Best Operating Grants for Nonprofits in North Carolina

The FY 2027 Service Area Competition (SAC) funding aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive preventive and primary care. This initiative allows for a competitive selection of service areas, ensuring that health centers can effectively deliver high-quality healthcare. Additional service areas may be announced throughout the year to accommodate changes in service availability, supporting continuous care for those in need.

The Store-Based Giving Program by Ross Stores Foundation supports socioeconomically disadvantaged youth by providing gift cards for school or professional clothing. Organizations must be federal tax-exempt and serve at least 60% low-income youth. Eligible programs include academic achievement and life skills initiatives. Award amounts typically range from $300 to $500, depending on budget and mission alignment. Applications are not accepted from organizations that have received donations within the past 12 months.

The American Heart Association is inviting proposals for research on the effects of GLP-1 and GIP agonists in individuals with cardiovascular, kidney, and metabolic diseases. This initiative aims to explore how these medications can alleviate the CKM burden. Researchers with expertise in causal inference, machine learning, and cardiovascular research are encouraged to apply, particularly those working in multidisciplinary teams and leveraging various data sources.

The AAAAI Distinguished Scientist Award recognizes exceptional contributions in allergy and immunology research, honoring those who have significantly advanced the field and demonstrated leadership. This prestigious award is presented by the American Academy of Allergy, Asthma & Immunology, a leading organization for over 7,000 professionals dedicated to improving patient care and promoting research in allergic diseases. The award highlights the commitment to excellence and innovation within the specialty.

The National Trappers Foundation (NTF) offers grants to individuals and organizations for projects related to furbearers. Founded in 1988, NTF supports educational and conservation initiatives that promote the management and restoration of furbearers and natural resources. Grants are available for research, habitat development, and educational programs. Contributions to NTF are tax-deductible, reflecting its commitment to conservation and community engagement.

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

• Skilled Trades Training Support
• Pre-Apprenticeship or Apprenticeship Programs
• Youth Career Exploration Camps

The Bezos Scholars Program, supported by the Bezos Family Foundation, is a transformative, no-cost leadership development initiative designed for high school juniors. Each year, selected scholars from the U.S. and Africa engage in a year-long program, developing leadership skills through civic engagement and community projects. Participants receive personalized college advising, funding for their projects, and an all-expenses-paid trip to the Aspen Ideas Festival, fostering a diverse community of changemakers committed to making a difference.

The Holloway Family Foundation, established in North Central Texas, aims to enhance community quality of life regardless of race, gender, or religion. Their mission focuses on financial security, creative expression for under-resourced youth, and mentorship for personal development. The foundation supports organizations that provide workforce training, artistic opportunities for children, and guidance for youth in need. By fostering individual growth and economic stability, they empower families and strengthen communities, staying true to the founders' core values and personal experiences.

The Juliette P. Doster Scholarship Fund honors the legacy of Mrs. Doster, who dedicated forty years to improving healthcare in Calhoun County. This renewable scholarship supports students pursuing associate's or bachelor's degrees, as well as approved workforce training programs. Awarded yearly for up to four years, recipients must maintain academic standards. Funding varies based on the Community Foundation's annual income, and the award covers tuition, housing, supplies, and other educational expenses.

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

The Young Forester Leadership Award, presented by the Society of American Foresters (SAF), recognizes exceptional leadership from young forestry professionals under 40 years old. This award highlights contributions to forestry through innovative projects and sustained leadership roles. Recipients receive a $500 honorarium, complimentary registration for the SAF national convention, and support for travel expenses up to $500. This prestigious accolade aims to encourage the next generation of forestry leaders to excel in their professional endeavors.

The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.

The SAF National Awards Program includes the John A. Beale Memorial Award, recognizing exceptional voluntary service in forestry by SAF members. Established to honor John Beale's legacy, this award is presented at the SAF national convention and includes a $500 honorarium, complimentary registration, and up to $500 for travel expenses. Nominees must demonstrate sustained commitment to the SAF and its mission, showcasing leadership and promotion of forestry principles.

