Best Operating Grants for Nonprofits in South Dakota

The A Woman’s Work Founders Scholarship, provided by the Longmont Community Foundation, supports women in the Longmont and St. Vrain Valley area who demonstrate financial need and a commitment to their education. With awards ranging from $500 to $5,000, this scholarship prioritizes applicants who have shown resilience in overcoming challenges. By empowering women, the scholarship aims to foster individual achievement and strengthen the community, creating pathways to sustainable futures.

The Braly Trade / Vocational Scholarship, offered by the Longmont Community Foundation, supports individuals over 21 pursuing a trade or vocational education. This one-time award of $5,000 is allocated for tuition, fees, books, and other educational expenses. The scholarship honors the Braly family’s legacy in trades and aims to empower recipients to positively impact their communities. Applicants must be high school graduates or hold a GED and plan to attend an accredited institution in the U.S.

The Undiagnosed Diseases Network (UDN) aims to enhance diagnostic excellence through multiple clinical Networks of Diagnostic Excellence (NODEs). These NODEs will operate as regional networks, leveraging partnerships with various healthcare facilities to provide participant-centered evaluations for complex conditions. They will also engage in research and training to improve diagnostic tools and strategies. This initiative encourages collaboration and aims to improve the overall experience and access for participants in need of specialized care.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

The OJJDP FY 2026 Community and Schools Youth Drug Prevention Program aims to combat youth substance use through comprehensive prevention strategies. This initiative invites applications from states, local governments, and nonprofit organizations to develop programs that educate and support youth in schools and community settings. By fostering collaboration with law enforcement and community coalitions, the program seeks to build capacity and implement effective interventions to protect the well-being of American youth.

The BJA FY 2026 National Center for Veterans Justice aims to enhance support for veterans in the criminal justice system. By providing specialized training and resources to law enforcement and service providers, the center will address critical gaps in veteran identification and coordination among agencies. This initiative seeks to improve outcomes for veterans experiencing issues like PTSD and military sexual trauma, ultimately strengthening public safety and ensuring effective responses to their unique needs.

The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.

The Project Lifesaver International Grant by the Alzheimer’s Foundation of America aims to fund programs that prevent wandering and enhance public safety for individuals with dementia-related illnesses. This grant supports public safety agencies that are members of AFA and Project Lifesaver International, focusing on essential training, supplies, and community outreach. Grants are awarded biannually, promoting better care and safety for individuals living with Alzheimer’s disease and related dementias.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Sharon Bradley Johnson & Carl Johnson Scholarship

This scholarship has been made possible by the generosity of Sharon Bradley Johnson and Carl Johnson, who established the Sharon Bradley Johnson and Carl Johnson Scholarship of the Community Foundation for Mason County.

There is a high demand for Board Certified Behavior Analysts. Sharon Bradley Johnson and Carl Johnson, retired CMU professors who live in our community, are passionate about this work. They established a scholarship for students entering the Board Certified Behavior Analyst field of study and are helping educate youth in our area about this career path.

The Alliance for Innovation on Maternal Health (AIM) program aims to enhance maternal health outcomes by providing technical assistance across all U.S. states and territories. This initiative focuses on implementing best practices to improve safety during childbirth, ultimately saving lives. By supporting jurisdictions and birthing facilities involved in AIM, the program seeks to promote quality improvements in maternal health care, ensuring safer births and better health for mothers and infants.

The Radiation Oncology Institute (ROI) Innovation Awards, offered by the American Society for Radiation Oncology, aim to accelerate innovative ideas in radiation therapy. Currently accepting applications for the 2026 awards, the program focuses on optimizing the combination of radiation therapy and immunotherapy to enhance cancer treatment outcomes. By supporting practical research, ROI strives to transform clinical practices and improve patient care in the fight against cancer.

The National Institute on Aging (NIA) is inviting applications for the Alzheimer's Drug-Development Program (U01 Clinical Trial Optional). This initiative seeks to support pre-clinical and early-stage clinical development of innovative drug candidates aimed at preventing Alzheimer's disease or treating its symptoms. The program encourages collaboration among researchers and aims to enhance the therapeutic pipeline for AD through targeted approaches. This notice allows potential applicants time to prepare robust projects.

