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Best Operating Grants for Nonprofits in North Carolina

Find the perfect Operating grants for nonprofits in North Carolina on Instrumentl. 10,000+ Operating grants for nonprofits in North Carolina in the United States.

10,000+

Available grants

$2.70B

Total funding

$5K

Median grant

10,000+ grants
$2.70B total
$5K median

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9,802 Results based on applied filters

Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
US $2,500,000
The National Institutes of Health is launching a funding opportunity to explore the mechanisms of skin injuries caused by toxic chemicals. This initiative aims to understand the common pathways of injury from various harmful substances, facilitating the discovery of therapeutic targets. Researchers are encouraged to collaborate and apply their expertise in cutaneous wound healing. The goal is to develop broad-spectrum medical countermeasures for mass casualty events involving toxic exposures, enhancing public health safety.
Cell Biology Environmental Chemistry & Toxicology Wounds & Injuries +1 more

Futrell-Mauldin Community Fund for Greater Rocky Mount

North Carolina Community Foundation Inc
Private
Edgecombe County, North Carolina, Nash County, North Carolina
US $500 - US $7,500
The Futrell-Mauldin Community Fund for Greater Rocky Mount supports local nonprofit organizations by providing annual grants ranging from $500 to $7,500. Established in 2005, the fund is overseen by a local advisory board that identifies and addresses community needs. It encourages diverse organizations, including tax-exempt charities and local government units, to apply for funding to enhance the quality of life in the Rocky Mount area, promoting inclusivity and community engagement.
Education Human & Social Services Basic Human Needs +7 more

Curriculum and Instruction Honor Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Curriculum and Instruction Honor Award, presented by SHAPE America, recognizes outstanding contributions to health and physical education curriculum research. This prestigious award highlights the importance of effective instructional practices that prepare students for active and healthy lives. Award recipients are selected based on their scholarship in health education and physical education, demonstrating commitment to excellence since the organization's founding in 1885. SHAPE America advocates for quality education and promotes the well-being of preK-12 students across the United States.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

Helen M. Heitmann Young Scholar Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Helen M. Heitmann Young Scholar Award, presented by SHAPE America, honors young professionals who have made significant contributions to research in curriculum and instruction within health and physical education. Eligible candidates must be current SHAPE America members and have 3 to 6 years of experience post-doctorate. This award emphasizes active involvement and scholarship in the field, encouraging innovative research that enhances educational practices for preK-12 students.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

IRSS RIFM Special Award for Inhalation Toxicology

Society of Toxicology
Association/Society
United States
US $500
The IRSS RIFM Special Award for Inhalation Toxicology offers a $500 prize for trainees contributing to inhalation toxicology research. Sponsored by the Society of Toxicology, this award encourages innovative evaluations of inhaled toxicants, exposure science advancements, and risk assessment research. Applicants must submit a one-page summary of their work and a pending abstract for presentation at the SOT Annual Meeting, alongside a mentor's support letter. This award aims to promote excellence in the field.
Respiratory Diseases & Systems Environmental Chemistry & Toxicology Environmental Health

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows (Tier 2: Mid-stage Development Awards)

Gates Foundation
Private
Countries
Up to US $600,000

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.

Epidemiology & Public Health Molecular Biology Non-Medical Bioinformatics +3 more

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows (Tier 3: Advanced Development and Validation Awards)

Gates Foundation
Private
Countries
Up to US $800,000

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

Epidemiology & Public Health Molecular Biology Non-Medical Bioinformatics +3 more

Miller Indigenous Economic Development Fellowship

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Miller Indigenous Economic Development Fellowship, established by the Native Forward Scholars Fund, provides financial assistance to American Indian and Alaska Native doctoral candidates engaged in economic research impacting Native communities. This fellowship supports costs associated with data collection, analysis, and travel. It aims to enhance the representation of Native scholars in economics, addressing the current underrepresentation in the field. Eligible candidates are encouraged to apply to further their research and contribute to their communities.
Education - Higher Education Academic Success & Enrichment Native American Services +3 more

Guidelines to Develop Best-In-Class Maintenance Strategies for Vertical Assets RFP

