Best Operating Grants for Nonprofits in Minnesota

The Broadcasters Foundation of America Emergency Grant provides vital financial assistance to broadcasters facing acute financial hardship due to natural disasters or emergencies. These one-time grants support those who have dedicated years to the broadcasting profession and are in need of help to recover. Applications can be submitted by individual broadcasters or their employers within 30 days of the event, ensuring timely support for those affected.

The Graduate Education Fund offers the South Australia Defence, Space & Cyber Scholarship for scholars from the USA and South Australia. This scholarship supports PhD and Post-Doctoral research in Defence, Space, and Cyber Security, ensuring candidates have affiliations with educational institutions. Awarded funds, up to US $40,000, can cover tuition, travel, and living expenses. Applications are due in March for USA to Australia and September for Australia to USA, promoting collaboration in research between the two nations.

The AAFP Family Medicine Chapter Alliance Grant Awards support the philanthropic efforts of AAFP Constituent Chapters and Chapter Foundations. Since 2006, these grants have been designed to fund activities that align with specific priority areas including education, outreach, and public health initiatives. Eligible applicants include AAFP Chapters and Foundations, focusing on projects that promote community health and wellness.

The R01 grant program aims to address disparities in liver diseases and liver cancer in the United States. It supports multi-level intervention research targeting populations with significant health disparities. With deadlines spanning from February 2024 to June 2027, this initiative encourages innovative approaches to improve health outcomes in underserved communities, ultimately enhancing public health and reducing inequities in healthcare access and treatment.

Our Home State Grant Program

Our Home State works to ensure Minnesota’s housing ecosystem has the power and resources to create an equitable future where all Minnesotans have a stable home they can afford.

A collaborative effort by the Saint Paul & Minnesota Foundation, F. R. Bigelow Foundation and Mardag Foundation, with additional support from businesses, peer foundations and individual donors, the Our Home State Grant Program seeks to increase access to housing across Minnesota. Our Home State North Star: Minnesota’s housing ecosystem has the power and resources to create an equitable future where all Minnesotans have a stable home they can afford.

The grants support organizations and programs that provide pathways to affordable, quality housing supports organizations and programs that ensure access to affordable housing or emergency shelter.

Our Home State Ecosystem Grant Program 

The Our Home State Ecosystem Grant Program supports organizations and programs that ensure access to affordable housing or emergency shelter. Ecosystem Grants will be offered for general operating support.

• For shelter: grant amounts will be $100,000 per year for a five-year grant period, for total grant amounts of $500,000 per grantee.
• For affordable housing: grant amounts will be up to $150,000 per year for a five-year grant period, for total grant amounts of $750,000 per grantee.

In 2026, we plan to select ten shelter and ten affordable housing grantees. Seven East Metro and three Greater MN/Tribal grantees in each focus area. 

The AAFP Foundation offers Family Medicine Chapter Engagement Grants to support the philanthropic initiatives of its constituent chapters. Each chapter or chapter foundation can receive $750 to highlight programs focused on Student/Resident education, Member Outreach, or Public Health. This initiative not only showcases the impactful work being done at the chapter level but also aids in fundraising efforts, fostering stronger community connections and improving health outcomes.

The Blue Bird Auxiliary Scholarship Fund, established by the San Antonio Area Foundation, offers financial support for graduate and current college students pursuing degrees in healthcare-related fields. Eligible candidates must maintain a GPA of 3.1 and be active volunteers with the Blue J/Blue Bird organization. This scholarship, renewable for up to three years, covers tuition, fees, books, and living expenses, helping students achieve their educational goals while serving the community.

The Columbus Foundation

In 1943, during the darkness of World War II, a group of passionate citizens, led by Columbus businessman Harrison M. Sayre, envisioned a way to improve the well-being of the community and the quality of life in central Ohio. With little more than this sound idea and faith, The Columbus Foundation was established.

