Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement -- Cycle 1 2026
Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $22,000,000
The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.
Addiction & Substance Use Disorders
Mental Health & Psychiatric Diseases
Cardiovascular Diseases & Systems
+2 more
Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed) (348960)
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $400,000
This funding opportunity aims to support Early Stage Investigators (ESIs) in conducting preclinical HIV/AIDS research using Nonhuman Primate (NHP) models. Eligible applicants must have at least two years of postdoctoral experience and be within ten years of their terminal degree. The initiative aligns with the NIH Strategic Plan for HIV and HIV-Related Research, targeting the reduction of HIV incidence, development of therapies, and advancement in research areas related to HIV.
HIV / AIDS
Chipotle Cultivate Foundation Grant Program
Chipotle Cultivate Foundation
Private
United States
Unspecified amount
The Chipotle Cultivate Foundation Grant Program supports 501(c)3 non-profits dedicated to making real food accessible and fostering community growth. Established in 2011, this initiative aligns with Chipotle's mission to cultivate a better world. Eligible organizations can apply through an invitation-only process, focusing on those paving the way for a better future. The foundation also offers mentorship and resources to innovative ventures in the food industry.
Farms & Farming
Nutrition & Healthy Eating
Food Access & Hunger
+1 more
Grief Reach: Changemaker Supported Community Expansion Cycle- up to $160,000
National Alliance for Children's Grief (NACG)
Private
United States
Up to US $160,000
The Grief Reach grant program, supported by the New York Life Foundation and the National Alliance for Children's Grief, invites innovative community expansion proposals to better serve grieving children. Eligible organizations can apply for funding up to $160,000 to enhance their programs, focusing on unique community needs. By collaborating with the Judi's House/JAG Institute, participants will receive essential training and resources for impactful program evaluation, fostering a supportive environment for children and families facing grief.
Mental Health & Psychiatric Diseases
Youth Services
Family Services
+1 more
Grief Reach: Changemaker Supported Community Expansion Cycle - up to $110,000
National Alliance for Children's Grief (NACG)
Private
United States
Up to US $110,000
The Grief Reach: Changemaker Supported Community Expansion Cycle offers up to $110,000 to enhance community programs for grieving children. Organizations are encouraged to innovate and expand their services to better meet community needs. The initiative, in partnership with the Judi’s House/JAG Institute, emphasizes training and resources for effective program evaluation over a three-year period, culminating in impactful community expansion projects.
Children’s Mental Health
Mental Health & Psychiatric Diseases
Family Services
+1 more
HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.
Epidemiology & Public Health
Addiction & Substance Use Disorders
Health Care Access & Delivery
+3 more
Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $130,000
The Mentored Career Development Award (K01) from the NIH aims to diversify the biomedical research workforce by supporting candidates from underrepresented backgrounds. It provides mentoring and training in research independence, focusing on cardiovascular, pulmonary, hematologic diseases, and sleep disorders. Eligible institutions can guide faculty members in special studies, but applicants should not lead their own clinical trials. This initiative promotes diversity and enhances research capability in health disparities populations.
Cardiovascular Diseases & Systems
Hematological Systems
Respiratory Diseases & Systems
+2 more
Bonnie Sorenson Scudder Scholarship
Community Foundation of Northern Illinois
Private
United States
Unspecified amount
The Bonnie Sorenson Scudder Scholarship aims to support female students aspiring to become teachers, particularly those passionate about women's physical education. Established in memory of Bonnie Sorenson Scudder, a dedicated physical education teacher at Harvard High School, this scholarship encourages future educators to continue her legacy. For more details, contact Marcia Miller at Harvard High School.
Academic Scholarship Programs
Education - Higher Education
Kinesiology & Sports Medicine
+3 more
United States Adult Cystic Fibrosis Association (USACFA): Higher Education Scholarship
United States Adult Cystic Fibrosis Association (USACFA)
Association/Society
United States
Up to US $2,500
The United States Adult Cystic Fibrosis Association (USACFA) offers a Higher Education Scholarship, honoring Lauren Melissa Kelly. This scholarship awards up to $2500 to two adults with cystic fibrosis pursuing various educational paths. Applicants must show proof of enrollment for the relevant academic year and can cover education-related costs, including tuition and materials. This initiative not only supports education but also commemorates Lauren's legacy, inspiring others to pursue their dreams despite challenges.
Cystic Fibrosis
Academic Scholarship Programs
Education - Higher Education
+1 more
Music Therapy Grants
Music Movement
Association/Society
United States
US $1,500 - US $2,500
Music Movement offers grants for music therapy aimed at children and young adults with Autism Spectrum Disorder (ASD) and other developmental challenges. Grants typically range from $1,500 to $2,500, providing financial relief to families seeking therapeutic resources. Eligible applicants include legal guardians of children in the U.S. who select qualified therapists. The organization focuses on enhancing communication, social skills, and emotional well-being through music, benefiting diverse communities and promoting personal growth.
Autism
Children With Disabilities
Music Education
Instrument Donations Program
Music Movement
Association/Society
United States
US $500 - US $1,500 in in-kind support
The Instrument Donations Program by Music Movement supports children and young adults with Autism and learning differences by providing funding for musical instruments. This initiative fosters self-expression, personal growth, and emotional well-being through music. Grants typically range from $500 to $1,500 and are available to applicants within the United States. The program encourages artistic development and enhances social skills, making a significant impact on the lives of those facing developmental challenges.
