Best Large Grants for Nonprofit Organizations in Mississippi

Costco Foundation provides Mississippi 501(c)(3) nonprofits focused on children, education, and health and human services with monetary support for community programs. Eligible organizations must show clear community need, measurable outcomes, collaboration, and a broad funding base. Mississippi nonprofits seeking larger program support may be eligible if they meet these priorities and guidelines.

Nonprofit 501(c)(3) organizations with innovative human services programs, including those in Mississippi, can seek support for new approaches to social problems. Creag Foundation considers organizations that have held 501(c)(3) status for at least one year and are developing creative solutions to societal issues; funding is by invitation, beginning with a letter of inquiry.

Nonprofit 501(c)(3) organizations, government entities, and educational institutions in Mississippi can receive in-kind intermodal transportation services and donated railroad equipment to support community services, military, and first responder initiatives. Grants from CSX Foundation help eligible organizations reduce transportation costs or obtain railroad-related materials within the CSX rail network and designated service areas.

Early-stage nonprofit and mission-driven for-profit organizations tackling major social or environmental challenges can access funding and support from Draper Richards Kaplan Foundation. Focused on scalable, systems-based solutions for underserved communities, this opportunity offers up to US $300,000 plus intensive capacity-building; Mississippi organizations that meet these criteria may be competitive applicants.

Nonprofit organizations, educational institutions, government programs, and volunteer fire companies in Mississippi can seek funding for safety, education, and community development initiatives. Grants from State Farm Companies Foundation help support projects like auto and home safety, disaster preparedness, affordable housing, financial literacy, job training, food insecurity, and K–12 or higher education success programs across the U.S.

Nonprofit cultural institutions in Mississippi and across the U.S. can apply for the Hearst Foundation’s culture grants, which typically provide more than US $100,000 for arts and science programming. Eligible 501(c)(3)s with audited expenses over $2 million may seek program, capital, or limited general/endowment support, especially for arts education, artist training, and STEAM initiatives.

Nonprofit 501(c)(3) organizations in Mississippi with audited expenses over $2 million can seek social service funding to address chronic poverty and strengthen families. William Randolph Hearst Foundation provides U.S. nonprofits with program, capital, or general operating support over $100,000, prioritizing scalable efforts in housing, food access, economic development, reentry, youth development, and related services.

Nonprofits and social enterprises in Mississippi working on education, childhood health, or family economic stability projects serving urban low-income children can seek more than US $50,000 for project support or scaling. The Michael & Susan Dell Foundation funds organizations with a U.S. Federal Taxpayer Identification Number whose work aligns with its mission and values.

The Oriental Trading Company Corporate Giving Program focuses on enhancing the lives of children through education, youth programming, healthcare, and human services. With a commitment to making the world a better place, they support organizations that are tax-exempt under Section 501(c)(3) or public educational institutions. Their initiatives aim to foster community partnerships and provide essential resources to youth in need, ensuring they have access to vital services and opportunities for growth.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

Mississippi nonprofits focused on health, education, or humanitarian services can access funding through Semnani Family Foundation to support marginalized and vulnerable communities. Organizations working on healthcare access, women and children’s health, disaster relief, literacy, or related human and social services may be eligible, alongside similar groups across the U.S. and internationally.

Grants from Sidney Stern Memorial Trust help Mississippi nonprofit organizations fund charitable, educational, scientific, and medical programs that significantly benefit their communities. Eligible applicants are 501(c)(3) organizations with tax-exempt status, using awarded funds within the U.S.; Mississippi nonprofits with strong management and broad community impact may be competitive.

Nonprofit and charitable organizations in Mississippi running community projects or events in arts, education, environment, or health and wellness can apply for Stantec’s Community Engagement Grant. Eligible initiatives should be near Stantec office locations; funding may support short- or long-term projects, as well as community events such as tournaments, dinners, or galas.

The Audacious Project Grant Program, supported by TED, aims to catalyze social impact by funding bold solutions to pressing global challenges. This initiative encourages changemakers to develop transformative ideas into actionable plans, with a focus on various issues, including health and education. The program operates on a rolling basis, welcoming applications from individuals and organizations with a proven track record and a budget of at least $2 million. Join us in creating lasting change for a better world.

