Best Large Grants for Nonprofit Organizations in New York

Environmental Protection Fund (EPF)

New York State's Environmental Protection Fund (EPF) is a source of funding for capital projects that protect the environment and enhance communities. Capital projects are usually large projects that purchase land or construct facilities. Most projects that receive grants of EPF money combine it with other funding sources that require matching funds.

Some examples of projects using EPF money are:

• Purchasing land for the NYS Forest Preserve
• Restoring historic sites
• Conserving farmland
• Restoring habitat
• Controlling invasive species
• Upgrading municipal sewage treatment plants
• Cleaning up waterfront property and creating a public park
• Helping business develop ways to recycle material

The EPF also supports the stewardship of public lands, including state parks and millions of acres of public lands throughout the state. Through partnerships with volunteer organizations, state agencies use stewardship funding to manage trails and lands, protect natural resources, preserve wildlife habitats, make critical capital improvements at parks and campgrounds, educate students about conservation and provide access to persons with disabilities.

The Region Grants Open Grant Round: Community Vitality, supported by Land O'Lakes Foundation, aims to enhance the vibrancy of dairy communities in the East and West Regions. With a total investment of $500,000 annually, grants ranging from $1,000 to $20,000 are available for organizations focused on rural development, education, and community resources. Eligible applicants must have a 501c3 status and serve specific geographic areas, ensuring support reaches those in need.

New York State Environmental Facilities Corporation

The mission of the Environmental Facilities Corporation is to assist communities throughout New York State to undertake critical water quality infrastructure projects by providing access to low-cost capital, grants and expert technical assistance. A primary goal is to ensure that these projects remain affordable while safeguarding essential water resources. We support this mission by consistently using an innovative approach to developing and advancing new financing strategies to maximize the funding that can be made available to our clients, aiding compliance with Federal and State requirements, and promoting green infrastructure practices.

EFC has broad knowledge and a breadth of experience as a national leader in the municipal bond market. Our distinction gives our partners significant advantages in funding projects: Low cost of capital through grants, low interest rates and reduced bonding costs; Multiple funding options to fit your needs through project planning to construction and completion; Expert support to guide you through the application process and help you comply with state and federal requirements. We ensure the participation of minority-, women-, and service-disabled, veteran-owned businesses through every stage of the construction process. We also partner with a wide variety of professional organizations

Strengthening Essential Cybersecurity for Utilities and Resiliency Enhancement (SECURE) Assessment Grant

EFC is offering $2.5 million dollars to strengthen cybersecurity readiness and resilience and support operational continuity for eligible water and wastewater systems across New York State. The SECURE program will provide funding for projects that enhance cyber protections, modernize digital infrastructure and reduce vulnerabilities for critical drinking water and wastewater systems. This strategic initiative expands upon Governor Hochul’s commitment to safeguard essential services, improve risk management practices, and support communities meeting evolving cybersecurity expectations. Funding is available for both cybersecurity assessments and implementation based on best practices and regulatory requirements. 

The SECURE Assessment grant will assist eligible clean water and drinking water systems to evaluate their cybersecurity posture, identify vulnerabilities, and prioritize risk mitigation needs. A municipality may apply for up to $50,000 with a 0% match.   

The Waterman Fund Grant aims to preserve the ecological, cultural, and recreational values of the alpine regions in Northeastern North America. It supports projects such as trail rehabilitation, alpine education, and research to enhance stewardship of these areas. Eligible applicants include nonprofit organizations and government agencies, with a requirement for matching funds. The Fund also encourages long-term sponsorships for impactful educational and conservation initiatives, particularly in alpine ecosystems.

The Therapeutic Giving: Oncology program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatments and services, promote health equity, and strengthen healthcare workforces. It supports programs that raise disease awareness, empower patients, and improve health systems with measurable outcomes. Eligible applicants include nonprofit organizations with 501(c)(3) status, emphasizing innovative programs addressing healthcare disparities and unmet needs.

The Therapeutic Giving program from Johnson & Johnson Innovative Medicine aims to support local and regional organizations focused on improving patient access to treatment and advancing health equity. Eligible applicants include 501(c)(3) nonprofit organizations, with funding preferences for programs that address significant healthcare disparities, mental health initiatives, and innovative solutions with measurable outcomes. The application period for local organizations runs from March 1 to May 31, while national organizations can apply in September.

The Therapeutic Giving initiative by Johnson & Johnson focuses on funding programs in neuroscience aimed at enhancing patient access to treatments and promoting health equity. Nonprofit organizations classified as 501(c)(3) can apply for support from March 1 to May 31. The initiative emphasizes innovative, measurable programs in areas like Alzheimer’s disease and mental health, prioritizing those that address healthcare disparities and improve quality of life for affected individuals.

The Lower Esopus Stream Management Implementation Plan Grants, administered by the Hudson River Foundation, aim to support projects that mitigate water quality impairments in the Lower Esopus Stream. This initiative focuses on actionable projects addressing turbidity, stormwater management, and nutrient loads, among others. By funding these projects, the program seeks to enhance environmental benefits and ensure a healthier ecosystem. Applicants are encouraged to align their proposals with the priorities outlined in the Implementation Plan.

The Scherman Foundation focuses on empowering Black, Indigenous, and People of Color (BIPOC) communities through economic, political, and cultural transformation. They prioritize organizations led by or accountable to these communities, fostering intersectional practices and movement-building efforts. Their funding aims to address systemic inequities in New York, particularly in housing, workers' rights, and cultural initiatives, promoting justice and community resilience. The Foundation's commitment to racial justice reflects in its strategic framework and grantmaking priorities.

