Best Seed Grants for Nonprofits in Puerto Rico

The Ocean Technology and Interdisciplinary Coordination (OTIC) Program, funded by the National Science Foundation (NSF), supports innovative research and technology development in ocean science. This program welcomes unsolicited proposals for instrumentation that enhances the capabilities of the ocean research community. It also announces specific funding opportunities aimed at improving facilities and equipment at Biological Field Stations and Marine Laboratories, promoting interdisciplinary collaboration in oceanographic studies.

The Organizational Change in the Professional Formation of Engineers (ENGINEER:OC) initiative promotes innovative research and activities aimed at transforming engineering education and workforce development. Supported by the National Science Foundation (NSF), it seeks to enhance access to quality engineering programs across diverse institutions. Projects may involve implementing new curricular innovations or adapting existing models to different contexts, ultimately advancing the professional formation of engineers and fostering inclusive educational pathways.

The American Bar Endowment's Opportunity Grant Program provides funding for innovative, boots-on-the-ground initiatives that address urgent legal needs of the public. This grant focuses on increasing access to justice for underserved populations, improving the justice system, and enhancing public understanding of legal rights. Eligible applicants include public charities and organizations directly impacting local communities, with a strong emphasis on projects that leverage technology and address immediate legal challenges.

The National Biomedical Research Centers (NBRCs) aim to enhance biomedical research by providing advanced equipment, scientific expertise, and innovative human-based models. Supported by NIH and other federal agencies, this initiative focuses on reducing reliance on live animal models through the development of New Approach Methodologies (NAMs). The program invites applications that propose actionable plans to refine and replace animal use, promoting innovative research at centers with existing nonhuman primate colonies.

The Collaborative Program Grant for Multidisciplinary Teams, funded by the US Dept. of Health & Human Services: National Institutes of Health (NIH), supports integrated teams of researchers tackling ambitious projects that individual efforts cannot achieve. This program promotes collaboration among experts with complementary skills, aiming for significant advancements in their fields. Teams are encouraged to pursue innovative objectives that have the potential to transform research landscapes.

The Professional Formation of Engineers (PFE) initiative aims to enhance the engineering workforce through integrated research and education. It focuses on developing ethical engineers who can adapt to a changing technical landscape. PFE supports diverse training contexts, including formal education, internships, and community experiences, ensuring clear pathways into the profession. This initiative fosters collaboration among engineers, technical workers, and communities, enhancing the skills needed for global competition and technological advancement.

The Medical Scientist Training Program (MSTP) aims to cultivate skilled clinician-scientist leaders to meet the nation's biomedical research demands. It supports domestic organizations in developing dual-degree training that integrates clinical and research education, leading to both a clinical degree (e.g., M.D., D.O.) and a Ph.D. Through comprehensive mentoring and career development, MSTP prepares trainees for impactful careers in health-related research, ensuring a robust pipeline of qualified scientists.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Medical Scientist Training Program (MSTP) aims to cultivate a diverse group of physician-scientist leaders to address the nation's biomedical research needs. This program supports institutions in creating integrated dual-degree training that results in both medical and research doctorate degrees. By combining clinical practice with scientific research, MSTP graduates will advance health-related research, focusing on improving training effectiveness, alumni retention in research careers, and workforce diversity. NIGMS emphasizes comprehensive training elements for impactful careers.

The Amgen Foundation, established in 1990, focuses on enhancing science education and strengthening communities. It supports nonprofit organizations that align with its mission, emphasizing teacher development and hands-on science experiences. Grants are awarded annually, with a commitment of $180 million to impactful programs. Eligible organizations include public schools and libraries, while ineligible requests involve individual support, religious organizations, and political activities. This approach aims to inspire the next generation of innovators through quality educational opportunities.

The Engineering Biological and Biomedical Systems (EBBS) program, funded by the National Science Foundation (NSF), aims to advance our understanding of biological systems and improve human health through innovative engineering solutions. It supports research that combines mechanistic insights with experimental techniques to develop novel biomedical technologies, enhance biomanufacturing processes, and explore therapeutic applications. Projects focusing on engineering principles for biological responses and rehabilitation are encouraged, while drug design and clinical trials are outside the program's scope.

