Best Operating Grants for Nonprofits in Mississippi

The DanPaul Foundation aims to enhance early childhood development by training teachers and parents, protecting children from abuse, and promoting social responsibility. They provide grants to non-profits for programs that focus on education, health, and welfare of youth. Key initiatives include scholarships, environmental education, and support for underprivileged children. Grant amounts range from a few hundred dollars to $15,000 annually, with a focus on impactful, community-driven projects.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The MAC Underserved Initiative Grant Program aims to enhance access to quality arts programming across all 82 counties in Mississippi. By identifying underserved areas that lack recent grants or services, the Mississippi Arts Commission facilitates outreach and support for local arts initiatives. This program not only promotes cultural engagement but also fosters community development and collaboration among various organizations, ensuring that all citizens can participate in diverse artistic experiences.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.

The MAC Mini-Grants for Organizations provide vital funding to support professional development and capacity building for Mississippi-based arts organizations. Eligible applicants, including non-profit organizations and local government entities, can receive matching grants to engage professional artists for various activities like performances, workshops, and curriculum development. Priority is given to organizations in underserved areas and those led by BIPOC individuals. This initiative aims to enhance public engagement and appreciation for the arts statewide.

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

Ameriprise Community Grants focus on supporting nonprofits that enhance community vitality and meet basic needs. With over 120 years of commitment to philanthropy, Ameriprise Financial engages employees in volunteerism and grantmaking. Key giving areas include hunger relief, housing stability, and community development. Priority is given to organizations with active volunteer engagement from Ameriprise advisors and employees, creating a meaningful impact on financial independence and community resilience.

Mississippi Maternal Health Project

The Women’s Foundation of Mississippi is now accepting grant proposals for the Mississippi Maternal Health Project. We are seeking community-based, equity-centered strategies from nonprofit organizations that have a proven track record in maternal and infant health. These organizations will lead interventions in East Biloxi, Jackson, and Sunflower County, Mississippi. 

Funding Opportunity

WFM intends to award grants ranging from $75,000 to $100,000 each year for projects that will operate over three years. This request for proposals is open to nonprofit organizations located in Mississippi that provide services in East Biloxi, Jackson, and Sunflower County, Mississippi.

Submission Requirements

The Mississippi Maternal Health Project’s goal is to improve maternal and infant health by reducing maternal mortality, infant mortality, and preterm births through expanded access to comprehensive maternal health services and early interventions. 

We are prioritizing projects that clearly demonstrate measurable outcomes in maternal and infant health. These projects should be deeply rooted in the three service areas and trusted by women and families. We aim to serve populations with the greatest racial and geographic disparities. Additionally, we are committed to learning, data collection, and continuous improvement to inform statewide system changes. 

Proposals must address at least one or two of the following outcomes during the three-year grant cycle for consideration: 

• Expanded equitable access to quality care for 1,500 low-income and at-risk women, with at least 75% enrolled in health or support services during the first trimester. 
• Enhanced local capacity with 150 trained providers and sustained collaboration networks among healthcare and community partners. 
• Embed community voice and data-driven learning into statewide systems, culminating in a maternal health sustainability policy plan by 2028

The MAC Operating Grant supports arts-focused organizations in Mississippi, enabling them to cover essential expenses like salaries, marketing, and rent. These grants are tailored for nonprofits with a primary mission in the arts, encouraging them to maintain financial stability while enhancing community access to artistic programming. Eligible organizations must have been established for at least two years and demonstrate a commitment to arts development through diverse programs. This initiative aims to foster cultural growth and strengthen community ties through the arts.

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

Toyota Motor Manufacturing, Mississippi, Inc. (TMMMS) Grants aim to create impactful community partnerships through funding initiatives that enhance quality of life. The program focuses on STEM education and workforce readiness, supporting eligible 501(c)(3) nonprofits, public schools, and governmental organizations in specific counties. Toyota emphasizes sustainable, long-term benefits, engaging volunteers and sharing expertise to foster inclusivity and address pressing community challenges.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

Tides Foundation

Tides is a partner for justice in the social sector, working closely with doers and donors to build the power of historically excluded groups who face systemic barriers. We provide fiscal sponsorship, donor advised funds, impact investing, and a variety of grantmaking solutions to advance social justice and equity. 

