Best Large Grants for Nonprofit Organizations in New York

About the New York State Education Department

The New York State Education Department is part of the University of the State of New York (USNY), one of the most complete, interconnected systems of educational services in the United States.

Our mission is to raise the knowledge, skill, and opportunity of all the people in New York. Our vision is to provide leadership for a system that yields the best educated people in the world.

Library Services and Technology Act (LSTA) Competitive Grant Program

Purpose of Grant

To improve public libraries’ and library systems’ capacity to offer services and information resources in their communities in the areas of outreach and community engagement; best practices in literacy; and social wellbeing and improving the lives of New Yorkers. 

Project components may include outreach, programming, consultations from outside experts, and the purchase of supplies and technology which support a larger library initiative. 

All projects are encouraged to include an outreach or partnership component.

The ASPCA is offering grants to New York State animal welfare organizations to enhance compliance with the new shelter standards effective December 15, 2025. Eligible organizations can utilize these funds for facility upgrades and operational changes necessary for licensing under Article 26-C. Grant funding can encompass various needs, from retrofitting housing to training staff in euthanasia protocols, ensuring improved animal care and welfare across the state.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

Cascades Donations and Sponsorships focuses on building sustainable partnerships in education, entrepreneurship, and amateur sports. They support community organizations, promote healthy lifestyles, and recognize student engagement through grants. Cascades prioritizes projects in its operational regions and encourages initiatives that address climate change and foster inclusivity. Their funding approach is rooted in creating lasting positive impacts and supporting the next generation of leaders while adhering to their values and philosophy.

Key Bank Philanthropic Support - Community Sponsorships aims to enhance community welfare by providing financial backing to nonprofit organizations. With grants ranging from $500 to $5,000, these sponsorships focus on fundraising events and operational support for initiatives that foster economic inclusion and community growth. Applications are accepted from January to October, with decisions typically made within 90 days, ensuring timely support for impactful local projects.

KeyBank's Community Grants support tax-exempt organizations that align with the Foundation's funding priorities, focusing on improving community well-being. With grants ranging from $10,000 to $25,000, eligible organizations must have an operating budget of at least $100,000 and a minimum of three years in operation. The application process is invitation-only, requiring interested organizations to submit an Expression of Interest for review, typically receiving feedback within 90 days.

Project Lead The Way is offering a rolling grant opportunity for schools to implement the PLTW Engineering program for the 2025-2026 academic year and beyond. Eligible institutions include public, private, and charter schools located in the US. Grant recipients will receive funding to cover participation fees and training costs. Total funding amounts to $16,000, distributed over three years. Schools are encouraged to create pathways for students in engineering through this initiative.

Office of Children and Family Services

OCFS is dedicated to improving the integration of services for New York’s children, youth, families and vulnerable populations; to promoting their development; and to protecting them from violence, neglect, abuse and abandonment. The agency provides a system of family support, juvenile justice, youth development, child care and child welfare services that promote the safety and well-being of children and adults. Among the operating principles across all program areas are that services should be developmentally appropriate, family-centered and family-driven, community-based, locally responsive, and evidence and outcome based.

AmeriCorps New York FY 2026 Competitive Funding

On behalf of the New York State Commission on National and Community Service (the Commission), the New York State Office of Children and Family Services (OCFS) seeks applicants for AmeriCorps New York FY 2026 competitive grant funding.

Application Overview

AmeriCorps improves lives, strengthens communities, and fosters civic engagement through service and volunteering. AmeriCorps grants are awarded to eligible organizations that engage AmeriCorps members in evidence-based or evidence-informed interventions to tackle some of the country’s most pressing challenges.

AmeriCorps State and National funding is intended to support a wide range of community service initiatives that encourage individuals to engage with others, to address local challenges, and to improve the quality of life in our communities.

An awardee of AmeriCorps funding recruits and enrolls individuals as AmeriCorps members, who may receive a living allowance and other benefits while serving. After successful completion of their service terms, AmeriCorps members earn a Segal AmeriCorps Education Award that they can use to pay for higher education expenses or qualified student loans.