The Capacity Building for Global, Regional, and National Immunization Programs aims to enhance immunization efforts in key countries, focusing on the prevention and control of vaccine-preventable diseases like polio and measles. By strengthening immunization services and surveillance systems, the program will better address emerging health threats and reach under-immunized populations. Additionally, it will support sustainable practices through National Immunization Technical Advisory Groups and manage the National Stop Transmission of Polio program in Pakistan.

The CDC has announced funding for FY 2027 to enhance state capacity in alcohol epidemiology and prevent excessive alcohol use through the NOFO CDC-RFA-DP-27-0072. This initiative aims to equip states with essential tools and knowledge for effective public health measures against excessive alcohol use, a major preventable cause of death in the U.S. The program will also provide expert technical assistance and training on effective prevention strategies over a 5-year performance period.

Vanguard Resident FellowshipThe American Psychiatric Association has participated in the Minority Fellowship Program (MFP) since 1973. The program goals are to advance the quality of mental and substance use disorder prevention and treatment services and improve mental health care outcomes for all. The program seeks to increase the number and quality of psychiatrists who teach, administer services, conduct research, and provide direct mental and/or substance use disorder services to our Nation’s communities, and to treat and serve populations with higher prevalence of behavioral health challenges and conditions more effectively.Program Benefits: 

• Funding to support your own innovative and creative Capstone Project
• Monthly virtual professional development sessions
• Gain access to employment opportunities through a virtual job fair
• Gain an understanding of gaps in mental health care through the LEAD Institute curriculum
• Receive mentorship from leaders in psychiatry through the Advocate & Protégé Program
• Attend the Learning Lab, Fall Mental Health Summit, and Spring Leadership Summit, with the goal of enhancing your leadership skills in psychiatry by advancing your understanding of mental health inequities
• Attend the APA Annual Meeting with the opportunity to present a poster or oral presentation of your Capstone Project
• Gain understanding of APA Governance through service on an APA Council, committee or work group
• Receive access to a lifetime network of psychiatrists
• Establish long term relationships with resident fellows with similar career interests and goals

Community Diversity FellowshipThe Community Diversity Fellowship is a unique opportunity for psychiatry residents from diverse backgrounds and residents who are committed to serving minority and vulnerable populations. The fellowship provides professional development, training, mentorship, and a field placement component (up to 15 hours per month) designed to add exponential impact in the delivery of culturally competent psychiatric care across hard to reach and traditionally underrepresented communities. These populations include—but are not limited to—American Indians/Native Alaskans, Asian Americans/Native Hawaiians/Native Pacific Islanders, Blacks/African Americans, Hispanics/Latinos, LGBTQ, and religious minorities.Program Benefits:

• Attend one APA Annual Meeting
• Attend one Fellowship Forum
• Develop leadership skills in the field of psychiatry and advance understanding of the life experiences of racial ethnic minority communities
• Gain hands on experience through field placement in a traditional underrepresented community mental health setting (up to 15 hours per month)
• Gain an understanding of APA/APAF Governance through service on an APA Council, Committee, or APAF initiative 
• Cultivate a professional network with psychiatrists interested in minority mental health and services through exclusive events through engagements with APA leaders.
  • Establish relationships and peer-mentorship with a diverse group of resident fellows with similar career interests and goals

American Headache Society

The American Headache Society (AHS) is a professional society of healthcare providers dedicated to the study and treatment of headache and face pain. The Mission of the AHS is to improve the lives of people impacted by migraine and other headache disorders. AHS advocates for those impacted by headache and the headache field, to meet our core objectives. AHS provides educational courses, scientific meetings, a journal, research support, career development opportunities, Special Interest Groups, advocacy training, and a professional community. The AHS strives to meet its objectives while fostering an inclusive sense of belonging and community.

Headache & Migraine Competitive Grant Program

The Headache & Migraine Competitive Grant Program stands at the forefront of advancing headache medicine by funding groundbreaking quality improvement initiatives. This highly competitive grant program, offered through the collaboration between the American Headache Society and Pfizer, supports projects that have the potential to reshape the field by creating widely applicable tools and driving measurable improvements in patient care. 

