Best Grants for Capital Funding in Puerto Rico

The U.S. Healthcare Donations program by Amgen aims to support not-for-profit organizations in the healthcare sector. As a leading biotechnology company, Amgen provides funding for initiatives that improve science, technology, education, and public awareness on medical conditions. Organizations eligible for funding must be tax-exempt entities, focusing on genuine philanthropic efforts that align with Amgen's mission to enhance health outcomes and reduce the burden of diseases.

The Ernest F. Hollings Undergraduate Scholarship offers up to $9,500 annually for two years, alongside a paid summer internship at NOAA. This program enhances students' training in oceanic and atmospheric sciences, aiming to increase public understanding and support for environmental stewardship. Eligible students must be U.S. citizens, enrolled full-time in relevant disciplines, and maintain a minimum GPA of 3.0. The experience fosters valuable skills and networks, with 100% of alumni recommending the scholarship.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The Office of National Drug Control Policy is inviting applications to create a surveillance system that connects drug toxicology testing results and interviews from emergency department patients with the illicit drug supply in various U.S. communities. This project aims to enhance drug consumption surveillance, identify deficiencies in current drug testing methods, and promote collaboration among public health and safety organizations to effectively tackle the ongoing drug crisis.

The Community Connect Grants Program provides financial assistance to eligible applicants aiming to deliver broadband services in rural areas where access is limited. This initiative fosters economic growth and enhances educational, healthcare, and public safety benefits, improving the quality of life in underserved communities. By supporting projects that create better market opportunities and promote equitable access, the program plays a vital role in advancing rural development and addressing environmental justice.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The National Child Traumatic Stress Initiative aims to enhance trauma-focused treatment and services for children and adolescents affected by traumatic events. By increasing access to these vital services, the initiative seeks to support families in overcoming the challenges posed by trauma. Eligible applicants include public and private nonprofit entities, ensuring a broad reach for effective intervention and support within communities.

The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.

The Rapid Response Opioid and Pain Management ECHO Funding Opportunity by the Association of State and Territorial Health Officials (ASTHO) aims to enhance clinician training in effective pain management strategies. This initiative focuses on non-opioid treatments, substance use screening, and risk reduction counseling, promoting compassionate care while addressing public health challenges and ensuring continuity for patients affected by prescription disruptions. The program seeks to improve overall health outcomes and reduce risks associated with opioid use.

The Alice M. Ditson Fund provides organizational support for professional performing ensembles and institutions committed to advancing the work of younger and relatively unknown living American composers. Grants are available for general operating or project support, emphasizing contemporary American classical concert music. Eligibility includes organizations without non-profit status if sponsored by a 501(c)(3) entity, while projects featuring American music are prioritized. This funding opportunity encourages innovative performances and fosters greater recognition of emerging talents in the classical music sphere.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

The Desalination and Water Purification Research Program, led by the Bureau of Reclamation, aims to enhance water supply through innovative research in water treatment technologies. This initiative seeks proposals for laboratory and pilot-scale projects that demonstrate significant benefits and commercialization pathways. By addressing cost and energy barriers, the program aligns with federal priorities to improve resource management and support the development of sustainable water solutions for the American public.

The Limited Competition Small Grant Program for NIDDK K01/K08/K23/K25 recipients offers funding opportunities for pilot studies and feasibility research. This program aims to support researchers transitioning to independent investigator roles by providing resources for small projects that can yield preliminary data for future R01 applications. Key deadlines for applications range from February 2025 through January 2028, with specific dates for standard, renewal, and AIDS-related applications.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) invites proposals for high-risk, multi-center observational studies on diseases relevant to NIDDK's mission. Applicants are encouraged to consult with NIDDK staff and must complete planning activities before submission. Key deadlines for applications span from February 2025 to October 2026, with optional Letters of Intent due 30 days prior to full proposals.

