Best Unrestricted Grants for Nonprofits in Puerto Rico

The Rehabilitation Engineering Research Center on Recreational, Sport, and Exercise Technologies for People with Disabilities aims to enhance rehabilitation services through innovative technological solutions. This initiative focuses on promoting health and exercise among individuals with disabilities by addressing unique rehabilitation challenges. Funded by the US HHS Administration for Community Living, the project spans 60 months, involving advanced research and development to create effective support mechanisms and overcome environmental barriers.

The DOJ FY 2026 ANGEL Grant Program aims to enhance public safety by funding state, local, and tribal government initiatives to combat violent crime committed by criminal illegal aliens. This program supports hiring law enforcement personnel, retaining critical staff, and acquiring advanced technology. The objective is to prevent harm to American citizens and support Homeland Security Task Force operations. Applications must be submitted by October 27, 2026, to qualify for funding.

The NSF Geosciences Core Research program funds innovative projects across atmospheric, geospace, earth, and ocean sciences. It encourages proposals that push the boundaries of knowledge in fundamental research, promoting interdisciplinary approaches. This initiative seeks transformative ideas that may not have immediate commercial applications but are crucial for advancing scientific understanding and addressing complex environmental challenges. Researchers are invited to explore various domains or integrate multiple disciplines to enhance our comprehension of the Earth and its systems.

The Air Force Fiscal Year 2027 Young Investigator Program (YIP) is designed to support early career scientists and engineers who have recently obtained their Ph.D. This initiative aims to promote innovative basic research in science and engineering while enhancing the professional growth of promising investigators. Awards are available to U.S. institutions where the principal investigator is a full-time employee. Eligible candidates must be U.S. citizens, nationals, or permanent residents.

The National Institutes of Health (NIH) is continuing support for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), which focuses on clinical trials and biomarker validation studies for neurological disorders. This initiative aims to foster innovation in neurotherapeutics by providing essential infrastructure and expertise. The program encourages the establishment of Clinical Coordinating Centers (CCC) and Data Coordinating Centers (DCC) to enhance collaborative efforts. Note that applications are not currently being solicited.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

About Borealis Philanthropy

Borealis Philanthropy is a philanthropic social justice intermediary that works to resource grassroots leaders and social justice movements for transformative change. We help funders expand their reach and strengthen their impact through donor collaboratives that support a variety of issues, communities, and movements. Borealis is home to nine donor collaboratives, including the Disability Inclusion Fund and Disability x Tech.

DIF x Tech Fund

For the Disability Inclusion Fund at Borealis, part of our efforts for disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. The DIF x Tech initiative, supported by the Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest, invites proposals that are working to bring about transformational change at the intersections of disability, justice, and technology

About the Disability Inclusion Fund and DIF x Tech

The Disability Inclusion Fund (DIF) supports U.S.-based groups run by and for people with disabilities to lead transformational change. The Fund is supported by donors including the Presidents’ Council on Disability Inclusion in Philanthropy, which is comprised of foundation presidents who are committed to disability inclusion as part of improving diversity, equity, and inclusion within philanthropy.

Part of the efforts of disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. This newly launched initiative is housed at the Disability Inclusion Fund (DIF) and supported by Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest. 

DIF x Tech Fund Values

All Disability x Tech award decisions will align with the DIF guiding values. The DIF guiding values are:

• Participation: Movement funding accountable to the disability rights movement. Those impacted by injustice/exclusion should be involved in strategies to advance justice/inclusion.
• Intersectionality: Acknowledging that disabled people have multiple and intersecting social and political identities that can influence their ability to have access and inclusion including race, gender identity, class, sexual orientation.
• Radical inclusion: Deeply committed to removing barriers and ensuring access so that those most affected by intersecting identities can participate, valuing lived experience.
• Leadership of those most impacted by ableism: Emphasis is given to organizations led by people subject to systemic bias and impacted by underrepresentation, particularly disabled people of color, queer, gender nonconforming and women with disabilities.
• Cross-movement solidarity: Intentional focus on collaboration and bridge- building amongst disability justice activists and across movements.
• Sustainability: Resources and tools that support the growth of grassroots disabled-led organizations, and expand operational capacities for ongoing movement building. 

What we fund

We invite proposals that are at the nexus of technology, disability rights and justice. This opportunity may be a good fit for your organization, if you are doing work in any of these areas below:

• Disabled people sharing technical skills and knowledge with others in the community.
• Disabled people leading policy, rights, and disability justice activism work related to tech. 
• Disabled people participate in all stages of the design and development of new tech that will enrich lives of people with disabilities.
• Enabling collective and equitable access to digital infrastructure. 
• Expanding the participation, leadership, and thought partnership of overlooked and under-resourced people with disabilities in all areas of the technology sector.
• Partnerships between disability-focused engineering design labs and maker spaces within schools, centers for independent living, or local nonprofit organizations.
• Permissible Policy Work:
  • We may support nonpartisan policy education and advocacy related to disability and technology. Any lobbying must remain within applicable 501(c)(3) limits and Borealis grant restrictions.

