Best Large Grants for Nonprofit Organizations in Massachusetts

About Alex’s Lemonade Stand Foundation

Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4- year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding research projects and providing programs to families affected by childhood cancer. ALSF is one of the only childhood cancer research organizations that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.

Bio-Therapeutic Impact Award

The Bio-Therapeutic Impact Award accelerates the development of clinical trials for promising biologic approaches to treating childhood cancer. These approaches include, but are not limited to, immunotherapy, gene therapy and small molecules. The award, intended for investigators who are initiating clinical trials, totals the maximum of $1.8 million awarded over three years.

The Viola Pfaff Bowman Memorial Scholarship, offered by the Hamilton County Community Foundation, supports high school students in Hamilton County, particularly those from Hamilton Heights, Noblesville, Sheridan, and Westfield High Schools. Candidates must be pursuing a degree in communications or business and demonstrate financial need. This scholarship honors Viola Pfaff Bowman, a dedicated alumna who inspired many through her involvement in school media. It encourages students with media program experience to apply.

The Cynthia Davis Sculco Scholarship, established by Nurses Educational Funds, Inc., supports nurses pursuing doctoral programs in nursing education. To qualify, applicants must hold a current RN license and be enrolled in an accredited nursing program with a minimum GPA of 3.6. This permanent scholarship, initiated with a generous $50,000 donation in 2012, honors Cynthia Sculco, a dedicated NEF Board member known for her leadership roles. It aims to promote nursing leadership through financial assistance for advanced education.

The Patient-Centered Outcomes Research Institute (PCORI) will announce funding for patient-centered comparative clinical effectiveness research (CER) studies focusing on rare diseases. This initiative encourages collaboration and aims to fill critical research gaps affecting approximately 30 million Americans with rare diseases. Applications can request up to $12 million over five years, including coverage for patient care costs. This funding opportunity is set to open on August 12, 2025, with a focus on addressing pressing patient-centered CER questions.

The Michael Hurewitz Scholarship, offered by The Community Foundation for the Greater Capital Region, supports high school seniors in the region who have a passion for journalism and demonstrate financial need. This scholarship aims to empower students by providing them the necessary financial assistance to pursue their educational goals in journalism, fostering the next generation of storytellers and communicators in our community.

The Columbia University – Presbyterian Hospital School of Nursing Alumni Association Inc./Penny Hund West Scholarship, established by Nurses Educational Funds, Inc., offers support to graduate nursing students. It aims to honor Penny Hund West, a dedicated nurse and culinary enthusiast. Applicants must have two semesters remaining in their studies and meet specific eligibility criteria, including maintaining a minimum GPA of 3.6. This scholarship reflects NEF's commitment to fostering nursing leadership through advanced education.

About Pfizer

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement, or education) to improve patient outcomes in areas of unmet medical need that are aligned with medical and/or scientific strategies.

About the American Headache Society

The American Headache Society strives to improve the lives of people impacted by migraine and other headache disorders. The AHS is a professional society of health care providers dedicated to the study and treatment of headache and face pain. The Society’s objective is to promote the exchange of information and ideas concerning the causes and treatments of headache and related painful disorders. Educating physicians, health professionals, and the public while encouraging scientific research are the primary functions of the Society.

Quality Improvement and/or Research Grants: Migraine and Women’s Health

Migraine is a prevalent and debilitating neurological disease that disproportionately affects women, impacting quality of life, productivity, and overall health. Recognizing the need for innovative solutions and enhanced care, Pfizer and the American Headache Society (AHS) are collaborating to offer a new grant opportunity inviting proposals for collaborative quality improvement and research projects focused on migraine and women's health. This Request for Proposals (RFP) aims to foster high-impact research and initiatives that advance scientific understanding, improve patient outcomes, and address gaps in care. Projects should also contribute to the core goal of the AHS – improving the lives of people impacted by migraine and other headache disorders.

Objectives

• To advance research in migraine and women's health through collaborative pre-clinical and clinical projects
• To promote quality improvement initiatives that enhance diagnosis, treatment, and management of migraine in women
• To encourage multidisciplinary approaches that integrate clinical expertise, patient-centered care, and innovative research methodologies
• To generate measurable and actionable outcomes that contribute to improved standards of care and inform future research directions for women with migraine

The Mech SS Sheldon D. Murphy Student and Postdoctoral Endowment Award, established by the Society of Toxicology, honors the legacy of Dr. Sheldon D. Murphy, a pioneer in toxicology. This award supports PhD candidates and postdoctoral trainees who demonstrate excellence in mechanistic toxicology. Nominees are selected based on the scientific quality of their abstracts, ensuring a focus on impactful research. This initiative fosters the next generation of toxicologists dedicated to advancing human and environmental health.

