Best Operating Grants for Nonprofits in Minnesota

The FY26 Peer Reviewed Medical Research Program Clinical Trial Award promotes the swift initiation of impactful clinical trials for diseases outlined in specific topic areas. It offers two application categories: Clinical Trial Only and Clinical Trial with Planning Phase, supporting various funding levels based on trial phases and participant counts. The total funding of approximately $94.5M aims to support up to 9 applications, with a maximum award period of 4 years, ensuring significant advancements in medical research.

The AHA Quest for Quality Prize recognizes hospitals and health systems that demonstrate exceptional leadership in improving care quality and advancing health. Applicants should showcase innovative models of care and effective partnerships with community organizations. One winner and two finalists will be honored at the 2026 AHA Leadership Summit in Denver. This award aims to inspire hospitals to commit to patient-centered care and address healthcare disparities, ultimately enhancing community health outcomes.

Montgomery County Community Foundation Inc.

The Montgomery County Community Foundation (MCCF) bridges the gap between donors and our community – a community full of mission-driven nonprofits and ambitious students looking for a bright future.

Donors work with us to facilitate progress in Montgomery County. With their generous support, we are able to invest their gifts, manage them for growth, and use a portion of the earnings for grants for nonprofits and scholarships for students that are truly making a difference.

Durham Foundation Fund in Honor of Shirley O'Neall

The Durham Foundation was established in 1944 for the purpose of maintaining Durham Home as a residence for independent women. In 1937, Sarah Durham established a trust to provide a comfortable home environment for women. The Durham Foundation operates as a 501c3 organization and oversees the home located at 215 West Main Street, Crawfordsville. 

The Durham Foundation Fund was created by the Durham Foundation board of directors to honor Shirley O’Neall’s service to the organization for over 50 years. It is their wish to support local women pursuing education to better themselves and their contributions to the community.

Carlisle and Troiano Scholarship Fund

Established to provide scholarships for graduating high school seniors who are pursuing a postsecondary degree and are enrolled in Akron Public Schools or any public school district serving Medina County.

Amount:

• Varies
• $2,500 - $7,500

Number of awards:

• Varies (contingent on available funds)

Renewal:

• May reapply annually by submission of a new application.

The Biocodex Microbiota Foundation invites early career researchers in the microbiome field from U.S. institutions to apply for the 2024 grant. This initiative focuses on groundbreaking research into gut microbiota's role in human health and disease, particularly in areas like circadian rhythms and metabolic disorders. The grant supports operational costs, allowing for innovative projects aimed at fostering independent research careers in microbiota studies.

Medina County Women's Scholarship FundOriginally established by the American Association of University Women of Medina County to award scholarships to nontraditional female students. A nontraditional student is a woman whose undergraduate education has been interrupted or delayed.Amount:

• Varies

Number of awards:

• Varies

Renewal:

• Must reapply annually by submission of a new application; however, any applicant cannot be selected more than twice for this scholarship.

About OSAC

The Office of Student Access and Completion (OSAC) is an office of the Higher Education Coordinating Commission (HECC) committed to assisting Oregonians in their pursuit of higher education and a brighter future. Established in 1959 by the Oregon Legislature, OSAC provides innovative funding and programs to Oregon students and families.

OSAC Scholarship Program

The OSAC Scholarship Application provides current and future Oregon students one easy application to apply for multiple scholarships at one time. OSAC awards more than $10 million in scholarships annually through more than 600 scholarships. 

The Oregon Barber and Hairdresser Grant Program, administered by the Oregon Higher Education Coordinating Commission, offers one-time financial assistance to low-income students attending eligible barbering and cosmetology schools in Oregon. This grant aims to support students with significant financial need, ensuring they can pursue their education without financial barriers. Limited funding means only those with a demonstrable need receive support, and grant amounts may vary yearly based on fund performance.

The Edward Payson and Bernice Piilani Irwin Scholarship honors Bernice Pi'ilani Irwin, a notable figure in Hawaiian journalism. Open to undergraduate and graduate students residing in Hawaii, the scholarship aims to support those pursuing careers in journalism or communications. Applicants must demonstrate financial need and maintain a minimum GPA of 2.75 while attending an accredited U.S. college or university. This scholarship is an excellent opportunity for aspiring journalists to follow in Bernice's footsteps.

