Best Operating Grants for Nonprofits in Michigan

The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in computational sciences. Established in 1991, it provides a $45,000 annual stipend, full tuition, and a $1,000 professional development allowance over a maximum of four years. The program encourages interdisciplinary research, offering fellows practical experience in DOE laboratories, enhancing their careers in high-performance computing and scientific research across various fields.

The Indigenous Scholarships: Arts Fund facilitates artistic development for Aboriginal Australian, Torres Strait Islander, Native American, Alaskan Native, and Native Hawaiian artists. Offering up to $5,000, it supports projects in each other's countries, with applications due in March and September. Since 2002, over $1 million has been awarded to more than 500 artists, fostering cultural exchange and growth in the arts between Australia and the USA.

The Wild Felid Legacy Scholarship, established by the Wild Felid Research and Management Association in 2009, supports graduate students researching wild felids in the Western Hemisphere. It awards one to three scholarships ranging from $1200 to $1500, based on financial need and research impact. To date, 38 scholarships totaling over $44,000 have been awarded in memory of dedicated biologists who contributed to wildlife conservation. Recipients are recognized in the WFA's newsletter, the Wild Felid Monitor.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The Cass County Opioid Settlement Funds aim to support organizations addressing opioid use through prevention, treatment, and community support initiatives. The funding prioritizes services for individuals and families affected by opioid use, focusing on racial equity and youth prevention. Grants are available for both emergency and non-emergency interventions, ensuring a fair and transparent process for fund allocation. This initiative seeks to make a significant impact on the community by addressing unmet needs and leveraging collaboration with local service providers.

The Cass County Opioid Settlement Funds provide crucial financial resources to address opioid-related issues in Michigan. Originating from a $26 billion settlement, nearly $800 million will be allocated over 18 years, with half directed to local governments. Priority funding areas include naloxone distribution, treatment for pregnant women, and support for incarcerated individuals. Additional settlements are expected to enhance resources, emphasizing the importance of community support and addressing the needs of underserved populations impacted by the opioid crisis.

The Rural Maternity and Obstetrics Management Strategies Program (Rural MOMS) aims to enhance access to maternity and obstetrics care in rural areas through collaborative networks. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative focuses on innovative strategies to improve healthcare delivery for mothers and infants in underserved regions, ensuring that quality care is accessible where it is needed most.

The Building Hope: Future Forward Schools Prize & Fellowship Program aims to enhance career exploration for middle and high school students. This initiative, launched by Building Hope in partnership with American Student Assistance, recognizes schools that excel in career-connected learning. Awardees receive funding, mentorship, and resources to empower students from diverse backgrounds, ensuring they develop essential skills for future success. With $50,000 available for five schools, this program fosters innovation and prepares students for a changing economy.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS)

Help with healthcare costs for Multiple sclerosis (MS)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The T32 Training Program for Institutions That Promote Diversity aims to increase the involvement of individuals from underrepresented backgrounds in research related to cardiovascular, pulmonary, hematologic, and sleep disorders. This initiative seeks to support institutions dedicated to serving health disparity populations, ensuring they develop robust training programs. While trainees cannot lead independent clinical trials, they can gain valuable experience under the guidance of mentors, ultimately contributing to improved health outcomes for underserved communities.

The Saginaw Community Foundation offers the General Grant to support a variety of nonprofit projects in Saginaw County. With five distinct grantmaking committees, it provides funding for programs that enhance community life. Grants typically range from $1,000 to $15,000, depending on the committee. Eligible applicants include 501(c)3 nonprofits and local government entities, with a focus on initiatives that leverage additional resources and promote collaboration.

Michael Dean Guilliams Memorial Scholarship Fund

Fund provides scholarship assistance to deserving students who are pursuing further educational studies in a career and technical field.

Amount

$1,500+

The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers in quantitative science and engineering to focus on NIH-relevant health research. This award provides protected time for supervised study and research, allowing professionals from fields like mathematics, statistics, and engineering to integrate their expertise into health-related studies. The K25 is specifically for lead investigators of independent clinical trials or related studies, fostering innovation in clinical research and career development.

The Koerner Family Foundation Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from Almont, Dryden, and Romeo High Schools. Eligible students must plan to major in business, engineering, IT, medical health fields, natural sciences, or vocational training, with a minimum GPA of 2.50. Award recipients will be honored at a Scholarship Celebration in May and at their respective high school awards events.

The NCMA Education and Research Foundation Grant aims to support the concrete masonry and hardscape industry through research and educational initiatives. With over $2 million invested, the Foundation invites proposals from qualified professionals, emphasizing national and regional benefits. Eligible projects should focus on workforce development, educational opportunities for students, and collaborative efforts with other organizations. Notably, certain entities, such as those involved in political campaigns or proprietary projects, are ineligible for funding.

