Best Operating Grants for Nonprofits in Massachusetts

The Chipotle Cultivate Foundation Grant Program supports 501(c)3 non-profits dedicated to making real food accessible and fostering community growth. Established in 2011, this initiative aligns with Chipotle's mission to cultivate a better world. Eligible organizations can apply through an invitation-only process, focusing on those paving the way for a better future. The foundation also offers mentorship and resources to innovative ventures in the food industry.

The Native Performing Arts Live Production Grant (LPG) supports Native artists and organizations in staging live performances, fostering cultural expression. With a $30,000 grant for one year, this initiative prioritizes projects that actively engage Native performers, enhancing their artistic skills and community connections. By addressing the unique needs of Native creators, the program aims to empower them with resources, mentorship, and equitable opportunities in the performing arts landscape.

Burger Family Foundatio

Our Mission

Inspired by our daughter Penelope and the powerful symbolism of the extra 21st chromosome, our foundation is dedicated to creating opportunities for individuals with Down syndrome and their families. Through direct financial assistance, therapy, community, and the healing power of ranch life, we’re building spaces that foster hope, purpose, and belonging.

Pens Pearls

Named after Penelope, Pens Pearls is the financial support arm of our foundation, providing direct assistance to families navigating the unique joys and challenges of raising a child with a disability. From therapy grants to life-changing opportunities, we’re here to lighten the load and ensure every child has the resources they need to thrive.

Through Pens Pearls, eligible families can apply for funding to help cover essential needs, services, or opportunities that make a meaningful impact in their lives. The Burger Family Foundation is a 501(c)(3) organization, and this program is one of the ways we work to create lasting change—one story at a time.

Qualifications for Pens Pearls Grant Program, are deemed by the strict bylaws of the Burger Family Foundation. Funds are paid directly to provider. 

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

The United States Adult Cystic Fibrosis Association (USACFA) offers a Higher Education Scholarship, honoring Lauren Melissa Kelly. This scholarship awards up to $2500 to two adults with cystic fibrosis pursuing various educational paths. Applicants must show proof of enrollment for the relevant academic year and can cover education-related costs, including tuition and materials. This initiative not only supports education but also commemorates Lauren's legacy, inspiring others to pursue their dreams despite challenges.

This grant aims to enhance national immunization programs in the Eastern Mediterranean Region by focusing on capacity building, disease control, and outbreak response. It seeks to eliminate vaccine-preventable diseases, reduce morbidity and mortality, and improve access for under-immunized populations. The initiative will promote sustainability through evidence-based decision-making and program evaluation, aligning with CDC goals to address public health threats and improve overall immunization impact in the region.

Music Movement's Independent Living Initiatives grant supports individuals with Autism and developmental differences in the U.S. Grants, typically ranging from $1,500 to $5,000, aid in various areas including independent living, camps, and continued education. Applicants must be legal guardians of eligible individuals aged 18 and older. The grant portal will reopen for submissions on March 28, 2026, encouraging early review of guidelines to ensure complete applications.

The Instrument Donations Program by Music Movement supports children and young adults with Autism and learning differences by providing funding for musical instruments. This initiative fosters self-expression, personal growth, and emotional well-being through music. Grants typically range from $500 to $1,500 and are available to applicants within the United States. The program encourages artistic development and enhances social skills, making a significant impact on the lives of those facing developmental challenges.

Music Movement offers grants for music therapy aimed at children and young adults with Autism Spectrum Disorder (ASD) and other developmental challenges. Grants typically range from $1,500 to $2,500, providing financial relief to families seeking therapeutic resources. Eligible applicants include legal guardians of children in the U.S. who select qualified therapists. The organization focuses on enhancing communication, social skills, and emotional well-being through music, benefiting diverse communities and promoting personal growth.

Single Ventricle Research Fund (SVRF)

Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care.