The BJA FY 2026 Smart Reentry Demonstration Program aims to support state, local, and tribal governments in implementing effective reentry strategies for individuals transitioning from correctional facilities back to their communities. This program encourages comprehensive interventions designed to reduce recidivism by addressing various reentry needs, as outlined in the Second Chance Act. Applications are due by October 1, 2026, at 8:59 PM ET, and are submitted through JustGrants.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.

The Jobs Plus NOFO for FY2026, issued by the US HUD's Office of Public and Indian Housing, aims to enhance job opportunities for public housing residents. This initiative encourages innovative programs that prepare individuals for employment in high-demand fields, ultimately fostering economic stability within communities. By focusing on workforce development, this funding opportunity seeks to empower residents through education and training, paving the way for long-term success and self-sufficiency.

The Higher Education Challenge Grants Program, managed by the USDA's National Institute of Food and Agriculture, aims to enhance institutional capacities in food and agricultural sciences education. This initiative focuses on improving curriculum, faculty, and student recruitment for master's and doctoral programs, particularly in veterinary medicine. By strengthening these educational frameworks, the program seeks to ensure the availability of skilled professionals in critical agricultural sectors.

The Affirm Cares Employee Foundation Grant, established by Affirm, aims to support non-profit organizations making a significant impact in financial literacy, community enrichment, and technology education. Grants range from $1,000 to $10,000, focusing on sustainable initiatives that empower communities and alleviate housing insecurity. Eligible applicants must be 501(c)(3) designated non-profits operating within the U.S. The foundation prioritizes measurable outcomes in its funding efforts, fostering civic engagement and vibrant communities.

The Fair Housing Initiatives Program (FHIP), established by Congress in 1988, aims to fund organizations to combat discriminatory housing practices. The Education and Outreach Initiative (EOI) educates stakeholders about their rights under fair housing laws. Key components include the National Media Campaign, which promotes fair housing awareness nationally, and local programs that support community-based outreach. HUD oversees the process, ensuring compliance and monitoring of funded initiatives to enhance fair housing practices.

The USDA Forest Service's Invasive Species Program funding opportunity invites proposals aimed at enhancing invasive species prevention. By leveraging existing research and knowledge, projects can create actionable solutions to protect American agriculture. This initiative seeks to connect scientific insights with practical regulatory improvements, thereby reducing the introduction and establishment of new invasive pests. Previous research, including horizon scanning and monitoring sentinel trees, serves as a foundation for developing effective strategies.

The BJA FY 2026 Second Chance Act Family-Based Substance Use Disorder Treatment Program aims to provide essential treatment and recovery support services for parents with substance use disorders (SUD) who have minor children or are pregnant. Eligible applicants include state, local, tribal governments, and nonprofit organizations, which can apply for funding to implement family-based programs in various settings. This initiative seeks to reduce recidivism and enhance reentry outcomes for both parents and their children.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Site-Based Program aims to combat the rising crisis of substance use and overdose deaths. This funding opportunity supports state, local, territorial, and tribal governments in implementing comprehensive responses, including law enforcement initiatives, prevention programs, and recovery services. Applications are due by October 1, 2026, providing a crucial chance to enhance community safety and health through targeted interventions.

The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.

The FY26 Bureau of Land Management Wildlife Resource Management Program aims to enhance wildlife resource management on public lands across the nation. With a focus on habitat protection, species reintroduction, and collaborative conservation efforts, the program addresses critical ecological needs while supporting the social and economic well-being of communities. Key initiatives include habitat treatments, monitoring efforts, and partnerships with state agencies to ensure effective management and recovery of priority wildlife species.

The National Estuarine Research Reserve System (NERRS) Land Acquisition and Construction Program for Fiscal Year 2026, funded by NOAA, aims to enhance research and education by supporting land acquisition and construction projects. With approximately $8.5 million available, the program prioritizes strategic expansions of Reserve boundaries and facility enhancements, ensuring sustainable design standards. Funding will support 5-20 projects over 12-36 months, with potential extensions for complex projects, contingent on available funds and negotiations.