The National Science Foundation (NSF) is funding initiatives to enhance the value of scientific datasets through innovative artificial intelligence (AI) methods. This program aims to facilitate interdisciplinary research and unlock new insights by applying AI for feature extraction, metadata generation, and dataset integration. Proposals should ensure data security and promote collaboration with various sectors to advance AI-driven scientific discovery. By aligning with NSF priorities, researchers can contribute to cutting-edge science and technology for broader participation in STEM.

The NIDCR is inviting applications for the continuation or revision of ongoing clinical trials through the UH3 Clinical Trial Required grant. This opportunity supports extensions for completing trials or longer follow-up periods, as well as revisions that are well justified. Key deadlines for submissions are set from March 2025 to January 2028, with optional Letters of Intent encouraged thirty days prior to application due dates. Ensure compliance with the outlined requirements to enhance your chances of funding.

The Veterans Cemetery Grants program, administered by the U.S. Department of Veterans Affairs, provides financial assistance to establish, expand, and improve Veterans cemeteries across the United States. With over $910 million awarded, this initiative ensures that state and tribal governments can maintain these sacred sites, supporting the interment of Veterans and their eligible family members. Grants cover up to 100% of project costs, reinforcing the commitment to honor those who served.

The Limited Competition grant supports High Impact Specialized Innovation Programs to enhance clinical and translational science capabilities at UM1 CTSA Program Hubs. Eligible applicants include primary UM1 CTSA hub organizations, aiming to address significant gaps in research and development. Successful proposals will foster foundational innovations for broader dissemination among CTSA hubs, paving the way for future advancements in clinical practices and research methodologies.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The Aging Research Dissertation Awards aim to enhance diversity in the scientific workforce by funding research on aging and related health conditions. The program encourages applicants from underrepresented backgrounds to apply for dissertation awards that align with the National Institutes of Health's strategic priorities. Key deadlines for applications include February 16, June 16, and October 16 for the years 2024 through 2026.

The Limited Competition Small Grant Program supports NCATS CTSA Program KL2 scholars, enhancing their transition to independent academic translational scientists. This R03 funding facilitates various research projects, including pilot studies and methodology development, aimed at generating preliminary data for future R01 applications. The program is designed for short-term projects utilizing limited resources, promoting innovative research in clinical and translational science.

The U.S. Department of Labor's Bureau of International Labor Affairs has announced $11 million for a cooperative agreement to combat unfair labor practices and Illegal, Unreported, and Unregulated (IUU) fishing in Indonesia and the Philippines. This initiative aims to protect American seafood workers by improving labor enforcement and addressing abusive practices in the global seafood supply chain, ultimately ensuring a fair competitive environment for U.S. businesses and their workers.

The Innovative Traffic Safety Enforcement (ITSE) Grant Program aims to develop effective traffic safety enforcement initiatives to reduce motor vehicle crashes caused by risky driving behaviors. It encompasses three evaluation phases, with deadlines from September 2026 to September 2027. This program seeks to fund scalable and repeatable projects that align with the Department of Transportation's mission and executive priorities, enhancing safety across the United States.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.

The Abbey Mural Prize, established in 1932, supports the creation and restoration of public murals across the United States. This prestigious award, administered by the National Academy of Design since 1940, emphasizes projects that enhance community engagement and social activism through art. Grants typically range from $10,000 to $40,000, with a total annual funding cap of $125,000. Eligible applicants include artists, architects, and nonprofit organizations committed to impactful mural projects.

The BJA FY 2026 Edward Byrne Memorial Justice Assistance Grant (JAG) Program—State Formula aims to enhance public safety through formula funding to states. This initiative supports hiring personnel and acquiring vital resources for law enforcement and criminal justice systems. Eligible state agencies can apply for grants to address various public safety challenges, including violent crime and human trafficking, ensuring the protection of American citizens. Applications are due by September 25, 2026.

The NIH is announcing a funding opportunity for competitive revisions of ongoing grants to tackle unforeseen public health crises. This Urgent Competitive Revision program aims to facilitate timely responses to emerging health challenges. Once the Notice of Funding Opportunity is published, eligible applications will be directly routed to the appropriate NIH awarding component. Only submissions in response to an Urgent Guide Notice published by an NIH Institute or Center will be accepted.