Water Research Foundation
Private
Countries
Up to US $250,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5415 - Guidelines to Develop Best-In-Class Maintenance Strategies for Vertical Assets

Grant Information

  • Develop a clear understanding of the background and benefits associated with implementing well-rounded maintenance strategies for vertical assets.
  • Develop a structured approach to identify and implement best-in-class maintenance strategies for vertical assets that improve reliability, increase asset availability, reduce unplanned work and emergency shutdowns, support the transition from reactive to proactive maintenance, and minimize total lifecycle cost.
  • Apply leading practices such as Reliability Centered Maintenance (RCM) and cutting-edge technologies and analytics to vertical assets.
Water Resource Management

Cynthia and Alan Baran Fine Arts and Music Scholarship Fund

Community Foundation of Middle Tennessee
Private
United States
Unspecified amount
The Cynthia and Alan Baran Fine Arts and Music Scholarship Fund, established by passionate artists Cynthia and Alan Baran, aims to support young individuals pursuing their dreams in visual arts and music. This fund, administered by the Community Foundation of Middle Tennessee, offers scholarships to rising college students majoring in Fine Arts or Music, emphasizing the importance of creativity and academic achievement. With a commitment to fostering talent, this initiative empowers future generations to thrive in the arts.
Education - High School Academic Scholarship Programs Fine Art +2 more

Solid Waste Management Grant Program (364018)

USDA: Rural Utilities Service (RUS)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The Solid Waste Management Grant Program, administered by the USDA's Rural Utilities Service, invites applications for FY 2027 funding. This initiative aims to enhance solid waste management in rural communities through technical assistance and training. Eligible organizations can receive grants to develop sustainable waste management practices, addressing critical issues like water pollution and emerging contaminants, while promoting hazardous waste collection. This program supports operational improvements and capital financing applications to ensure long-term environmental health.
Freshwater Conservation Environmental Contamination & Pollution Environmental Health +1 more

Production Grants: Fiddler on the Roof Grant

Educational Theatre Foundation (EdTA)
Association/Society
United States
Up to US $2,500

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

  • Subsidizing new, emerging, and underserved student theatre programs;
  • Creating paths for theatre educators to develop new skills; and
  • Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

Fiddler on the Roof Grant

The Fiddler on the Roof Grant covers performance royalties and support resources for middle or high school Thespian troupes to perform Fiddler on the Roof or Fiddler on the Roof JR. through Music Theatre International. Funders Helene and Edward Cole created the grant to help educate students and communities about Jewish heritage and culture.

Community Culture & Heritage Theater Arts / Culture Access & Participation +2 more

Elizabeth Pastor Ashland University Music Education Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Elizabeth Pastor Ashland University Music Education Scholarship supports music students at Ashland University, honoring the legacy of Elizabeth Pastor, a renowned pianist and educator. This scholarship aims to assist students pursuing a music-related career, reflecting Pastor's belief in the transformative power of art. Established through her estate plan, it embodies her commitment to fostering musical talent and enriching the community through education and the arts.
Education - Higher Education Academic Scholarship Programs Music Education +2 more

Charles and Joan Hermanowski Family Foundation Grant

Charles And Joan Hermanowski Family Foundation Inc
Private
United States
Up to US $10,000
The Charles and Joan Hermanowski Family Foundation aims to enhance the lives of children and young adults in the U.S. by providing financial support to 501(c)(3) organizations focused on arts, education, health, and welfare. Grants, capped at $10,000, must be utilized within one year and are not automatically renewable. The foundation seeks to support smaller charities that may not receive broad public backing, thus creating a more significant impact on individual communities.
Youth Development & Leadership Youth Involvement in the Arts Youth Services +3 more

Mastercard Innovation Fund

Mastercard Center for Inclusive Growth
Corporate
United States
US $200,000 - US $250,000
The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.
Entrepreneurship Business Education Business Development +2 more

United States Adult Cystic Fibrosis Association (USACFA): Higher Education Scholarship

