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Best Operating Grants for Nonprofits in South Dakota

Find the perfect Operating grants for nonprofits in South Dakota on Instrumentl. 9,000+ Operating grants for nonprofits in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,206 Results based on applied filters

Foist Family Perseverance Scholarship Fund

The Berkshire Taconic Community Foundation
Private
United States
Unspecified amount
The Foist Family Perseverance Scholarship Fund, established by the Berkshire Taconic Community Foundation, aims to support adult learners and graduating high school seniors from Berkshire County pursuing careers in healthcare and sciences. With a focus on clinical and research fields such as nursing and occupational therapy, this fund seeks to empower individuals in their educational and professional journeys, promoting economic mobility and high quality of life in the community.
Education - Higher Education Health & Medicine Career / College Preparation

The XENO PRIZE for Artists’ Books

Franklin Furnace Fund
Private
United States
US $5,000
The XENO PRIZE for Artists’ Books offers a $5000 grant to support the publication of an artist's book addressing the themes of book banning and burning. Open to independent artists in the U.S., the prize will be awarded based on submissions to be accepted starting March 1, 2025. A minimum of 100 copies must be printed, with winners announced in September 2025. This initiative aims to highlight and preserve avant-garde art forms and their cultural significance.
Art & Culture Art Education Cross-Cultural Understanding & Exchanges +1 more

EDA FY25 Disaster Supplemental

US Department of Commerce: Economic Development Administration (EDA)
Federal Government
United States
Up to US $50,000,000
The EDA FY25 Disaster Supplemental program provides critical funding to support communities recovering from severe economic distress caused by natural disasters in 2023 and 2024. With no submission deadlines for Readiness and Implementation Paths, and a specific deadline for Industry Transformation applications, this initiative aims to enhance community resilience and improve economic trajectories through strategic projects that engage local stakeholders and private industries.
Economic Services & Development Disaster Preparedness Disaster Relief / Humanitarian Aid +1 more

United Airlines Trust Fund Grant

Siouxland Community Foundation
Private
Burt County, Nebraska, Cedar County, Nebraska +17 more
Up to US $2,500
The United Airlines Trust Fund Grant, established by United Airlines in recognition of Siouxland's response to the Flight 232 incident, supports community projects and scholarships. Two-thirds of the fund's annual income is dedicated to scholarships, while the remaining third is available for grants that enhance social services, public education, and crisis response capabilities within the Siouxland area. Grant amounts typically do not exceed $2,500, with funding decisions based on project merit and community impact.
Community / Public Safety Disaster Relief / Humanitarian Aid Emergency Medical Care & Services

Domtar Community Investment Grant

Domtar
Corporate
United States
Unspecified amount
The Domtar Community Investment Grant supports nonprofits and charities in areas where the company operates, focusing on education, environmental sustainability, and community humanitarian needs. Eligible organizations include charitable groups, while ineligible entities encompass individuals, discriminatory organizations, and political causes. Applications are accepted online from January 1 to November 30, with reviews conducted bi-monthly. This initiative aims to create meaningful connections between charitable efforts and the social benefits derived from Domtar's business operations.
Education Environment Disaster Relief / Humanitarian Aid +1 more

Owen Family Foundation Grant

Louis and Peaches Owen Family Foundation
Private
United States
Unspecified amount
The Owen Family Foundation Grant supports charitable organizations primarily in East Texas and the Minneapolis/St. Paul area, focusing on health, education, human services, and religious initiatives. Organizations must have a 501(c)(3) status and past funding is required for Twin Cities applicants. The foundation is committed to promoting philanthropy and ensuring access to funding for eligible charities, while maintaining a non-discriminatory policy.
Health & Medicine Education Human & Social Services +2 more

Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Small Business Transition Grant for New Entrepreneurs supports new investigators transitioning into entrepreneurship, particularly in small business settings. This NIH initiative aims to bolster their development as Program Directors or Principal Investigators while fostering their research and entrepreneurial skills. By promoting training and mentorship, this grant encourages the growth of promising technologies that align with NIH's mission to enhance health and save lives. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.
Science Entrepreneurship Emerging Technology Development +1 more

Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Small Business Transition Grant for New Entrepreneurs, funded by the NIH, supports new investigators in entrepreneurship. This grant aims to enhance the entrepreneurial skills of researchers while facilitating their research and development efforts in small businesses. It encourages the employment of Program Directors/Principal Investigators (PDs/PIs) who possess strong scientific expertise but limited entrepreneurial experience, fostering innovation aligned with NIH's mission to improve health and save lives.
Science Entrepreneurship Emerging Technology Development +1 more

ISF Narrative Film Grant

Islamic Scholarship Fund
Association/Society
United States
More than US $20,000
The ISF Narrative Film Grant, established by the Islamic Scholarship Fund, supports emerging Muslim filmmakers by providing funding for narrative films in production or post-production stages. With a focus on compelling storytelling and positive portrayals of the Muslim community, the grant offers mentorship and networking opportunities to enhance the filmmakers' projects. Since its inception in 2014, it has awarded $625,000 to over 111 filmmakers, promoting diverse narratives that resonate with audiences.
Film Islam & Islamic Culture Social Justice / Human Rights

ISF Policy Scholarship Program

Islamic Scholarship Fund
Association/Society
United States
US $3,000 - US $5,000
The ISF Policy Scholarship Program offers financial assistance ranging from $3,000 to $5,000 for scholars dedicated to improving Muslim representation in media and government. Since 2009, ISF has awarded 747 scholarships to students in fields that influence public policy and opinion, such as political science and international relations. With a commitment to mentorship and real-world experience, ISF aims to foster positive narratives about American Muslims and encourage their involvement in the policymaking process.
Sociology Anthropology & Cultural Studies Political Science +2 more

Graduate Education Fund: Specialty Field Scholarships - Graduate Education Scholarships

American Australian Association
Private
Australia, United States
Up to US $40,000
The Graduate Education Fund offers scholarships for American and Australian graduate students to study in each other's countries. With deadlines in March and September, eligible applicants can receive up to $40,000 to support their education in fields like Science and Technology. This initiative fosters cross-cultural academic collaboration and requires applicants to be enrolled in accredited programs, ensuring a high standard of educational exchange.
Education - Higher Education Cross-Cultural Understanding & Exchanges Sustainability +4 more

The Edward M. Nagel Endowed Scholarship

United Negro College Fund Inc
Private
United States
Up to US $5,000
The Edward M. Nagel Endowed Scholarship, provided by the United Negro College Fund, supports undergraduate students pursuing business-related studies. With a focus on academic excellence and leadership, applicants must maintain a GPA of 3.0 or higher and demonstrate financial need. This scholarship plays a vital role in promoting education for future leaders, reflecting UNCF's mission to empower minority students for over seventy years.
Education - Higher Education Academic Scholarship Programs Economics +1 more

Damon Runyon-Scholars Program for Advancing Research and Knowledge

Damon Runyon Cancer Research Foundation
Private
United States
Up to US $61,000
The Damon Runyon Scholars Program for Advancing Research and Knowledge (SPARK) aims to empower exceptional college seniors and recent graduates to excel in cancer research. This year-long program provides hands-on training in research labs, mentorship from Damon Runyon scientists, and support for graduate school applications. SPARK particularly encourages applicants from underrepresented backgrounds, fostering inclusivity in science and preparing future leaders in the fight against cancer. Through SPARK, young talents gain the skills and networks needed for successful careers in biomedical research.
Biology Cancer / Oncology Medical Education & Professional Training

Martin Luther King Jr. (MLK) Corridor Community Grants

Keep America Beautiful (KAB)
Private
United States
US $5,000 - US $20,000
The Martin Luther King Jr. (MLK) Corridor Community Grants, provided by Keep America Beautiful, aim to empower communities to revitalize and beautify MLK corridors across the U.S. These grants support various projects, including murals, community gardens, and cleanup efforts, contributing to the initiative's goal of beautifying 25,000 communities by 2026. Eligible applicants include nonprofits, local governments, and community organizations, with a focus on sustainable impacts and local engagement.
Community Development & Revitalization Greening & Beautification Public / Community Art +1 more

