Best Large Grants for Nonprofit Organizations in Massachusetts

The NCI Pathway to Independence Award (K99/R00) supports talented postdoctoral researchers in transitioning to independent faculty positions. This program provides essential NCI research funding to facilitate the development of competitive, independent research careers. Applications are due by 5:00 PM local time of the applicant's organization, emphasizing the importance of timely submissions for prospective awardees.

The TKoster’s Charitable Innovated Health Care Award, established by Teresa Koster, aims to enhance students' access to quality health care. With a funding amount of $3,500, this award supports innovative practices in student health centers. It addresses critical areas such as understanding health care needs, improving service delivery, and leveraging technology. Eligible applicants include members of the American College Health Association, encouraged to demonstrate partnerships and financial support in their proposals.

The James Paul Sutton Medical Research Fund Grant supports non-profit organizations engaged in cancer and medical research, established through a trust by the Sutton family. Eligible organizations must be 501(c)(3) exempt. Preference is given to cancer research initiatives, while grants are not available for individuals, political groups, or for-profit entities. This fund aims to sustain medical research efforts for the long term, continuing the legacy of the Sutton family.

The Land and Water Conservation Fund's Outdoor Recreation Legacy Partnership Program aims to enhance recreational opportunities in underserved communities through significant funding. Offering matching grants up to 50%, with awards ranging from $300,000 to $15,000,000, this program encourages applicants to connect with the Connecticut Department of Energy and Environmental Protection early in the application process for guidance. This initiative supports large-scale projects that improve access to recreational facilities.

Textile Tool Grant Program

Bring Back the Trades Inc. is embarking on a Pilot Textile Tool Grant to be awarded to a public school in the Boston area that offers education in the Textile Industry. Designer Draperies of Boston is sponsoring this pilot program in 2026.

One Boston-area public high school will be awarded two commercial-grade industrial sewing machines and a semester of professional mentorship.

ASEEES Internship Grant Program

Funded by an external grant, ASEEES’s Internship Grant Program provides incoming, current, and recent (i.e. those who have graduated no more than two years prior to the competition deadline) MA, PhD, and professional school students with grants that make it possible for them to accept unpaid or underpaid internships in areas broadly related to Russia, including Russia’s relations with other regions/countries.

The grant offers $2,000 a month, to be paid directly to the grantee (intern) during their internship. In the case of underpaid internships, ASEEES will work with the host institutions and the grantees to make sure the grantee receives a combined stipend of $2,000 per month or has an extended duration for the internship.

The Regenerative Agriculture Foundation Grant supports organizations that promote regenerative practices, emphasizing the value of people, plants, animals, and the planet. With a focus on BIPOC-led initiatives, the foundation encourages systemic change in agricultural systems through collaborative funding. Grants are available to U.S.-based organizations that align with RAF's vision and engage in transformative efforts. The competitive grantmaking process is by invitation only, ensuring targeted support for impactful projects.

The Environmental Health Sciences Core Centers Program (P30) invites grant applications to support innovative research in environmental health. These centers serve as critical hubs for advancing the goals of the 2025-2029 NIEHS Strategic Plan, providing essential infrastructure and resources for collaborative research. By fostering community engagement and translational research, the program aims to enhance understanding of the connections between environmental factors, human biology, and disease, ultimately improving public health outcomes.

LaFrancine Stallings Math & Science College Scholars

The LaFrancine Stallings Math & Science College Scholarship will provide renewable need-based scholarships of up to $6,375 to undergraduate juniors enrolled full-time pursuing a Science Technology Engineering Mathematics (STEM) major at any four-year accredited HBCU in the 2026-2027 school year.

The Bernie Smillie Memorial Scholarship was established in 2010, in memory of Freeland resident and business owner Bernie Smillie. Bernie passed away in 2000, due to complications from a lung transplant he had received in 1994. In 2005, family and friends of Bernie established the Bernie Smillie Memorial Golf Outing. Proceeds of this outing has helped to promote organ donor support and awareness and establish this scholarship fund.

Bernie Smillie Memorial Scholarship - Medical

Evaluation Criteria

• Leadership ability
• Financial need
• Academic performance
• Standardized test scores
• Special skills
• Awards and honors
• Community service
• Work experience
• Extracurricular school activities
• Overall involvement
• Career goals as demonstrated in essay
• Letter of recommendation.

The Kevin Flanagan Student Travel Award offers up to $800 for undergraduate and graduate students pursuing diving science to attend AAUS scientific meetings. This competitive, merit-based award honors Kevin Flanagan's legacy in scientific diving and support for AAUS. Established in collaboration with his family, it aims to encourage the development of safe and effective scientific divers through education and research, while promoting standards in scientific diving practices.

The Philanthropic Impact Fund (PIF) by Vanguard Charitable aims to strengthen nonprofit organizations and philanthropic infrastructure. It focuses on integrating AI, educating donors, and enhancing the narrative around the nonprofit sector. Grants typically range from $50,000 to $100,000, with larger requests considered. Organizations must be 501(c)(3) registered nonprofits to apply. This funding is a strategic investment in resilience and sustainability, addressing critical needs in the sector.

The Academic Research Enhancement Award (AREA) supports small-scale research at institutions that receive limited NIH funding, emphasizing biomedical research for undergraduate students. This program aims to enhance the research environment and provide valuable experiences for students. Eligible institutions must award baccalaureate science degrees and have received no more than $6 million in NIH support over four of the last seven years. This funding opportunity encourages investigator-initiated minimal risk clinical trials to advance NIH missions.