The Doyle Undergraduate Fellowship, offered by New Hampshire Sea Grant, provides a unique opportunity for undergraduates to engage in marine resource projects while receiving mentorship and training. This paid fellowship supports students interested in marine-related research and education, with potential earnings of up to $5,000 over a 10-week summer period. By participating, fellows gain valuable insights into coastal and marine management, enhancing their skills and expanding their professional networks.

The Mother Cabrini Health Foundation's Basic Needs Grant Program aims to address the essential needs of New Yorkers facing challenges such as food insecurity, inadequate housing, and economic instability. This initiative supports organizations that provide access to social services, promote economic mobility, and ensure stable housing and nutrition for underserved communities. Grants of $75,000 or more are available for programs that align with the foundation's mission of fostering health and well-being in New York State.

The U.S. Healthcare Donations program by Amgen aims to support not-for-profit organizations in the healthcare sector. As a leading biotechnology company, Amgen provides funding for initiatives that improve science, technology, education, and public awareness on medical conditions. Organizations eligible for funding must be tax-exempt entities, focusing on genuine philanthropic efforts that align with Amgen's mission to enhance health outcomes and reduce the burden of diseases.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The Extension Risk Management Education (ERME) Competitive Grants program aims to enhance the economic viability of agricultural producers through targeted risk management education. Funded by the University of Delaware, this initiative offers grants of up to $75,000 for projects addressing production, marketing, financial, legal, or human risks. The grants are expected to support 12-15 new projects over an 18-month duration, from April 2026 to September 2027, subject to funding availability and application quality.

Webster Bank Corporate Giving focuses on supporting underserved communities through essential programs in workforce development, community development, financial empowerment, and basic human services. The bank prioritizes registered nonprofit organizations that align with its strategic goals, encouraging initiatives that promote economic inclusion and address racial equity. Eligible applicants must be 501(c)(3) nonprofits operating within Webster's footprint, demonstrating a history of success and a commitment to community enhancement.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

The Ralph J. Torraco Food Bank/Shelter Fund Grant, offered by the UNICO Foundation Inc., aims to combat hunger and provide shelter for the homeless and indigent. Eligible applicants include registered non-profit food pantries, soup kitchens, and shelters in 13 U.S. states. The grant focuses on direct services, ensuring that all funds are used for food and shelter, not for operating expenses, thereby promoting effective community support for vulnerable populations.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

The Architecture + Design Independent Projects Grants program, a collaboration between the New York State Council on the Arts and The Architectural League of New York, offers 25 grants of $10,000 each for innovative design proposals. Open to individuals and teams in various design fields, including architecture and graphic design, this initiative encourages creative exploration and public engagement with design. Applications will be evaluated by a panel of design experts, ensuring support for impactful projects that advance the discipline.

Water Quality Improvement Project (WQIP) Program

The Water Quality Improvement Project (WQIP) program is a competitive, statewide reimbursement grant program that funds projects that directly improve water quality or habitat, promote flood risk reduction, restoration, and enhanced flood and climate resiliency, or protect a drinking water source.

The Ron Goellner Conservation Fund Award, administered by the Cryptobranchid Interest Group, offers grants up to $2,000 for projects focused on the conservation of giant salamanders. This initiative supports innovative research, field conservation, and educational initiatives that aim to protect these species and their habitats. Open to all applicants, the fund prioritizes projects that demonstrate broad conservation impact and partnerships. Applications are automatically considered for two separate grants of up to $1,000 each.

TC Energy’s Build Strong program supports vital organizations in communities near its operations. By providing grants, scholarships, and in-kind support, the program aims to enhance safety, education, environmental protection, and community well-being. Eligible applicants include non-profits and community groups addressing local needs. Ineligible activities include operational expenses and for-profit endeavors. The program prioritizes projects demonstrating measurable community impact, fostering a collaborative relationship between TC Energy and local stakeholders.

The McKinney-Vento Competitive Grant Program in New York supports educational initiatives for homeless children and youth, ensuring they have equal access to quality education. Funded by the New York State Education Department, the program allocates substantial financial resources to local educational agencies based on the number of identified homeless students. This grant is pivotal in providing essential services like tutoring, health care, and transportation, ultimately promoting academic success and stability for vulnerable populations.

The PCLB Foundation Grant supports organizations in Connecticut and New York that align with its mission of empowering individuals through strategic philanthropy. Founded in 1999, the foundation seeks to provide general operating support and restricted grants in five key areas: education, outdoors, science, medicine, and family projects. By fostering high-quality initiatives, PCLB aims to create systemic change while encouraging innovative solutions to pressing community issues.

The Cloudsplitter Foundation offers Program and Project Support Grants aimed at well-defined initiatives with specific needs and budgets. With a focus on the Adirondack region, these grants prioritize projects that foster community support and collaboration among stakeholders. Applicants are encouraged to submit their proposals early due to high demand, as funding is limited to a percentage of project costs. The Foundation seeks to empower organizations that show potential for significant community impact.

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The Gorman Foundation Grants, established in 2003, aim to enhance quality of life through funding for IRS 501(c)(3) organizations in areas such as social welfare, community education, and environmental efforts. Focused primarily on Madison County, NY, the foundation supports projects that promote healthcare access, education, and wildlife preservation, while strictly adhering to non-discrimination policies. Organizations must meet eligibility criteria to qualify for grant support.