Nonprofit 501(c)(3) organizations in Mississippi working on basic needs, workforce development, community development, arts, environment, or inclusion programs can seek sponsorship support for community-focused initiatives. Bank of America Charitable Foundation’s regional U.S. sponsorships may benefit nonprofits advancing economic mobility, preserving neighborhoods, addressing hunger and shelter, or enhancing local cultural and sports activities.

Mississippi nonprofit organizations working on environment, justice, human rights, or related community programs can access funding through the Zegar Family Foundation, which considers grants by invitation only. Support may also extend to science and medicine, human services, arts and culture, education, health, and community development initiatives with meaningful, tangible impact.

Mississippi 501(c)(3) nonprofits addressing hunger, food access, waste reduction, health, youth development, or community resilience can access funding through Kroger Foundation in the form of cash donations, sponsorships, gift cards, or product support. Organizations advancing Zero Hunger | Zero Waste or related community programs may be eligible across the U.S.

Nonprofit 501(c)(3) organizations and aligned for-profits in Mississippi can seek the Storytelling Grant to showcase the impact of their preservation, education, or wellness work. Jesse W Couch Charitable Foundation offers more than US $50,000 to help eligible U.S. organizations create compelling stories about conservation, historic preservation, education, mental health, and related community initiatives.

Nonprofit 501(c)(3) organizations serving Mississippi and the broader Southern region can seek program support for education, poverty relief, health, veterans, families, and related services. Robinson Foundation supports large, single-year grants that create tangible, meaningful impact, including work in animal welfare, disaster relief, nature and wildlife conservation, and religious or spiritual endeavors.

Nonprofit 501(c)(3) organizations working on community services, environmental conservation, or peacebuilding in Mississippi can seek support for their programs and initiatives. Dudley T Dougherty Foundation provides flexible funding to charitable organizations, which may benefit Mississippi nonprofits planning impactful projects that respect people, life, and the environment.

Mississippi 501(c)(3) nonprofits, public schools, and eligible local government entities can seek funding for education, environmental, entrepreneurship, and community enrichment projects that serve Georgia-Pacific communities. Focused on strengthening areas near its manufacturing facilities, Georgia-Pacific Foundation invites organizations within 30 miles of a GP community to apply for support that improves long-term community well-being.

Mississippi 501(c)(3) organizations, schools, government agencies, religious institutions, and qualifying civic, youth, and veterans groups can access funding through J.B. Hunt for health care, veterans’ support, education, and crisis management projects. Eligible U.S. nonprofits must be in good IRS standing, have at least two years of community advocacy, and keep overhead below 25% of expenses.

With a mission to strengthen communities, Ameriprise Financial provides Mississippi nonprofits with support for basic needs, community vitality, and volunteer-driven programs. Eligible 501(c)(3) organizations serving U.S. clients may apply for projects such as hunger relief, shelter and supportive housing, workforce readiness, financial literacy, and community or cultural development, especially where Ameriprise volunteers are actively engaged.

RBC Foundation – USA aims to enhance community quality of life by supporting non-profit organizations that promote diversity and positive change. In 2023, it awarded over $2.8 million in grants, prioritizing youth programs for ages 15-29, arts access for diverse populations, and mental well-being initiatives. The foundation encourages sustainable projects that foster economic independence, providing critical support for education, mental health, and cultural enrichment, thereby making a significant impact across various communities.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

Nonprofit 501(c)(3) organizations in Mississippi working on youth education, housing, food security, or environmental stewardship can apply for Chick Fil A Foundation’s True Inspiration Awards, with grants of US $30,000 - US $350,000. Programs serving underserved youth and their families, including food access, housing support, and community or environmental projects, may be competitive.

Nonprofit organizations working on poverty alleviation, disability services, disaster relief, or human and social services, including those in Mississippi, can apply for Gupta Family Foundation’s US $5,000 - US $250,000 grants. This private foundation supports smaller, non-sectarian organizations worldwide that help disadvantaged people become self-reliant and are led by deeply committed founders or successors.