Best Grants for Small Nonprofits in Mississippi

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Joe W. and Dorothy Dorsett Brown Foundation's Summer Camp Program aims to support overnight camps for children with special needs, particularly those unable to attend other camps. The program prioritizes STEM education and seeks to mitigate summer learning loss through high-quality instruction and academic enrichment. Only camps located in Louisiana or Mississippi are eligible, and applicants must be non-profit organizations operating for at least three years.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Norfolk Southern Trades on Track SkillPointe Scholarship offers $5,000 scholarships for students pursuing trades education related to the rail industry. Eligible candidates must be enrolled in a post-secondary institution and focused on railway-related trades. With over 1,000 scholarships funded and a mission to close the skills gap, this initiative empowers individuals towards high-demand careers without requiring a four-year degree, ultimately strengthening the workforce and economy.

Strategic Multi-Modal Investment Funds

Recognizing the significance Multi-Modal infrastructure has on the State’s economy and its importance to the citizens for jobs and the transportation of goods and services, the Mississippi Legislature established the Strategic Multi-Modal Investments Fund (SMIF) during the 2023 Regular Session. The SMIF was established to increase the capacity for the movement of freight and increase economic activity at the airports, ports and railroads located in this state and to support long-term economic growth in the state. The legislature provided the necessary authority to initially fund the program up to $30 million.

In continuation of the program, the 2026 Legislative Session earmarked $10 million of Capital Expense funds received by MDOT. In accordance with Miss. Code Ann. § 65-1-901 and rules and regulations established by the Department, MDOT will administer the Strategic Multi-Modal Investments Fund for necessary investments and repairs to airports, ports, and railroads in the state.

In accordance with the legislation, the following goals have been established:

• Goal 1 – Fund projects that increase the capacity for freight movement in the State.
• Goal 2 – Fund projects that increase economic activity at the ports, airports and railroads within the State.
• Goal 3 – Fund projects that support long-term economic growth in the State.

Multi-Modal Transportation Improvement Program

The Multi-Modal Transportation Improvement Program (MTIP) is administered by the Mississippi Department of Transportation for the improvement of airports, ports, railroads, and transit systems in the state.

Airport, port, and rail projects must be related to capital improvements or the rehabilitation of basic infrastructure and outside of the normal operating budget. Transit projects include capital and certain other expenses that meet FTA eligibility requirements. Projects cannot be for routine maintenance or administrative or operational expenses.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Region 4 Small Business Transportation Technical Assistance Center (SBTTAC) aims to empower small businesses by providing essential technical assistance and business development support. Funded by the U.S. Department of Transportation, this initiative will facilitate access to capital resources, connect businesses with key transportation agencies, and ensure compliance with regulatory standards. The program is dedicated to minimizing barriers for small enterprises while fostering a robust support system in the transportation sector.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The Watson-Brown Foundation Grant supports organizations dedicated to preserving the history and culture of the South. It offers various types of grants, including for educational programming and historic preservation, with a focus on southern studies. Eligible recipients include public charities in the southeastern United States. The Foundation's Junior Board of Trustees also awards grants to preservation projects in east central Georgia, emphasizing youth engagement in cultural heritage.

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

The Sidney B. Meadows Scholarship, established in 1989, offers financial support to students pursuing degrees in horticulture across 16 southeastern states. Administered by the Sidney B. Meadows Scholarship Endowment Fund, this scholarship honors the legacy of Sidney B. Meadows, a dedicated advocate for education in the horticultural industry. Applicants must meet specific eligibility criteria related to academic standing and residency, with preference given to those intending to work in the field after graduation.

Entergy’s Open Grants Program in Mississippi aims to enhance community well-being through support for arts, education, poverty solutions, and health initiatives. The program prioritizes requests from organizations with 501(c)(3) status and local projects that improve public access to the arts and promote self-sufficiency. Funding is not available for utility payments, political activities, or religious organizations. Preference is given to projects serving Entergy's customer areas, ensuring community-focused impact.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Southern Partners Fund's Discretionary Fund Grant aims to support grassroots community organizing for social, economic, and environmental justice in the Southeastern United States. It provides financial resources and technical assistance to rural organizations and leaders focused on transformative change. Eligible applicants include self-governed rural groups engaging in advocacy and community development. The fund prioritizes education reform, immigration rights, and voter engagement, allowing up to two requests per year, with a maximum award of $3,500.

The Enbridge Community Grant aims to enhance the quality of life in North American communities through strategic donations and sponsorships. With funding ranging from $1,000 to $10,000, the grant supports organizations focused on safety, education, environmental stewardship, and Indigenous culture. Enbridge encourages early applications, with decisions typically made within eight weeks. The grant seeks to empower local initiatives that foster community strength, vibrancy, and sustainability.

Jack’s Family Fund

At Jack’s Family Restaurants, we’ve always thought of ourselves as one big family — employees and guests alike. Giving back to the communities in which we do business is part of our DNA. That’s why we’ve established the Jack’s Family Fund.

We think of our guests as part of the Jack’s family, and we’ll be there in times of need. With your help, we can make a difference in people’s lives and support those we call family, friends, and neighbors.

Jack's Family Fund Grant

The Jack's Family Fund is a non-profit charitable organization established to provide emergency financial assistance to members of the communities that Jack’s Family Restaurants (JFR) serve. Fund grants are made to assist those who have temporarily found themselves in need, but under normal circumstances are self-sustaining.

Our grants assist with:

• Immediate, short- term needs of individuals who may be victims of disasters or other emergency hardship situations including floods, fires, riots, hurricanes, tornadoes, earthquakes and similar large-scale events, or
• Emergency hardship caused by illness, death, accident, violent crime or other types of personal injury.
• Community 501(c)(3) organizations working to respond to these types of needs on a broad scale.

