Best Large Grants for Nonprofit Organizations in New York

The Robert E & Evelyn McKee Foundation Grant focuses on charitable purposes, primarily supporting organizations that qualify under 501(c)(3) of the IRS Code. It awards funds in various areas including civic, cultural, education, healthcare, and youth activities. Eligible recipients are local charities and certain selected colleges for scholarships. However, the foundation does not fund other foundations, organizations outside the U.S., or individual financial aid. Awards are guided by IRS minimum requirements.

The Arkansas Audubon Society Trust Grants support conservation, research, and education projects focused on Arkansas bird species and their habitats. Established in 1972, the trust offers grants ranging from $100 to $1200, prioritizing projects within the state but considering broader initiatives as well. Eligible applicants include individuals, students, educators, and nonprofits. Proposals are accepted biannually, with meetings held to discuss funding decisions, fostering a community dedicated to avian conservation.

The NAILBA Charitable Foundation Grant aims to support small, well-managed U.S. charities that assist those in need, particularly children. Grants are available to organizations with backing from a NAILBA member and that meet specific criteria, such as nonsectarian operation and appropriate fiscal accountability. Since its inception in 2002, the foundation has invested in community transformation by funding initiatives that directly engage in beneficial services, thereby enhancing the welfare of underprivileged groups.

The McInnes Charitable Trust, founded by Sally and John McInnes, aims to support organizations in Colorado focused on animal welfare, children's health, education, and empowerment. The Trust prioritizes funding for exempt organizations under Section 501(c)(3) with a proven track record. It typically does not fund capital improvements or multi-year commitments. By fostering a spirit of generosity, the Trust honors the McInnes family's legacy and commitment to various charitable causes.

The Institutional Challenge Grant aims to foster collaborative research by requiring institutions to adapt their policies and enhance capacities for meaningful partnerships. It encourages applications from diverse leadership teams in youth-serving areas, focusing on addressing inequalities in youth outcomes. The grant outlines four key goals: strengthening partnerships, pursuing a joint research agenda, facilitating institutional change, and enhancing collaborative capacities for producing actionable research evidence.

Con Edison is committed to fostering a clean and equitable energy future by supporting community-based organizations in New York City and Westchester. Focus areas include climate change adaptation, social justice initiatives, and clean energy careers. The funding prioritizes programs that serve historically marginalized communities, promote environmental stewardship, and enhance economic opportunities. Through these efforts, Con Edison aims to empower local organizations to address systemic inequities and build resilience against climate challenges.

The Fred C. Gloeckner Foundation Research Fund, established in 2024 through a partnership with the American Floral Endowment (AFE), is dedicated to advancing floriculture research and education. With over 120 years of combined funding experience, it supports innovative projects across various fields related to floriculture. Grants are available for substantial research initiatives at U.S. universities and institutions, focusing on outcomes beneficial to the public, while ensuring projects are reviewed annually for renewal.

The AHRQ Health Services Research Demonstration and Dissemination Grants (R18) aim to support innovative health services research that addresses priorities in quality, safety, and effective healthcare delivery. These grants encourage collaboration among various stakeholders, including patients and policymakers, to enhance healthcare practices across diverse settings. Applications are due by 5:00 PM local time of the applicant organization. This initiative fosters improvements in healthcare outcomes and delivery systems.

The ALL RISE Mini-Grant Program, initiated by the Aaron Judge All Rise Foundation, empowers youth in Bronx, Fresno, and San Joaquin Counties. Established in 2019, it awards $3,000 grants to organizations fostering youth leadership, citizenship, mental well-being, and community involvement. Projects may include skill-building programs or school activities aimed at enhancing youth development and community engagement, ensuring that children and families receive essential support from various sectors.

The EA Funds: Long-Term Future Fund Grant focuses on improving civilization's long-term trajectory by funding projects that mitigate global catastrophic risks. With grant sizes ranging from $1,000 to over $500,000, it welcomes applications from individuals and organizations globally. The fund particularly supports innovative small teams and individuals, emphasizing projects that reduce existential risks from AI and enhance global governance of transformative technologies. Applicants are encouraged to apply even if unsure of eligibility.

