Best Operating Grants for Nonprofits in Minnesota

The LUNGevity Career Development Award supports emerging research leaders focused on lung cancer. It funds innovative projects aimed at enhancing early detection and personalized treatments, including targeted therapies and immunotherapy. With a maximum award of $300,000 over three years, this opportunity is limited to US applicants. The funding is contingent upon annual progress reviews, with the first payment expected after November 1, 2025. This award aims to foster groundbreaking advancements in lung cancer research.

The FY26 Bus Safety, Accessibility, and Innovation Notice of Funding Opportunity offers up to $10 million for innovative projects aimed at enhancing bus safety and accessibility. Administered by the Federal Transit Administration, this competitive grant invites applications for the development of concepts that improve safety for operators and vulnerable road users, ensuring that public transportation is safer and more accessible for all passengers.

The NIMH Career Transition Award (K22) supports tenure-track intramural investigators at NIMH in their transition to independent research faculty positions. This program aims to foster innovative research in mental health, encouraging applicants with a strong record of research excellence. Key deadlines for applications vary, including those for standard and renewal submissions, emphasizing the importance of timely applications to secure funding and advance mental health research initiatives.

This initiative aims to support research interventions targeting disparities in liver diseases and liver cancer among underserved populations in the U.S. It encourages innovative approaches to reduce health inequities and improve health outcomes. The funding opportunity is available through various deadlines for both standard and renewal applications, promoting multi-level strategies to address these critical health issues effectively.

Rapid Response Grants 

Emergency funding after mass tragedies.

In the wake of tragic mass events, such as shooting, speed matters. Our Rapid Response Grants provide expedited funding to victims and their families when time is of the essence. These grants ensure that families aren’t left waiting for critical support when they need it most.

• Awarded swiftly after mass casualty events
• Designed to provide urgent, compassionate support in crisis situations

The Jim and Fran Foss Scholarship, administered by the Sioux Falls Area Community Foundation, supports graduating seniors from Sioux Falls public high schools. This scholarship encourages students who plan to attend accredited four-year colleges or universities, maintain a GPA of 3.0 or higher, and demonstrate financial need. With over 70 scholarships awarded annually, it aims to empower local students to achieve their educational aspirations and contribute positively to the community.

The NCAA Jim McKay Graduate Scholarship honors the legacy of journalist Jim McKay by awarding a one-time $10,000 scholarship to one male and one female student-athlete annually. Eligible candidates must have a minimum GPA of 3.5, demonstrate integrity, and show interest in sports communication. There is no limit to the number of nominations from institutions, highlighting the NCAA's commitment to supporting student-athletes in their academic and professional pursuits.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

Contractors for Implementation and Evaluation of Healthy Native Babies Project (HNBP) Materials

The CDC Foundation is re-releasing this RFP to allow for additional applicants to partner with us in this work. The CDC Foundation invites proposals from Tribes, Tribal Serving Organizations (TSOs), and Urban Indian Organizations (UIOs) [T/TSOs/UIOs] to implement and evaluate the updated Healthy Native Babies Project (HNBP) materials within their service areas. This initiative aims to strengthen culturally relevant infant safe sleep education, increase community awareness, and support Native families in reducing -sleep related- infant deaths. Selected T/TSOs/UIOs will adapt, disseminate, and assess the use of HNBP materials in ways that reflect the cultural, linguistic, and community-specific needs of the Native populations they serve. This project is a rapid turnaround project to support

T/TSOs/UIOs in:

• Implementing HNBP materials in clinical, community, and family setting.
• Training staff and community partners.
• Evaluating reach, effectiveness, and community feedback.
• Identifying barriers, facilitators, lessons learned, and best practices for future replication.

Funding Amount:

• Up to $100,000

Performance Period:

• May 18, 2026 to September 29, 2026

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support postdoctoral fellows from underrepresented backgrounds in transitioning to tenure-track positions. This award provides essential funding for salary and research support for three years, enabling candidates to establish independent biomedical careers. Key deadlines for applications range from February 2025 to October 2027, ensuring ample opportunity for eligible researchers to secure funding for their career development.

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

 Advancing Markets for Producers Grants

ALB has received a USDA AMP (Advancing Markets for Producers) grant, and we’re excited to invite sheep producers to be part of this opportunity to help grow the US sheep industry. This grant will integrate new technology and sustainable management strategies to boost productivity, open new markets, and strengthen opportunities for the next generation of producers.

Producer Program

The project will provide an opportunity for 150 sheep producers to identify production inefficiencies and to develop conservation plans. Producers will also modify management plans through technology implementation to mitigate emissions and improve their overall productivity. Enrolled producers will work with a Technical Service Provider (TSP) to establish operational plans, implement recommended changes and organize farm data to identify best management practices for productivity improvements. 