The SAF National Awards Program recognizes exceptional contributions to forestry through its Honorary Membership award. This accolade is presented to individuals whose impact on the field is acknowledged by their peers, highlighting their distinguished service in advancing forestry knowledge and societal awareness. Awardees receive lifetime membership in SAF along with complimentary convention registration. The program seeks to honor those, including non-professional foresters, who have made significant strides in forestry, both domestically and internationally.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

Incyte Corporation invites organizations to submit membership requests aimed at enhancing healthcare access for patients and advocates. As a biopharmaceutical leader, Incyte supports initiatives that align with its mission to improve patient lives through grants and contributions. Eligible entities include medical schools, associations, non-profits, and advocacy groups. Requests should comply with Incyte's regulatory standards and be submitted at least 60 days prior to the required decision date.

The Florence Merriam Bailey Award, presented by the American Ornithological Society, honors outstanding articles published by early career members in AOS journals within the last two years. Awarded annually, it includes a $1,500 cash prize to the lead author. Papers recognized alternate between the journals 'Ornithology' and 'Ornithological Applications'. Nominees must adhere to high ethical standards as outlined in the AOS Code of Conduct.

The AOS-Sponsored Student Memberships provide one year of free membership to students globally interested in ornithology. Awardees gain full access to AOS membership benefits and are encouraged to participate in various opportunities, including the annual meeting and travel grants. This initiative aims to foster the next generation of ornithologists by supporting their academic and professional growth while upholding high ethical standards aligned with the AOS Code of Conduct.

The Katma Award, established by the American Ornithological Society in 2003, honors innovative research that challenges existing theories in avian biology. This award encourages submissions of research articles, commentaries, or short communications published within the last two years. Nominees are expected to uphold high ethical standards, and the award includes a $2,500 prize and a certificate. Ideal submissions include papers authored by one or two researchers, with self-nominations also accepted.

The Wesley Lanyon Award, presented by the American Ornithological Society, honors early-career ornithologists for the best integrative avian science review paper published in AOS journals. With a $1,500 honorarium and $1,000 travel stipend, this biennial award encourages doctoral students and recent Ph.D. graduates to contribute novel insights to ornithology. Winners can organize a symposium at the AOS annual meeting, fostering collaboration and advancing research in the field.

The Harry Kramer Memorial Fund Grant supports U.S. charitable organizations that assist individuals and institutions in Israel, focusing on welfare, healthcare for the sick and aged, and education in South Florida. Founded by Harry A. Kramer, a successful entrepreneur and veteran, the fund reflects his deep commitment to charitable causes. Organizations must qualify under Section 501(c)(3) and meet specific eligibility criteria to apply for funding, ensuring that aid reaches those in need.

The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.

The Native Performing Arts Live Production Grant (LPG) supports Native artists and organizations in staging live performances, fostering cultural expression. With a $30,000 grant for one year, this initiative prioritizes projects that actively engage Native performers, enhancing their artistic skills and community connections. By addressing the unique needs of Native creators, the program aims to empower them with resources, mentorship, and equitable opportunities in the performing arts landscape.

The Ochylski Family Foundation supports registered 501(c)(3) nonprofit organizations through grants aimed at enhancing their operational capacity. With an application deadline of October 1, organizations must submit a detailed request outlining their initiatives. The foundation's mission aligns with its commitment to foster community development and nonprofit effectiveness in Iowa, ensuring that resources are allocated to impactful projects that serve the public good.

The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.

The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.

The Hoke County Community Foundation Grant Program, part of the North Carolina Community Foundation, supports charitable organizations across 67 counties. It offers funding for diverse purposes, including education, health, and arts. Eligible applicants must be tax-exempt public charities or local government units, ensuring programs are accessible without discrimination. The program also includes the Mary Archie McNeill Endowment, specifically for music and cultural arts in Hoke County, with $12,650 available for grants.