AmeriCorps State and National Funding Priorities

For this funding opportunity, AmeriCorps will prioritize consideration from organizations that: Are Faith-Based; Serve Communities; Benefit AmeriCorps Members; Use Evidence

The Public Health Laboratory Fellowship Program, supported by the Association of Public Health Laboratories, develops future public health scientists through experiential learning in laboratory science. Participants receive training aligned with core competencies and work on impactful projects in various focus areas such as bioinformatics, food safety, and infectious disease. With flexible terms and potential for extension, this fellowship ensures a robust foundation for a career in public health laboratory science.

The Puffin Foundation's Environmental Artistic Activism Grant Program supports artists addressing environmental issues through diverse artistic genres such as film, music, and theater. Grants, typically around $1,750, fund projects that prioritize sustainability and innovative solutions to the climate crisis. Eligible applicants include U.S. citizens, permanent residents, and current DACA recipients. The foundation emphasizes projects that avoid contributing to environmental harm while fostering artistic expression and community engagement.

What is Emergency Assistance Fund

Emergency Financial Assistance is available to eligible performing arts and entertainment professionals:

• In times of unexpected critical need.
• To assist towards basic living expenses, such as health care, housing and utilities to prevent eviction or shut-offs.

Hunter Brown Emergency Assistance Fund

The Hunter Brown Emergency Assistance Fund offers emergency financial assistance to current or former employees of Oregon Shakespeare Festival.

The Career Development Bridge Funding Award: K Supplement, offered by the Rheumatology Research Foundation, supports junior investigators transitioning to independent research. Awarded up to $50,000 annually for a maximum of two years, it supplements NIH K series or VA CDA awards. Eligible applicants must hold a doctoral degree and be in the second, third, or fourth year of their existing award. This funding is crucial for developing new projects that contribute to the field of rheumatology.

Bob's Discount Furniture Charitable Foundation supports non-profit organizations with resources rather than individual sponsorships. They require requests to be submitted on the letterhead of a qualified 501(c)(3) organization. This ensures that assistance reaches those in need through established channels. Interested parties should provide specific details regarding their requests to facilitate the application process. With a commitment to fairness, Bob's Cares aims to effectively support community initiatives across the country.

The Water Quality Protection and Restoration Program (WQPRP) provides funding for projects aimed at safeguarding Suffolk County's water resources. This program allocates 11.75% of the revenues from the ¼% Drinking Water Protection Program to support municipalities and non-profits in initiatives like pollution prevention, habitat restoration, and education. Grants range from $50,000 to $250,000, ensuring impactful projects enhance the community's environmental health and sustainability.

The Chatlos Foundation provides grants to nonprofit organizations in the U.S. and globally, focusing on Bible colleges, religious causes, liberal arts colleges, medical concerns, and social issues. Grants typically range from $2,000 to $20,000, depending on the category. The Foundation prioritizes program support and typically funds requests under $10,000. Eligible organizations must be U.S.-based, tax-exempt for at least two years, and aligned with the Foundation's mission, ensuring that funded projects achieve independence.

The Quality of Life Grants Program, established by the Dana Reeve Foundation, supports individuals with disabilities through nonprofit grants. The Tier 3 Priority Impact Grants provide up to $40,000 for projects that enhance accessibility and community engagement for those living with paralysis, particularly in rural, underserved areas. Successful applicants will demonstrate their ability to manage the grant effectively, focusing on areas such as transportation, health services, and assistive technology, with projects needing completion within 18 months.

The NFL Grants program, in partnership with the Bob Woodruff Foundation, is dedicated to supporting veterans, service members, and their families. This initiative funds programs aimed at improving health and well-being, enhancing opportunities, and reducing barriers to care. Organizations providing direct services to the military community can apply for funding, ensuring financial responsibility and sustainability. Grants are awarded twice a year, with applications reviewed year-round.