Enrollment Benefits

Producers enrolled in the program will be paid up to $23,000 to develop and implement improved sheep and land stewardship management plans. Additional enrollment benefits:

• Technical Service Provider
• Electronic livestock identification system
• Soil sampling
• NSIP ultrasound and genetic consulting services

Ramsey County Violence Prevention Grant

Ramsey County, in partnership with Youthprise, seeks to expand access to culturally responsive and community-based supports for youth and young adults through a violence prevention grantmaking process. This request for proposal will fund small programmatic grants to community-based organizations delivering services that promote healing, stability, academic success, and long-term wellbeing for youth and young adults. Priority will be given to projects that serve participants who are system-impacted, marginalized, or disproportionately affected by inequities. Priority services identified by Ramsey County include mentoring and relationship-based supports, school-based and education aligned supports, licensed alcohol and drug counseling, and holistic healing and mindfulness practices. Funded projects will operate for a minimum of six months and a maximum of fifteen months and will serve youth and young people in Ramsey County or involved in Ramsey County systems.

Funding Available:

• $236,250

Number of Awards:

• 8 to 10 awards anticipated ranging from $15,000 to $25,000

Grant Term:

•  6 to 14 months, services must be concluded on or before August 1st, 2027

Funding Use:

• Programmatic services to include direct service delivery, staff time, materials, facilitation, program-related costs, and administrative costs

Grant funds may be used for:

• Program staff or facilitator stipends/salaries
• Direct service delivery costs
• Supplies, curriculum, and materials
• Space rental for program activities
• Participant supports (e.g., food, transportation, incentives)
• Program-related administrative costs

JFS–David Rubenstein Memorial Scholarship

The JFS–David Rubenstein Memorial Scholarship, established by Dr. Robert Rubenstein and Marie Raftery, honors the memory of Dr. Robert’s son, David. The program provides financial support to students from San Diego’s Jewish community pursuing college or vocational education, and encourages them to cultivate intellectual curiosity, reflect on Jewish values, and give back to their community.

Scholarships of up to $10,000 will be awarded based on academic achievement, community involvement, and financial need.

Students are eligible to receive up to a total of four (4) years of JFS-David Rubenstein Memorial Scholarship funding, and the funding years do not have to be consecutive. Scholarships are made on a year-to-year basis and are not automatically renewed. Scholarship recipients must submit a new application and the required documentation in compliance with the application deadlines, stated herein, for each year that they seek funding.

Scholarship funds will be sent directly to the academic institution the student is attending solely for use toward qualifying academic expenses, including tuition, school-provided housing, books, school fees, or required academic supplies/equipment. Should the recipient not matriculate college by the date listed in the award, he or she agrees to forfeit the scholarship award.

The Central Minnesota Special Needs Grant provides funding between $5,000 and $10,000 to support services, equipment, and projects for individuals with complex intellectual and physical disabilities. Eligible applicants include 501(c)(3) nonprofits, schools, and government entities serving Benton, Stearns, and Sherburne counties, as well as specific communities. The grant prioritizes initiatives that foster diversity, equity, and inclusion while excluding general operating costs and capital campaigns.

The Statewide Perinatal Quality Collaboratives initiative aims to enhance the health of pregnant and postpartum women and their newborns through quality improvement strategies. Funded by the CDC, the program encompasses two components: state-based Perinatal Quality Collaboratives and a National Network coordinating center. Key strategies include strengthening data systems and fostering partnerships to improve healthcare services and outcomes. Ultimately, this initiative seeks to implement successful quality improvement initiatives that ensure better coordination and health outcomes for mothers and newborns across the United States.

FY25 Veterans Treatment Court Program

Executive Summary

This NOFO will support the implementation and enhancement of veterans treatment court (VTC) operations. VTCs connect veterans who come in contact with the justice system to treatment for substance use disorders (SUD), mental health disorders (MHD), co-occurring mental health and substance use disorders (MHSUD), post-traumatic stress disorder (PTSD), and traumatic brain injury (TBI). Funding supports service coordination, and recovery support services. VTCs integrate mandatory drug testing, incentives and sanctions, and transitional services in judicially supervised criminal court settings that have jurisdiction over veterans with behavioral health treatment needs. These courts aim to reduce recidivism and overdose fatalities, while increasing access to treatment and recovery support that leads to long-term recovery.

Category 1 supports the planning and implementation and/or launch of a VTC. These courts will support core capacity and provide critical behavioral health treatment, case management and coordinated judicial supervision, sanctions and incentives, and other supportive services, such as transitional housing, peer recovery services, relapse prevention and employment services, that can reduce recidivism.

Program Description

Planning and Implementation grants are available to eligible jurisdictions ready to commit to a 6- month planning phase followed by an implementation and/or launch of a VTC that supports core capacity and provides critical behavioral health treatment, case management and coordinated judicial supervision, sanctions and incentives, and other supportive services, such as transitional housing, peer recovery services, relapse prevention and employment services, that can reduce recidivism, including serving veterans who cannot or do not have access to Department of Veterans Affairs (VA) services

The Veterans Treatment Court Program Enhancement Grant aims to bolster the operations of veterans treatment courts (VTCs) that serve veterans involved in the justice system. By addressing substance use and mental health disorders, these courts facilitate access to essential treatment services, reducing recidivism and overdose fatalities. The grant supports jurisdictions in enhancing their VTC capacity, improving service quality, and ensuring veterans receive the necessary support for long-term recovery. Funding of up to $1,000,000 is available for eligible jurisdictions.