The AISES ARDC Scholarship provides $5,000 annually to undergraduate and graduate students pursuing degrees in Electrical Engineering, Physics, Computer Science, or related fields. Funded by the American Indian Science and Engineering Society (AISES), this scholarship aims to support Indigenous students who are current AISES members and enrolled full-time. Eligible applicants must also be citizens or descendants of recognized Indigenous tribes, ensuring a commitment to enhancing representation in STEM education and careers.

The Ferguson Cares Grant is an essential aspect of Ferguson's Sustainability strategy, focusing on social challenges and community wellbeing. This grant supports nonprofit organizations in the U.S. dedicated to affordable housing, skilled trades workforce development, clean water access, and enhancing local economic quality of life. Ferguson aims to create lasting partnerships that drive positive impact within their operational regions, reflecting their commitment to social responsibility and community support.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Harry Emley and Mary Joslin Bennett Scholarship

Selection based upon:

• Academic achievement, financial need, community and school service, and recommendations.

Awards

• One $500 scholarship

The Skillman Foundation's President's Discretionary Fund offers annual grants between $2,500 and $10,000 to 501(c)(3) nonprofits serving Detroit youth. This $1M fund supports innovative, one-time projects or pilot programs that enhance education, health, and community services, while also addressing systemic issues. Grants are not intended for ongoing support, and eligibility includes tax-exempt status. Stay informed about future funding opportunities by subscribing to the Foundation's newsletter.

The Safe Arborist Techniques Fund Grant Program, established by the Tree Research and Education Endowment Fund and the International Society of Arboriculture, aims to enhance worker safety in arboriculture through research and development. Grants focus on biomechanics and tree failure mechanisms, supporting innovative practices that protect both workers and the community. Proposals are evaluated on their potential impact, scientific rigor, and the experience of the investigative team, ensuring they align with the mission of the TREE Fund.

This funding opportunity invites applications for a Research Coordinating Center (RCC) to lead a consortium aimed at optimizing anti-obesity medication (AOM) strategies for children and adolescents. The RCC will manage collaborative trials, focusing on developmental stages for AOM use, treatment effectiveness, and lifestyle interventions. By harmonizing data collection and analysis, the RCC aims to enhance research efforts and outcomes in combating youth obesity while ensuring safe AOM usage.

The Intervention Research to Improve Native American Health (IRINAH), led by the National Institute on Drug Abuse, focuses on enhancing health outcomes in Native populations. It supports research to identify causes of health issues, develop and test effective interventions, and implement strategies that promote sustainability. Emphasizing community strengths, the initiative aims to rigorously evaluate solutions to reduce health disparities, ensuring interventions can be adapted and shared across diverse communities.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers with quantitative science backgrounds to NIH-relevant studies. It provides support and protected time for professionals to integrate their expertise in areas like mathematics and statistics with health research. Notably, it does not support independent clinical trials, focusing instead on collaborative experiences under mentorship. The application process involves specific deadlines for submissions, including standard, renewal, and AIDS-related grants, encouraging diverse participation in significant health research.

About All Points North Foundation

All Points North Foundation is dedicated to navigating communities upward.

All Points North Foundation was founded in 2011 by a family who believes passionately that everyone has a “true North” – a place of achievement – and that everyone should have equal opportunity and access to realize their goals.

Our Vision

We envision a nation where the middle school years are seen as an important, vital time in the lives of youth, and where the public middle school education experience in underserved communities measurably improves

We also envision a nation where the integration of solar benefits families, local economies and the environment.

Our Priorities

All Points North Foundation funds grantees in two areas – public middle school education (grades 6-8) and solar – that have the power to help communities nationwide navigate upward.

Grant Making

All Points North Foundation seeks collaborative partnerships with grantees in our two priority areas.

Solar Energy

All Points North Foundation is focused on finding ways to significantly advance the penetration of solar through education, job training and use of solar electric technologies in the United States.

All Points North Foundation has three priority areas:

Providing solar and workforce development training for Tribal communities to expand and diversify the solar job pipeline.

Working with small- to medium-sized science centers to engage students, families and local communities on the benefits and science behind solar.

Providing solar installations to nonprofit organizations that build high-quality, safe and affordable residential housing, offsetting energy costs and enabling cost savings for households.

The cost of solar has dropped dramatically over the last decade, however the upfront cost of going solar remains a hurdle for most families, communities and nonprofits.

All Points North Foundation does consider funding solar projects outside of these focal areas, but the programs must demonstrate how solar will have a broader impact on local communities (e.g., economic, social or environmental), as well as showcase the potential for replication across the nation.

The Zone VI Fellowship in Urban Forestry, funded by the Garden Club of America, aims to promote urban forestry education among U.S. graduate and advanced undergraduate students. Established in 2006, this fellowship awards $7,500 annually to support students studying urban forestry and related fields. Recipients can reapply for additional funding, fostering ongoing research and engagement with the urban forest ecosystem. This initiative highlights the importance of healthy urban forests and their impact on communities.