Our Mission

To assist donors and others in strengthening and improving our community for the benefit of all its residents.

Craig Memorial Scholarship Fund

This scholarship fund was established by the family of John E. Craig, Jr. and Larry William Craig. Both John and Larry were extremely gifted musicians. John was a noted musician in the central Ohio community, studying at the Berklee College of Music in Boston at the time of his death. A well-known musician and businessman, Larry excelled at playing the piano and worked with his father in Craig & Sons Wrecking Company. This scholarship fund will provide support to students who are pursuing careers in musical arts, theatre or drama.

The Family Unification Program (FUP) aims to assist families and youth at risk of homelessness by providing Housing Choice Voucher (HCV) assistance. It targets families facing housing issues that could lead to out-of-home placement for children and youth aged 18-24 who have aged out of foster care. The program offers flexible voucher durations, with extensions available under specific conditions, ensuring support for those in need of stable housing.

The FY26 Bollards Competitive Grant Program aims to enhance pedestrian safety by funding bollard installation projects. This initiative targets areas frequented by large crowds to prevent injuries and potential acts of terrorism. Eligible applicants include State Departments of Transportation and local government entities, with a 100% federal funding share for projects. This program is vital for improving public safety in urban environments.

About Alex’s Lemonade Stand Foundation

Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4- year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding research projects and providing programs to families affected by childhood cancer. ALSF is one of the only childhood cancer research organizations that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.

Bio-Therapeutic Impact Award

The Bio-Therapeutic Impact Award accelerates the development of clinical trials for promising biologic approaches to treating childhood cancer. These approaches include, but are not limited to, immunotherapy, gene therapy and small molecules. The award, intended for investigators who are initiating clinical trials, totals the maximum of $1.8 million awarded over three years.

The IEN-WMAN Mini-Grant Program provides crucial financial support to Indigenous communities and grassroots organizations impacted by mining in the U.S. and Canada. With over $200,000 distributed annually in $4,000 grants, the program aims to address mining-related environmental and health issues. Priority is given to proposals that demonstrate a direct impact on affected communities, particularly Indigenous-led initiatives, ensuring that financial assistance is directed where it is most needed.

The CAFE Group 

We resource leaders, invest in their genius, and bring people together to reimagine what philanthropy can do.

Founded by Liz and Don Thompson, The CAFE Group is a national nonprofit transforming how change is resourced. 

With a focus on education equity, social capital, and philanthropic transformation, we pair catalytic funding, community-rooted leadership development, and cross-sector collaboration to strengthen the people and institutions shaping a more just future. Everything we do is grounded in relationship, because we believe the way resources move matters just as much as where they land.

The 1954 Project Luminary Award

The 1954 Project Luminary Award celebrates transformational education nonprofit leaders dedicated to serving Black students and communities through powerful investments in their organizations' ability to create lasting change.

The Luminary Experience

Each Luminary organization gets more than funding. Through The 1954 Project, leaders gain a community, a platform, and space to grow with tailored support over the course of the three year journey.​

• $1 Million, Unrestricted: Catalytic funding to expand what’s working.
• Leadership Coaching + Capacity Support: Guidance from peers and experts who are committed to helping you build a lasting, impactful organization.
• National Network: Luminaries join a powerful community of innovators, change-makers, and visionaries driving systemic progress to support students and communities across the U.S.

The 1954 Project’s Impact Areas

We focus on three interconnected areas critical to advancing equity:

• Innovation in Teaching and Learning: Create education models that center Black students through culturally affirming approaches that challenge traditional structures and transform how learning happens, ultimately serving all students. 
• Diversity in Education: Build pathways that increase and sustain Black educators and education leaders who transform where and how students learn.
• Pathways to Economic Mobility: Build pathways to wealth, ownership, and economic power for Black students, families, and communities through innovative educational programming.

