Best Unrestricted Grants for Nonprofits in Puerto Rico

The NIH is set to release a funding opportunity for pragmatic and implementation trials aimed at evaluating the effectiveness of interventions in real-world healthcare settings. This initiative encourages collaborations across various health systems to assess the effectiveness and feasibility of interventions. By focusing on commonly encountered conditions in everyday clinical care, the trials aim to provide actionable insights for patients, clinicians, and policymakers. Interested investigators are encouraged to start developing their project proposals.

The BJA FY 2026 Paul Coverdell Forensic Science Improvement- Competitive Grants Program aims to enhance forensic science and medical examiner/coroner services across the U.S. This funding opportunity supports state and local government laboratories in improving their capabilities to ensure justice and public safety. Applications are due by November 5, 2026, at 8:59 p.m. ET, promoting advancements in forensic practices to better serve law enforcement and communities.

The NIAID is dedicated to advancing research on medical countermeasures against chemical and radiation threats, focusing on innovative technologies to diagnose and treat exposure effects. The initiative promotes the development of models, biomarkers, and devices that enhance survival and reduce morbidity during public health emergencies. It supports preclinical efforts to address injuries from designated Chemicals of Concern, emphasizing the need for effective solutions in civilian mass casualty scenarios.

The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.

The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.

The NIH Mentored Patient-Oriented Research Career Development Award (K23) aims to enhance the career development of clinical doctoral degree holders dedicated to patient-oriented research. It supports individuals in their commitment to focus their research efforts on improving patient outcomes. The award has multiple application deadlines, including June 12, 2024, and October 12, 2024, among others, catering to various grant types, including standard, renewal, and AIDS-related applications.

The NIH Common Fund Data Ecosystem aims to enhance the reusability of biomedical data through collaboration between Common Fund programs and external data resources. This funding opportunity encourages projects that connect various biomedical data ecosystems, including the HEAL Data Ecosystem and the BRAIN Initiative. By fostering partnerships, the initiative seeks to improve the accessibility and interoperability of valuable datasets, ultimately advancing research efforts. Note that clinical trials are excluded from this funding opportunity.

The CCS High School Chemical Safety Grant, offered by the American Chemical Society, aims to enhance chemical safety in secondary education. Educators can apply for up to $3,000 to support initiatives like curriculum integration of safety practices, advocating for safe chemical usage, and improving safety infrastructure. Eligible applicants include middle and high school science teachers in the U.S. Grants cover training, equipment, and workshops to promote a culture of safety in educational environments.

The Leadership Education in Adolescent Health (LEAH) Program, funded by the US HHS: Health Resources & Services Administration, aims to enhance the quality of care for adolescents and young adults. By establishing graduate training programs, LEAH prepares healthcare professionals to effectively address chronic disease prevention and improve access to team-based healthcare services for this population, ultimately fostering better health outcomes and empowering future leaders in adolescent health.

The FY 2027 Service Area Competition (SAC) funding aims to enhance healthcare access in underserved communities across the U.S. by providing grants for comprehensive primary and preventive health services. This initiative addresses essential health needs through competitive funding opportunities, ensuring that health centers can effectively serve their designated areas. Additional service areas may be announced as needed if current centers are unable to continue their operations, thus maintaining service continuity.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. and its territories. This funding opportunity supports comprehensive preventive and primary health care delivery. Each SAC announcement details service areas available for competition, with potential additional areas announced throughout the year. This initiative is crucial for ensuring continuous access to quality health care for vulnerable populations.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive primary and preventive care. This initiative will support health centers in delivering high-quality services, addressing the needs of populations that face barriers to care. Each funding opportunity will specify service areas available for competition, ensuring effective resource allocation to improve community health outcomes.

The BJA FY26 Paul Coverdell Forensic Science Improvement - Formula Grants Program supports state agencies in enhancing forensic science capabilities. The program aims to improve public safety by funding initiatives that strengthen forensic science and support law enforcement efforts. Eligible applicants can submit their full applications through JustGrants by November 6, 2026. This funding is crucial for addressing ongoing challenges in the justice system, including violent crime and public safety concerns.

The FY 2027 Service Area Competition (SAC) funding aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive preventive and primary health care. The initiative supports health centers in delivering essential services, ensuring that vulnerable populations receive the care they need. Service areas for competition are announced periodically, and additional areas may be added if existing centers are unable to continue their services.

The Organizational Change in the Professional Formation of Engineers (ENGINEER:OC) initiative promotes innovative research and activities aimed at transforming engineering education and workforce development. Supported by the National Science Foundation (NSF), it seeks to enhance access to quality engineering programs across diverse institutions. Projects may involve implementing new curricular innovations or adapting existing models to different contexts, ultimately advancing the professional formation of engineers and fostering inclusive educational pathways.

The Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI) by NIGMS aims to enhance research productivity and flexibility for early career scientists. This program consolidates funding into a single award, allowing investigators to pursue ambitious projects while reducing administrative burdens. By supporting diverse research initiatives, MIRA helps cultivate a new generation of innovative researchers, ensuring essential breakthroughs in fundamental science.