United States Adult Cystic Fibrosis Association (USACFA)
Association/Society
United States
Up to US $2,500
The United States Adult Cystic Fibrosis Association (USACFA) offers a Higher Education Scholarship, honoring Lauren Melissa Kelly. This scholarship awards up to $2500 to two adults with cystic fibrosis pursuing various educational paths. Applicants must show proof of enrollment for the relevant academic year and can cover education-related costs, including tuition and materials. This initiative not only supports education but also commemorates Lauren's legacy, inspiring others to pursue their dreams despite challenges.
Cystic Fibrosis Academic Scholarship Programs Education - Higher Education +1 more

IDNR: State Duck Stamp Funding

Illinois Department of Natural Resources
State/Local Government
Canada, United States
Up to US $500,000
The IDNR: State Duck Stamp Funding program supports the development of waterfowl propagation areas in the Mississippi Flyway. Funded by sales of State Migratory Waterfowl Stamps, it focuses on projects in Canada and the U.S. that enhance waterfowl populations. Eligible applicants include not-for-profit organizations aiming to implement the North American Waterfowl Management Plan. This initiative not only fosters wildlife conservation but also strengthens ecological sustainability in the region.
Habitat & Ecosystem Restoration Land / Habitat Conservation Ornithological Conservation

HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.
Epidemiology & Public Health Addiction & Substance Use Disorders Health Care Access & Delivery +3 more

Native Public Health Resilience

Indian Health Service
Federal Government
United States
Unspecified amount
The Native Public Health Resilience (NPHR) program is a new funding opportunity aimed at supporting Tribes and Tribal Organizations in delivering essential public health services. Sponsored by the Indian Health Service, this initiative seeks to bolster public health infrastructure and resilience within tribal communities, ensuring they have the necessary resources to address health challenges effectively. Eligible applicants will receive financial assistance to enhance their public health capabilities and improve community health outcomes.
Epidemiology & Public Health Health Care Access & Delivery Native American Services +2 more

Incyte Healthcare Sponsorships

Incyte Corporation
Corporate
United States
Unspecified amount
Incyte Corporation, a biopharmaceutical leader, offers healthcare sponsorships to support organizations focused on improving patient care and access to healthcare information. Eligible applicants include medical schools, associations, non-profits, advocacy groups, and hospitals. Requests should align with Incyte's commitment to enhancing the lives of patients affected by cancer and other diseases, ensuring compliance with regulatory guidelines. Organizations must enter a written agreement with Incyte to receive funding.
Cancer / Oncology Diseases & Conditions Nursing +2 more

Glass Foundation Grant

Glass Foundation, Inc.
Private
Avery County, North Carolina, Buncombe County, North Carolina +17 more
Up to US $200,000
The Glass Foundation Grant supports initiatives that enhance the quality of life in Western North Carolina. Established in 2000, the foundation provides funding for capital campaigns, construction, and program supplies, focusing on environmental education and youth development. Eligible applicants include 501(c)(3) organizations operating in specified WNC counties. The foundation prioritizes projects that foster educational and cultural opportunities while preserving natural resources, aiming to create a thriving community.
Environmental Education Environmental Conservation Education - K through 12 +3 more

ASSP Foundation Academic Scholarships

American Society of Safety Professionals (ASSP) Foundation
Association/Society
United States
Unspecified amount
The ASSP Foundation Academic Scholarships provide vital financial support to students in environmental health and safety programs. With over $6 million awarded since 1990, the foundation aims to enhance career prospects through education and leadership development. In the 2024-2025 academic year, $215,000 was allocated to 117 recipients, fostering a sustainable talent pipeline in EHS. This initiative not only promotes the profession but also ensures a safer future for workers by encouraging new talent to enter the field.
Occupational Health & Safety Environmental Health Workforce Preparation & Job Readiness +1 more

Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship, managed by the Central Indiana Community Foundation, supports Latinx and Hispanic students pursuing post-secondary education. Applicants must be Indiana residents with a GPA of 3.0 or higher, demonstrating financial need and community service. Preference is given to first, second, or third generation Latinx and/or Hispanic students. Scholarship funds assist with tuition, fees, and other educational expenses, reinforcing the foundation's mission to build inclusive opportunities.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

