Best Grants for Grassroots Organizations in South Dakota

Pre-clinical Investigation of anti-TFPI-mediated Rebalancing Mechanisms in Non-Hemophilic Bleeding Disorders 

There remains a scientific gap in understanding of the role of anti-TFP Imediated hemostatic rebalancing in the context of inherited or non-hemophilic bleeding disorders. This competitive grant program encourages competitive submissions focsed on generating preclinical/foundational data exploring the therapeutic potential and mechanisms of TFPI modulation in bleeding disorders other than hemophilia.

Geographic Scope

Brazil, China, Europe, Israel, Japan, Saudi Arabia, South Korea, Turkey, USA

Funding Range and Project Length

Individual projects requesting up to $50,000 USD will be considered.

Request for study drug or compound is allowed (max $50,000 USD), additionally to the study project costs.

Maximum project length is 1 year.

The Shubert Foundation is the largest funder in the U.S. providing unrestricted grants to not-for-profit theatres and dance companies. It focuses on supporting professional dance organizations that demonstrate artistic activity, community service, and fiscal responsibility. The foundation emphasizes equity, diversity, and inclusion in its grant-making process, with a commitment to evaluating organizations based on their impact and contributions to the field. Funding is limited to U.S. organizations with established track records.

The Indian Land Tenure Foundation (ILTF) offers a Cultural Awareness Grant aimed at revitalizing the cultural and spiritual values related to Indian land. This initiative supports American Indian nations in enhancing their ties to the land, which is vital for traditional practices and beliefs. Eligible entities include tribal governments and 501(c)(3) nonprofit organizations. Ineligible activities encompass advocacy efforts, land purchases, and direct funding to individuals, ensuring resources focus on community-centered cultural preservation.

The Shubert Foundation offers grants to not-for-profit professional theatre and dance companies in the U.S., focusing on general operating support rather than project-specific funding. Eligible organizations must have 501(c)(3) status and a proven track record in artistic and administrative excellence. Evaluations consider artistic achievement, community service, fiscal responsibility, and commitment to diversity and inclusion, ensuring support reaches those making significant contributions to the arts community.

The James McKeen Cattell Sabbatical Grant, provided by the James McKeen Cattell Fund, offers supplementary financial support for psychologists' sabbaticals. This grant is designed for faculty members at U.S. and Canadian institutions who meet specific eligibility criteria, including tenure status and recent leave history. The maximum award is capped at $40,000 or half the recipient's salary, ensuring that recipients can extend their research time effectively.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The Scheidel Foundation offers Integrative Cancer Care Grants aimed at enhancing the quality of life for individuals living with cancer. This initiative supports organizations that promote awareness and adoption of integrative practices, targeting both the medical community and patients. The Foundation seeks proposals that foster long-term solutions and innovative programs, focusing on evidence-based information and practices. Grants are available through a selective process, emphasizing transformative impacts in the field.

The Alexandra Armstrong Innovation Grant, offered by the Foundation for Financial Planning, recognizes nonprofits that demonstrate exceptional creativity and impact in pro bono financial planning services. Established in honor of Alexandra Armstrong, a dedicated advocate for community service and financial planning, this grant aims to expand access to vital financial advice for underserved populations. Eligible organizations can apply annually to receive funding that supports innovative programs designed to enhance financial well-being.

About She+ Foundation The SHE+ Foundation, formerly known as The Patty Brisben Foundation for Women’s Sexual Health, was founded by Patty Brisben in 2005 after she recognized the profound need for a movement to address the too often ignored aspects of women’s sexual health. The SHE+ Foundation is committed to changing the narrative. We are here to advocate, educate, and fund research that advances the understanding and treatment for women’s sexual health, and improves quality of life for all women.Mission: Our mission is to advance women's sexual health and well-being through groundbreaking research, comprehensive education, and unwavering support. We strive to eradicate stigma, empower women with knowledge, and ensure equitable access to quality healthcare for all, regardless of socioeconomic status, race, or geography.About She+ Foundation GrantWe fund a wide range of projects that align with our mission to advance women's sexual health. This includes:

• Research Studies: Clinical and academic research aimed at understanding and improving women's sexual health.
• Educational Programs: Initiatives that provide education and awareness on topics related to women's sexual health.
• Community Outreach: Programs that engage and support local communities, offering resources and support for women's sexual health.
• Innovative Treatments: Development and implementation of new treatments and therapies for women's sexual health issues.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

Extreme Terrain’s Clean Trail Initiative Program aims to enhance trail integrity by supporting groups in the U.S. with grants for projects like trail clean-up, restoration, and expansion. Eligible applicants include Wrangler and 4x4 clubs, environmental organizations, and those managing public or private trails. The initiative emphasizes responsible off-roading while encouraging volunteers to engage in improving our natural landscapes. This program fosters community involvement and promotes sustainable practices in outdoor activities.