The American Bar Endowment's Opportunity Grant Program provides funding for innovative, boots-on-the-ground initiatives that address urgent legal needs of the public. This grant focuses on increasing access to justice for underserved populations, improving the justice system, and enhancing public understanding of legal rights. Eligible applicants include public charities and organizations directly impacting local communities, with a strong emphasis on projects that leverage technology and address immediate legal challenges.

The Centers of Biomedical Research Excellence: Development Phase (COBRE-D) program aims to enhance biomedical research capacity in IDeA states, which historically receive low NIH funding. By providing critical support for early-career investigators and essential infrastructure, COBRE-D facilitates a long-term vision for institutions. This initiative not only supplements start-up packages for new hires but also establishes research facilities and improves administrative services, paving the way for less-resourced institutions to transition into the COBRE E/S program.

The Professional Formation of Engineers (PFE) initiative aims to enhance the engineering workforce through integrated research and education. It focuses on developing ethical engineers who can adapt to a changing technical landscape. PFE supports diverse training contexts, including formal education, internships, and community experiences, ensuring clear pathways into the profession. This initiative fosters collaboration among engineers, technical workers, and communities, enhancing the skills needed for global competition and technological advancement.

The National Science Foundation (NSF) is funding initiatives to enhance the value of scientific datasets through innovative artificial intelligence (AI) methods. This program aims to facilitate interdisciplinary research and unlock new insights by applying AI for feature extraction, metadata generation, and dataset integration. Proposals should ensure data security and promote collaboration with various sectors to advance AI-driven scientific discovery. By aligning with NSF priorities, researchers can contribute to cutting-edge science and technology for broader participation in STEM.

The Engineering Biological and Biomedical Systems (EBBS) program, funded by the National Science Foundation (NSF), aims to advance our understanding of biological systems and improve human health through innovative engineering solutions. It supports research that combines mechanistic insights with experimental techniques to develop novel biomedical technologies, enhance biomanufacturing processes, and explore therapeutic applications. Projects focusing on engineering principles for biological responses and rehabilitation are encouraged, while drug design and clinical trials are outside the program's scope.

Bureau of Justice Assistance

The Bureau of Justice Assistance (BJA) was created in 1984 to reduce violent crime, create safer communities, and reform our Nation’s criminal justice system.

BJA strengthens the Nation’s criminal justice system and helps America’s state, local, and tribal jurisdictions reduce and prevent crime, reduce recidivism, and promote a fair and safe criminal justice system. BJA focuses its programmatic and policy efforts on providing a wide range of resources, including training and technical assistance, to law enforcement, courts, corrections, treatment, reentry, justice information sharing, and community-based partners to address chronic and emerging criminal justice challenges nationwide. 

Special Attorneys Program

This program will support state, local, Tribal, and territorial prosecuting agencies in assigning or hiring qualified prosecutors to serve full time as Special Attorneys within the National Fraud Enforcement Division or the Criminal Division or as Special Assistant United States Attorneys (SAUSAs) within a United States Attorney’s Office. These cross-designated prosecutors will investigate and prosecute fraud and other crimes committed by aliens within the United States (hereafter referred to as “criminal aliens”) and will investigate and prosecute crimes involving drug or human trafficking committed within the United States.

This grant program, authorized under Public Law 119-21, Title X, Subtitle A, Part II, Section 100055 (codified at 34 U.S.C. § 61101), is intended to strengthen investigative and prosecutorial capacity, expand intergovernmental coordination, and enhance the ability of jurisdictions to investigate and prosecute fraud and other crimes committed by aliens within the United States and drug and human trafficking crimes. The program is also intended to increase the availability of cross-designated prosecutorial personnel who can pursue these matters in coordination with federal authorities and contribute to the effective enforcement of applicable criminal laws.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The National Biomedical Research Centers (NBRCs) aim to enhance biomedical research by providing advanced equipment, scientific expertise, and innovative human-based models. Supported by NIH and other federal agencies, this initiative focuses on reducing reliance on live animal models through the development of New Approach Methodologies (NAMs). The program invites applications that propose actionable plans to refine and replace animal use, promoting innovative research at centers with existing nonhuman primate colonies.

The Amgen Foundation, established in 1990, focuses on enhancing science education and strengthening communities. It supports nonprofit organizations that align with its mission, emphasizing teacher development and hands-on science experiences. Grants are awarded annually, with a commitment of $180 million to impactful programs. Eligible organizations include public schools and libraries, while ineligible requests involve individual support, religious organizations, and political activities. This approach aims to inspire the next generation of innovators through quality educational opportunities.

The National Science Foundation (NSF) Directorate for Engineering (ENG) fosters groundbreaking research in electrical, communications, and computing systems through programs like Electronic, Photonic, Magnetic, and Quantum Devices (EPMQD) and Circuits and Systems for Communications and Sensing (CSCS). These initiatives emphasize innovative foundational research, particularly in power and energy systems, while being open to transformative ideas without immediate commercial outcomes. Funding availability will shape the portfolios of ECCS awards.

The NIAID Physician-Scientist Pathway to Independence Award (K99/R00) aims to support new independent physician-scientists by facilitating their transition from postdoctoral research to tenure-track faculty positions. This program provides essential research funding to help awardees establish their careers in biomedical research, addressing the national shortage of physician-scientists. Applicants must propose research that does not lead an independent clinical trial, but may include mentorship in clinical trials.