Best Operating Grants for Nonprofits in Puerto Rico

The Jacquilyn Billey Memorial Scholarship, offered by the National Federation of the Blind, provides thirty merit-based scholarships of $10,000 each to legally blind students pursuing post-secondary education in the U.S. The scholarship emphasizes academic excellence, community service, and leadership. Finalists are selected in spring and must attend the NFB National Convention in July for the award announcement. This initiative empowers blind individuals to pursue their educational and career aspirations, reflecting a commitment to inclusivity and opportunity.

The CDC's initiative, 'Holistic and Evidence-Informed Wellness for STI Prevention', addresses the significant public health burden of STIs in the U.S. by promoting a comprehensive approach that emphasizes healthy choices and relationships. By supporting a coalition of sexual health experts, the program aims to enhance STI prevention through strategic resource allocation and the dissemination of high-quality, evidence-based materials, targeting priority groups most affected by STIs. This holistic strategy seeks to reduce STI morbidity and improve overall sexual health.

The Kenneth Jernigan Scholarship, offered by the National Federation of the Blind, honors the legacy of Jacquilyn Billey, a dedicated advocate for the blind. With thirty merit-based scholarships of $10,000 each available, applicants must be legally blind, reside in the U.S., and plan to pursue full-time post-secondary education. Awards are based on academic excellence, community service, and leadership, with finalists attending the NFB National Convention in July for selection.

The Rural Communities Opioid Response Program (RCORP) - Community Systems Development aims to enhance behavioral health systems in rural areas by providing funding for the development and expansion of services. This initiative supports the establishment of formalized networks to boost operational and clinical capacity, ensuring effective implementation of evidence-based substance use disorder prevention, treatment, and recovery services tailored to community needs.

The John Jamison Iron Mountain Education Fund provides scholarships to encourage educational pursuits among the children of Iron Mountain employees. Established in 2004, it awards $2,000 to selected applicants and $4,000 to those majoring in STEM fields. Eligibility includes dependent children of full-time employees at the Director level and below, along with deceased employees' children. The number of scholarships varies annually based on available funds, supporting students in their quest for higher education.

The National Institute of Environmental Health Sciences (NIEHS) is launching a funding opportunity for research hubs focused on the health impacts of extreme weather. This initiative encourages multidisciplinary teams to engage with community partners on issues such as wildfire smoke and extreme heat. Emphasizing collaboration, the program aims to develop scalable solutions and measurable public health outcomes, leveraging resources and expertise across institutions to address climate-related health challenges effectively.

The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.

The National Institutes of Health (NIH) is seeking to enhance the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) through the establishment of a Clinical Coordinating Center (CCC) and Data Coordinating Center (DCC). This initiative aims to improve emergency care outcomes by supporting trials that focus on effective treatments for non-stroke neurological and cardiovascular emergencies. Although applications are not currently being solicited, this notice allows potential applicants to prepare collaborative proposals.

The Focused Technology Research and Development (R01) grant supports innovative projects aimed at developing technologies to enhance biomedical research. This funding opportunity emphasizes the creation of laboratory instruments, algorithms, and biological systems that can significantly improve research capabilities. Key deadlines for applications are set for February, June, and October of 2025 through 2027, ensuring ample time for proposal submissions. The initiative is funded by the National Institutes of Health (NIH), part of the US Department of Health and Human Services.

The U.S. Department of Energy (DOE) is launching the PROSPECT Program to enhance education in critical technologies, targeting an investment of up to $100 million. This initiative aims to develop a skilled workforce across the critical minerals and materials sector, supporting the entire value chain from resource extraction to recycling. By fostering collaboration among academia, industry, and national laboratories, the program seeks to strengthen U.S. economic competitiveness and energy security.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Impact Aid Discretionary Construction Grant Program (84.041C) offers $19M in funding to Local Educational Agencies (LEAs) to address urgent school facility needs. This initiative supports repairs, renovations, or replacements required to maintain safe educational environments. Grants cover projects that improve accessibility in compliance with the Americans with Disabilities Act (ADA) and ensure that facilities meet health standards. The program aims to enhance learning conditions by responding effectively to emergency situations.

The Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership (ESSSP) aims to enhance NOAA's mission through collaborative research and activities. It focuses on understanding changes in Earth's systems and their impacts on ecosystems and communities. Eligible applicants include academic institutions offering doctoral degrees in NOAA-related sciences. The total funding available is approximately $10 million, supporting initiatives that encompass research, data evaluations, and stakeholder engagement.

The Paul Calabresi Career Development Award for Clinical Oncology aims to enhance the training of clinician-scientists in clinical and translational cancer research. This funding opportunity encourages the career growth of researchers but does not permit Scholars to lead independent clinical trials. Instead, it allows participation in clinical trials under the mentorship of an experienced researcher, fostering a collaborative approach to cancer research.