The Jane Bruckel Early Career Investigator Award in Axial Spondyloarthritis

Spondylitis Association Of America
Private
Canada, United States
US $30,000
The Jane Bruckel Early Career Investigator Award in Axial Spondyloarthritis, offered by the Spondylitis Association of America, aims to support MDs and PhDs at the Instructor or Assistant Professor level in the US and Canada. This annual $30,000 research grant promotes innovative research in ankylosing spondylitis and enhances patient care by encouraging emerging researchers to contribute to this important field.
Skeletal Diseases Arthritis

Community Development Block Grant Program for Indian Tribes and Alaska Native Villages (364031)

US HUD: Office of Public and Indian Housing (PIH)
Federal Government
United States
US $500,000 - US $2,250,000
The Community Development Block Grant Program for Indian Tribes and Alaska Native Villages aims to foster the development of viable communities by providing funding for housing, living environments, and economic opportunities, primarily benefiting low- and moderate-income individuals. The program is competitive, offering both single-purpose and imminent threat grants to address urgent public health and safety issues, ensuring that tribes can improve their community welfare effectively.
Economic Services & Development Community Development & Revitalization Community / Public Safety +2 more

RSLAAIS Leadership Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The RSLAAIS Leadership Award, presented by the American Academy of Allergy, Asthma & Immunology (AAAAI), honors exemplary leaders within state, regional, or local allergy societies. This prestigious award recognizes individuals for their significant contributions to community involvement, clinical education, and the advancement of the AAAAI's mission. Candidates are nominated by the RSLAAIS Board of Governors and must demonstrate a commitment to enhancing their local allergy societies and the broader medical community.
Asthma Vaccines & Immunizations Immune System Diseases

F26AS00071 Cooperative Endangered Species Conservation Fund: Habitat Conservation Plan Land Acquisition Grants

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $26,000,000
The Cooperative Endangered Species Conservation Fund supports habitat conservation through land acquisition grants. Established in 1997, this program aims to minimize conflicts between listed species conservation and land use. The U.S. Fish and Wildlife Service provides matching grants to state agencies for projects that ensure the long-term protection of habitats. By acquiring land or conservation easements, this initiative facilitates species recovery and helps prevent future listings under the Endangered Species Act, enhancing overall ecosystem health.
Environmental Conservation Habitat & Ecosystem Restoration Land / Habitat Conservation

Operating Grants for Nonprofits in North Carolina Highlights

Looking for operating grants for nonprofits in North Carolina?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in North Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in North Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Operating grants for nonprofits in North Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

70 Operating grants for nonprofits in North Carolina over $25K in average grant size

51 Operating grants for nonprofits in North Carolina over $50K in average grant size

35 Operating grants for nonprofits in North Carolina supporting general operating expenses

200+ Operating grants for nonprofits in North Carolina supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in North Carolina?

Most grants are due in the first quarter.

Q1
30.4%
Q2
22.4%
Q3
26.2%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in North Carolina?

Grants are most commonly $17,500.

$500 $500 Min.
$17,500 $17.5 K Median
$477,452 $477.5 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for North Carolina?

Grants are most commonly $131,121.

$131,121

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in North Carolina year over year?

In 2024, funders in North Carolina awarded a total of 70,602 grants.

2022 63,850

2023 62,335

2024 70,602

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in North Carolina given out in North Carolina, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Operating Grants for Nonprofits in North Carolina changing over time?

Funding has increased by 15.49%.

2022 $7,927,620,616

2023 $7,987,830,464
0.76%

2024 $9,224,796,270
15.49%

North Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Durham County, Orange County, and Mecklenburg County receive the most funding.

County Total Grant Funding in 2024
Durham County $2,942,551,198
Orange County $2,549,339,233
Mecklenburg County $1,468,677,341
Wake County $1,122,908,782
Buncombe County $444,853,701

Related Grants in North Carolina

Browse Other Nonprofit Operations & Capacity Grants in North Carolina

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Browse Grants by Major US Cities within North Carolina