Best Sioux Falls Grants for Nonprofits in South Dakota

The Society of Women Engineers (SWE) offers Program Development Grants to support the initiatives of SWE Organizations. These micro-grants range from a minimum of $250 to a maximum of $5,000 and are available in three application cycles. To qualify, organizations must be in good standing, and the event must occur at least 45 days post-application deadline. Active SWE membership for the event manager and treasurer is also required for grant submission.

The Midwest Culture Bearers Award honors and supports nine folk arts practitioners annually, providing each with a $5,000 unrestricted grant. This initiative aims to amplify the essential work of culture bearers across the Midwest, fostering opportunities for recognition and community connection. By prioritizing traditional practices and knowledge sharing, the award not only celebrates cultural heritage but also strengthens the creative roots of the region, ensuring vibrant artistic expression for future generations.

The Cystic Fibrosis Foundation's Program for Adult Care Excellence (PACE) aims to enhance adult care for cystic fibrosis patients by recruiting and training physicians. With an increasing life expectancy for CF patients, the program addresses the need for specialized adult caregivers. Physicians can apply for funding up to $38,435 per year for three years, enabling them to develop expertise in adult CF care. This initiative supports both the medical community and the CF population significantly.

The AO North America VET Preceptorships Program offers surgical residents from the American College of Veterinary Surgeons the chance to enhance their skills in Veterinary Trauma and Orthopedics through a structured training experience. Participants can receive up to four weeks of advanced training in AO techniques at designated surgical centers, with funding available for housing and travel expenses, totaling up to $2,750. This initiative aims to foster professional development and improve patient care outcomes.

The CF Foundation/NIH K-Unfunded Award aims to support exceptional research projects in cystic fibrosis (CF) that have been approved by the NIH but lack funding. This award provides temporary financial assistance of up to $80,000 per year for two years to ensure that promising CF research continues without interruption. The initiative focuses on fostering a new generation of researchers dedicated to advancing CF studies while encouraging the NIH to provide long-term support.

The CFF/NIH R01-Unfunded Award, offered by the Cystic Fibrosis Foundation, supports exceptional CF-related research projects that have been submitted to NIH but lack funding. This program aims to bridge the gap for meritorious projects, providing up to $125,000 per year for two years. By facilitating research in cystic fibrosis, the foundation helps ensure that innovative ideas can continue to progress toward improving care and outcomes for individuals affected by this disease.

The ASF Family Fund Grant, offered by the Angelman Syndrome Foundation, provides crucial financial assistance to families of individuals with Angelman syndrome. This rare neuro-genetic disorder affects approximately 500,000 people globally. The fund aims to enhance the quality of life for affected individuals, allowing caregivers to apply for up to $5,000 to cover essential needs. Limitations include restrictions on certain expenses and prior grant awards. This initiative aims to support families through education and necessary resources.

The James Madison Graduate Fellowship supports U.S. citizens pursuing master's degrees focused on the Constitution, enhancing their constitutional knowledge for teaching. Fellows are required to teach American history, government, or civics at the secondary level for one year per funding year. Financially, the fellowship awards up to $24,000, covering tuition and fees, and must be repaid if fellowship conditions are unmet. This program ensures future educators embody constitutional principles in their teaching.

The Valley Hospital Auxiliary has been supporting future healthcare professionals since 1961 by providing scholarships to high school seniors and undergraduate students. In 2025, they awarded $30,000 to 21 exceptional students who have shown academic excellence and a commitment to healthcare. This initiative not only benefits the recipients but also contributes to the community by nurturing the next generation of medical leaders. Eligible high school students can reapply throughout their college years, ensuring continuous support for their educational journeys.

The VFW's Sport Clips Help A Hero Scholarship offers financial support of up to $5,000 to eligible veterans and service members pursuing their educational goals. This initiative, backed by the Veterans of Foreign Wars organization, aims to alleviate the burden of student debt for those who have served our country. By partnering with Student Veterans of America and Sport Clips, the VFW ensures that veterans receive the assistance they deserve to succeed in their academic endeavors.

The Truman Scholarship, established by the Truman Foundation, supports college juniors committed to public service. It offers up to $30,000 for graduate studies, alongside mentoring and career development opportunities. Ideal candidates demonstrate leadership, a strong commitment to public service, and the potential for success in graduate school. This prestigious award aims to cultivate future leaders dedicated to making a positive impact in their communities and beyond.

The PCORI Call for Proposals for HSII Implementation Projects invites innovative approaches to address barriers in healthcare settings. These projects should enhance practice change through active, multi-component strategies and include rigorous evaluations to measure implementation effectiveness. While developing tools to support these strategies is permitted, it should not be the main focus. Successful proposals will demonstrate their potential impact on healthcare outcomes and patient experiences.

The Ollie Hinkle Heart Foundation's Technology Grant aims to improve pediatric heart care outcomes through innovative collaborations. By focusing on predictive technologies for early recognition, precision for personalized care, and preventive measures for quality of life, the foundation seeks to transform care for heart children and their families. Their mission emphasizes community support, education, and advocacy to ensure no family faces unmet needs alone, creating a legacy of love and courage in the heart community.

