an endowment of up to $5,000, this fund encourages submissions of Master’s Theses, Doctoral Dissertations, and complete research proposals from qualified investigators. Award recipients will receive cash, a certificate of recognition, airfare, lodging, and registration for the AARC Congress, promoting advancements in respiratory health.

ExtremeTerrain's Clean Trail Grant Program offers $250 for trail improvement projects, encouraging responsible off-roading. Eligible participants include Wrangler and 4x4 clubs, environmental organizations, and trail managers. The program aims to enhance trails through clean-ups, restorations, and expansions. Grants can be used for tools, food for volunteers, and promotional materials. Applicants must meet specific criteria, such as having a website and providing project photos. This initiative promotes stewardship of the natural landscapes we cherish.

The Rural Health Fellows Leadership Program, offered by the National Rural Health Association (NRHA), is an intensive yearlong initiative aimed at cultivating a diverse network of rural health leaders. Selected participants engage in leadership training, policy advocacy, and collaborative projects. The program includes monthly virtual sessions, in-person meetings at key conferences, and opportunities for financial support, thereby empowering fellows to make a significant impact on rural healthcare.

The Parker B. Francis Respiratory Research Grant, offered by the American Respiratory Care Foundation, aims to support innovative research in respiratory care. Grants are available to qualified investigators, with a focus on projects involving respiratory therapists or technicians. Awards typically do not exceed $10,000 annually and are intended to supplement other funding sources. This initiative underscores the foundation's commitment to enhancing respiratory health through research and education.

The Stone Owl Scholars Scholarships, offered by the Community Foundation of Abilene, provide a one-time award of $3,000 to 120 high school juniors and seniors who complete a 9-week program. This initiative aims to support students entering vocational schools or colleges, with additional matching scholarships available for those enrolling in specific institutions. The foundation manages over 150 scholarship funds, ensuring financial aid for a diverse group of students pursuing various educational paths.

Trinity Grants: Capacity - Mission Real Estate Development empowers Episcopal Church parishes and Anglican Communion organizations to enhance community impact through innovative church property development. With a focus on sustainability, the initiative addresses pressing community needs by generating revenue streams, providing affordable housing, and improving education in underserved neighborhoods. Grants support real estate feasibility studies, pre-development expenses, and construction of income-generating projects, fostering strategic advisory and training for faith leaders.

The Actors' Equity Foundation, established in 1962, is dedicated to supporting the professional theatre community through grants. Annually, it funds over 150 nonprofit theatres and arts organizations, promoting initiatives that enhance the performing arts landscape. The Theatre Grants are specifically aimed at organizations with 501(c)(3) status, ensuring a commitment to artistic excellence and fiscal responsibility. By investing in diverse programs, the Foundation plays a pivotal role in nurturing both emerging and established talent within the theatre industry.

The Access Fund's Climbing Conservation Grant supports projects that enhance climbing access and conserve the climbing environment across the U.S. Grants typically range from $1,000 to $4,000, with larger requests considered for projects of national significance. Emphasizing local collaboration and measurable outcomes, this program seeks action-oriented initiatives that promote climber responsibility and community engagement, while also adhering to environmental regulations and securing necessary approvals.

The KaBOOM! Adventure Courses Grant Program offers funding to create engaging playspaces for older children and teens. This initiative encourages community involvement through a collaborative design and build process, aiming to address the need for physical activity in low-income areas. Eligible applicants include organizations that serve youth and can demonstrate community support. Grants are available on a rolling basis, with a focus on priority cities impacted by recent events, including rural Colorado and Hurricane Harvey-affected Texas communities.

The Maria and Paolo Alessio Southern Italy Scholarship, offered by the UNICO Foundation, supports students of Southern Italian descent pursuing a degree at an accredited U.S. college or university. Valued at $2,500, this scholarship aims to empower students who demonstrate academic excellence with a minimum GPA of 2.7. Eligible applicants must be U.S. citizens and can be Freshmen, Sophomores, or Juniors, continuing their studies in the 2026-2027 academic year.

The UNICO Foundation Inc. offers the Cancer Research & Prevention Grant to support vital research projects addressing various types of cancer, including colon, breast, and prostate cancer. Established in 1962, this non-profit organization aims to enhance lives through charitable contributions and educational initiatives. Grants are exclusively for direct research and preventive measures, ensuring that all funds are utilized effectively. This initiative reflects UNICO's commitment to combating cancer and its impact on individuals and families across the United States.

Each year, Innovia awards over $500,000 in scholarships to deserving students like you who are college-bound or pursuing vocational or technical training. Single scholarship awards range between $500 and $10,000.

Eilleen Hutchison Scholarship

Primary factors for consideration are academic achievement, financial need and good personal character. Previous recipients of this award are eligible to reapply.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Judge Gary R. McDonald Memorial Scholarship

January 2004 marked the passing of a true champion of justice and compassion for the men and women of Michigan. Judge Gary R. McDonald, beloved father and friend, served the citizens of Saginaw and the rest of Michigan for over 30 years.

In honor of his esteemed service, the family and colleagues of this respected Michigan leader have created the Judge Gary R. McDonald Memorial Scholarship Fund. Its purpose is to grant students of Saginaw County the financial means to pursue a career in a law-related field so that Judge McDonald’s unrelenting pursuit of justice may continue in his honor.