The F26AS00083 Aquatic Invasive Species Grants are part of the Great Lakes Restoration Initiative for Fiscal Year 2026. These grants, administered by the U.S. Fish and Wildlife Service, aim to support state-level management plans to combat aquatic invasive species in the Great Lakes region. Eligible applicants include Great Lakes states and their designees, with funding awarded through a competitive selection process.

The Stenzel Scholarship, established in 2023, awards $2,500 annually to individuals with cystic fibrosis enrolled in higher education programs in health or environmental sciences. This scholarship honors Isa and Ana Stenzel, who dedicated their lives to supporting others with CF. Applicants must provide proof of enrollment and can receive funding based on their enrollment status. This initiative aims to empower those affected by cystic fibrosis to pursue meaningful educational opportunities.

The Park Foundation Grants: Sustainable Ithaca aims to support initiatives fostering a fully sustainable community in Ithaca and Tompkins County. The foundation prioritizes projects that integrate environmental, social, and economic systems, with a focus on accessibility for low-income and communities of color. Eligible organizations must be 501(c)(3) non-profits, and grants are limited to local sustainability projects. Proposals outside Tompkins County are generally not considered.

The Bernie Bahr Forestry and Natural Resources Scholarship, managed by the Community Foundation of the Ozarks, awards a $1,000 grant to undergraduate students pursuing a Bachelor’s degree in Forestry or related fields. Eligible applicants must have completed at least two years of college and maintain a minimum GPA of 2.5. Preference is given to graduates from specific high schools in Missouri. This scholarship aims to support students dedicated to environmental and natural resource management.

The Russell Sage Foundation's Core Research Grants support innovative research in Behavioral Science and Decision Making. This program emphasizes interdisciplinary approaches, inviting insights from economics, psychology, sociology, and law to enhance our understanding of decision-making processes across various societal contexts. Applications are open to scholars with a doctorate, focusing on critical issues such as policing, housing, and immigration, while encouraging a blend of theoretical and empirical research to inform public policy.

West Pharmaceutical Services, Inc. offers the WPS Community Support Grants & Sponsorships, emphasizing a culture of giving and community involvement. The program supports 501(c)3 organizations that address healthcare challenges and focus on children, disabled individuals, and STEM education. Through financial support and volunteerism, West aims to foster healthier communities where its employees live and work, reinforcing its commitment to philanthropy and social responsibility.

The John A. Hartford Foundation offers scholarships for the Age-Friendly Health Systems Cohort as part of the AHA Next Generation Leaders Fellowship. This initiative targets healthcare leaders aiming to implement the 4Ms Framework, enhancing care for older adults. Selected fellows will receive a program fee scholarship of $13,995, enabling them to focus on transformation efforts in health systems. This fellowship seeks diverse leaders to address critical healthcare challenges and improve quality, safety, and affordability.

The Suicide Prevention, Intervention, and Postvention program aims to reduce suicide rates among American Indian and Alaska Native populations. By enhancing care coordination and culturally relevant behavioral health services, it targets at-risk youth with early intervention strategies. This initiative emphasizes community engagement and collaboration among families, youth, and partners, fostering a comprehensive approach to prevention and support for those affected by suicide.

Community Action Fund

A grant for Indigenous frontline organizations, groups, and individuals for direct action initiatives.

The Community Action Fund (CAF) grants support non-violent direct actions and organizing efforts that are often urgent and time sensitive. CAF prioritizes frontline, grassroots and community-based efforts that defend Indigenous peoples rights, communities and Nations.

Community Action Fund Intent

This grant supports Indigenous frontline, grassroots, community-based groups and organizations, Tribes, communities and villages, and individuals leading non-violent direct action or movement-building work in their effort to DEFEND Indigenous People’s rights, and protect their land, air, water, and natural resources.

The Voelcker Fund Grant supports 501(c)(3) non-profit organizations conducting medical research, focusing on diseases like cancer and heart disease. It provides restricted grants, emphasizing research that seeks cures in the Greater Bexar County area, particularly for conditions affecting the retina. The fund prioritizes organizations in San Antonio and offers various funding structures, including seed and matching grants, while ensuring compliance with non-discrimination policies.