The Implementation Awards by PCORI aim to fund projects that translate patient-centered research into real-world practices. With budgets up to $2.5 million for implementation projects lasting up to 48 months, applicants must present a clear plan for broad evidence uptake. Additionally, those proposing implementation projects need an accepted Draft Final Research Report related to their original PCORI-funded research to qualify for funding.

This funding opportunity aims to enhance the development of medical products in rare diseases through innovative natural history studies. By generating high-quality data, the FDA seeks to bridge critical knowledge gaps and eliminate barriers in rare disease research. The initiative focuses on diseases with unmet needs, fostering significant impacts for those affected and facilitating the development of effective therapeutic solutions.

The NARMS Cooperative Agreement Program aims to enhance antibiotic resistance surveillance in retail food specimens. Funded by the FDA, this initiative strengthens the National Antimicrobial Resistance Monitoring System established in 1996. By improving detection methods and expanding sampling sites, the program seeks to protect public health and align with NARMS objectives, ultimately combating the growing threat of antibiotic resistance in food commodities.

The RFA-FD-23-001 funding opportunity aims to support clinical trials for orphan products targeting rare diseases. It focuses on evaluating the efficacy and safety of treatments to address unmet medical needs. By promoting innovative and collaborative trial designs, the FDA seeks to enhance the approval rates of effective therapies for rare conditions, ultimately benefiting patients and advancing drug development in this critical area.

The Yéigo Action Grant, provided by the First Peoples Fund, offers financial support ranging from $100 to $2,500 for Native artists and culture bearers facing hardships that affect their creative practices. This grant aims to assist artists with specific professional opportunities, such as workshops or emergencies. By honoring the spirit of encouragement embodied in the Diné word 'yéigo', the grant helps ensure that artists can continue their vital work within their communities.

The Rooted Pathways Program, initiated by First Peoples Fund, offers essential support to Native-led arts organizations, fostering their growth and stability. This funding empowers these organizations to thrive in their missions, providing unrestricted operating support and participation in a Learning Cohort. Eligible applicants include Native nonprofits and collectives with budgets under $500,000, and the program aims to uplift artists from U.S. federally recognized tribes. This initiative is part of the Wallace Foundation's broader commitment to enhancing well-being in the arts.

The ILSG Student Research Fund, established by the Institute on Lake Superior Geology, aims to support student research in the Lake Superior region with annual awards totaling US$1,000. This initiative encourages the presentation of research findings at ILSG meetings, fostering academic growth and collaboration. The fund originated from a US$10,000 contribution by the Board of Directors in 2005, with ongoing financial support from annual meeting proceeds, ensuring its sustainability for future student researchers.

The American Academy of Optometry Foundation is inviting applications for the 2025-26 Allison Summers Pediatric Pilot Grant. This $10,000 grant aims to support mid-career optometrists in conducting pilot research that fosters new collaborations and innovative projects in pediatric optometry. Eligible candidates must be Fellows of the Academy and demonstrate a commitment to advancing pediatric research. The deadline for submitting the Letter of Intent is August 4, 2025.

The AABE National & Regional Scholarship, awarded by the American Association of Blacks in Energy, supports students pursuing careers in the energy sector. Annually, over $350,000 is distributed through multiple scholarships, including six regional awards of $3,000 and one national award of $5,000, renewable for up to four years. Applicants must maintain a GPA of 3.0 and demonstrate commitment to energy-related fields, promoting diversity and equity in education.

The Local Filmmaker Fund by the People's Media Fund supports filmmakers in Greater Philadelphia, enhancing their skills and film projects through a 12-month cohort program. This initiative prioritizes under-resourced filmmakers committed to social justice, offering funding up to $400,000. Eligible applicants must be at least 18 years old, live in designated areas, and either direct their film or secure fiscal sponsorship. The program fosters community storytelling and aims to amplify diverse voices in media.

The Hans-Olaf Pfannkuch & E. Calvin Alexander, Jr. Hydrogeology Field Camp Award, provided by the Minnesota Ground Water Association Foundation, offers two $1,500 scholarships for the summer of 2025. This award aims to support students enrolled in hydrogeology or related fields by alleviating educational costs associated with field camps. It seeks to foster a diverse learning environment and build a stronger community of hydrogeology professionals through shared life experiences.

The Gil Gabanski Student Scholarship, provided by the MGWA Foundation, offers multiple $2,000 awards for undergraduate and graduate students studying at accredited institutions in Minnesota and nearby areas. This scholarship aims to ease educational expenses and foster interest in groundwater-related careers, including hydrogeology and groundwater geology. It also promotes mentorship opportunities for early-career students, honoring Gil Gabanski's legacy in the geosciences community.

The John C. Lasko Foundation Trust Grant supports the construction of worship spaces across the nation, requiring churches to fund at least 50% of the project costs. Established by John C. Lasko, the foundation aims to build enduring churches that adhere to its mission. Grants are specifically for sanctuary construction, and applicants must own the land designated for the church. Notably, funds are not available for debt repayment or non-sanctuary areas.

The Kenneth Rainin Foundation seeks to promote innovative research in Inflammatory Bowel Disease (IBD) by encouraging diverse perspectives from early career investigators and those underrepresented in science. The Innovator Awards do not require preliminary data and are evaluated based on the potential for innovation and scientific merit. Eligible researchers must hold advanced degrees and can apply for funding through their home institutions, fostering groundbreaking ideas that can transform IBD treatment and prevention.