The Community Partnership Grant, administered by the Sons of Norway Foundation, offers up to $5,000 for projects that promote and preserve Norwegian culture and heritage. Open to individuals and groups from Norway and the U.S., the grant encourages initiatives that reflect the foundation's core values such as lifelong learning and community generosity. Applications must be submitted online in English and should demonstrate a commitment to celebrating Norwegian cultural traditions.

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

The Visionary Prize for Women’s Economic Empowerment, established in 2022 by Visionary Women and the Hostetler/Wrigley Foundation, honors a visionary woman leader of a nonprofit focused on advancing women's economic empowerment in the U.S. This prestigious award provides $100,000 in unrestricted funds to support the recipient's agency and its initiatives. Eligible candidates must have a minimum of four years of operation and an annual budget exceeding $500,000, actively working towards women's economic advancement.

The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.

The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.

The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.

The CATCH Grant, offered by USA Football, provides essential support to organizations facing critical challenges such as natural disasters or theft. This program aims to enhance the athlete experience by assisting with unexpected hardships affecting operations. Eligible organizations enrolled with USA Football can apply for varying award amounts based on their specific circumstances. For more information, refer to the FAQs available on the USA Football website.

Excellence in Medicine Awards

The AMA Foundation’s Excellence in Medicine Awards honor physicians and medical advocates who exemplify the highest values of the profession—volunteerism, community engagement, leadership, and service to underserved populations. Each recipient is recognized at a ceremony during the AMA Annual Meeting in Chicago and receives a $2,500 grant honorarium directed to a nonprofit health organization of their choice. Since 2005, more than 100 honorees have been celebrated through this program, with over $250,000 awarded to strengthen community health and advance equitable care nationwide. 

Jack B. McConnell, MD, Award for Excellence in Volunteerism

Honors senior physicians (55+ years old) who are committed to providing medical care to those without access to health care in the U.S.

The 14th Quartermaster/Operation Desert Storm Scholarship Fund, established by The Pittsburgh Foundation, supports Westmoreland County High School students pursuing military careers or whose parents are veterans. Eligible applicants must maintain a minimum GPA of 3.0 and articulate the impact of military service on their family dynamics. This scholarship does not consider financial need, but applicants are encouraged to provide financial information. It aims to foster academic growth and honor military service within the community.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

American Advertising Federation Pittsburgh Scholarship Fund

The Pittsburgh Advertising Federation Scholarship Fund was created to provide scholarships for undergraduate students who are pursuing a curriculum suited for careers in communication, marketing or advertising.

Award Type: Single Year. Previous recipients are encouraged to re-apply in consecutive years.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

Carnegie-Collier Rotary Scholarship Fund

The Carnegie-Collier Rotary Scholarship Fund was created at The Pittsburgh Foundation to provide scholarships to students entering post-secondary education programs from the Carnegie-Collier area.

Award Type: Single Year Award. Previous recipients are encouraged to re-apply in consecutive years provided they maintain a cumulative GPA of 2.5.

The DEWALT Trades Scholarship, offered by the SkillPointe Foundation, supports individuals pursuing education in high-demand trade fields such as construction, manufacturing, and mechanics. This scholarship covers essential costs like tuition, tools, and transportation. Open to applicants 17 years and older who are enrolled in accredited programs, it aims to bridge the skills gap in the U.S. and create opportunities for a diverse range of students seeking to enhance their careers.

The Andrew Lloyd Webber Initiative: University Scholarships, by the American Theatre Wing, supports high school seniors from underrepresented backgrounds with a $10,000 annual scholarship for four years. This initiative addresses financial barriers for students pursuing theatre disciplines, including performance, design, and administration. Scholars are matched with mentors and gain exclusive opportunities such as master classes. This program aims to cultivate a diverse future in theatre, ensuring that talent is nurtured and accessible to all.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

Charles J. Lieberth Scholarship Fund

The Charles J. Lieberth Scholarship Fund was created at The Pittsburgh Foundation to provide scholarships for City of Pittsburgh employees completing an undergraduate or graduate program in government or public service.

Award Type: Single-Year Award

The George L. Mosse Prize, awarded by the American Historical Association, honors exceptional works in European intellectual and cultural history since 1500. This prestigious award, with a prize amount of $1,000, recognizes scholarly distinction and originality. Eligible submissions include books published in 2024, with a focus on research accuracy and literary merit. Winners will be announced on the AHA website in October 2025 and celebrated at the January 2026 AHA annual meeting in Chicago.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

Unknown Donor Scholarship Fund

The Unknown Donor Scholarship Fund was established at The Pittsburgh Foundation to provide scholarships to graduating high school seniors of Pittsburgh Public Schools with a preference for applicants who have faced social, economic, or educational barriers due to systemic gender inequity.

Award Type: Single Year Award.