In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

What Fits

Through the SVRF, Additional Ventures aims to accelerate foundational research that will lead to improved care and new therapeutic opportunities grounded in a mechanistic understanding of single ventricle heart disease.

The 2027 SVRF welcomes research aligned with the focus areas and strategic topics described in the Additional Ventures’ 2026 Research Roadmap. We are particularly interested in proposals that seek to elucidate the mechanisms underlying, prevent, or reverse the interrelated organ- and multi-organ-level sequelae that contribute to long-term morbidity and mortality.

Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

The Nicholas Dahl Visiting Artist Scholarship, offered by the Provincetown Art Association and Museum, supports LGBTQIA+ artists aged 30 and under with a passion for various art forms. This one-week scholarship, available from November to April, includes lodging, workshop materials, and studio access. It aims to foster creativity and connections within the vibrant Provincetown arts community while promoting educational opportunities in the arts.

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Never Let Go Fund

The purpose of the Never Let Go Fund is to provide funds to qualified individuals to cover expenses related to the treatment of childhood cancer. Grant requests will be considered for children under the age of 18.

St. Baldrick's Foundation

The St. Baldrick's Foundation is a volunteer and donor powered charity committed to supporting the most promising research to find cures for childhood cancers and give survivors long and healthy lives. It started with a friendly dare: would you shave your head to raise money for kids’ cancer research? What happened next would change the world. This bold act of baldness has gained major momentum, since its start in 2000. Today, we have more than 1,000 head-shaving events taking place around the world at pubs, restaurants, schools, churches, parks, firehouses, military bases – you name it. It is our constituents’ way of changing the world, in a meaningful way. Volunteers also raise funds through athletic challenges, livestream fundraisers and many other activities.

Since the Foundation's first grants as an independent charity in 2005, St. Baldrick's has invested more than $380 million in childhood cancer research grants worldwide.

About Allied World

Allied World Assurance Company Holdings, Ltd, through its subsidiaries, is a global provider of insurance and reinsurance solutions. The company operates under the brand Allied World and has supported clients, cedents and trading partners with thoughtful service and meaningful coverages since 2001. Since the inception of St. Baldrick’s, Allied World has supported childhood cancer research through the Foundation, and it is the largest of many reinsurance company sponsors, making this life-saving mission a top priority.

Survivorship and Supportive Care Research Grant

These grants are for specific one-year research projects which are hypothesis-driven and focus on areas related to survivorship and supportive care of children and adolescents with cancer. Examples include but are not limited to: studies related to the burden of morbidity, cause-specific mortality, understanding the pathogenesis of treatment-related complications, patient-reported outcomes or quality of life, health communication, health promotion, and psychosocial support across the trajectory from diagnosis to survivorship or end-of-life care.

Projects must have direct applicability and relevance to pediatric cancer. They may be in any discipline of basic, clinical, translational, or epidemiological research.

About Colin Farrell FoundationThe Colin Farrell Foundation is committed to transforming the lives of individuals and families living with intellectual disability through education, awareness, advocacy, and innovative programs. Inspired by his two sons, he is excited and deeply humbled by the hope that the Colin Farrell Foundation can help those who the larger systems of governance have neglected.

CFF Innovation GrantsWe’re looking for bold, scalable solutions focused on one or more of these priority areas:

• Affordable co-housing models for individuals and families
• Employer-partnered day programs and inclusive job opportunities
• Tools and technologies that enhance accessibility at home and in community spaces
• Cross-sector collaborations between public, private, and nonprofit organizations

The ASSP Foundation Academic Scholarships provide vital financial support to students in environmental health and safety programs. With over $6 million awarded since 1990, the foundation aims to enhance career prospects through education and leadership development. In the 2024-2025 academic year, $215,000 was allocated to 117 recipients, fostering a sustainable talent pipeline in EHS. This initiative not only promotes the profession but also ensures a safer future for workers by encouraging new talent to enter the field.

