Best Operating Grants for Nonprofits in Mississippi

The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The MAC Underserved Initiative Grant Program aims to enhance access to quality arts programming across all 82 counties in Mississippi. By identifying underserved areas that lack recent grants or services, the Mississippi Arts Commission facilitates outreach and support for local arts initiatives. This program not only promotes cultural engagement but also fosters community development and collaboration among various organizations, ensuring that all citizens can participate in diverse artistic experiences.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

The Community Foundation of Greater Memphis offers Nonprofit Capacity Building Grants to enhance the organizational health of nonprofits in the Mid-South. These one-time financial grants, averaging $15,000 with a total of $210,000 available, are for projects that improve governance and management, rather than direct programming. Organizations must raise matching funds dollar-for-dollar to leverage additional resources. Eligibility requires a reviewed profile on LIVEGIVEmidsouth.org and meeting specific operational criteria.

The Emergency Community Water Assistance Grants in Mississippi support eligible communities in preparing for or recovering from emergencies that threaten safe drinking water. These grants can be used for water transmission lines, construction of new water sources, and other related needs. Open to state and local governments, nonprofit organizations, and federally recognized tribes, this program aims to ensure reliable access to clean water in rural areas, particularly after natural disasters.

The Water & Waste Disposal Loan & Grant Program in Mississippi offers vital funding to enhance drinking water systems, sewage disposal, solid waste management, and storm water drainage for rural households and businesses. Eligible applicants include local governments, private nonprofits, and tribes facing challenges in securing commercial credit. Funds can be used for construction, legal fees, land acquisition, and other essential project costs. This program aims to ensure access to clean water and sanitation in underserved areas.

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

Toyota Motor Manufacturing, Mississippi, Inc. (TMMMS) Grants aim to create impactful community partnerships through funding initiatives that enhance quality of life. The program focuses on STEM education and workforce readiness, supporting eligible 501(c)(3) nonprofits, public schools, and governmental organizations in specific counties. Toyota emphasizes sustainable, long-term benefits, engaging volunteers and sharing expertise to foster inclusivity and address pressing community challenges.

The Hancock Whitney Opportunity Grant, in collaboration with the Greater New Orleans Foundation, invites applications from eligible nonprofits starting October 7, 2025. This grant aims to enhance capacity building and sustainability for organizations focused on food insecurity, workforce development, and youth programs. Eligible applicants include 501(c)(3) organizations serving low to moderate-income communities within Hancock Whitney's service areas, fostering impactful changes with AmeriCorps support.

The MAC Mini-Grants for Organizations provide vital funding to support professional development and capacity building for Mississippi-based arts organizations. Eligible applicants, including non-profit organizations and local government entities, can receive matching grants to engage professional artists for various activities like performances, workshops, and curriculum development. Priority is given to organizations in underserved areas and those led by BIPOC individuals. This initiative aims to enhance public engagement and appreciation for the arts statewide.

The Nissan Foundation Grants support nonprofit organizations that promote cultural diversity and heritage. Established in 1992, the foundation focuses on enhancing community quality of life where Nissan operates. Eligible organizations must have 501(c)(3) status, be active for over three years, and serve specific communities. Ineligible programs include those not aligned with the foundation's mission, such as disease advocacy and political activities. The foundation does not provide multi-year grants, but organizations can reapply for funding in subsequent cycles.

The Nordstrom Community Grant focuses on supporting youth and families by providing over $1 million in grants annually. It aims to assist grassroots organizations that address essential community needs such as food, shelter, and clothing, as well as creating opportunities for economic mobility through mentorship and workforce development. Eligible organizations must be 501(c)(3) nonprofits located in areas where Nordstrom operates. Applications are encouraged for those meeting these criteria.

Mississippi Maternal Health Project

The Women’s Foundation of Mississippi is now accepting grant proposals for the Mississippi Maternal Health Project. We are seeking community-based, equity-centered strategies from nonprofit organizations that have a proven track record in maternal and infant health. These organizations will lead interventions in East Biloxi, Jackson, and Sunflower County, Mississippi. 

Funding Opportunity

WFM intends to award grants ranging from $75,000 to $100,000 each year for projects that will operate over three years. This request for proposals is open to nonprofit organizations located in Mississippi that provide services in East Biloxi, Jackson, and Sunflower County, Mississippi.

Submission Requirements

The Mississippi Maternal Health Project’s goal is to improve maternal and infant health by reducing maternal mortality, infant mortality, and preterm births through expanded access to comprehensive maternal health services and early interventions. 