The Medical Student Mentored Summer Research Program offers medical students in the U.S. and Canada a unique opportunity to engage in a 10-week research experience under expert mentorship in pediatric gastroenterology, hepatology, or nutrition. With a stipend of $4000 paid in installments, this program is designed for students who have completed at least their first year of medical training. Preference is given to those seeking research experience between their first and second years.

The Beacon Scholarship for Rural America, sponsored by Carrot-Top Industries, Inc., offers $1,000 scholarships to support low-income students from rural areas pursuing higher education. Eligible applicants must be graduating high school seniors, current college students, or adult learners with a GPA of 3.0 or higher, and reside in a rural area. The scholarship aims to empower students by alleviating financial burdens as they enroll in accredited college programs.

The FY26 Arthritis Research Program Clinical Research Award supports innovative clinical research addressing factors and interventions for arthritis. This program encourages proposals focusing on Prevention and Early Diagnosis or Treatment and Mitigation of Disease Progression. Applicants can choose between two research levels, with the requirement of a community collaborator for Research Level 2. Projects should aim to provide actionable evidence to enhance patient care and outcomes, making significant contributions to the field of arthritis research.

This funding opportunity invites applications for R01 grants focused on molecular imaging methods to explore cancer inflammation in vivo. It aims to enhance understanding of dynamic interactions between inflammation and cancer through innovative imaging techniques. The initiative encourages collaborations between cancer researchers and imaging scientists to leverage molecular imaging for identifying cellular physiology changes in response to treatment. Deadline dates for applications range from February 2025 to October 2027, emphasizing timely submission for prospective researchers.

The Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) aims to enhance cancer treatment by integrating imaging and liquid biopsy assays. This initiative, led by the National Cancer Institute (NCI), encourages grant applications focused on assessing therapy responses and resistance emergence in patients. Key deadlines for submissions span from February 2025 to January 2028, providing ample opportunities for researchers to contribute to this vital area of cancer research.

The Simply Organic Giving Fund Grant aims to combat food insecurity in the U.S. and Canada by providing access to nutrient-dense organic food for those in need. Since its inception, the fund has supported various initiatives, including training centers for organic agriculture and community food projects. With a focus on sustainable practices, the grant program seeks to empower communities and improve food access for vulnerable populations, ensuring that healthy, organic options are available to all.

Manuel And Fillie Garcia Hispanic Scholarship

The Manuel & Fillie Garcia Hispanic Scholarship was established as a permanent fund of Taos Community Foundation in 2011.

The award is available to graduating seniors in Taos and western Colfax counties with preference to Hispanic students pursuing advancement of higher education. The scholarship is available to those applying to 4 year colleges and universities as well as 2 year vocational/trade schools.

The award amount will be determined at the time of committee review. This award is typically renewable for up to three years if a 2.5 GPA is maintained and all required paperwork is returned in accordance with the Scholarship Agreement.

Youth Service America

Youth Service America believes that youth, communities, and our democracy thrive when we all work together for the common good. YSA is a leading global nonprofit that activates young people, ages 5-25, to find their voice, take action, and acquire powerful civic and 21st Century skills as they solve problems facing their communities. YSA supports its activation campaigns with grants, training and resources, and recognition programs for young people and their adult champions. Youth-led projects use Awareness, Service, Advocacy, and Philanthropy (ASAP) strategies to create social and environmental change.

We Serve To Remember Grants

Projects that Engage 100 Youth Volunteers

YSA’s We Serve to Remember 9/11 Day of Service Grants are for organizations, schools, and youth changemakers ages 5-25 to lead service projects on or around September 11, 2026. Programming efforts should also honor and pay tribute to those who lost their lives on September 11, 2001, their families, and those who rose in service in response to that tragedy. (We suggest starting with eleven reflections about 9/11/01 and related ideas for service or service-learning projects.)

Grantees are required to engage at least 100 youth as volunteers in planning and implementing the service activities.

What are we looking for?