The National Fish Passage Program (NFPP) offers vital assistance for removing barriers to aquatic life, enhancing safety, and promoting local economies. By investing in projects like culvert replacements and floodplain restorations, the program not only supports native fish populations but also delivers significant economic benefits, estimated at $1.5 million for every $1 million invested. With a recent allocation of $15 million, including $5 million for specific restoration initiatives, NFPP continues to advance aquatic connectivity nationwide.

The Cooperative Endangered Species Conservation Fund supports habitat conservation through land acquisition grants. Established in 1997, this program aims to minimize conflicts between listed species conservation and land use. The U.S. Fish and Wildlife Service provides matching grants to state agencies for projects that ensure the long-term protection of habitats. By acquiring land or conservation easements, this initiative facilitates species recovery and helps prevent future listings under the Endangered Species Act, enhancing overall ecosystem health.

The Helen M. Heitmann Young Scholar Award, presented by SHAPE America, honors young professionals who have made significant contributions to research in curriculum and instruction within health and physical education. Eligible candidates must be current SHAPE America members and have 3 to 6 years of experience post-doctorate. This award emphasizes active involvement and scholarship in the field, encouraging innovative research that enhances educational practices for preK-12 students.

The Curriculum and Instruction Honor Award, presented by SHAPE America, recognizes outstanding contributions to health and physical education curriculum research. This prestigious award highlights the importance of effective instructional practices that prepare students for active and healthy lives. Award recipients are selected based on their scholarship in health education and physical education, demonstrating commitment to excellence since the organization's founding in 1885. SHAPE America advocates for quality education and promotes the well-being of preK-12 students across the United States.

The Eastern Bird Banding Association is offering the Memorial Fund Research Grants to support research utilizing avian marking techniques, such as banding. Applicants must submit a detailed project proposal, including significance and budget, alongside their background in ornithology. Grants are open to all, particularly encouraging student applications, with no lifetime award limit per individual. Projects must focus on species within EBBA territory, ensuring marking techniques are integral to the research.

The Atlantic Salmon Federation Olin Fellowships support individuals aiming to enhance their knowledge and skills in salmon conservation and management. These fellowships are available annually for various pursuits, including research and graduate studies, without the requirement of being enrolled in a degree program. Eligible applicants must be legal residents of the U.S. or Canada, and the fellowships can be conducted at accredited institutions or active management programs.

The Alliance for Innovation on Maternal Health (AIM) Capacity Program aims to enhance the capacity of state, territorial, and Tribal entities in the U.S. to implement and sustain AIM Patient Safety Bundles. By promoting evidence-based maternal safety practices, the program strives to improve the quality of maternity care, enhance maternal health outcomes, and significantly reduce preventable maternal mortality and severe morbidity.

This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.

The Goodnow Fund is a family foundation that provides approximately $1.5 million in grants annually to nonprofit organizations. Focused on supporting vulnerable children, Alzheimer's research, educational opportunities for low-income students, and environmental improvement, the Fund primarily aids organizations in Fairfield County, Connecticut. It identifies potential grantees directly and does not accept unsolicited proposals. For more information, organizations can contact the Fund's Executive Director.

The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.

Incyte Corporation invites organizations to submit membership requests aimed at enhancing healthcare access for patients and advocates. As a biopharmaceutical leader, Incyte supports initiatives that align with its mission to improve patient lives through grants and contributions. Eligible entities include medical schools, associations, non-profits, and advocacy groups. Requests should comply with Incyte's regulatory standards and be submitted at least 60 days prior to the required decision date.

The AHRF Discovery Grants support innovative research on hearing and balance disorders, offering up to $50,000 for one year. Targeting early-career investigators, these grants aim to generate preliminary data for larger funding applications. Special consideration is given to projects exploring Meniere's disease and sudden hearing loss. Grants cover direct research costs, excluding principal investigator salaries and indirect expenses. The initiative strives to fund promising studies that can advance our understanding of auditory and vestibular health.