Piñon Foundation Grant

Pinon Foundation
Private
United States
Unspecified amount
The Piñon Foundation Grant supports 501(c)(3) organizations and educational institutions focused on enhancing the education, health, and well-being of children and the elderly. Although it primarily funds initiatives in West Texas, the Dallas Fort Worth area, and Oklahoma City, it is open to proposals from other regions that can positively impact community growth. The foundation believes in the transformative power of education and health to foster community success and development.
Senior Services Human & Social Services Volunteerism & Philanthropy +1 more

Northeast Asia Council Japan Studies Grants - Seminars on Teaching about Japan

Association for Asian Studies
Association/Society
United States
Up to US $5,000
The Northeast Asia Council Japan Studies Grants support seminars that enhance knowledge of Japan and improve Japanese language pedagogy. With grants up to $5,000, these projects are aimed at educators and scholars, emphasizing the importance of teaching Japan in academic disciplines. Eligibility includes a detailed project proposal, budget, and current membership in AAS. Preference is given to new projects and those not recently funded by NEAC, ensuring a broad impact on Japanese studies in the U.S.
Anthropology & Cultural Studies Asian / Pacific Island Culture & Heritage Cross-Cultural Understanding & Exchanges

Northeast Asia Council Japan Studies Grants - Small Scholarly Conferences on Japanese Studies

Association for Asian Studies
Association/Society
United States
Up to US $5,000
The Northeast Asia Council Japan Studies Grants provide funding for small scholarly conferences on Japanese studies in the U.S. These grants, up to $5,000, support events that foster collaboration among scholars, focusing on cutting-edge research. Eligible applicants must be U.S. citizens or Japanese nationals and current AAS members. Priority is given to those securing matching funds and for projects not previously funded by NEAC. Ineligible costs include stipends for organizers and travel to unrelated seminars.
Anthropology & Cultural Studies Asian / Pacific Island Culture & Heritage Cross-Cultural Understanding & Exchanges

Robert Glenn Rapp Foundation Grants

Robert Glenn Rapp Foundation
Private
United States
Unspecified amount
The Robert Glenn Rapp Foundation, established in 1951 in Oklahoma, aims to support charitable organizations across the U.S., with a focus on education and local initiatives. Grants are awarded to qualified 501(C)(3) organizations, prioritizing projects that align with the foundation's mission in areas such as education, health, arts, and literacy. Interested applicants must submit a Letter of Inquiry before applying for funding, ensuring alignment with the foundation's priorities.
Art & Culture Education Wellness & Healthy Living +2 more

Scholarships for Conferences and Professional Development

Michigan Health Endowment Fund
Private
United States
Up to US $2,500
The Michigan Health Endowment Fund offers Scholarships for Conferences and Professional Development to support health-related events. These scholarships, up to $2,500 per person and $5,000 per organization, are available for current or past grantees and partners. Applications are accepted on a rolling basis, with a requirement to submit at least four weeks before the event. Priority is given to organizations that haven't received funding in the previous year, ensuring equitable access to professional development opportunities.
Health & Medicine Aging / Gerontology Food Access & Hunger

Sparklight/Cable One Charitable Giving Fund

Sparklight
Corporate
Ada County, Idaho, Adair County, Missouri +291 more
Unspecified amount
The Sparklight/Cable One Charitable Giving Fund supports local nonprofits and organizations focused on education, food insecurity, and community development. They prioritize impactful partnerships that strengthen communities. The fund welcomes various funding requests, including special projects and capital campaigns, while adhering to specific eligibility requirements such as tax-exempt status. However, they do not fund basic operating expenses, loans, or religious organizations for general support, ensuring that their contributions foster meaningful community growth.
Education Food Access & Hunger Community Development & Revitalization +2 more

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) (356927)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,400,000
This funding opportunity aims to advance mechanistic research for precision probiotic therapies. It invites R33 applications focused on characterizing individual differences in probiotic responses, identifying responder subgroups, and enhancing clinical outcomes. The goal is to develop strategies addressing barriers to effective probiotic use, accounting for human variability. Proposals should include innovative studies using animal models or human subjects, supported by preliminary data to test biological patterns and their effects on health outcomes.
Biology Microbiology Microbiomes