The J. Margaret Ada Mutch Scholarship, established by the Columbia University-Presbyterian Hospital School of Nursing Alumni Association, offers financial support for nursing students pursuing master's or doctoral degrees. Applicants must have at least two semesters of study remaining and maintain a minimum GPA of 3.6. Preference is given to Columbia University School of Nursing students and alumni. This scholarship honors the legacy of Ms. Mutch, a pioneering nurse who contributed significantly to nursing education and practice.

Benjamin Moore & Co. Charitable Giving is dedicated to uplifting North American communities through support for educational programs, housing development, and preservation efforts. They focus on workforce development, community transformation, and sustainable practices. The initiative emphasizes philanthropy through financial and in-kind donations, alongside volunteer work from employees. Partnering with various organizations, they aim to create lasting impacts on local communities while adhering to strict eligibility criteria for support.

The Maternal, Infant, and Early Childhood Home Visiting Program (MIECHV) aims to enhance maternal and child health, promote early childhood development, and support family well-being. By providing voluntary, evidence-based home visiting services to pregnant women and families with young children, the program addresses critical needs in communities. Funded by the US HHS: Health Resources & Services Administration (HRSA), MIECHV empowers families through tailored support and resources, fostering healthier outcomes for mothers and their children.

The Sidney R. Baer, Jr. Foundation offers Clinical Research Grants to support advancements in the treatment and understanding of schizophrenia and bipolar disorder. Focused on organizations with IRS tax-exempt status, these grants aim to enhance mental health services and research. By funding initiatives in cognitive and behavioral sciences, the foundation seeks to improve the lives of those affected by serious mental illness, ensuring they receive the support and resources necessary for a better quality of life.

Who We Are

Our Mission

“The mission of the National Federation of the Blind is to achieve widespread emotional acceptance and intellectual understanding that the real problem of blindness is not the loss of eyesight but the misconceptions and lack of information which exist. We do this by bringing blind people together to share successes, to support each other in times of failure, and to create imaginative solutions.”

The NFB of Colorado, a state affiliate of the national organization, shares this mission and works as a whole and in concert with its state-wide chapters to accomplish it.

Announcing the Scott C LaBarre Memorial Scholarship Program for Colorado blind and low-vision post-secondary students

This year the National Federation of the Blind of Colorado will be awarding up to $10,000 in scholarship funds for deserving students. We have decided to expand the eligibility to students attending an accredited technical educational program. Technical programs must be appropriately accredited and at least one year in duration. For questions on whether the program qualifies please reach out to the scholarship committee chairs (contact info below) for a determination.

Each year at its state convention, the National Federation of the Blind of Colorado (NFBCO) gives a broad array of scholarships to recognize achievement by blind scholars. The National Federation of the Blind of Colorado is an organization dedicated to creating opportunities for all blind persons. Recipients of Federation scholarships need not be members of the National Federation of the Blind of Colorado nor the National Federation of the Blind.

All scholarships are awarded based on academic excellence, service to the community, and financial need.

The CAFE Group 

We resource leaders, invest in their genius, and bring people together to reimagine what philanthropy can do.

Founded by Liz and Don Thompson, The CAFE Group is a national nonprofit transforming how change is resourced. 

With a focus on education equity, social capital, and philanthropic transformation, we pair catalytic funding, community-rooted leadership development, and cross-sector collaboration to strengthen the people and institutions shaping a more just future. Everything we do is grounded in relationship, because we believe the way resources move matters just as much as where they land.

The 1954 Project Luminary Award

The 1954 Project Luminary Award celebrates transformational education nonprofit leaders dedicated to serving Black students and communities through powerful investments in their organizations' ability to create lasting change.

The Luminary Experience

Each Luminary organization gets more than funding. Through The 1954 Project, leaders gain a community, a platform, and space to grow with tailored support over the course of the three year journey.​

• $1 Million, Unrestricted: Catalytic funding to expand what’s working.
• Leadership Coaching + Capacity Support: Guidance from peers and experts who are committed to helping you build a lasting, impactful organization.
• National Network: Luminaries join a powerful community of innovators, change-makers, and visionaries driving systemic progress to support students and communities across the U.S.