Adult Population  RFP (Quality Improvement Solutions for the Diagnosis and Management of Migraine and Headache Disorder)

Seeking projects that drive meaningful impact in headache care through advancements in safety, clinical effectiveness, timely diagnosis, and equitable, patient-centered treatment. Submissions should feature bold, practical solutions in primary care and non-headache specialty settings, supporting adult populations with scalable, real-world innovations. 

American Headache Society

The American Headache Society (AHS) is a professional society of healthcare providers dedicated to the study and treatment of headache and face pain. The Mission of the AHS is to improve the lives of people impacted by migraine and other headache disorders. AHS advocates for those impacted by headache and the headache field, to meet our core objectives. AHS provides educational courses, scientific meetings, a journal, research support, career development opportunities, Special Interest Groups, advocacy training, and a professional community. The AHS strives to meet its objectives while fostering an inclusive sense of belonging and community.

AHS Investigator-Initiated Research Awards

Empowering Innovation in Headache Research

The American Headache Society (AHS) Investigator-Initiated Research Awards support AHS members conducting pre-clinical and clinical research in headache and migraine. With a focus on early-career investigators, the program funds investigator-driven projects that advance scientific understanding and improve patient care.

Projects should contribute to the core goal of the AHS – improving the lives of people impacted by migraine and other headache disorders. 

Funding may be used for:

• Investigator effort (limited to 25% of the budget for PI salary support).
• Experimental costs, data collection, supplies, and statistical analysis.
• Other research-related expenses as appropriately justifie

Friends of NRA

Friends of NRA is the National Rifle Association’s premier fundraising program, supporting the future of shooting sports. Since day one, Friends of NRA has been a 100% grassroots effort fueled by a united front to secure the Second Amendment and raise money for the shooting sports.

Committee volunteers are appointed to State Fund Committees to make recommendations for local grant funding in areas such as youth education, women-focused clinics, law enforcement training, hunter safety, range improvement, firearms and marksmanship training and safety. Recognizing the impact American youth has on the future of the shooting sports, State Fund Committees frequently recommend grants for youth programs, allocating the most significant portion of monies to this vital area.

Grant awards fund activities and support programs in the United States to promote firearms and hunting safety, to enhance marksmanship skills of those in the shooting sports, and to educate the public about firearms in their historic, technological and artistic context.

Friends of NRA: Capital Improvement Grants

Any request to support a project that seeks to improve a facility is considered a capital improvement. This includes, but is not limited to:

• Range improvements
• Berm improvements
• Clubhouse/Classroom facility improvements
• Shelter structures/covered firing lines/pavilions
• Road improvements
• Commercial-grade trap machines (see section regarding trap machines, below)
• Any other permanent improvement to an organization’s property or facility

The Grant Program considers requests for certain trap machines to be a capital improvement to the facility. Specifically, requests for commercial grade trap machines that have a capacity of 300 clays and up.

American Academy of Family Physicians Foundation

The AAFP Foundation focuses on improving health for everyone, and your support makes an immediate impact on the good work we do—from leadership development and education scholarships to funding social and health care services.

The AAFP Foundation strives to create a sense of belonging through an inclusive environment that embraces the family medicine community by recognizing individual uniqueness and contributions to family medicine.

Richard D. Feldman, M.D. Student and Resident Essay Contest

Each year, the Center for the History of Family Medicine (CHFM) sponsors a contest to encourage medical students and family medicine residents to write scholarly essays relevant to the history of family medicine in the United States. The first-place winner will receive $2,000 and the second-place winner will receive a $1,000 award.

We encourage all to apply and are committed to developing scholarly essays relevant to the history of Family Medicine in the United States by medical students and residents who reflect the rich diversity of the specialty and the patients served.

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

The FY26 Breast Cancer Research Program's Breakthrough Award supports transformative research aimed at significant advancements in breast cancer treatment. This award offers various funding levels, including Population Science Studies, allowing for innovative approaches that can lead to clinical applications. Each application must align with overarching BCRP challenges, ensuring a focus on impactful research. The program acknowledges both individual and collaborative Principal Investigators, emphasizing the importance of timely submissions to avoid administrative issues.