We are prioritizing projects that clearly demonstrate measurable outcomes in maternal and infant health. These projects should be deeply rooted in the three service areas and trusted by women and families. We aim to serve populations with the greatest racial and geographic disparities. Additionally, we are committed to learning, data collection, and continuous improvement to inform statewide system changes. 

Proposals must address at least one or two of the following outcomes during the three-year grant cycle for consideration: 

• Expanded equitable access to quality care for 1,500 low-income and at-risk women, with at least 75% enrolled in health or support services during the first trimester. 
• Enhanced local capacity with 150 trained providers and sustained collaboration networks among healthcare and community partners. 
• Embed community voice and data-driven learning into statewide systems, culminating in a maternal health sustainability policy plan by 2028

The MAC Operating Grant supports arts-focused organizations in Mississippi, enabling them to cover essential expenses like salaries, marketing, and rent. These grants are tailored for nonprofits with a primary mission in the arts, encouraging them to maintain financial stability while enhancing community access to artistic programming. Eligible organizations must have been established for at least two years and demonstrate a commitment to arts development through diverse programs. This initiative aims to foster cultural growth and strengthen community ties through the arts.

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

The Hansen Family Foundation Grant seeks to empower organizations that uphold the American values of life, liberty, and the pursuit of happiness. Focused on diverse causes like children, education, animals, environmental conservation, humanitarian efforts, and arts, the foundation is committed to supporting initiatives that create positive change. Eligible applicants must be 501(c)(3) nonprofits, while political campaigns and organizations with high budgets or overheads are ineligible. This grant fosters impactful contributions to society.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

Tides Foundation

Tides is a partner for justice in the social sector, working closely with doers and donors to build the power of historically excluded groups who face systemic barriers. We provide fiscal sponsorship, donor advised funds, impact investing, and a variety of grantmaking solutions to advance social justice and equity. 

Through Tides Foundation, we partner with individuals and families, foundations, corporations, and social change leaders to design and deliver social impact initiatives that shift decision-making power back to the communities we serve. Our mission is our North Star — and a beacon for those who share our commitment to social justice. Together, we work to shift resources and power to communities historically denied both, so they can create a just and equitable future.

Neighborhood Power Grant 

The VYV Neighborhood Power grant entails a swift and concentrated allocation of resources to a designated geographic area to attain immediate, quantifiable outcomes within that specific area before or immediately following a pivotal date.  

The grant is designed to be a short cycle, rapid response investments in esteemed neighborhood-based organizations and leaders who mobilize civic participation within a defined local footprint. These grants support small teams collaborating closely with the community to enhance turnout and engagement around pivotal civic events.  

The tiered structure ensures a “right need, right time” approach by matching funding to an organization’s specific capacity and geographic footprint. 

Tier 1: Surgical Focus

• The Target: Small, grassroots organizations or neighborhood civic associations. 
• The Logic: This is laser-focused on SPLC-priority precincts. These are majority-minority areas where voters of color have lower-than-average turnout and face structural barriers. 
• The Footprint: Designed for a highly localized reach of approximately 2,000 to 5,000 voters. 

Tides Foundation

Tides is a partner for justice in the social sector, working closely with doers and donors to build the power of historically excluded groups who face systemic barriers. We provide fiscal sponsorship, donor advised funds, impact investing, and a variety of grantmaking solutions to advance social justice and equity. 

Through Tides Foundation, we partner with individuals and families, foundations, corporations, and social change leaders to design and deliver social impact initiatives that shift decision-making power back to the communities we serve. Our mission is our North Star — and a beacon for those who share our commitment to social justice. Together, we work to shift resources and power to communities historically denied both, so they can create a just and equitable future.

Neighborhood Power Grant 

The VYV Neighborhood Power grant entails a swift and concentrated allocation of resources to a designated geographic area to attain immediate, quantifiable outcomes within that specific area before or immediately following a pivotal date.  

The grant is designed to be a short cycle, rapid response investments in esteemed neighborhood-based organizations and leaders who mobilize civic participation within a defined local footprint. These grants support small teams collaborating closely with the community to enhance turnout and engagement around pivotal civic events.  

The tiered structure ensures a “right need, right time” approach by matching funding to an organization’s specific capacity and geographic footprint. 

Tier 2: Emergent Opportunity Areas A

• The Target: Small-to-medium-sized organizations.
• The Logic: Supports groups ready to scale beyond a single neighborhood into “place-based clusters,” such as specific cultural corridors.