Progressive Multiplier Grants

Progressive Multiplier Fund
Private
United States
Unspecified amount
The Progressive Multiplier Grants support U.S. based nonprofits and subsidiaries focused on generating independent revenue through innovative projects. These grants aim to empower organizations working towards democracy, justice, and environmental restoration, fostering civic engagement and equality. By funding campaigns and civic mobilization, the program seeks to build sustained progressive power, avoiding direct service or public education initiatives. Interested parties can submit letters of inquiry on a rolling basis when funding aligns with grant criteria.
Environment Social Justice / Human Rights Governance & Democracy +1 more

ASPCA Fund to End Factory Farming Grant Program

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
Canada, United States
Up to US $75,000
The ASPCA Fund to End Factory Farming Grant Program aims to transform the U.S. food system by promoting humane practices and reducing reliance on factory farming. By funding eligible projects, the program seeks to improve animal welfare, support farmers, and enhance public health. Projects must include educational components to raise awareness about their impact. This initiative reflects ASPCA's commitment to ethical treatment of animals and fostering a culture of compassion and inclusion.
Farms & Farming Animal Welfare - General Agriculture

Wireless Family Fund

Music Movement
Association/Society
United States
US $1,500 - US $2,500
The Wireless Family Fund, supported by Music Movement, provides financial aid to families in the Wireless and Tech Industries, focusing on living expenses, medical bills, and educational support. Grants typically range from $1,500 to $2,500 and are available to families within the United States. Music Movement enriches the lives of individuals with Autism and other developmental differences through music-centric programs that enhance communication, social skills, and emotional expression.
Music Family Services Health & Medicine

Park Foundation Grants: Civic Participation

Park Foundation, Inc.
Private
United States
Unspecified amount
The Park Foundation Grants for Civic Participation aim to enhance democracy through active civic engagement. Focused on mobilizing voters and protecting their rights, this program supports grassroots organizations addressing social injustices. By fostering year-round involvement rather than just election-focused efforts, the foundation seeks to empower communities and ensure robust participation in the democratic process, ultimately contributing to a more equitable society.
Civic Engagement & Education Voting & Elections Social Justice / Human Rights

ARL Distinguished Postdoctoral Fellowships

The National Academies of Sciences, Engineering, and Medicine
Private
United States
Unspecified amount
The ARL Distinguished Postdoctoral Fellowships offer early career researchers a chance to engage in independent research aligned with the Army Research Laboratory's mission. Candidates should demonstrate exceptional scientific abilities and a potential for leadership, having addressed significant scientific or engineering challenges during their doctoral studies. Fellowships provide a stipend of $115,000 per year, along with health insurance and other benefits. Applicants must have completed their Ph.D. by October 1, 2025, and are required to undergo a Department of Defense clearance.
Engineering Computer Science & Engineering Energy +2 more

Damon Runyon Physician-Scientist Training Award

Damon Runyon Cancer Research Foundation
Private
United States
US $460,000
The Damon Runyon Physician-Scientist Training Award aims to address the shortage of physician-scientists by supporting U.S. Specialty Board eligible physicians in cancer research. This award provides funding for up to four years, enabling awardees to dedicate 80% of their time to research while maintaining clinical skills. The program seeks to eliminate financial barriers, allowing talented clinicians to transform into leading researchers capable of advancing cancer treatment and prevention.
Cancer / Oncology Biology Medical Education & Professional Training

Operating Grants for Nonprofits in South Dakota Highlights

Looking for operating grants for nonprofits in South Dakota?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in South Dakota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Operating grants for nonprofits in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Operating grants for nonprofits in South Dakota over $25K in average grant size

23 Operating grants for nonprofits in South Dakota over $50K in average grant size

23 Operating grants for nonprofits in South Dakota supporting general operating expenses

91 Operating grants for nonprofits in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

2,000+ Grants on Instrumentl focused on Community Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Operating Grants for Nonprofits in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538