Music
Autism
Children With Disabilities
Independent Living Initiatives
Music Movement
Association/Society
United States
US $1,500 - US $5,000
Music Movement's Independent Living Initiatives grant supports individuals with Autism and developmental differences in the U.S. Grants, typically ranging from $1,500 to $5,000, aid in various areas including independent living, camps, and continued education. Applicants must be legal guardians of eligible individuals aged 18 and older. The grant portal will reopen for submissions on March 28, 2026, encouraging early review of guidelines to ensure complete applications.
Music
Autism
Physical Therapy
Melanoma Career Development Award (CDA)- New Application
Melanoma Research Foundation
Private
United States
Up to US $50,000
The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.
Cancer / Oncology
Pediatric Cancers
Skin Diseases & Dermatology
ASF Olin Fellowships
Atlantic Salmon Federation (ASF)
Private
Canada, United States
C $1,000 - C $3,000
The Atlantic Salmon Federation Olin Fellowships support individuals aiming to enhance their knowledge and skills in salmon conservation and management. These fellowships are available annually for various pursuits, including research and graduate studies, without the requirement of being enrolled in a degree program. Eligible applicants must be legal residents of the U.S. or Canada, and the fellowships can be conducted at accredited institutions or active management programs.
Ichthyology (Fish)
Fisheries
NMDP Barbara Buchbinder Nurse Research Program Grant
National Marrow Donor Program
Private
United States
US $25,000
The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.
Children’s Health & Pediatrics
Hematological Systems
Cell Biology
+1 more
Alzheimer’s Association: Center for Dementia Respite Innovation Grant (CDRI)
Alzheimer's Association
Private
United States
US $50,000 - US $100,000
The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.
Dementia & Alzheimer’s Disease
Caregiver Support / Respite Care
Melanoma: Established Investigator Award
Melanoma Research Foundation
Private
United States
Up to US $125,000
The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.
Cancer / Oncology
Pediatric Cancers
Skin Diseases & Dermatology
Troutville Volunteer Fire Department Scholarship Fund
Community Foundation Serving Western Virginia
Private
United States
Approximately US $1,000
Troutville Volunteer Fire Department Scholarship Fund
Fund provides higher educational scholarship assistance to deserving students.
Amount
Education - Higher Education
Emergency Medical Care & Services
Career / College Preparation
+2 more
MRF Breakthrough Consortium (MRFBC) Young Investigator Team Award to Advance the Field of Translational Immuno-Oncology
Melanoma Research Foundation
Private
United States
Up to US $150,000
The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.
Cancer / Oncology
Skin Diseases & Dermatology
Pediatric Cancers
Direct-to-Consumer Distribution of HIV and other STI Self-Tests
Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity aims to enhance a web-based ordering portal for distributing 1.5 million HIV and STI self-tests to high-burden communities. By optimizing access to these self-tests, the initiative seeks to raise awareness, prevent new infections, and improve the health outcomes of users, thereby contributing to better overall public health and wellbeing.
HIV / AIDS
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) (352061)
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $3,600,000
The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.
Allergies & Allergic Diseases
Infectious & Parasitic Diseases
Immune System Diseases
Comprehensive Suicide Prevention Program for States (363329)
Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $650,000 - US $1,200,000
The CDC's Comprehensive Suicide Prevention Program for States aims to enhance public health approaches to suicide prevention across the U.S. By targeting high-risk groups, such as veterans and rural populations, the program utilizes data to identify prevention areas, assess existing programs, and implement evidence-based strategies. Key outcomes include improved partner engagement and a measurable reduction in suicide rates. This initiative allows potential applicants to prepare by reviewing relevant data and forming strategic partnerships ahead of future opportunities.
Suicide Prevention
Tribal Transportation Safety Strategy Pilot Program
69A355 Research and Technology
Federal Government
United States
Up to US $2,000,000
The Tribal Transportation Safety Strategy Pilot Program, funded by the Office of the Assistant Secretary for Research and Technology, aims to address high traffic fatality rates among American Indian and Alaska Native populations. With a $2 million budget over three years, the program will create a university-led consortium to develop a strategic safety plan using artificial intelligence for risk analysis, culminating in a pilot project that showcases effective safety infrastructure in a Tribal community.
Public Transportation & Mass Transit Systems
Native American Services
Indigenous Services
AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) (362945)
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.
HIV / AIDS
Improved Drug Susceptibility Testing (DST) for Mycobacteria
US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.
Infectious & Parasitic Diseases
Tuberculosis
Drug-Resistant Bacteria
Corporate Giving - Charitable Contributions
McCormick & Company, Inc
Corporate
United States
Unspecified amount
McCormick & Company, Inc. actively supports charitable contributions through its Charitable Donations Committee (CDC), which prioritizes donations to non-profit organizations that enhance education, health, environment, and culture. The CDC focuses on organizations that benefit communities where McCormick employees live and work, ensuring a positive impact. Eligible groups must be tax-exempt and demonstrate a commitment to non-discrimination. However, donations are not made to individuals, political organizations, or entities that conflict with corporate values.
Environment
Art & Culture
Health & Medicine
+4 more
Mishler Brown Fund Grant
Community Foundation of Elkhart County
Private
United States
Unspecified amount
The Mishler Brown Fund Grant, managed by the Community Foundation of Elkhart County, supports nonprofits dedicated to agriculture and historic preservation. Applications are accepted annually from October 1 to December 31, with funds awarded in January. Organizations must have a 501(c)(3) status but do not need to be located in Elkhart County. The fund honors Helen Mishler's legacy by preserving farming heritage, including her family's historic homestead.
Agriculture
Historic Preservation
Farms & Farming
+1 more