The 1954 Project’s Impact Areas

We focus on three interconnected areas critical to advancing equity:

• Innovation in Teaching and Learning: Create education models that center Black students through culturally affirming approaches that challenge traditional structures and transform how learning happens, ultimately serving all students. 
• Diversity in Education: Build pathways that increase and sustain Black educators and education leaders who transform where and how students learn.
• Pathways to Economic Mobility: Build pathways to wealth, ownership, and economic power for Black students, families, and communities through innovative educational programming.

Our Selection Criteria

We seek out extraordinary applicants who embody our values and vision across three categories:

Leader: We look for leaders whose influence and vision contribute to the collective well-being and advancement of the Black community. These leaders:

• Are Visionary: They demonstrate a strategic and pragmatic mindset, articulating a transformative vision for significant, positive change.
• Show Demonstrated Commitment: They embody steadfast dedication to your cause, inspiring and influencing others, and galvanizing community involvement.
• Are Adaptive: They assertively tackle challenges, turning setbacks into opportunities for innovation, while maintaining humility and thoughtfulness in problem-solving.

Organization: We look for organizations that drive significant change, anchored by a deep love for people and driven by the genius within communities of color. These organizations: 

• Have a Defined Problem: They clearly identify the issue they are addressing and explain in detail how your organization tackles root causes. 
• Take a Strategic Approach: They have clear, measurable, and achievable organizational goals with a well-defined strategy informed by thorough analysis. 
• Show Demonstrated Impact: They have a tested model that has produced positive results, incorporating continuous learning and iteration. 
• Have a Transformation Plan: They present a clear plan for using the $1M award to advance your organization's mission, vision, and long-term goals. 
• Embrace Collaboration: They use collaborate to build partnerships based on trust, love, and common goals. 

Radical Imagination: We seek leaders who challenge and redesign societal norms to build a just and equitable future. They demonstrate:

• Community-Rooted Leadership: They maintain and cultivate genuine community ties, integrating professional expertise and personal commitment to drive visionary, impactful strategies. 
• Long-Term Commitment: They are in it for the long haul, committing to sustained impact across generations and prioritizing long-lasting solutions over short-term gains. 
• Collectivism: They embody the philosophy of "I am because we are," actively engaging in collaborative networks and fostering community-reflective solutions. 

The Pulmonary Hypertension Fund, supported by the Patient Advocate Foundation, offers financial assistance for patients dealing with pulmonary hypertension. This fund covers essential healthcare costs, including medication copays and health insurance premiums. Patients must meet specific eligibility criteria, such as having a confirmed diagnosis and appropriate health insurance. Since 1996, the foundation has empowered millions to navigate healthcare challenges, ensuring they receive the care they need without financial burden.

The Sex Worker Giving Circle Grant, launched by the Third Wave Fund, prioritizes funding for grassroots movements led by individuals directly impacted by gender oppression, especially within the sex work community. With a commitment to gender justice, the grant supports organizations that operate with a participatory approach to grantmaking, enabling them to address systemic inequalities. In recent years, the fund has distributed significant resources to empower and sustain these vital movements across the United States.

The Multiple Sclerosis Clinical Care Physician Fellowship: Pediatric Care, offered by the National Multiple Sclerosis Society, aims to enhance the training of physicians in providing specialized care for pediatric patients with MS. This one-year post-residency program emphasizes direct patient care and multidisciplinary collaboration. Participants will learn under the supervision of MS specialists, gaining essential skills to improve clinical practices and contribute to the MS community, ultimately leading to better outcomes for those affected by this condition.

The Michael Herman Scholarship, established by the Grand Haven Area Community Foundation, honors a talented young soccer player who passed away tragically at 15. This scholarship is awarded to graduating high school seniors from the Tri-Cities area who have played soccer and wish to continue participating in college-level soccer. Financial need is not a priority, and all eligible students are encouraged to apply for this opportunity to further their education while pursuing their passion for sports.

About Us

Mission Statement

The Westfield Center for Historical Keyboard Studies offers a unique environment for the study, appreciation, use, and promotion of a wide range of keyboard instruments. To serve an increasingly diverse audience, the Center presents keyboard-related conferences, workshops, concerts, masterclasses, educational programs, and publishes scholarly work at regular intervals; longstanding priorities have included the intersections of historical practices and technologies with larger social and artistic developments. In its activities and governance, the Center seeks to foster inclusion and equity among artists, builders, scholars, educators, students, enthusiasts, and partner organizations.

Since its founding in 1979, the Center has sponsored over one hundred events, including workshops, research conferences and symposia, tours to historic instruments, solo recitals and early music concerts, and educational programs designed to interest the general public in keyboard instruments and their repertoire.