Our Selection Criteria

We seek out extraordinary applicants who embody our values and vision across three categories:

Leader: We look for leaders whose influence and vision contribute to the collective well-being and advancement of the Black community. These leaders:

• Are Visionary: They demonstrate a strategic and pragmatic mindset, articulating a transformative vision for significant, positive change.
• Show Demonstrated Commitment: They embody steadfast dedication to your cause, inspiring and influencing others, and galvanizing community involvement.
• Are Adaptive: They assertively tackle challenges, turning setbacks into opportunities for innovation, while maintaining humility and thoughtfulness in problem-solving.

Organization: We look for organizations that drive significant change, anchored by a deep love for people and driven by the genius within communities of color. These organizations: 

• Have a Defined Problem: They clearly identify the issue they are addressing and explain in detail how your organization tackles root causes. 
• Take a Strategic Approach: They have clear, measurable, and achievable organizational goals with a well-defined strategy informed by thorough analysis. 
• Show Demonstrated Impact: They have a tested model that has produced positive results, incorporating continuous learning and iteration. 
• Have a Transformation Plan: They present a clear plan for using the $1M award to advance your organization's mission, vision, and long-term goals. 
• Embrace Collaboration: They use collaborate to build partnerships based on trust, love, and common goals. 

Radical Imagination: We seek leaders who challenge and redesign societal norms to build a just and equitable future. They demonstrate:

• Community-Rooted Leadership: They maintain and cultivate genuine community ties, integrating professional expertise and personal commitment to drive visionary, impactful strategies. 
• Long-Term Commitment: They are in it for the long haul, committing to sustained impact across generations and prioritizing long-lasting solutions over short-term gains. 
• Collectivism: They embody the philosophy of "I am because we are," actively engaging in collaborative networks and fostering community-reflective solutions. 

The NIHCM Foundation's Trade Journalism Award honors outstanding reporting aimed at specialty audiences, focusing on enhancing the affordability, accessibility, and quality of healthcare in the U.S. A $15,000 prize will be awarded to the winner. Entries, which can be individual stories or series published in 2025, must provide valuable insights relevant to health plans, policymakers, and stakeholders, addressing the critical issues of rising healthcare costs and access.

The NIHCM Foundation's Policy Research Award honors outstanding research published in peer-reviewed journals that significantly contributes to improving the affordability, accessibility, and quality of healthcare in the U.S. The winner will receive a $20,000 prize. Eligible entries must address healthcare affordability and be published in 2025, with a maximum of three submissions per author. This award aims to recognize innovative insights that can inform policymakers and stakeholders in the healthcare sector.

The FY26 Toxic Exposures Research Program (TERP) Clinical Trial Award supports clinical trials aimed at addressing health issues from military-related toxic exposures. This initiative encourages collaboration through a Partnering Principal Investigator Option, enhancing interdisciplinary research efforts. Projects range from early-phase trials to large-scale studies, focusing on innovative treatments and management strategies for affected populations. The goal is to expedite the translation of research findings into effective clinical applications.

Our Story

Established over 50 years ago, our founders redefined local philanthropy, fostering connections around a shared sense of place and purpose. As Virginia's largest community foundation, we bring people together to pool resources, co-create solutions and align actions for impactful change in the Richmond region.

Scholarships are offered to students living in the Richmond region and other Virginia locations. Each scholarship was established by a generous individual, family, or organization with a desire to assist high school students, recent high school graduates, and adult learners to continue their education. 

Rappahannock Industrial Academy Alumni Association Scholarship

Rappahannock Industrial Academy Alumni Association Scholarship Fund was established in 2004 by the Academy’s alumni to provide educational scholarships to qualifying African American students residing in one of the following counties: Essex, King and Queen and Middlesex. Students may attend public or private school.

Recipients will be encouraged to use this educational opportunity to enrich the lives of others in their home community. The Rappahannock Industrial Academy opened its doors on January 1, 1902 to provide secondary education for African American residents in the area. The Alumni Association has for many years awarded scholarships to students from Essex, Middlesex, and King and Queen Counties. 