The Partnership Agreement Grants for FY 2027, offered by the National Endowment for the Arts (NEA), support state and regional arts agencies in enhancing community arts accessibility. These grants leverage federal funding to attract significantly more state contributions, fostering a robust federal-state partnership. Each state arts agency develops a tailored arts plan, ensuring that local priorities and goals are effectively addressed. This collaborative approach amplifies the impact of federal arts funding across the nation.

The Health Workforce Research Center (HWRC) aims to enhance understanding of health workforce needs across various levels of governance. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative supports vital research that informs decision-makers, ensuring effective resource allocation and workforce planning to meet healthcare demands.

The OJP FY 2026 Special Attorneys Program provides funding for state, local, Tribal, and territorial prosecuting agencies to hire qualified prosecutors and support staff. These professionals will work under the National Fraud Enforcement Division to investigate and prosecute crimes committed by criminal aliens, as well as drug and human trafficking cases. This initiative aims to enhance law enforcement capabilities, improve intergovernmental coordination, and strengthen the prosecution of fraud and other serious crimes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The BJA FY 2026 Rural Violent Crime Reduction Initiative aims to empower local law enforcement in rural areas to combat violent crime effectively. This funding opportunity provides resources for personnel, technology, and data analytics to enhance crime prevention strategies. Eligible applicants can utilize updated equipment and training to address specific violent crime challenges, ensuring safer communities through innovative approaches and strategic resource allocation. Applications are due by November 6, 2026.

The 2025 Vilcek Foundation Grants aim to support nonprofit organizations that celebrate immigrant contributions to the arts and sciences. The foundation invites applications from organizations operating under U.S. IRS Section 501(c)(3) that promote diversity and inclusivity. Grants will be prioritized for new partners and those in states without prior funding. This initiative underscores the foundation's commitment to fostering appreciation for immigrant communities and their impact on society.

The Northeast Sea Grant Consortium and NOAA’s Northeast Fisheries Science Center invite proposals to explore the interactions between fishing communities and offshore wind development in the U.S. Northeast. This initiative aims to enhance understanding of community resilience and economies, while fostering collaborative research that informs decision-making. Proposals should utilize qualitative and quantitative methods and involve at least one Co-PI from the six states of the NESGC, with a requirement for a 25% non-federal match.

The National Cancer Institute (NCI) plans to issue a Notice of Funding Opportunity (NOFO) for the Paul Calabresi Career Development Award in Clinical Oncology (K12). This program aims to enhance training for clinician-scientists in cancer research, fostering their career development and collaboration with basic research scientists. It mandates diverse oncology specialties in faculty, individualized career development plans, and mentorship, supporting Scholars for up to three years to promote their research initiatives in clinical trials.

The John Lewis NIMHD Research Endowment Program aims to enhance research infrastructure and training at higher education institutions to address health disparities. Key objectives include improving physical infrastructure, acquiring research equipment, developing technical expertise, expanding academic science programs, and recruiting accomplished researchers. This limited competition invites applications from eligible organizations, with a rigorous peer-review process to ensure only high-quality proposals receive funding.

The Level 2 Rural Outreach Grant, offered by the National Association of Realtors, supports initiatives aimed at addressing rural issues through collaboration with public and private stakeholders. Grants up to $7,500 are available for studies, events, and outreach efforts. Each association can receive one grant annually, and funds are distributed via reimbursement. Recipients must complete an evaluation form for their project, promoting effective advocacy and community engagement.

Local Data for Equitable Communities CFP

This call for proposals (CFP) invites eligible nonprofit organizations in the U.S. to apply for a grant to collect, analyze, and use data to address inequities in the physical, economic, and social conditions of a place. Improving these conditions is key to achieving health equity where health is no longer a privilege, but a right. Structural racism is one of the leading barriers that results in inequities in conditions within and across communities. The Robert Wood Johnson Foundation (RWJF) expects to award up to 30 grants of $50,000 each, with a period of performance of nine months. The Urban Institute, as the national coordinating center for this program, is collaborating with RWJF on program design, grantee support, and communications.

Local data can be valuable tools to make progress on building places that offer everyone the chance to be as healthy as possible. Community organizations and residents can use data to understand challenges, set priorities, advocate for what is important to them, and hold others accountable for promised changes.

The goals of the Local Data for Equitable Communities grant program are to:

• Inform public policy and improve the physical, social, and economic conditions of places
• Build local capacity to use data for action
• Strengthen the use of equitable data practices
• Document successful practices for more communities to learn from and adapt

Funding

• Type of Award: Awards funded under this opportunity will be structured as grants.
• Number of Awards: Up to 30 awards will be funded.
• Amount of Award: Each award will be up to and including $50,000.
• Award Duration: Awards will be nine months.

This funding opportunity aims to bolster the cancer surveillance workforce through educational initiatives. By enhancing collaborations with cancer partners and developing tools for improved data quality, this program will expand the capacity of registrars. Efforts will focus on recruitment and retention, ultimately ensuring compliance with Public Law 102-515. Strengthening the cancer registrar workforce will lead to timely and accurate cancer data submission, supporting public health objectives.

The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.