Members include highly acclaimed artists, noted scholars, some of the world’s greatest instrument builders, and music lovers.

The Barbara Owen Research Grant

A lifelong member of the Westfield Center, Barbara Owen made immense contributions to our understanding of the organ and its music. She was especially known for her scholarship on the American organ and organists, and she co-wrote the Grove Dictionary article on the organ, a standard reference work. To honor her memory, the Westfield Center will award a $2000 grant for research into historical keyboard instruments (organ, harpsichord, clavichord, fortepiano). The research may culminate in a scholarly article or other format for presenting the information.

The BUILD Grant Program, managed by the USDOT, focuses on enhancing surface transportation infrastructure with substantial local impact. It supports a variety of project sponsors, including state and local governments, in pursuing complex multi-modal initiatives that are often challenging to fund through traditional grants. Established under the American Recovery and Reinvestment Act of 2009, this program reflects a commitment to sustainable and equitable infrastructure development.

The Care Camps Grant supports children with cancer by funding medically supervised oncology camps that provide joy, hope, and healing through outdoor experiences. With the mission to foster a sense of community and shared healing, Care Camps Foundation aims to serve every child and family affected by pediatric cancer in the US and Canada. By collaborating with donors and volunteers, the foundation ensures that each contribution maximizes benefits for the families in need.

The MSA Climate Change Research Award, offered by the Mycological Society of America, supports innovative research addressing the impacts of climate change through the lens of fungal studies. Ideal candidates include undergraduates, graduate students, and post-doctoral scientists who are MSA members or have applied for membership. This award encourages collaboration and aims to disseminate research findings to the global scientific community, fostering inclusivity across various demographics.

American Headache Society

The American Headache Society (AHS) is a professional society of healthcare providers dedicated to the study and treatment of headache and face pain. The Mission of the AHS is to improve the lives of people impacted by migraine and other headache disorders. AHS advocates for those impacted by headache and the headache field, to meet our core objectives. AHS provides educational courses, scientific meetings, a journal, research support, career development opportunities, Special Interest Groups, advocacy training, and a professional community. The AHS strives to meet its objectives while fostering an inclusive sense of belonging and community.

Headache & Migraine Competitive Grant Program

The Headache & Migraine Competitive Grant Program stands at the forefront of advancing headache medicine by funding groundbreaking quality improvement initiatives. This highly competitive grant program, offered through the collaboration between the American Headache Society and Pfizer, supports projects that have the potential to reshape the field by creating widely applicable tools and driving measurable improvements in patient care. 

Migraine & Women's Health

Migraine is a prevalent and debilitating neurological disease that disproportionately affects women, impacting quality of life, productivity, and overall health. Recognizing the need for innovative solutions and enhanced care, Pfizer and the American Headache Society (AHS) are collaborating to offer a new grant opportunity inviting proposals for collaborative quality improvement and research projects focused on migraine and women's health.

The James W. Junior and Jane T. Brown Scholarship, established by Jane and James Brown in 2006, offers financial support to adult students over 21 in the Tri-Cities. This scholarship aims to ease the financial burdens faced by those returning to education. Applicants must demonstrate financial need and provide necessary documentation, including transcripts and a Student Aid Report. The program encourages recipients to assist others in their educational journeys, fostering a cycle of support in the community.

The Racial Equity & Women’s Intercultural Ministries Grants and Scholarships, supported by the Presbyterian Mission Agency, aim to empower leaders, congregations, and organizations that promote racial equity and women's rights. This initiative reflects the Presbyterian Church's commitment to justice and inclusivity, fostering an environment where diverse voices can thrive and contribute to the community. By providing these resources, the program seeks to uplift marginalized groups and promote social equity within faith-based settings.

The H. Wayne VanAgtmael Cosmetology Scholarship, established in 2005 by Wayne Van Agtmael's family, honors his legacy in the cosmetology field. This scholarship supports high school graduates from the Tri-Cities pursuing a cosmetology degree, focusing on financial need and academic achievement. Applicants must provide transcripts and additional required documents. The scholarship aims to empower students, particularly those who are the first in their families to succeed beyond high school, in their educational journeys.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

NFB STEM Scholarship

The NFB STEM Scholarship is jointly supported by the Science and Engineering and Computer Science divisions, and it is awarded to a student studying in science, technology, engineering, mathematics or a related field. Members of these divisions wish to encourage the success of blind STEM students in their chosen field of study.