Through Tides Foundation, we partner with individuals and families, foundations, corporations, and social change leaders to design and deliver social impact initiatives that shift decision-making power back to the communities we serve. Our mission is our North Star — and a beacon for those who share our commitment to social justice. Together, we work to shift resources and power to communities historically denied both, so they can create a just and equitable future.

Neighborhood Power Grant 

The VYV Neighborhood Power grant entails a swift and concentrated allocation of resources to a designated geographic area to attain immediate, quantifiable outcomes within that specific area before or immediately following a pivotal date.  

The grant is designed to be a short cycle, rapid response investments in esteemed neighborhood-based organizations and leaders who mobilize civic participation within a defined local footprint. These grants support small teams collaborating closely with the community to enhance turnout and engagement around pivotal civic events.  

The tiered structure ensures a “right need, right time” approach by matching funding to an organization’s specific capacity and geographic footprint. 

Tier 1: Surgical Focus

• The Target: Small, grassroots organizations or neighborhood civic associations. 
• The Logic: This is laser-focused on SPLC-priority precincts. These are majority-minority areas where voters of color have lower-than-average turnout and face structural barriers. 
• The Footprint: Designed for a highly localized reach of approximately 2,000 to 5,000 voters. 

Tides Foundation

Tides is a partner for justice in the social sector, working closely with doers and donors to build the power of historically excluded groups who face systemic barriers. We provide fiscal sponsorship, donor advised funds, impact investing, and a variety of grantmaking solutions to advance social justice and equity. 

Through Tides Foundation, we partner with individuals and families, foundations, corporations, and social change leaders to design and deliver social impact initiatives that shift decision-making power back to the communities we serve. Our mission is our North Star — and a beacon for those who share our commitment to social justice. Together, we work to shift resources and power to communities historically denied both, so they can create a just and equitable future.

Neighborhood Power Grant 

The VYV Neighborhood Power grant entails a swift and concentrated allocation of resources to a designated geographic area to attain immediate, quantifiable outcomes within that specific area before or immediately following a pivotal date.  

The grant is designed to be a short cycle, rapid response investments in esteemed neighborhood-based organizations and leaders who mobilize civic participation within a defined local footprint. These grants support small teams collaborating closely with the community to enhance turnout and engagement around pivotal civic events.  

The tiered structure ensures a “right need, right time” approach by matching funding to an organization’s specific capacity and geographic footprint. 

Tier 2: Emergent Opportunity Areas A

• The Target: Small-to-medium-sized organizations.
• The Logic: Supports groups ready to scale beyond a single neighborhood into “place-based clusters,” such as specific cultural corridors. 

The Community Foundation of Greater Memphis offers Nonprofit Capacity Building Grants to enhance the organizational health of nonprofits in the Mid-South. These one-time financial grants, averaging $15,000 with a total of $210,000 available, are for projects that improve governance and management, rather than direct programming. Organizations must raise matching funds dollar-for-dollar to leverage additional resources. Eligibility requires a reviewed profile on LIVEGIVEmidsouth.org and meeting specific operational criteria.

The Emergency Community Water Assistance Grants in Mississippi support eligible communities in preparing for or recovering from emergencies that threaten safe drinking water. These grants can be used for water transmission lines, construction of new water sources, and other related needs. Open to state and local governments, nonprofit organizations, and federally recognized tribes, this program aims to ensure reliable access to clean water in rural areas, particularly after natural disasters.

The Water & Waste Disposal Loan & Grant Program in Mississippi offers vital funding to enhance drinking water systems, sewage disposal, solid waste management, and storm water drainage for rural households and businesses. Eligible applicants include local governments, private nonprofits, and tribes facing challenges in securing commercial credit. Funds can be used for construction, legal fees, land acquisition, and other essential project costs. This program aims to ensure access to clean water and sanitation in underserved areas.

The Hancock Whitney Opportunity Grant, in collaboration with the Greater New Orleans Foundation, invites applications from eligible nonprofits starting October 7, 2025. This grant aims to enhance capacity building and sustainability for organizations focused on food insecurity, workforce development, and youth programs. Eligible applicants include 501(c)(3) organizations serving low to moderate-income communities within Hancock Whitney's service areas, fostering impactful changes with AmeriCorps support.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.