The DoW Toxic Exposures Translational Research Award aims to foster translational research that bridges military-related toxic exposure studies and clinical applications. This program encourages innovative collaborations by allowing for a Partnering Principal Investigator Option, enhancing interdisciplinary partnerships. By integrating basic science with clinical insights, the initiative seeks to expedite the development of impactful health care products and interventions to address toxic exposures faced by military personnel.

The NIA Expanding Research in AD/ADRD Postbaccalaureate Research Education Program aims to enhance the research workforce by providing intensive research experiences for recent graduates. This initiative supports early-stage investigators in Alzheimer's Disease and related dementias, addressing a critical shortage of researchers in the field. Participants engage in independent research, mentorship, and professional development, equipping them with skills necessary for advanced degrees and research careers in aging and dementia. The program fosters innovation and interdisciplinary collaboration essential for advancing AD/ADRD research.

The Department of Defense Research and Education Program aims to support Historically Black Colleges and Universities and Minority-Serving Institutions by enhancing defense-related research and educational capabilities. This initiative encourages collaboration with other educational institutions and government organizations to increase STEM graduates and strengthen national defense. Eligible applicants include accredited minority institutions and community colleges. The program is open until July 31, 2029, providing a significant opportunity for institutions meeting the defined criteria.

The Native American Research Centers for Health (NARCH) program supports federally-recognized American Indian and Alaska Native Tribes and organizations in advancing health-related research. It aims to enhance research careers and infrastructure through a competitive application process. Funded by the US Dept. of Health & Human Services, this initiative invites eligible entities to apply, ensuring that only high-quality proposals undergo peer review for potential funding.

The David E. Rogers Student Fellowship Award, offered by the New York Academy of Medicine, aims to enhance the educational journey of medical and dental students through impactful community health projects. This initiative supports research endeavors during the summer, providing stipends of $4,000 for up to five selected projects. Eligible candidates must be U.S. citizens or authorized residents, pursuing research that addresses health disparities and the needs of underserved populations.

The Ruth Mitchell Hanson Scholarship is designed to support talented students from Saginaw County pursuing a career in music. Established in memory of Ruth Mitchell Hanson, a passionate composer and music instructor, this scholarship aims to honor her legacy and encourage future musicians. Eligible applicants must have a minimum GPA of 3.25, be high school seniors, and be enrolled full-time in a music program at an accredited college or university. Awards typically range from $500 to $4,000.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) program, supported by the National Institutes of Health, aims to fund pharmacodynamic and pharmacokinetic studies. These studies will assess the biological activity of therapeutic agents, including small molecules and biologics, for diseases prioritized by participating institutes. The initiative emphasizes the development of non-opioid analgesics with minimal addiction risks. Although applications are not currently solicited, this notice encourages potential applicants to prepare collaborative projects.

ATS/PHA Early Career Award

One grant is available for early-career investigators interested in pulmonary hypertension research who are likely to make a strong and sustained impact in PH research. This grant is co-funded by the Pulmonary Hypertension Association and ATS.

Areas of interest for proposals include:

• Investigating the pathophysiology of PH
• Elucidating mechanistic pathways
• Identifying novel therapeutic targets or biomarkers in adult or pediatric pulmonary hypertension

The project should have potential applicability to human pulmonary vascular diseases.

Applicants may request up to $50,000 for one year for salaries or supplies or a combination thereof.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

The Sex Worker Giving Circle Grant, launched by the Third Wave Fund, prioritizes funding for grassroots movements led by individuals directly impacted by gender oppression, especially within the sex work community. With a commitment to gender justice, the grant supports organizations that operate with a participatory approach to grantmaking, enabling them to address systemic inequalities. In recent years, the fund has distributed significant resources to empower and sustain these vital movements across the United States.