Best Private Grants for Nonprofits in South Dakota

The Donald & Ruby Branson Foundation Grant aims to promote environmental, educational, and social progress in America. Established by the Branson family, it seeks to instill values of community involvement and charitable responsibility in future generations. The foundation primarily supports tax-exempt organizations under Section 501(c)(3) and emphasizes the importance of education and environmental stewardship, ensuring a cleaner and more attractive world for all.

The Washington Tree Fruit Research Commission is inviting research proposals aimed at apple crop protection, emphasizing organic practices and pollinator protection. Key areas of focus include the management of pests like Codling Moth and Fire Blight, testing new crop protection products, enhancing soil health, and developing efficient monitoring techniques. Collaboration among institutions is encouraged, and projects should aim for practical industry applications to ensure sustainable and profitable tree fruit production.

The Alcon Foundation focuses on enhancing global eye health through charitable monetary donations to 501(c)(3) organizations. Grants aim to support programs that improve access to quality eye care and education, fostering community development. Eligible applicants must demonstrate high-quality services, well-defined goals, and the ability to report outcomes. The foundation does not fund organizations that discriminate or are not 501(c)(3) compliant, ensuring that resources are directed towards impactful initiatives.

The Autism Care Today Grant provides vital funding assistance to families affected by Autism Spectrum Disorders across the United States. Since its inception in 2005, it has supported over 1,562 families with more than $1.85 million in grants. The program focuses on enhancing the quality of life for children with autism through various initiatives, including safety measures, assistive technologies, and behavioral therapy funding, while also addressing the unique challenges faced by military families.

The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.

The Raskob Foundation offers domestic grants to organizations located in the U.S. and its territories. Founded in 1945, this private, non-profit foundation focuses on supporting Catholic institutions. Eligible applicants must be tax-exempt 501(c)(3) organizations, listed in the P.J. Kenedy Official Catholic Directory. However, requests from individuals and certain projects, such as debt reduction or completed projects, are not accepted. The foundation emphasizes its commitment to philanthropy and community support.

The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.

The Bay Area Lyme Foundation's Emerging Leader Award supports innovative research in Lyme disease, offering two $150,000 grants to post-doctoral and early-career scientists. Applicants are encouraged to propose proof-of-concept projects that enhance diagnostics or therapeutics. The award seeks to attract talent and foster scientific leadership in biomedical sciences. Evaluation criteria include the potential for novel therapies, scientific rationale, and support from institutions. This opportunity is ideal for those new to tickborne disease research.

The Rapid Outcomes from Agricultural Research (ROAR) Grant Program, managed by the Foundation for Food and Agriculture Research (FFAR), provides urgent funding for research addressing unexpected threats to the food supply. This program supports diverse projects related to pest and pathogen outbreaks, facilitating quicker responses than traditional funding avenues. With grants up to $150,000, ROAR aims to enhance agricultural resilience by fostering collaborations among researchers, institutions, and organizations to combat emerging challenges in the food and agriculture sector.

The WAEF Scholarships, supported by the Washington Apple Education Foundation, offer over $1 million in educational awards to more than 300 students this year. These scholarships are primarily for individuals with ties to the tree fruit industry in Washington, with a special focus on the Danna Gebbers Guzman Memorial Scholarship, aimed at nursing students. Eligible recipients can use the funds at accredited institutions with nursing programs.

The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.

The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

The ASTR Selma Jeanne Cohen Conference Presentation Award supports scholars participating in plenary or working sessions at the ASTR conference. This award encourages exploration of the intersections between theatre and dance, providing funds for travel and hotel expenses. Eligible applicants include graduate students, independent scholars, and faculty members accepted to present at the 2025 conference. The award offers a $1000 honorarium and complimentary registration, promoting active engagement in ASTR's community.

This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.

The Peer Education Grant, offered by the Organization for Autism Research, aims to enhance autism acceptance among children by providing educational resources and funding for initiatives. Grants of up to $10,000 support school-wide projects, with smaller grants available for other activities. Eligible applicants include educators and community organization leaders focused on autism awareness, particularly in low-income areas. This initiative fosters inclusive relationships and understanding between children and their autistic peers.

The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The 2026 Innovation Grant by Alex’s Lemonade Stand Foundation aims to foster groundbreaking research in pediatric oncology. This grant provides crucial seed funding of up to $250,000 over two years to established researchers proposing innovative ideas that have the potential to significantly impact childhood cancer treatment. The program emphasizes clinical translation and encourages novel approaches that diverge from previous research directions, ensuring a focus on impactful solutions for children battling cancer.

The Celiac Disease Foundation offers the Jocelyn Silvester Rising Villus Student Research Award to encourage medical students and residents to pursue celiac disease research. This prestigious award provides a $5,000 stipend for a 10-week mentored research experience across North America, honoring Dr. Jocelyn Silvester's contributions to the field. Recipients must secure a mentor and maintain good standing in their academic programs, ensuring a commitment to advancing celiac disease research.

The Sherry Wagner-Henry Board Fellowship, initiated by the United States Institute for Theatre Technology (USITT), offers a unique opportunity for emerging leaders in the theatre and entertainment industry. This 12-18 month program connects Fellows with experienced board members to enhance their professional skills. Participants gain access to board resources, attend meetings, and receive support for conferences, all valued at approximately $3,000 to $3,500. Ideal for individuals with 2-5 years of experience, this Fellowship fosters growth and leadership in nonprofit governance.

The Pathway to Stop Diabetes Accelerator Award supports innovative early-career researchers tackling diabetes-related challenges. It offers flexible funding up to $325,000 annually for transformative research. Candidates must have independent faculty status and demonstrated productivity in diabetes research. The program aims to inspire groundbreaking discoveries by providing essential resources and mentorship, thereby improving the lives of those affected by diabetes. Nominations focus on translational research that bridges basic science with practical benefits for patients.

The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention for patients with RUNX1 familial platelet disorder (RUNX1-FPD). This program supports interdisciplinary research teams investigating the mechanisms of leukemogenesis and innovative treatment strategies. With funding of up to $430,000 per year, LEAP encourages projects focused on both understanding clonal evolution and developing novel therapeutic approaches. The initiative seeks to bridge critical knowledge gaps and provide urgent interventions for high-risk populations.

The CLRA Research Grant Program, led by the Children’s Leukemia Research Association, focuses on funding innovative research aimed at uncovering the causes of leukemia and improving treatment options. Grants totaling $30,000 are awarded to U.S.-based researchers, with the intention of advancing scientific understanding and ultimately finding a cure. The program has made significant contributions to the high cure rates for childhood leukemia, showcasing the importance of continued research in this field.

The Amit Gosalia Scholarship in Private Practice Audiology, funded by the American Academy of Audiology, offers two $1,500 scholarships to full-time audiology students (AuD, PhD) who demonstrate exceptional promise and have completed their first year of studies. Eligible candidates must be enrolled at a U.S. university for the Fall 2025 semester and cannot graduate in Spring/Summer 2025. This initiative aims to support future audiologists pursuing careers in private practice.

The Earthwatch Institute's Teach Earth Fellowship connects K-12 teachers with scientists through immersive research expeditions. Celebrating 50 years, this program empowers educators to inspire students with hands-on environmental science experiences. Teachers gain confidence, collaborate with peers, and develop impactful curricula. The fellowship includes workshops, networking opportunities, and resources to enhance environmental education in classrooms. Participants return with renewed purpose, ready to engage their communities in conservation efforts.