The AHRQ Health Services Research Projects (R01) aims to fund innovative health services research that aligns with AHRQ's priorities, such as enhancing healthcare quality and safety. This initiative encourages applications from various healthcare settings including hospitals and home care, promoting collaboration among diverse stakeholders like patients and policymakers. By addressing key areas of healthcare delivery improvement, this funding opportunity seeks to foster advancements in patient care and overall health system performance.

The AHRQ Small Health Services Research Grant Program (R03) invites applications for health services research focused on enhancing healthcare quality and patient safety. This funding opportunity supports diverse research settings, including hospitals and home healthcare. Projects may involve collaboration with various stakeholders such as patients, clinicians, and policymakers. By addressing AHRQ research priorities, this initiative aims to improve healthcare delivery and practice while promoting effective partnerships across the healthcare spectrum.

The Humanity United Grant focuses on addressing human exploitation and violent conflict through a strategic approach. It emphasizes support for registered charities and initiatives globally, particularly in regions like Asia-Pacific and South Sudan. The grant fosters collaboration among partners to promote human dignity, racial justice, and peacebuilding. Interested organizations are encouraged to align their proposals with the outlined themes and engage with the funder for potential support.

The Paul & Helen Charitable Trust Grants focus on enhancing the lives of children and senior adults in Niagara and Erie Counties, NY, especially in the Black Rock/Riverside area. They support organizations providing essential services and promote public green space beautification. Grant amounts typically range from $10,000 to $25,000. Note that starting in 2026, requests will be considered every other year, emphasizing education programs, food insecurity, and respite care.

The AERA Minority Dissertation Fellowship in Education Research aims to enhance diversity in education research by supporting doctoral dissertation projects from advanced graduate students belonging to historically underrepresented racial and ethnic groups. By providing a $25,000 stipend and opportunities for mentorship, the program encourages high-quality research across various educational topics, including STEM education and achievement gaps. This fellowship not only aids in academic development but also fosters the competitiveness of minority scholars in higher education.

The Change Happens Foundation Grant focuses on supporting charitable initiatives aligned with environmental science, education, and human services. With a commitment to diversity, equity, and inclusion, the foundation prioritizes funding for organizations holding 501(c)(3) status, while advocating for innovative solutions to pressing global challenges. Grants aim to foster systemic change, empower underrepresented communities, and bridge gaps in access to nutrition and healthcare. The foundation operates nationally and internationally, seeking to create significant impact through strategic investments.

The NRF Foundation x Licensing International Scholarship offers a $5,000 tuition scholarship and a trip to New York City for undergraduate students pursuing careers in brand licensing. Eligible candidates must be enrolled full-time at an accredited U.S. college, have a minimum GPA of 3.0, and be available to attend the NRF Foundation Student Program in January 2026. Bilingual students are especially encouraged to apply, enhancing diversity in the retail industry.

The National Science Foundation (NSF) seeks proposals for Arctic research to enhance understanding of the rapidly changing Arctic environment and its social systems. This initiative encourages innovative research that connects the Arctic region with lower latitudes, aiming to improve projections of future changes. Collaborations with federal and international partners are encouraged for co-reviewing proposals. Proposals that extend beyond the Arctic must clearly articulate their relevance to Arctic knowledge advancement.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

The Elizabeth M. Pfriem Foundation, established in 2015 in Rye Brook, New York, is committed to enhancing the human condition through grants to 501(c)(3) public charities. Focusing primarily on the greater Bridgeport, Connecticut area, it supports initiatives in education, healthcare, food security, and housing. The foundation prioritizes organizations demonstrating fiscal responsibility and innovative programs with significant impact potential, ensuring sustainable support for vulnerable populations, especially children and families in need.

The National Institutes of Health (NIH) is inviting applications for the Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV) program. This initiative aims to enhance understanding of hepatitis B persistence and pathogenesis, identify biomarkers, validate drug targets, and create non-invasive diagnostics. It supports observational cohorts paired with multidisciplinary teams utilizing existing clinical data, contributing to innovative research in hepatitis B cure strategies.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

The Spencer T. and Ann W. Olin Foundation Wetlands and Waterfowl Research Fellowship supports graduate students in North America conducting research on waterfowl or wetland biology. The fellowship, offering up to $9,500 annually, emphasizes applicant qualifications, research proposal soundness, originality, and potential contributions to conservation efforts. This competitive opportunity is renewable for up to two additional years for PhD students and once for Masters students, pending satisfactory progress reports.