KKR Charitable Donations supports impactful collaborations and programs addressing current needs while paving the way for future progress. Through their Corporate Citizenship program, KKR focuses on philanthropy, employee engagement, and sustainable community initiatives. The KKR Cares initiative enables employees to engage with communities worldwide via matching gifts, board service, and volunteer opportunities, aiming to enhance economic opportunity and security for underserved populations.

The FINRA Investor Education Foundation's General Grant Program funds educational and research projects aimed at enhancing financial literacy among underserved populations. Grants ranging from $50,000 to $100,000 support initiatives that promote financial inclusion and address systemic inequities. The foundation prioritizes projects that utilize existing data to improve understanding of financial capability and well-being. Applications are accepted anytime, with a focus on sustainability beyond the grant period.

Tiderington Family Scholarship

The Tiderington Family Scholarship was established in 1996 by Dr. Robert H. and Charlotte Hughes Tiderington and their three sons, Robert III, James and Thomas, to provide funding for students pursuing a vocational career. Neither Dr. Tiderington nor his wife Charlotte graduated from college. Dr. Tiderington remarked: “It was important to us that our boys went to college. We always stressed education. When you give a gift of education, you give a gift for life.”

Saginaw Country Club Golf Scholarship

The Saginaw Country Club has been one of the premier private clubs in Michigan for over 116 years. In honor of its centennial year in 1998, the Club’s Board of Governors established the Saginaw Country Club Golf Scholarship.

The scholarship is offered to promote and reward golf playing among Saginaw County’s youth.

The Micro Grant Program, offered by Cape and Islands United Way, provides one-time funding of up to $5,000 to support local volunteer projects. With an average grant amount of $2,500, this initiative encourages community engagement on Cape Cod, Martha's Vineyard, and Nantucket. Eligible applicants include nonprofits, schools, and community organizations focused on volunteerism. Projects can range from local beautification efforts to youth-centered services, fostering a spirit of collaboration and environmental stewardship.

The AMVETS Children/Grandchildren Scholarship supports the educational aspirations of children and grandchildren of honorably discharged U.S. veterans and active military. This scholarship aims to bridge financial gaps after all federal and state assistance has been utilized. Eligible applicants must be U.S. citizens, high school seniors, and demonstrate financial need while enrolled in accredited four-year universities. Incomplete applications will be disqualified, ensuring that the award goes to deserving candidates committed to their education.

The NIDCR Dentist Scientist Career Transition Award (K22) supports dentists transitioning from NIH postdoctoral roles to tenure-track faculty positions. It provides two years of mentored research training in the NIH Intramural Research Program, followed by three years of independent research funding at an extramural institution. Key deadlines for grant applications include February 12, 2025, and subsequent dates in June and October 2025, with additional deadlines for renewal and AIDS-related applications.

The Dr. Doris R. Corbett-Johnson Leaders for Our Future Award, presented by SHAPE America, honors young professionals under 36 who exhibit exceptional promise in scholarship, teaching, and leadership. This prestigious award is available in two categories: college/university and non-college/university, with a maximum of two recipients per category each year. By recognizing emerging leaders, SHAPE America aims to inspire a new generation dedicated to advancing health and physical education.

The Etsy Uplift Fund, managed by Brooklyn Org, supports nonprofits that eliminate barriers to entrepreneurship for creators. By addressing challenges like lack of digital education, access to capital, and insufficient benefits, the Fund aims to foster equal opportunities in creative entrepreneurship. Customers can contribute by rounding up their purchases, with the collected funds directly supporting organizations that help creators build successful businesses. This initiative underscores Etsy's commitment to empowering diverse communities.

The Forecast for Clinical Trial Readiness for Rare Diseases (R21) aims to enhance the development and testing of diagnostics and therapeutics for rare diseases. This funding opportunity invites researchers to facilitate clinical trial readiness by developing rigorous biomarkers and clinical outcome measures. Through collaborative efforts with various stakeholders, NCATS seeks to improve the efficiency of moving candidate therapeutics towards clinical trials, ultimately increasing the likelihood of successful treatments for rare diseases.

The Artemas W. Stearns Trust Grant supports projects that benefit the indigent aged and deserving poor in Lawrence, Massachusetts. Organizations must demonstrate a direct impact on these communities to qualify for funding. With a focus on improving the lives of vulnerable populations, this trust aims to foster meaningful contributions to the well-being of its recipients. Applications are encouraged from those aligned with the mission of aiding the less fortunate in the city.

The Research With Activities Related to Diversity (ReWARD) program by the NIH aims to enhance research diversity and inclusion across the United States. It supports scientists contributing to Diversity, Equity, Inclusion, and Accessibility (DEIA) who lack current NIH funding. The program funds both scientific research and DEIA activities, addressing the needs of various NIH Institutes and Centers to foster a more diverse biomedical research landscape.

The CDC's grant aims to enhance global public health emergency responses by engaging partners to improve rapid detection and intervention strategies. It seeks to build sustainable programs that strengthen resilience in communities affected by humanitarian crises. With periodic openings for applications, this initiative ensures a diverse roster of partners ready to tackle emerging public health threats effectively. The program underscores the importance of federal support in managing complex health emergencies worldwide.

The USTA Facility Services Grant Program offers comprehensive support for developing and maintaining tennis facilities. Whether you're planning a new construction or need repairs, this program provides essential business and technical services, such as financial forecasting and facility assessments. Additionally, you can access advocacy resources and digital tools to enhance operations. By utilizing these complimentary services, projects can save costs while benefiting from expert guidance in creating high-quality tennis environments.