The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) program is designed to enhance research on muscular dystrophy through a collaborative, center-based approach. By fostering interdisciplinary projects and providing essential training for emerging scientists, the MDSRCs aim to drive innovation in both basic and clinical research. Engaging patient and advocacy communities is a key component, ensuring research is patient-centered and informed by real-world needs. This initiative is supported by various legislative authorities.

The National Institutes of Health is funding a groundbreaking project to enhance our understanding of Type 1 diabetes (T1D) through multimodal AI. This initiative aims to integrate diverse datasets to explore the interactions of biological processes in T1D development. By leveraging advanced AI models, the research will uncover critical insights, identify biomarkers, and pave the way for personalized medicine approaches, ultimately improving prevention and treatment strategies for this complex disease.

About

The Community Foundation of Central Georgia was founded in 1993 by a group of citizens interested in encouraging philanthropy and strengthening communities.

The Foundation provides donors a simple, powerful, and highly personal approach to giving. Through their funds, CFCG donors support the causes and organizations that they care about, which enhances the quality of life for the people of Central Georgia.

Our vision is a Central Georgia where philanthropy thrives, communities are strong, and citizens work toward common goals.

Al Lucas Memorial Scholarship Fund

Albert James “Big Luke” Lucas was born September 1, 1978, to David E. and Elaine H. Lucas. He passed away on April 10, 2005, from a spinal cord injury he suffered during a Los Angeles Avengers arena football game. He was married to De’Shonda, and had a daughter, Mariah.

Al was a native of Macon, Georgia, graduating from Northeast High School in 1996. Following graduation, he attended Troy State University on a full athletic scholarship, and shined as a defensive lineman for the Trojans. Throughout college Al studied hard and cherished his time on the field and in 2000 was awarded the distinguished Buck Buchanan Award as the top defensive player in Division 1-AA. He was also an outstanding member of Omega Psi Phi Fraternity, Inc. He graduated in 2000 with a Bachelor of Science degree in Criminal Justice. Al went on to join the National Football League, signing as a free agent with the Pittsburgh Steelers and later playing for the Carolina Panthers. Later he joined the Arena Football League, playing for the Tampa Bay Storm, and finally the Los Angeles Avengers.

Al was a strong athlete with a heart of gold who believed in giving back to the community that supported him over the years. He especially loved working with children and served as a substitute teacher and coach at Northeast High School during the off-season. He was a member of Steward Chapel A.M.E. Church where he first learned the responsibility and power of tithing.

Al Lucas exemplified the characteristics of a scholar-athlete. He loved athletics, but knew his studies came first. He served his community and the Lord. He expected the best of himself and others. He excelled on the football field and in life. Recipients of the Al Lucas Memorial Scholarship will reflect Al’s ideals and carry on his legacy of excellence.

Purpose

• To honor the memory of Al Lucas by providing college scholarships to scholar athletes in Al’s hometown of Macon, Georgia.

Awards

• Amount of Award: $1,000, non-renewable.
• Number of Awards: 7 per year. Two awards will be given to scholar-athletes graduating from Northeast High School, Al’s alma mater. One winner shall be female and one male. The other five awards will be given to student-athletes from each of the other five Bibb County public high schools. One will be awarded at each school.

The Clifton-Whitehead Scholarship Fund, established by Edward S. Whitehead, Jr. in honor of his relatives, supports deserving students in Middle Georgia, particularly in Bibb County. This fund aims to assist students of good character facing financial challenges in obtaining a college education. Annually, approximately 12 awards of around $1,000 are granted. Eligible recipients must maintain a minimum GPA and can renew the scholarship for up to four years, provided they meet the established criteria.

The Christine Riggins Shepherd Scholarship Fund, established by the Community Foundation of Central Georgia, aims to support students from Lamar, Pike, Monroe, Upson, or Spalding counties attending Georgia Southern University. With at least one award given annually, the scholarship amount varies. Recipients can renew their scholarships for up to four years if they maintain eligibility. Preference is given to applicants from Lamar County, promoting educational opportunities for local students.