Types of expenses grants may be awarded for include (but are not limited to):

• funeral expenses
• past due utilities (electric, water, natural gas)
• past due rent/mortgage
• emergency housing

Grants from the Fund are not intended to replace personal or homeowners insurance, federal disaster relief or other types of aid, but rather to assist on an immediate and short-term basis when other sources of assistance are not available.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5430 - Unlocking Value and Opportunities from Carbon Flows in Water Utilities

Grant Information

• Identify carbon flows across drinking water, stormwater, wastewater, and advanced treatment systems. Carbon flows may include source water, stormwater, process emissions, process inputs, residuals, and biogas.
• Identify the most relevant carbon recovery, capture, conversion, storage, and avoidance opportunities.
• Evaluate value creation pathways, including products, avoided costs, and environmental attributes, and mechanisms and partnerships needed to put them into practice.
• Assess how opportunities vary across system types and local contexts by focusing on more common scenarios for utilities.
• Provide practical, research-based insights to support identification, prioritization, evaluation, and advancement of carbon management opportunities under site-specific conditions and constraints.
• Evaluate implications for greenhouse gas (GHG) accounting, environmental attribute claims, and other potential benefits across pathways.

The Waste Management Charitable Contributions Program supports initiatives that enhance environmental stewardship, sustainability education, and community vitality. With a commitment to civic pride and economic development, the program prioritizes organizations that address local needs and promote sustainable practices. Eligible applicants include 501(c)(3) organizations that focus on public purposes, while ineligible requests include funding for operating costs and individual fundraising events. This initiative fosters a collaborative approach to community betterment.

The Coaching Enhancement Grant by the NCAA Division III aims to increase diversity in assistant coaching roles by providing financial support to member institutions. Over two years, selected schools receive $15,000 to cover salaries, requiring a matching contribution. This initiative encourages ethnic minority and gender representation, allowing up to 11 institutions to benefit annually, thus enhancing inclusivity in collegiate sports.

The Stimulating Hematology Investigation: New Endeavors (SHINE) program aims to enhance nonmalignant hematology research aligned with the goals of the NIDDK, NIA, and NHLBI. It invites R01 grant applications focused on innovative and early translational hematology topics, fostering growth in this critical research area. Key deadlines for applications span from February 2025 to October 2027, allowing for both standard and renewal submissions.

The NRP Research Grant Program offers up to $50,000 for healthcare professionals to explore optimal neonatal resuscitation methods. It encourages innovative research addressing gaps in transitional physiology and effective teaching of resuscitation skills. Applications must focus on evidence-based practices and demonstrate potential for meaningful impact in delivery room care. Researchers from Canadian and US institutions are eligible, though applications primarily focused on quality improvement without a research emphasis will not be considered.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

The Mississippi Civil Money Penalty Grant Awards Program aims to utilize Federally Imposed Civil Money Penalty Funds to enhance the quality of care and life for residents in nursing facilities. Eligible applicants include certified nursing facilities, academic institutions, and government agencies. The program supports initiatives that promote resident protection and involvement, while ensuring compliance with CMS standards. Funding may cover relocation expenses, facility improvements, and educational projects, but cannot be used for capital improvements or ongoing operational costs.

About

The Costume Society of America (CSA) is a 501(c)(3) non-profit organization founded on March 23, 1973, and incorporated in the state of New York on September 12, 1973. CSA serves it members, and promotes its goals with national symposia and publications including the journal Dress and its monthly electronic newsletter CSA e-News.

The organization began forming regional groups in 1978. There are six regional groups in the United States and Canada, and one international group. Individual regions hold annual meetings, sponsor programs and publish newsletters.

Our Mission

The Costume Society of America fosters an understanding of appearance and dress practices of people across the globe through research, education, preservation, and design. Our network of members studies the past, examines the present, and anticipates the future of clothing and fashion.

Jim Liles Student Award

 The Jim Liles Student Award is intended to assist students who want to make presentations at a CSA Southeastern Region symposium. These presentations may be on any costume-related topic. The work should be well researched and may or may not be thesis, dissertation, course research project, independent study research, or senior project related. Up to TWO students whose papers are accepted will receive up to $1,000 each to cover travel and other related expenses. The Registration fee will be waived for all student presenters, regardless of whether they receive this award.

About Us

The governing board of the Mississippi Department of Mental Health is composed of nine members appointed by the Governor of Mississippi and confirmed by the State Senate. Members’ terms are staggered to ensure continuity of quality care and professional oversight of services. By statute, the nine-member board is composed of a physician, a psychiatrist, a clinical psychologist, a social worker with experience in the field of mental health, and one citizen representative from each of Mississippi’s five congressional districts (as existed in 1974).

Behavioral Health FY27 - Supported Employment for Transition NOFO

The purpose of the Supported Employment program is to enhance state and community capacity to provide and implement the Individual Placement and Support (IPS) model, an evidence-based supported employment program to transition-aged youth and young adults with serious mental illness/severely emotionally disturbed (SMI/SED), including persons with co-occurring mental and substance use disorders. The expected outcome of the program is to enhance partnerships with MDRS, MDES and CPS to eventually expand Supported Employment Services throughout the state using the IPS model, and have an increase in the number of competitive employment opportunities for transition-aged youth and young adults aged 15-24 with SMI/SED.

Using the IPS model, the Supported Employment Program for Transition-Age Youth will help young adults with mental illnesses discover paths to self-sufficiency and recovery rather than disability and dependence.

The purpose of this funding is to assist with travel expenses for the IPS Employment Specialist(s) and other needed supports to implement the IPS model and to promote gainful employment for young adults who indicate that employment is one of their goals.