Awarding this scholarship to those in need serves Judge McDonald’s personal mission of inspiring the hearts and minds of our youth to serve our communities for the good of all.

The Yann Weymouth Graduate Scholarship provides $5,000 and mentorship to a graduate student focusing on sustainability, resilience, wellness, and beauty in design. Administered by the Architects Foundation, candidates must have a GPA of 3.0 or higher, be U.S. citizens, and enrolled in a NAAB-accredited architecture program. Previous recipients can reapply. This scholarship honors the legacy of Yann Weymouth, an accomplished architect known for his significant contributions to major design projects.

Community Foundation Serving Western Virginia

Our Community Foundation was established in Roanoke in 1988. With our growth, we expanded into the Martinsville/Henry County area in 2005. Today, we administer many hundreds of named endowment funds ranging in size from a minimum of $10,000 to millions of dollars. To date, donors have also committed very significant resources to the Foundation through future estate gifts.

Our Mission:Enabling people who love their community to easily give back.

Scholarships

Community Foundation Serving Western Virginia, the region’s community foundation, administers a variety of scholarships to reward and assist capable and deserving students based on the criteria established by the fund donors.

Jim Barker Scholarship Fund

Fund provides higher educational scholarship assistance to deserving students.

The CDC's NCIPC is seeking research proposals to tackle implementation challenges in providing linkage to care services for individuals with opioid use disorder (OUD). This initiative encourages partnerships with public health entities and local healthcare champions to create actionable, evidence-based strategies. The goal is to enhance care access and ensure comprehensive overdose prevention services are available in real-world healthcare settings, thereby improving outcomes for those at risk of opioid overdose.

The Oak Foundation's Learning Differences Grant Programme aims to foster equitable educational experiences for students with learning differences, particularly those marginalized by racism and poverty. Through strategic partnerships with not-for-profit organizations, the program enhances understanding of diverse learners' needs, translates knowledge into effective practices, and influences systemic changes to create supportive learning environments. The initiative emphasizes the importance of community involvement, ensuring that students' voices are heard and their educational needs are met.

Middlesex County Medical Society Foundation

The Middlesex County Medical Society Foundation, founded in 1964 and was initially funded by contributions from the first mass polio vaccination in our county.

MCMS Foundation Scholarship Fund

Middlesex County Medical Society Foundation is an independent nonprofit organization that awards scholarships to deserving students from Middlesex County, New Jersey for the study of medicine. Scholarships are awarded to deserving students who are enrolled in an accredited medical school.

The David Roy Kovacs Scholarship, offered by the Community Foundation of Greater New Britain, supports local high school graduates from New Britain who plan to pursue further education at community colleges, trade schools, or vocational schools. This scholarship emphasizes financial need as determined by the FAFSA and is intended to help students acquire the skills necessary for career success and economic independence, fostering a brighter future for the community.

The AO Spine NA Fellowship Award aims to fund post-graduate fellowship programs at institutions in North America, covering expenses such as stipends, research, and education. This award is limited in number and contingent upon available funding as determined by the AO Spine NA Board. Applications undergo a rigorous review based on established criteria, while the engagement of faculty and compliance with eligibility requirements are critical for the selection process.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

James P. Konieczka Memorial Scholarship

The James P. Konieczka Memorial Scholarship was established by his three children, Bryan, Amy, and Katie, to honor their father’s wishes after his passing in 2016 following a courageous year-long battle with cancer.

Jim believed in the value of a college education, but he also understood that not everyone wants to pursue this post-secondary education path. It was his wish that this scholarship be made available to someone seeking Career and Techincal Education (CTE) training or to someone seeking a traditional college degree.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Iles Family Conservation Scholarship

The Iles Family Conservation Scholarship was established by Doug and Sandy Iles in memory of Clarence “Buck” Iles. A lifelong passion for conservation balanced with practical application is what Buck Iles stood for. A very avid sportsman, he was actively involved with leadership in the Michigan United Conservation Club and Saginaw Field and Stream, among others.

For more than 20 years, Buck Iles helped establish and operate the Saginaw Field and Stream Club annual scholarship raffle which supported over 40 different scholarships. Buck passed away in 2005 and this scholarship was established to continue the great raffle tradition that now no longer exists.

Doug and Sandy established this scholarship fund in “Dad’s” memory. Recipients should be students with an active interest in environmental issues. Although not limited to, emphasis will be placed on awarding this scholarship to a resident of Saginaw County. A minimum 3.0 GPA and a student who has the need for educational financial support are key determinants.

Scholarships

Since awarding our first $500 scholarship in 1987, the Saginaw Community Foundation has awarded college scholarships to area students totaling more than $13.7 million, thanks to our generous donors. Each year, over 500 college-bound or career and technical education students benefit from our scholarship awards.

Our single application process makes it easy to potentially qualify for one or more of our 260+ scholarships.

Gerald and Inez O’Brien Scholarship

Gerald and Inez O’Brien both grew up in Saginaw County and were married for over 30 years before Gerald passed away at an early age. 

Gerald and Inez both believed strongly in education and supporting family and friends. In addition, they each treasured their lifetime neighbors and knew the importance of building relationships with their community neighbors and enjoying life. 

This scholarship memorial fund was created by their daughter, Ann Pavlik, and son, Dr. Keith O’Brien. The fund will strive to recognize those giving back to the community and those facing challenges head on, even when life throws roadblocks along the way.