Bureau of Justice Assistance

The Bureau of Justice Assistance (BJA) was created in 1984 to reduce violent crime, create safer communities, and reform our Nation’s criminal justice system.

BJA strengthens the Nation’s criminal justice system and helps America’s state, local, and tribal jurisdictions reduce and prevent crime, reduce recidivism, and promote a fair and safe criminal justice system. BJA focuses its programmatic and policy efforts on providing a wide range of resources, including training and technical assistance, to law enforcement, courts, corrections, treatment, reentry, justice information sharing, and community-based partners to address chronic and emerging criminal justice challenges nationwide. 

FY25 Residential Substance Abuse Treatment (RSAT) for State Prisoners Training and Technical Assistance Program

Executive Summary

This NOFO will provide training and technical assistance (TTA) to state and local grantees of the Residential Substance Abuse Treatment (RSAT) for State Prisoners Program to enhance implementation of comprehensive residential substance use treatment during detention or incarceration and aftercare services to prepare individuals for successful reintegration into the community. The selected TTA provider will also maintain and update the RSAT TTA website to serve as single source of information for RSAT grantees that reflects evolving needs and emerging evidence-based approaches.

The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.

Residential Substance Abuse Treatment for State Prisoners (RSAT) Program

Overview

The Residential Substance Abuse Treatment (RSAT) Program is a formula grant program that enhances the capabilities of state, local, and tribal governments to provide residential substance use disorder (SUD) treatment to adult and juvenile populations during detention or incarceration, initiate or continue evidence-based SUD treatment in jails, prepare individuals for reintegration into the community, and assist them and their communities throughout the reentry process by delivering community-based treatment and other recovery aftercare services.

The RSAT Program encourages the establishment and maintenance of drug-free prisons and jails and development and implementation of specialized residential SUD treatment for individuals with co-occurring mental health and substance use disorders. The program also encourages the inclusion of medication-assisted treatment as part of any SUD treatment protocol.

The Gender Justice Organizing Fund Grant supports initiatives led by women, girls, trans, gender nonconforming, and LGBTQI+ individuals to achieve gender justice. Organizations must prioritize community organizing and demonstrate an understanding of systemic oppression. Grants from the Bread & Roses Community Fund are crucial for groups that lack traditional funding due to their commitment to amplifying marginalized voices. The fund emphasizes long-term strategies that foster sustainable social change in the Philadelphia area.

The AICEF Cultural Grant aims to enhance cultural ties between the United States and Indonesia by funding projects in the performing, visual, and literary arts. With grants ranging from $1,000 to $5,000, the foundation seeks to support distinguished individuals and groups whose work is accessible to the public and fosters goodwill between the two nations. This initiative not only promotes artistic excellence but also bridges cultural exchanges for a diverse audience.

Fuel Up

We’re Fuel Up – an initiative created by America’s Dairy Farmers to help meet the needs of schools across the country when it comes to fueling healthy bodies and healthy minds.

Fuel Up is all about educators, students and partners working together to make a difference in their schools and their communities.

Fuel Up is an initiative focused on helping educators and students fuel wellness in the areas that matter most, like being mindful and staying healthy. Our educational resources, partnerships and grant/funding opportunities aim to broaden access to good nutrition and overall wellness.

School Nutrition Equipment Grants

Nutrition equipment grants are now available through GENYOUth's End Student Hunger initiative, with applications now open in the new School Wellness Portal.

K-12 schools can apply for an equipment grant to help increase students' access to, and participation in, nutritious school meals.

Overview of Fuel Up Equipment Grant

• One of two nutrition equipment kits—each valued at $2,000—is available to qualified K-12 schools to improve access to nutritious foods.

• Your application must demonstrate how the funding will increase your students’ access to and their consumption of dairy products (milk, yogurt, cheese). Your local Dairy Council can help you with ideas for how to increase dairy.

• Applications will be evaluated based on a variety of factors, including school enrollment, student reach, in-school support, school location, and the sustainability of the proposed program. Consideration will be given to schools in underserved communities whose students are most at risk for poor nutrition and childhood obesity.

• You are encouraged to contact your local Dairy Council with questions about the application process. They can be especially helpful in suggesting ways to increase dairy consumption at your school.

Schools can visit the GENYOUth School Wellness Portal to review eligibility requirements, explore equipment options, and begin an application.  

Northwest Connecticut Community Foundation

For more than 50 years, NCCF has been taking on tough problems to improve the quality-of-life in Northwest CT by supporting nonprofits that speak to the charitable passions of our generous donors.

NCCF is a Community Foundation, a tax-exempt public charity that enables donors to establish funds that support the work of local nonprofits through grants and provide scholarships to local students.

Russell F. Bruno Scholarship

For Torrington High School graduating seniors who have excelled in the study of English and are planning to major in writing, literature, journalism or a related field.