The NASA ROSES 2025: A.18 Geosphere program provides funding for research on solid-Earth processes across various scales. It aims to enhance understanding of the Earth's structure and dynamics, particularly in the core, mantle, and lithosphere. Key areas of focus include Earth Surface Properties, Crustal Dynamics, and Earth Interior. This initiative supports advancements in managing natural resources, assessing geohazards, and exploring the forces driving plate tectonics, ultimately contributing to improved hazard forecasting and mitigation strategies.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

The Radiation Exposure Screening and Education Program aims to support organizations in their efforts to screen and educate individuals who have been exposed to radiation from uranium mining and U.S. nuclear weapons testing. This initiative emphasizes the importance of awareness and education in mitigating health risks associated with radiation exposure, ensuring affected communities receive the necessary resources and support for health management.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA) aims to enhance the capacity of grantees through dedicated training. It addresses critical operational issues related to overdose responses, targeting illicit opioids and stimulants. The program underscores the U.S. Department of Justice's commitment to public safety, law enforcement support, and the fight against substance misuse. Applications are due by November 9, 2026.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The HFM Foodservice Scholarship Fund supports students in Hawaii pursuing education in Culinary Arts or Agriculture. Applicants must demonstrate financial need, maintain a minimum GPA of 2.7, and attend an accredited institution in the U.S. Preference is given to prior recipients in good academic standing. This scholarship aims to empower future leaders in the foodservice industry by providing financial assistance to deserving candidates.

The BJA FY25 Capital Case Litigation Initiative aims to enhance the quality of legal representation in state capital cases, ensuring effective public representation and support for indigent defendants. This initiative is part of the OJP's commitment to uphold the rule of law, protect civil rights, and address public safety challenges. Through federal leadership and funding, OJP seeks to bolster law enforcement efforts and combat violent crime, thereby improving community safety and justice.

The Lifespan Respite Care Program invites state agencies to apply for grants aimed at enhancing respite services for caregivers of individuals with disabilities or chronic conditions. This initiative supports both new states and those re-establishing their programs, focusing on collaboration, training, and outreach to address the respite needs of diverse populations. Approximately ten cooperative agreements will be funded over three years, aligning with federal requirements for lifespan respite care.

The Field Initiated Projects Program (Development) aims to enhance the inclusion and self-sufficiency of individuals with disabilities through innovative research and development. This program supports the creation of tools, methods, and systems that assist people with disabilities, particularly those with significant support needs. With 16 grants available, the initiative will span 36 months, focusing on impactful projects that foster independence, employment, and community integration.

The NCI Pathway to Independence Award (K99/R00) aims to support early-stage postdoctoral researchers transitioning to independent faculty positions. This initiative focuses on talented individuals with doctoral degrees in research or clinical fields, providing essential NCI funding during this key career juncture. Researchers engaged in cancer control, prevention, and data sciences are encouraged to apply for this opportunity, which emphasizes experimental studies with human participants, thus aligning with NIH's clinical trial definitions.

The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.

The Technology Development Research for Establishing Feasibility and Proof of Concept (R21) grant supports innovative projects aimed at developing new technologies with high potential impact in biomedical research. Applicants are encouraged to submit Letters of Intent 30 days before application deadlines, which are set for February, June, and October from 2025 to 2027. This funding opportunity is administered by the NIH, focusing on high-risk, high-reward exploratory research.

The Surveillance and Case Control Study of Stillbirth and Birth Defects (SUCCSSBD) aims to enhance the quality of birth defects and stillbirth surveillance in the U.S. By modernizing data collection through electronic case reporting, the initiative seeks to improve data quality and timeliness. The study will focus on identifying risk factors for birth defects and stillbirths, addressing a significant public health issue that affects thousands of pregnancies annually. CDC funding will support three key components in this effort.

The Alleghany Foundation, a private 501(c)(3) organization in Virginia, focuses on enhancing the quality of life in the Alleghany Highlands through strategic funding initiatives. It seeks grant applications that address key areas such as economic transformation, educational excellence, health and wellness, community capacity, and civic leadership. By prioritizing innovative projects and supporting local organizations, the Foundation aims to foster sustainable growth and community engagement, ensuring a vibrant future for the region.

The Rehabilitation Engineering Research Center aims to enhance services for individuals who are blind or have low vision through innovative technology development. This initiative focuses on overcoming rehabilitation challenges and environmental barriers, promoting independence and community living. A grant of five years will support ongoing research efforts, ensuring advancements in assistive technologies that empower the target population. The project aligns with the Rehabilitation Act's goals, emphasizing the importance of accessibility and inclusion.

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center aims to enhance understanding of inflammatory bowel disease (IBD) by coordinating extensive genetic research. By leveraging diverse patient cohorts and advanced data science techniques, the center seeks to identify genetic risk factors, develop predictive biomarkers, and improve IBD patient management. This initiative will facilitate collaboration among various research centers and ensure efficient data collection and sharing to foster advancements in precision medicine for IBD.

The Level 1 Rural Outreach Grant, offered by the National Association of Realtors, aims to enhance REALTORS®' understanding of rural issues. With a maximum award of $3,000, this grant is available once per calendar year to associations. It supports educational efforts and promotes smart growth and diversity in rural communities. Grant recipients are required to complete an evaluation form for the funded activities, ensuring accountability and effectiveness in addressing rural challenges.

The EPSCoR Centers of Research Excellence in Science and Technology initiative, led by the National Science Foundation, aims to enhance the research capabilities of EPSCoR jurisdictions. By fostering STEM capacity and promoting geographic diversity, this program invites proposals that align with its goals. The focus is on strengthening local research infrastructure and talent development to boost competitiveness in science and technology fields across the nation.