• Projects must be youth-led;
• Projects must include elements to honor and pay tribute to those who lost their lives on 9/11, their families, and those who rose in service in response;
• Projects must take place on or around September 11th National Day of Service and Remembrance (Friday, September 11, 2026) – between Friday, September 4 and Friday, September 18;
• Project organizers must make their best effort to recruit and engage youth volunteers who are not usually asked to serve;

Grantees are also required to provide evidence of volunteer participation and number of hours served. Approved documention includes sign in sheets, copies of pre-and-post-surveys, or reports from school attendance or volunteer management system. These documents must contain a unique identifier for each volunteer, such as the volunteer’s full first and last name, their full first name and last initial, or a volunteer/student ID number.

Reflecting on the spirit of togetherness that brought people together in the days, weeks, and months after September 11th, we are especially looking for ideas that bring together all members of the community.

The FY26 Vision Research Program's Investigator-Initiated Research Award (IIRA) offers funding for innovative research addressing eye injury and visual dysfunction due to military exposure. This award supports preclinical to early translational studies aligned with specific focus areas. Unique features include two funding levels and a Partnering Principal Investigator Option. Applications undergo rigorous peer review based on research rationale, strategy, and impact, with potential for sharing with the National Eye Institute for additional funding consideration.

The Glenn D. and Bennie Lou Hammons Family Scholarship, established by the Central Kentucky Community Foundation in 1960, supports residents of Hardin County with a GPA between 2.5 to 3.5. This scholarship aims to empower local students by providing financial assistance for their educational pursuits, fostering community growth and development. As part of the Lincoln Trail Region's extensive network of community foundations, it reflects a commitment to enhancing educational opportunities for deserving applicants.

The FY26 Vision Research Program Clinical Trial Award supports the swift execution of clinical trials aimed at improving treatments for service-connected eye injuries and visual dysfunction. This award emphasizes the need for regulatory compliance, including IND/IDE submissions, and requires documentation confirming the application's active status by March 1, 2027. Review criteria focus on clinical impact, research feasibility, recruitment strategies, and ethical considerations, ensuring relevance to military health.

The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention strategies for patients with RUNX1 familial platelet disorder. This initiative, supported by the American Cancer Society, focuses on understanding the mechanisms behind leukemia development and fostering innovative research leading to effective treatment options. Grants of up to $215,000 per year for four years are available, emphasizing the urgent need for targeted therapies in high-risk populations.

The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention for patients with RUNX1 familial platelet disorder (RUNX1-FPD). This program supports interdisciplinary research teams investigating the mechanisms of leukemogenesis and innovative treatment strategies. With funding of up to $430,000 per year, LEAP encourages projects focused on both understanding clonal evolution and developing novel therapeutic approaches. The initiative seeks to bridge critical knowledge gaps and provide urgent interventions for high-risk populations.

The DoW Vision Research Program's FY26 Translational Research Award aims to accelerate the development of innovative drugs, devices, or clinical guidelines ready for clinical trials. It supports preclinical studies and pilot trials, ensuring alignment with specified VRP Focus Areas. Key features include a requirement for regulatory expertise in drug/device development and a unique Partnering Principal Investigator option. Review criteria focus on research rationale, strategy, feasibility, and impact, enhancing military health outcomes.

About NCCF

For more than 50 years, NCCF has been taking on tough problems to improve the quality-of-life in Northwest CT by supporting nonprofits that speak to the charitable passions of our generous donors.

NCCF is a Community Foundation, a tax-exempt public charity that enables donors to establish funds that support the work of local nonprofits through grants and provide scholarships to local students.

NCCF's Board and Staff champion the causes you care about with smart grant-making designed specifically to adapt over time and provide highly attentive, knowledgeable, and compassionate service that brings donors and organizations together to address community issues.

Scholarship Opportunities and Applications

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

Michele Farley Pittler Scholarship

• Academic Focus: Unspecified
• Award Average: $1,000

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.

The Mae Casali Bonvicini Scholarship, offered by the Northwest Connecticut Community Foundation, supports Torrington High School graduating seniors aiming for higher education. With awards ranging from $400 to $1,500, this scholarship is designed to ease financial burdens for students who are U.S. citizens or permanent residents in the NCCF’s service area. For over 50 years, NCCF has dedicated itself to enhancing the quality of life in Northwest Connecticut through grants and scholarships.